7YIN7J07X4 (BioDeep_00000396201)
PANOMIX_OTCML-2023
代谢物信息卡片
D-(+)-Trehalose dihydrate, from Saccharomyces cerevisiae, powder, BioReagent, suitable for cell culture, suitable for insect cell culture, >=99\\%
化学式: C12H26O13 (378.1373)
中文名称: D(+)-海藻糖二水合物, D-(+)-海藻糖 二水合物
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 94%
分子结构信息
SMILES: C(C1C(C(C(C(O1)OC2C(C(C(C(O2)CO)O)O)O)O)O)O)O.O.O
InChI: /m1../s1
描述信息
D-(+)-Trehalose dihydrate, isolated from Saccharomyces cerevisiae, can be used as a food ingredient and pharmaceutical excipient.
同义名列表
42 个代谢物同义名
D-(+)-Trehalose dihydrate, from Saccharomyces cerevisiae, powder, BioReagent, suitable for cell culture, suitable for insect cell culture, >=99\\%; 2-(hydroxymethyl)-6-[3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-tetrahydropyran-3,4,5-triol dihydrate;D-(+)-Trehalose dihydrate; (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxane-3,4,5-triol;dihydrate; (2R,2R,3S,3S,4S,4S,5R,5R,6R,6R)-6,6-Oxybis(2-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol) dihydrate; (2R,2R,3S,3S,4S,4S,5R,5R,6R,6R)-6,6-Oxybis(2-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol)dihydrate; Trehalose dihydrate; ?-d-Glucopyranosyl ?-d-glucopyranoside dihydrate (?,?-trehalose dihydrate); D-(+)-Trehalose dihydrate, from Saccharomyces cerevisiae, BioReagent, plant cell culture tested; D-(+)-Trehalose dihydrate (D-Trehalose dihydrate; alpha,alpha-Trehalose dihydrate); Trehalose, Pharmaceutical Secondary Standard; Certified Reference Material; D-(+)-Trehalose dihydrate, from Saccharomyces cerevisiae, >=98.5\\% (HPLC); Trehalose dihydrate, European Pharmacopoeia (EP) Reference Standard; D-(+)-Trehalose dihydrate, from Saccharomyces cerevisiae, >=99\\%; Trehalose, United States Pharmacopeia (USP) Reference Standard; .ALPHA.-D-GLUCOPYRANOSYL-.ALPHA.-D-GLUCOPYRANOSIDE DIHYDRATE; alpha-D-Glucopyranoside, alpha-D-glucopyranosyl, dihydrate; D-(+)-Trehalose dihydrate, Vetec(TM) reagent grade, >=99\\%; D-(+)-Trehalose dihydrate, SAJ special grade, >=99.0\\%; D-(+)-Trehalose dihydrate, for microbiology, >=99.0\\%; D-Trehalose dihydrate; ,-Trehalose dihydrate; 2,2-(1,6-Hexanediyldioxy)bisbenzaldehyde; a-d-glucopyranosyl-a-d-glucopyranoside; D-(+)-Trehalose dihydrate, p.a., 99\\%; .ALPHA., .ALPHA.-TREHALOSE DIHYDRATE; Trehalose (for injection) (sterile); TREHALOSE DIHYDRATE [EP MONOGRAPH]; Trehalose dihydrate, cell culture; alpha,alpha-Trehalose dihydrate; TREHALOSE DIHYDRATE [WHO-DD]; DPVHGFAJLZWDOC-PVXXTIHASA-N; D-(+)-Trehalose dihydrate; D-Trehalose; ,-Trehalose; TREHALOSE DIHYDRATE [MI]; a,a-Trehalose dihydrate; D-Trehalose dihydrate; TREHALOSE, DIHYDRATE; Trehalose dihydrate; MYCOSE DIHYDRATE; UNII-7YIN7J07X4; a,a-Trehalose; Tox21_201106; 7YIN7J07X4; α,α-Trehalose dihydrate
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Mu Chen, Xiaoyue Huo, Weiye Wang, Hongyun Shan, Pei Jiang, Wei Liang, Baolin Liu. Cryopreservation of Infant Gut Microbiota with Natural Cryoprotectants.
Biopreservation and biobanking.
2022 Apr; 20(2):138-148. doi:
10.1089/bio.2021.0029. [PMID: 34714122] - Mustafa Numan Bucak, Nazan Keskin, Mustafa Bodu, Bülent Bülbül, Mesut Kırbaş, Ali Erdem Öztürk, Fateme Frootan, Pınar İli, Hüseyin Özkan, Nuri Başpınar, Şükrü Dursun. Combination of trehalose and low boron in presence of decreased glycerol improves post-thawed ram sperm parameters: A model study in boron research.
Andrology.
2022 03; 10(3):585-594. doi:
10.1111/andr.13130. [PMID: 34779585] - Jin Wang, Xiaodi Shi, Minghao Xiong, Wen-Song Tan, Haibo Cai. Trehalose glycopolymers for cryopreservation of tissue-engineered constructs.
Cryobiology.
2022 02; 104(?):47-55. doi:
10.1016/j.cryobiol.2021.11.004. [PMID: 34800528] - Kevin F O'Connell. Cryopreservation of C. elegans and Other Nematodes with Dimethyl Sulfoxide and Trehalose.
Methods in molecular biology (Clifton, N.J.).
2022; 2468(?):43-49. doi:
10.1007/978-1-0716-2181-3_3. [PMID: 35320559] - Pawan Dulal, Robabeh Gharaei, Adam Berg, Adam A Walters, Nicholas Hawkins, Tim D W Claridge, Katarzyna Kowal, Steven Neill, Adam J Ritchie, Rebecca Ashfield, Adrian V S Hill, Giuseppe Tronci, Stephen J Russell, Alexander D Douglas. Characterisation of factors contributing to the performance of nonwoven fibrous matrices as substrates for adenovirus vectored vaccine stabilisation.
Scientific reports.
2021 10; 11(1):20877. doi:
10.1038/s41598-021-00065-4. [PMID: 34686689] - Faegheh Bahri, Mohammad Khaksari, Sajjadeh Movahedinia, Bentolhoda Shafiei, Mohammad Amin Rajizadeh, Mahdieh Nazari-Robati. Improving SIRT1 by trehalose supplementation reduces oxidative stress, inflammation, and histopathological scores in the kidney of aged rats.
Journal of food biochemistry.
2021 10; 45(10):e13931. doi:
10.1111/jfbc.13931. [PMID: 34494279] - Xiaojuan Chao, Shaogui Wang, Ling Yang, Hong-Min Ni, Wen-Xing Ding. Trehalose activates hepatic transcription factor EB (TFEB) but fails to ameliorate alcohol-impaired TFEB and liver injury in mice.
Alcoholism, clinical and experimental research.
2021 10; 45(10):1950-1964. doi:
10.1111/acer.14695. [PMID: 34486131] - Hasan Izanloo, Ali Soleimanzadeh, Mustafa Numan Bucak, Mehdi Imani, Mahdi Zhandi. The effects of varying concentrations of glutathione and trehalose in improving microscopic and oxidative stress parameters in Turkey semen during liquid storage at 5 °C.
Cryobiology.
2021 08; 101(?):12-19. doi:
10.1016/j.cryobiol.2021.07.002. [PMID: 34245722] - Wen-Qian Zhu, Ning-Ning Cai, Yu Jiang, Rui Yang, Jian-Zhong Shi, Chun-Ling Zhu, Bo-Yang Zhang, Bo Tang, Xue-Ming Zhang. Survivable potential of germ cells after trehalose cryopreservation of bovine testicular tissues.
Cryobiology.
2021 08; 101(?):105-114. doi:
10.1016/j.cryobiol.2021.05.001. [PMID: 33989617] - Helen Hertenstein, Ellen McMullen, Astrid Weiler, Anne Volkenhoff, Holger M Becker, Stefanie Schirmeier. Starvation-induced regulation of carbohydrate transport at the blood-brain barrier is TGF-β-signaling dependent.
eLife.
2021 05; 10(?):. doi:
10.7554/elife.62503. [PMID: 34032568] - Shirin Kouhpayeh, Laleh Shariati, Maryam Boshtam, Ilnaz Rahimmanesh, Mina Mirian, Yasaman Esmaeili, Malihe Najaflu, Negar Khanahmad, Mehrdad Zeinalian, Maria Trovato, Franklin R Tay, Hossein Khanahmad, Pooyan Makvandi. The Molecular Basis of COVID-19 Pathogenesis, Conventional and Nanomedicine Therapy.
International journal of molecular sciences.
2021 May; 22(11):. doi:
10.3390/ijms22115438. [PMID: 34064039] - Huiqi Yuan, Chaoyang Zheng, Li Zhu, Ziqing Song, Linfeng Dai, Qingzong Hu, Lei Wang, Yang Chen, Jing Xiong. Contribution of TFEB-mediated autophagy to tubulointerstitial fibrosis in mice with adenine-induced chronic kidney disease.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Jan; 133(?):110949. doi:
10.1016/j.biopha.2020.110949. [PMID: 33227703] - Hiroto Miura, Kazuhisa Mukai, Keigo Sudo, Satoshi Haga, Yutaka Suzuki, Yasuo Kobayashi, Satoshi Koike. Effect of trehalose supplementation in milk replacer on the incidence of diarrhea and fecal microbiota in preweaned calves.
Journal of animal science.
2021 01; 99(1):. doi:
10.1093/jas/skab012. [PMID: 33528019] - Huan Ye, Congli Zhou, Huamei Yue, Mengbin Wu, Rui Ruan, Hao Du, Chuangju Li, Qiwei Wei. Cryopreservation of germline stem cells in American paddlefish (Polyodon spathula).
Animal reproduction science.
2021 Jan; 224(?):106667. doi:
10.1016/j.anireprosci.2020.106667. [PMID: 33307489] - Shabnam Radbakhsh, Shiva Ganjali, Seyed Adel Moallem, Paul C Guest, Amirhossein Sahebkar. Antioxidant Effects of Trehalose in an Experimental Model of Type 2 Diabetes.
Advances in experimental medicine and biology.
2021; 1328(?):473-480. doi:
10.1007/978-3-030-73234-9_32. [PMID: 34981498] - Maryam Mollaei Alamuti, Mehrdad Ravanshad, Farahnaz Motamedi-Sedeh, Arezoo Nabizadeh, Elham Ahmadi, Seyedeh Maedeh Hossieni. Immune Response of Gamma-Irradiated Inactivated Bivalent Polio Vaccine Prepared plus Trehalose as a Protein Stabilizer in a Mouse Model.
Intervirology.
2021; 64(3):140-146. doi:
10.1159/000515392. [PMID: 33853059] - Kazuya Kusama, Mayuko Miyagawa, Koichiro Ota, Naoko Kuwabara, Kaori Saeki, Yuki Ohnishi, Yasuhiro Kumaki, Tomoyasu Aizawa, Toyokazu Nakasone, Shigemi Okamatsu, Hiroaki Miyaoka, Kazuhiro Tamura. Cordyceps militaris Fruit Body Extract Decreases Testosterone Catabolism and Testosterone-Stimulated Prostate Hypertrophy.
Nutrients.
2020 Dec; 13(1):. doi:
10.3390/nu13010050. [PMID: 33375244] - Rui-Feng Fan, Zi-Fa Li, Dong Zhang, Zhen-Yong Wang. Involvement of Nrf2 and mitochondrial apoptotic signaling in trehalose protection against cadmium-induced kidney injury.
Metallomics : integrated biometal science.
2020 12; 12(12):2098-2107. doi:
10.1039/d0mt00213e. [PMID: 33226392] - Shari Dhaene, Johan Van der Eycken, Koen Beerens, Jorick Franceus, Tom Desmet, Jurgen Caroen. Synthesis, trehalase hydrolytic resistance and inhibition properties of 4- and 6-substituted trehalose derivatives.
Journal of enzyme inhibition and medicinal chemistry.
2020 Dec; 35(1):1964-1989. doi:
10.1080/14756366.2020.1837125. [PMID: 33164573] - Daniel J Atwood, Carolyn N Brown, Sara J Holditch, Deepak Pokhrel, Andrew Thorburn, Katharina Hopp, Charles L Edelstein. The effect of trehalose on autophagy-related proteins and cyst growth in a hypomorphic Pkd1 mouse model of autosomal dominant polycystic kidney disease.
Cellular signalling.
2020 11; 75(?):109760. doi:
10.1016/j.cellsig.2020.109760. [PMID: 32866627] - Sara García-Viñuales, Rashik Ahmed, Michele F M Sciacca, Valeria Lanza, Maria Laura Giuffrida, Stefania Zimbone, Valeria Romanucci, Armando Zarrelli, Corrado Bongiorno, Natalia Spinella, Clelia Galati, Giovanni Di Fabio, Giuseppe Melacini, Danilo Milardi. Trehalose Conjugates of Silybin as Prodrugs for Targeting Toxic Aβ Aggregates.
ACS chemical neuroscience.
2020 09; 11(17):2566-2576. doi:
10.1021/acschemneuro.0c00232. [PMID: 32687307] - Rui Fang, Wasfy Obeidat, Michael J Pikal, Robin H Bogner. Evaluation of Predictors of Protein Relative Stability Obtained by Solid-State Hydrogen/Deuterium Exchange Monitored by FTIR.
Pharmaceutical research.
2020 Aug; 37(9):168. doi:
10.1007/s11095-020-02897-7. [PMID: 32794130] - Laurie Thouvenel, Gautier Prevot, Laura Chiaradia, Julien Parra, Emmanuelle Mouton-Barbosa, Marie Locard-Paulet, Julien Marcoux, Maryelle Tropis, Odile Burlet-Schiltz, Mamadou Daffé, Christophe Guilhot, Gilles Etienne, Christian Chalut. The final assembly of trehalose polyphleates takes place within the outer layer of the mycobacterial cell envelope.
The Journal of biological chemistry.
2020 08; 295(32):11184-11194. doi:
10.1074/jbc.ra120.013299. [PMID: 32554804] - Yi-Tei Wu, Wen-Yuan Yang, Yi-Hsieng Samuel Wu, Jr-Wei Chen, Yi-Chen Chen. Modulations of growth performance, gut microbiota, and inflammatory cytokines by trehalose on Salmonella Typhimurium-challenged broilers.
Poultry science.
2020 Aug; 99(8):4034-4043. doi:
10.1016/j.psj.2020.03.053. [PMID: 32731991] - Judith Schick, Johanna Schäfer, Christian Alexander, Stefanie Dichtl, Peter J Murray, Dennis Christensen, Ursula Sorg, Klaus Pfeffer, Ulrike Schleicher, Roland Lang. Cutting Edge: TNF Is Essential for Mycobacteria-Induced MINCLE Expression, Macrophage Activation, and Th17 Adjuvanticity.
Journal of immunology (Baltimore, Md. : 1950).
2020 07; 205(2):323-328. doi:
10.4049/jimmunol.2000420. [PMID: 32540999] - Chiyo Yoshizane, Akiko Mizote, Chikako Arai, Norie Arai, Rieko Ogawa, Shin Endo, Hitoshi Mitsuzumi, Shimpei Ushio. Daily consumption of one teaspoon of trehalose can help maintain glucose homeostasis: a double-blind, randomized controlled trial conducted in healthy volunteers.
Nutrition journal.
2020 07; 19(1):68. doi:
10.1186/s12937-020-00586-0. [PMID: 32646428] - Hiroki Ishikawa, Satoshi Ino, Takuji Nakashima, Hirotaka Matsuo, Yōko Takahashi, Chikara Kohda, Satoshi Ōmura, Masayuki Iyoda, Kazuo Tanaka. Oral administration of trehangelin-A alleviates metabolic disorders caused by a high-fat diet through improvement of lipid metabolism and restored beneficial microbiota.
Obesity research & clinical practice.
2020 Jul; 14(4):360-367. doi:
10.1016/j.orcp.2020.06.004. [PMID: 32620362] - Q Ye, Y H Wu, Y Gao, Z H Li, W J Gu, C G Zhang. A histological study of mouse tissues and water loss following lyophilization.
Biotechnic & histochemistry : official publication of the Biological Stain Commission.
2020 Jul; 95(5):325-332. doi:
10.1080/10520295.2019.1695945. [PMID: 31850810] - Nobuyuki Shimohata, Ryosuke Echigo, Kensuke Karatsu, Saori Uchikawa, Shigeki Suzuki, Ung-Il Chung, Nobuo Sasaki, Manabu Mochizuki. Trehalose decreases blood clotting in the cerebral space after experimental subarachnoid hemorrhage.
The Journal of veterinary medical science.
2020 May; 82(5):566-570. doi:
10.1292/jvms.19-0201. [PMID: 32173691] - Yiming Zhang, Nurmohammad Shaikh, Jeremie L Ferey, Umesh D Wankhade, Sree V Chintapalli, Cassandra B Higgins, Jan R Crowley, Monique R Heitmeier, Alicyn I Stothard, Belgacem Mihi, Misty Good, Takanobu Higashiyama, Benjamin M Swarts, Paul W Hruz, Kartik Shankar, Phillip I Tarr, Brian J DeBosch. Lactotrehalose, an Analog of Trehalose, Increases Energy Metabolism Without Promoting Clostridioides difficile Infection in Mice.
Gastroenterology.
2020 04; 158(5):1402-1416.e2. doi:
10.1053/j.gastro.2019.11.295. [PMID: 31838076] - Suwen Liu, Yunwen Yang, Huiping Gao, Ning Zhou, Peipei Wang, Yue Zhang, Aihua Zhang, Zhanjun Jia, Songming Huang. Trehalose attenuates renal ischemia-reperfusion injury by enhancing autophagy and inhibiting oxidative stress and inflammation.
American journal of physiology. Renal physiology.
2020 04; 318(4):F994-F1005. doi:
10.1152/ajprenal.00568.2019. [PMID: 32068461] - Diana Diaz-Dussan, Yi-Yang Peng, Jayeeta Sengupta, Rebecca Zabludowski, Madeleine K Adam, Jason P Acker, Robert N Ben, Piyush Kumar, Ravin Narain. Trehalose-Based Polyethers for Cryopreservation and Three-Dimensional Cell Scaffolds.
Biomacromolecules.
2020 03; 21(3):1264-1273. doi:
10.1021/acs.biomac.0c00018. [PMID: 31913606] - Myagmarjav Bumbat, Meixia Wang, Wei Liang, Ping Ye, Wendell Sun, Baolin Liu. Effects of Me2SO and Trehalose on the Cell Viability, Proliferation, and Bcl-2 Family Gene (BCL-2, BAX, and BAD) Expression in Cryopreserved Human Breast Cancer Cells.
Biopreservation and biobanking.
2020 Feb; 18(1):33-40. doi:
10.1089/bio.2019.0082. [PMID: 31800305] - Elizabeth Varela, Mauricio Rojas, Giovanni Restrepo. Membrane stability and mitochondrial activity of bovine sperm frozen with low-density lipoproteins and trehalose.
Reproduction in domestic animals = Zuchthygiene.
2020 Feb; 55(2):146-153. doi:
10.1111/rda.13599. [PMID: 31802545] - Ezgi P Yalcintas, Daniel S Ackerman, Emrullah Korkmaz, Cheryl A Telmer, Jonathan W Jarvik, Phil G Campbell, Marcel P Bruchez, O Burak Ozdoganlar. Analysis of In Vitro Cytotoxicity of Carbohydrate-Based Materials Used for Dissolvable Microneedle Arrays.
Pharmaceutical research.
2020 Jan; 37(3):33. doi:
10.1007/s11095-019-2748-7. [PMID: 31942659] - Daisy Martinon, Vanessa F Borges, Angela C Gomez, Kenichi Shimada. Potential Fast COVID-19 Containment With Trehalose.
Frontiers in immunology.
2020; 11(?):1623. doi:
10.3389/fimmu.2020.01623. [PMID: 32733488] - Raffaele Brogna, Harriëtte Oldenhof, Harald Sieme, Constança Figueiredo, Tobias Kerrinnes, Willem F Wolkers. Increasing storage stability of freeze-dried plasma using trehalose.
PloS one.
2020; 15(6):e0234502. doi:
10.1371/journal.pone.0234502. [PMID: 32525915] - Lingling Zhu, Yujia Yuan, Longhui Yuan, Lan Li, Fei Liu, Jingping Liu, Younan Chen, Yanrong Lu, Jingqiu Cheng. Activation of TFEB-mediated autophagy by trehalose attenuates mitochondrial dysfunction in cisplatin-induced acute kidney injury.
Theranostics.
2020; 10(13):5829-5844. doi:
10.7150/thno.44051. [PMID: 32483422] - Nathan E Wilson, Tarun Tejasvi Mutukuri, Dmitry Y Zemlyanov, Lynne S Taylor, Elizabeth M Topp, Qi Tony Zhou. Surface Composition and Formulation Heterogeneity of Protein Solids Produced by Spray Drying.
Pharmaceutical research.
2019 Dec; 37(1):14. doi:
10.1007/s11095-019-2738-9. [PMID: 31873808] - Dominique N Price, Nitesh K Kunda, Rajaun Ellis, Pavan Muttil. Design and Optimization of a Temperature-Stable Dry Powder BCG Vaccine.
Pharmaceutical research.
2019 Dec; 37(1):11. doi:
10.1007/s11095-019-2739-8. [PMID: 31873825] - Vitalii Mutsenko, Ariana Barlič, Tamara Pezić, Janja Dermol-Černe, Barbara Dovgan, Bulat Sydykov, Willem F Wolkers, Igor I Katkov, Birgit Glasmacher, Damijan Miklavčič, Oleksandr Gryshkov. Me2SO- and serum-free cryopreservation of human umbilical cord mesenchymal stem cells using electroporation-assisted delivery of sugars.
Cryobiology.
2019 12; 91(?):104-114. doi:
10.1016/j.cryobiol.2019.10.002. [PMID: 31593692] - Maedeh Shams Nouraei, Homa Faghihi, Abdolhossein Roulholamini Najafabadi, Amir Hossein Mohammad Zadeh, Majid Darabi, Alireza Vatanara. Human Serum Albumin, a Suitable Candidate to Stabilize Freeze-Dried IgG in Combination with Trehalose: Central Composite Design.
AAPS PharmSciTech.
2019 Oct; 20(8):327. doi:
10.1208/s12249-019-1509-6. [PMID: 31659590] - Sampreeti Jena, N S Krishna Kumar, Alptekin Aksan, Raj Suryanarayanan. Stability of lyophilized albumin formulations: Role of excipient crystallinity and molecular mobility.
International journal of pharmaceutics.
2019 Oct; 569(?):118568. doi:
10.1016/j.ijpharm.2019.118568. [PMID: 31352055] - C Consuegra, F Crespo, J Dorado, M Diaz-Jimenez, B Pereira, I Ortiz, M Hidalgo. Vitrification of stallion sperm using 0.25 ml straws: Effect of volume, concentration and carbohydrates (sucrose/trehalose/raffinose).
Animal reproduction science.
2019 Jul; 206(?):69-77. doi:
10.1016/j.anireprosci.2019.05.009. [PMID: 31138492] - Sebastian D Burz, Anne-Laure Abraham, Fernanda Fonseca, Olivier David, Audrey Chapron, Fabienne Béguet-Crespel, Stéphanie Cénard, Karine Le Roux, Orlane Patrascu, Florence Levenez, Carole Schwintner, Hervé M Blottière, Christel Béra-Maillet, Patricia Lepage, Joël Doré, Catherine Juste. A Guide for Ex Vivo Handling and Storage of Stool Samples Intended for Fecal Microbiota Transplantation.
Scientific reports.
2019 06; 9(1):8897. doi:
10.1038/s41598-019-45173-4. [PMID: 31222022] - Samantha Stewart, Xiaoming He. Intracellular Delivery of Trehalose for Cell Banking.
Langmuir : the ACS journal of surfaces and colloids.
2019 06; 35(23):7414-7422. doi:
10.1021/acs.langmuir.8b02015. [PMID: 30078320] - Patrick A Howson, Tom H Johnston, Paula Ravenscroft, Michael P Hill, Jin Su, Jonathan M Brotchie, James B Koprich. Beneficial Effects of Trehalose on Striatal Dopaminergic Deficits in Rodent and Primate Models of Synucleinopathy in Parkinson's Disease.
The Journal of pharmacology and experimental therapeutics.
2019 06; 369(3):364-374. doi:
10.1124/jpet.118.255695. [PMID: 30918068] - Habib Yaribeygi, Alijan Yaribeygi, Thozhukat Sathyapalan, Amirhossein Sahebkar. Molecular mechanisms of trehalose in modulating glucose homeostasis in diabetes.
Diabetes & metabolic syndrome.
2019 May; 13(3):2214-2218. doi:
10.1016/j.dsx.2019.05.023. [PMID: 31235159] - Peter Reinink, Jeffrey Buter, Vivek K Mishra, Eri Ishikawa, Tan-Yun Cheng, Peter T J Willemsen, Steffen Porwollik, Patrick J Brennan, Eva Heinz, Jacob A Mayfield, Gordon Dougan, Cécile A van Els, Vincenzo Cerundolo, Giorgio Napolitani, Sho Yamasaki, Adriaan J Minnaard, Michael McClelland, D Branch Moody, Ildiko Van Rhijn. Discovery of Salmonella trehalose phospholipids reveals functional convergence with mycobacteria.
The Journal of experimental medicine.
2019 04; 216(4):757-771. doi:
10.1084/jem.20181812. [PMID: 30804000] - Aneta Stachowicz, Anna Wiśniewska, Katarzyna Kuś, Anna Kiepura, Anna Gębska, Mariusz Gajda, Magdalena Białas, Justyna Totoń-Żurańska, Kamila Stachyra, Maciej Suski, Jacek Jawień, Ryszard Korbut, Rafał Olszanecki. The Influence of Trehalose on Atherosclerosis and Hepatic Steatosis in Apolipoprotein E Knockout Mice.
International journal of molecular sciences.
2019 Mar; 20(7):. doi:
10.3390/ijms20071552. [PMID: 30925684] - Zhong-Gui Gong, Xin-Yu Wang, Jun-Hong Wang, Rui-Feng Fan, Lin Wang. Trehalose prevents cadmium-induced hepatotoxicity by blocking Nrf2 pathway, restoring autophagy and inhibiting apoptosis.
Journal of inorganic biochemistry.
2019 03; 192(?):62-71. doi:
10.1016/j.jinorgbio.2018.12.008. [PMID: 30599315] - Somayeh Shokri, Mohammad Kazem Shahkarami, Abbas Shafyi, Ashraf Mohammadi, Fatemeh Esna-Ashari, Amir Hamta. Evaluation of the thermal stability of live-attenuated Rubella vaccine (Takahashi strain) formulated and lyophilized in different stabilizers.
Journal of virological methods.
2019 02; 264(?):18-22. doi:
10.1016/j.jviromet.2018.08.013. [PMID: 30144493] - Lucia Olexikova, Marsia Miranda, Barbora Kulikova, Andrej Baláži, Peter Chrenek. Cryodamage of plasma membrane and acrosome region in chicken sperm.
Anatomia, histologia, embryologia.
2019 Jan; 48(1):33-39. doi:
10.1111/ahe.12408. [PMID: 30334273] - Wei Yu, Wenliang Zha, Hu Peng, Qiurong Wang, Shuning Zhang, Jun Ren. Trehalose Protects against Insulin Resistance-Induced Tissue Injury and Excessive Autophagy in Skeletal Muscles and Kidney.
Current pharmaceutical design.
2019; 25(18):2077-2085. doi:
10.2174/1381612825666190708221539. [PMID: 31538882] - Y X Zheng, L Z Ma, S J Liu, C T Zhang, R Meng, Y Z Chen, Z L Jiang. Protective effects of trehalose on frozen-thawed ovarian granulosa cells of cattle.
Animal reproduction science.
2019 Jan; 200(?):14-21. doi:
10.1016/j.anireprosci.2018.11.005. [PMID: 30472065] - Liomara Andressa do Amaral Kwirant, Flávio Desessards De La Corte, Camila Cantarelli, Juliana Felipetto Cargnelutti, Mathias Martins, Mariê Wolski Cabral, Nayrema Maciel, Mara Iolanda Batistella Rubin. Cooling and Cryopreservation of Equine Platelet-Rich Plasma With Dimethyl Sulfoxide and Trehalose.
Journal of equine veterinary science.
2019 01; 72(?):112-116. doi:
10.1016/j.jevs.2018.10.009. [PMID: 30929774] - Hiroki Ishikawa, Satoshi Ino, Takuji Nakashima, Hirotaka Matsuo, Yōko Takahashi, Chikara Kohda, Satoshi Ōmura, Kazuo Tanaka. Improvement Effects of Trehangelin A on High-Fat Diet Causing Metabolic Clinical Conditions.
Biological & pharmaceutical bulletin.
2019; 42(12):2095-2101. doi:
10.1248/bpb.b19-00668. [PMID: 31787724] - Li-Fang Chou, Ya-Lien Cheng, Chun-Yih Hsieh, Chan-Yu Lin, Huang-Yu Yang, Yung-Chang Chen, Cheng-Chieh Hung, Ya-Chung Tian, Chih-Wei Yang, Ming-Yang Chang. Effect of Trehalose Supplementation on Autophagy and Cystogenesis in a Mouse Model of Polycystic Kidney Disease.
Nutrients.
2018 Dec; 11(1):. doi:
10.3390/nu11010042. [PMID: 30585217] - Hui Chen, Weizhu Chen, Bihong Hong, Yiping Zhang, Zhuan Hong, Ruizao Yi. Determination of trehalose by ion chromatography and its application to a pharmacokinetic study in rats after intramuscular injection.
Biomedical chromatography : BMC.
2018 Dec; 32(12):e4355. doi:
10.1002/bmc.4355. [PMID: 30063249] - Hao Li, Yi-Lin Bian, Nicola Schreurs, Xiao-Gang Zhang, Sayed Haidar Abbas Raza, Qian Fang, Li-Qiang Wang, Jian-Hong Hu. Effects of five cryoprotectants on proliferation and differentiation-related gene expression of frozen-thawed bovine calf testicular tissue.
Reproduction in domestic animals = Zuchthygiene.
2018 Oct; 53(5):1211-1218. doi:
10.1111/rda.13228. [PMID: 29956384] - Rayne S S Magalhães, Blagovesta Popova, Gerhard H Braus, Tiago F Outeiro, Elis C A Eleutherio. The trehalose protective mechanism during thermal stress in Saccharomyces cerevisiae: the roles of Ath1 and Agt1.
FEMS yeast research.
2018 09; 18(6):. doi:
10.1093/femsyr/foy066. [PMID: 30007297] - Stuart D Portbury, Dominic J Hare, David P Bishop, David I Finkelstein, Philip A Doble, Paul A Adlard. Trehalose elevates brain zinc levels following controlled cortical impact in a mouse model of traumatic brain injury.
Metallomics : integrated biometal science.
2018 06; 10(6):846-853. doi:
10.1039/c8mt00068a. [PMID: 29872801] - Casey M Rebholz, Bing Yu, Zihe Zheng, Patrick Chang, Adrienne Tin, Anna Köttgen, Lynne E Wagenknecht, Josef Coresh, Eric Boerwinkle, Elizabeth Selvin. Serum metabolomic profile of incident diabetes.
Diabetologia.
2018 05; 61(5):1046-1054. doi:
10.1007/s00125-018-4573-7. [PMID: 29556673] - Alex E Clark, Maite Sabalza, Philip L S M Gordts, Deborah H Spector. Human Cytomegalovirus Replication Is Inhibited by the Autophagy-Inducing Compounds Trehalose and SMER28 through Distinctively Different Mechanisms.
Journal of virology.
2018 03; 92(6):. doi:
10.1128/jvi.02015-17. [PMID: 29237845] - Stephanie N Hurwitz, Mujeeb R Cheerathodi, Dingani Nkosi, Sara B York, David G Meckes. Tetraspanin CD63 Bridges Autophagic and Endosomal Processes To Regulate Exosomal Secretion and Intracellular Signaling of Epstein-Barr Virus LMP1.
Journal of virology.
2018 03; 92(5):. doi:
10.1128/jvi.01969-17. [PMID: 29212935] - C C Pérez-Marín, F D Requena, A Arando, S Ortiz-Villalón, F Requena, E I Agüera. Effect of trehalose- and sucrose-based extenders on equine sperm quality after vitrification: Preliminary results.
Cryobiology.
2018 02; 80(?):62-69. doi:
10.1016/j.cryobiol.2017.12.002. [PMID: 29229561] - S Iqbal, S Naz, H Ahmed, S M H Andrabi. Cryoprotectant effect of trehalose in extender on post-thaw quality and in vivo fertility of water buffalo (Bubalus bubalis) bull spermatozoa.
Andrologia.
2018 Feb; 50(1):. doi:
10.1111/and.12794. [PMID: 28224657] - Xin-Yu Wang, Zhen-Yong Wang, Yi-Song Zhu, Si-Ming Zhu, Rui-Feng Fan, Lin Wang. Alleviation of cadmium-induced oxidative stress by trehalose via inhibiting the Nrf2-Keap1 signaling pathway in primary rat proximal tubular cells.
Journal of biochemical and molecular toxicology.
2018 Jan; 32(1):. doi:
10.1002/jbt.22011. [PMID: 29140578] - J J Kim, Y K Nam, I C Bang, S P Gong. Effective Condition for Whole Testis Cryopreservation of Endangered Miho Spine Loach (Cobitis choii) Through the Optimization of Mud Loach (Misgurnus mizolepis) Whole Testis Cryopreservation Condition.
Cryo letters.
2018 Jan; 39(1):53-59. doi:
NULL. [PMID: 29734415] - Ahana Das, Pijush Basak, Rudradip Pattanayak, Turban Kar, Rajib Majumder, Debadrita Pal, Anindita Bhattacharya, Maitree Bhattacharyya, Samudra Prosad Banik. Trehalose induced structural modulation of Bovine Serum Albumin at ambient temperature.
International journal of biological macromolecules.
2017 Dec; 105(Pt 1):645-655. doi:
10.1016/j.ijbiomac.2017.07.074. [PMID: 28735008] - AbdelRaouf M Ghallab, Abdallah M Shahat, Aya M Fadl, Mohamed M Ayoub, Adel R Moawad. Impact of supplementation of semen extender with antioxidants on the quality of chilled or cryopreserved Arabian stallion spermatozoa.
Cryobiology.
2017 12; 79(?):14-20. doi:
10.1016/j.cryobiol.2017.10.001. [PMID: 28986135] - Shu Hui Neo, Ka Yan Chung, Jia Min Quek, Heng-Phon Too. Trehalose significantly enhances the recovery of serum and serum exosomal miRNA from a paper-based matrix.
Scientific reports.
2017 11; 7(1):16686. doi:
10.1038/s41598-017-16960-8. [PMID: 29192155] - M Schulz, J Risopatrón, G Matus, E Pineda, C Rojas, V Isachenko, E Isachenko, R Sánchez. Trehalose sustains a higher post-thaw sperm motility than sucrose in vitrified human sperm.
Andrologia.
2017 Nov; 49(9):. doi:
10.1111/and.12757. [PMID: 28543267] - Xin-Yu Wang, Heng Yang, Min-Ge Wang, Du-Bao Yang, Zhen-Yong Wang, Lin Wang. Trehalose protects against cadmium-induced cytotoxicity in primary rat proximal tubular cells via inhibiting apoptosis and restoring autophagic flux.
Cell death & disease.
2017 10; 8(10):e3099. doi:
10.1038/cddis.2017.475. [PMID: 29022917] - S D Johnston, E Qualischefski, J Cooper, R McLeod, J Lever, B Nixon, A L Anderson, R Hobbs, J Gosálvez, C López-Fernández, T Keeley. Cryopreservation of saltwater crocodile (Crocodylus porosus) spermatozoa.
Reproduction, fertility, and development.
2017 Oct; 29(11):2235-2244. doi:
10.1071/rd16511. [PMID: 28356183] - Md Mahbubul Hassan, Xiaoxu Li, Jian G Qin. Improvement of post-thaw sperm survivals using liquid nitrogen vapor in a spermcasting oyster Ostrea angasi.
Cryobiology.
2017 10; 78(?):1-7. doi:
10.1016/j.cryobiol.2017.08.003. [PMID: 28803845] - Razieh Kamali Jamil, Mohammad Shayestehour, Zohreh-Azita Sadigh, Mohammad Taqavian, Mohammad-Kazem Shahkarami, Fatemeh Esna-Ashari, Reza Shahbazi, Ashraf Mohammadi, Abolhassan Foroughi, Bizhan Romani. The Effect of Various Stabilizers on Preserving Immunogenicity of Lyophilized Mumps Vaccines.
Journal of research in health sciences.
2017 Sep; 17(4):e00393. doi:
NULL. [PMID: 29233955] - Pankaj Attri, Minsup Kim, Thapanut Sarinont, Eun Ha Choi, Hyunwoong Seo, Art E Cho, Kazunori Koga, Masaharu Shiratani. The protective action of osmolytes on the deleterious effects of gamma rays and atmospheric pressure plasma on protein conformational changes.
Scientific reports.
2017 08; 7(1):8698. doi:
10.1038/s41598-017-08643-1. [PMID: 28821765] - Xiaoxu Zhang, Jianpan Zhang, Guilan Quan, Pianpian Yang, Xin Pan, Chuanbin Wu. The Serum-Resistant Transfection Evaluation and Long-Term Stability of Gene Delivery Dry Powder Based on Mesoporous Silica Nanoparticles and Polyethyleneimine by Freezing-Drying.
AAPS PharmSciTech.
2017 Jul; 18(5):1536-1543. doi:
10.1208/s12249-016-0617-9. [PMID: 27600322] - Lili Wen, Xianxian Zheng, Xinyue Wang, Hairong Lan, Zongning Yin. Bilateral Effects of Excipients on Protein Stability: Preferential Interaction Type of Excipient and Surface Aromatic Hydrophobicity of Protein.
Pharmaceutical research.
2017 Jul; 34(7):1378-1390. doi:
10.1007/s11095-017-2152-0. [PMID: 28401430] - Md Mahbubul Hassan, Xiaoxu Li, Yibing Liu, Jian G Qin. Sperm cryopreservation in the spermcasting Australian flat oyster Ostrea angasi by a programmable freezing method.
Cryobiology.
2017 06; 76(?):119-124. doi:
10.1016/j.cryobiol.2017.03.007. [PMID: 28341133] - Smita S Kale, Krishnacharya G Akamanchi. Rational approach for design and evaluation of anti-aggregation agents for protein stabilization: A case study of trehalose phenylalaninate.
International journal of pharmaceutics.
2017 May; 524(1-2):215-225. doi:
10.1016/j.ijpharm.2017.03.075. [PMID: 28365391] - Jared Hara, Jordan Tottori, Megan Anders, Smritee Dadhwal, Prashanth Asuri, Maryam Mobed-Miremadi. Trehalose effectiveness as a cryoprotectant in 2D and 3D cell cultures of human embryonic kidney cells.
Artificial cells, nanomedicine, and biotechnology.
2017 May; 45(3):609-616. doi:
10.3109/21691401.2016.1167698. [PMID: 27050441] - Chandak Upagupta, Rachel E Carlisle, Jeffrey G Dickhout. Analysis of the potency of various low molecular weight chemical chaperones to prevent protein aggregation.
Biochemical and biophysical research communications.
2017 04; 486(1):163-170. doi:
10.1016/j.bbrc.2017.03.019. [PMID: 28285140] - Zhendong Zhu, Xiaoteng Fan, Yang Pan, Yinghua Lu, Wenxian Zeng. Trehalose improves rabbit sperm quality during cryopreservation.
Cryobiology.
2017 04; 75(?):45-51. doi:
10.1016/j.cryobiol.2017.02.006. [PMID: 28223021] - Da Teng, Kiyoshi Kawai, Shuto Mikajiri, Yoshio Hagura. Stabilization of freeze-dried Lactobacillus paracasei subsp. paracasei JCM 8130T with the addition of disaccharides, polymers, and their mixtures.
Bioscience, biotechnology, and biochemistry.
2017 Apr; 81(4):768-773. doi:
10.1080/09168451.2017.1279852. [PMID: 28103748] - Yang Liu, Juneyoung Lee, Kathryn M Mansfield, Jeong Hoon Ko, Sahar Sallam, Chrys Wesdemiotis, Heather D Maynard. Trehalose Glycopolymer Enhances Both Solution Stability and Pharmacokinetics of a Therapeutic Protein.
Bioconjugate chemistry.
2017 03; 28(3):836-845. doi:
10.1021/acs.bioconjchem.6b00659. [PMID: 28044441] - Mengjie Xu, Guangming Chen, Cunhai Zhang, Shaozhi Zhang. Study on the Unfrozen Water Quantity of Maximally Freeze-Concentrated Solutions for Multicomponent Lyoprotectants.
Journal of pharmaceutical sciences.
2017 01; 106(1):83-91. doi:
10.1016/j.xphs.2016.05.007. [PMID: 27353209] - Stuart D Portbury, Dominic J Hare, David I Finkelstein, Paul A Adlard. Trehalose improves traumatic brain injury-induced cognitive impairment.
PloS one.
2017; 12(8):e0183683. doi:
10.1371/journal.pone.0183683. [PMID: 28837626] - K L Ngai, S Capaccioli, A Paciaroni. Dynamics of hydrated proteins and bio-protectants: Caged dynamics, β-relaxation, and α-relaxation.
Biochimica et biophysica acta. General subjects.
2017 Jan; 1861(1 Pt B):3553-3563. doi:
10.1016/j.bbagen.2016.04.027. [PMID: 27155356] - Allyson L Mayer, Cassandra B Higgins, Monique R Heitmeier, Thomas E Kraft, Xia Qian, Jan R Crowley, Krzysztof L Hyrc, Wandy L Beatty, Kevin E Yarasheski, Paul W Hruz, Brian J DeBosch. SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy.
Scientific reports.
2016 12; 6(?):38586. doi:
10.1038/srep38586. [PMID: 27922102] - Smita S Kale, Krishnacharya G Akamanchi. Trehalose Monooleate: A Potential Antiaggregation Agent for Stabilization of Proteins.
Molecular pharmaceutics.
2016 12; 13(12):4082-4093. doi:
10.1021/acs.molpharmaceut.6b00686. [PMID: 27726389] - Ellie Mok, Eugene Wee, Yuling Wang, Matt Trau. Comprehensive evaluation of molecular enhancers of the isothermal exponential amplification reaction.
Scientific reports.
2016 12; 6(?):37837. doi:
10.1038/srep37837. [PMID: 27910874] - Daniel S Moore, Steven C Hand. Cryopreservation of lipid bilayers by LEA proteins from Artemia franciscana and trehalose.
Cryobiology.
2016 10; 73(2):240-7. doi:
10.1016/j.cryobiol.2016.07.003. [PMID: 27393243] - Shun-Ichi Wada, Ryuichi Sawa, Shun-Ichi Ohba, Chigusa Hayashi, Maya Umekita, Yuko Shibuya, Kiyoko Iijima, Fumiki Iwanami, Masayuki Igarashi. Stability and Bioavailability of Lentztrehaloses A, B, and C as Replacements for Trehalose.
Journal of agricultural and food chemistry.
2016 Sep; 64(38):7121-6. doi:
10.1021/acs.jafc.6b02782. [PMID: 27595314] - Macarena Siri, Mariano Grasselli, Silvia Del V Alonso. Albumin-based nanoparticle trehalose lyophilisation stress-down to preserve structure/function and enhanced binding.
Journal of pharmaceutical and biomedical analysis.
2016 Jul; 126(?):66-74. doi:
10.1016/j.jpba.2016.04.037. [PMID: 27174378] - M Kikusato, F Nanto, K Mukai, M Toyomizu. Effects of trehalose supplementation on the growth performance and intestinal innate immunity of juvenile chicks.
British poultry science.
2016 Jun; 57(3):375-80. doi:
10.1080/00071668.2016.1166475. [PMID: 26986698] - Sajid Iqbal, Syed Murtaza Hassan Andrabi, Amjad Riaz, Aneela Zameer Durrani, Nasim Ahmad. Trehalose improves semen antioxidant enzymes activity, post-thaw quality, and fertility in Nili Ravi buffaloes (Bubalus bubalis).
Theriogenology.
2016 Mar; 85(5):954-959. doi:
10.1016/j.theriogenology.2015.11.004. [PMID: 26653954] - Chia-Fa Lin, Yen-Ting Kuo, Tsung-Ying Chen, Chiang-Ting Chien. Quercetin-Rich Guava (Psidium guajava) Juice in Combination with Trehalose Reduces Autophagy, Apoptosis and Pyroptosis Formation in the Kidney and Pancreas of Type II Diabetic Rats.
Molecules (Basel, Switzerland).
2016 Mar; 21(3):334. doi:
10.3390/molecules21030334. [PMID: 26978332]
