DHbetaE (BioDeep_00000395985)

 

Secondary id: BioDeep_00000009507

PANOMIX_OTCML-2023


代谢物信息卡片


1H,12H-BENZO(I)PYRANO(3,4-G)INDOLIZIN-12-ONE, 2,3,5,6,8,9,10,13-OCTAHYDRO-2-METHOXY-, (2S,13BS)-

化学式: C16H21NO3 (275.1521356)
中文名称:
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 8.41%

分子结构信息

SMILES: COC1CC=C2CCN3C2(C1)C4=C(CC3)COC(=O)C4
InChI: InChI=1S/C16H21NO3/c1-19-13-3-2-12-5-7-17-6-4-11-10-20-15(18)8-14(11)16(12,17)9-13/h2,13H,3-10H2,1H3/t13-,16-/m0/s1

描述信息

Dihydro-beta-erythroidine is an organic heterotetracyclic compound resulting from the partial hydrogenation of the 1,3-diene moiety of beta-erythroidine to give the corresponding 2-ene. It has a role as a nicotinic antagonist. It is an organic heterotetracyclic compound, a delta-lactone and a tertiary amino compound. It is functionally related to a beta-erythroidine.
Dihydro analog of beta-erythroidine, which is isolated from the seeds and other plant parts of Erythrina sp. Leguminosae. It is an alkaloid with curarimimetic properties.

同义名列表

28 个代谢物同义名

1H,12H-BENZO(I)PYRANO(3,4-G)INDOLIZIN-12-ONE, 2,3,5,6,8,9,10,13-OCTAHYDRO-2-METHOXY-, (2S,13BS)-; (1S,16S)-16-methoxy-5-oxa-10-azatetracyclo[8.7.0.0^{1,13}.0^{2,7}]heptadeca-2(7),13-dien-4-one; (12S,13aS)-12-Methoxy-1,4,5,6,9,11,12,13-octahydro-8H-pyrano[4,3:3,4]pyrido[2,1-i]indol-2-one; (4bs,6s)-6-Methoxy-1,4,6,7,9,10,12,13-Octahydro-3h,5h-Pyrano[4,3:3,4]pyrido[2,1-I]indol-3-One; (2S,13bS)-2-Methoxy-2,3,5,6,8,9,10,13-octahydro-1H,12H-benzo[i]pyrano[3,4-g]indolizin-12-one; (1S,16S)-16-methoxy-5-oxa-10-azatetracyclo[8.7.0.01,13.02,7]heptadeca-2(7),13-dien-4-one; 16(15H)-Oxaerythrinan-15-one, 1,6-didehydro-14,17-dihydro-3-methoxy-, (3beta)-; 16(5H)-Oxaerythrinan-15-one, 1,6-didehydro-14,17-dihydro-3-methoxy-, (3-beta)-; 3beta-methoxy-14,17-dihydro-16-oxa-erythrin-1(6)-en-15-one; 4-27-00-03544 (Beilstein Handbook Reference); DIHYDRO-.BETA.-ERYTHROIDINE [MI]; 2,7-DIHYDRO-.BETA.-ERYTHROIDINE; ERYTHROIDINE, BETA, DIHYDRO-; DIHYDRO-.BETA.-ERYTHROIDINE; B-Idroeritroidina [Italian]; beta-ERYTHROIDINE, DIHYDRO-; beta Erythroidine, Dihydro; Erythroidine, Dihydro beta; Dihydro-beta-erythroidine; Dihydro beta Erythroidine; Dihydro-|A-erythroidine; Dihydro-β-erythroidine; B-Idroeritroidina; UNII-RBN56W7U63; Lopac0_000468; RBN56W7U63; DHbetaE; dhbe



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Yancho Zarev, Kenn Foubert, Paul Cos, Louis Maes, Esameldin Elgorashi, Sandra Apers, Iliana Ionkova, Luc Pieters. HPLC-DAD-SPE-NMR isolation of tetracyclic spiro-alkaloids with antiplasmodial activity from the seeds of Erythrina latissima. Natural product research. 2020 Apr; 34(7):1037-1040. doi: 10.1080/14786419.2018.1539976. [PMID: 30602319]
  • An-Xiang Zhuang, Yi-Xi Zhang, Hui Zhang, Ze-Wen Liu. The insecticidal activity and action mode of an imidacloprid analogue, 1-(3-pyridylmethyl)-2-nitroimino-imidazolidine. Insect science. 2016 Oct; 23(5):688-94. doi: 10.1111/1744-7917.12217. [PMID: 25755197]
  • Sefirin Djiogue, Maria Halabalaki, Dieudonné Njamen, Georg Kretzschmar, George Lambrinidis, Josephine Hoepping, Francesca M Raffaelli, Emmanuel Mikros, Alexios-Leandros Skaltsounis, Günter Vollmer. Erythroidine alkaloids: a novel class of phytoestrogens. Planta medica. 2014 Jul; 80(11):861-9. doi: 10.1055/s-0034-1382861. [PMID: 25116117]
  • Kirsty Danielson, Fraser Putt, Penelope Truman, Bronwyn M Kivell. The effects of nicotine and tobacco particulate matter on dopamine uptake in the rat brain. Synapse (New York, N.Y.). 2014 Feb; 68(2):45-60. doi: 10.1002/syn.21715. [PMID: 23999947]
  • Carmen Frías-Domínguez, Julieta Garduño, Salvador Hernández, René Drucker-Colin, Stefan Mihailescu. Flattening plasma corticosterone levels increases the prevalence of serotonergic dorsal raphe neurons inhibitory responses to nicotine in adrenalectomised rats. Brain research bulletin. 2013 Sep; 98(?):10-22. doi: 10.1016/j.brainresbull.2013.07.006. [PMID: 23872451]
  • Tammy L Awtry, Julie G Frank, Linda L Werling. In vitro regulation of serotonin transporter activity by protein kinase A and nicotinic acetylcholine receptors in the prefrontal cortex of rats. Synapse (New York, N.Y.). 2006 May; 59(6):342-9. doi: 10.1002/syn.20251. [PMID: 16463401]
  • Pinar U Onganer, Mustafa B A Djamgoz, Kathryn Whyte, Susan A Greenfield. An acetylcholinesterase-derived peptide inhibits endocytic membrane activity in a human metastatic breast cancer cell line. Biochimica et biophysica acta. 2006 Mar; 1760(3):415-20. doi: 10.1016/j.bbagen.2005.12.016. [PMID: 16469451]
  • Salma Toma Hanna, Kun Cao, Rui Wang. Interaction of acetylcholine with Kir6.1 channels heterologously expressed in human embryonic kidney cells. European journal of pharmacology. 2005 May; 515(1-3):34-42. doi: 10.1016/j.ejphar.2005.04.015. [PMID: 15894309]
  • Rubén San Miguel-Chávez, Marcos Soto-Hernández, Ana C Ramos-Valdivia, Geoffrey Kite, Mariano Martínez-Vázquez, Ma del Rosario García M, Teresa Terrazas S. Production of alkaloids by in vitro culture of Erythrina americana Miller. Biotechnology letters. 2003 Jul; 25(13):1055-9. doi: 10.1023/a:1024142531691. [PMID: 12889814]
  • H Tanaka, H Etoh, H Shimizu, T Oh-Uchi, Y Terada, Y Tateishi. Erythrinan alkaloids and isoflavonoids from Erythrina poeppigiana. Planta medica. 2001 Dec; 67(9):871-3. doi: 10.1055/s-2001-18852. [PMID: 11745029]
  • Y Xiao, E L Meyer, J M Thompson, A Surin, J Wroblewski, K J Kellar. Rat alpha3/beta4 subtype of neuronal nicotinic acetylcholine receptor stably expressed in a transfected cell line: pharmacology of ligand binding and function. Molecular pharmacology. 1998 Aug; 54(2):322-33. doi: 10.1124/mol.54.2.322. [PMID: 9687574]
  • S A Lipton. Spontaneous release of acetylcholine affects the physiological nicotinic responses of rat retinal ganglion cells in culture. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1988 Oct; 8(10):3857-68. doi: 10.1523/jneurosci.08-10-03857.1988. [PMID: 2903915]
  • G Kemp, M Edge. Cholinergic function and alpha-bungarotoxin binding in PC12 cells. Molecular pharmacology. 1987 Sep; 32(3):356-63. doi: NULL. [PMID: 2890091]
  • N Cobos Barroso, J Canals Cadafalch, S Liñan Cortés, A Evangelista Masip, G Isturiz, N Barquet Esteve. [Bird breeder's lung in children]. Allergologia et immunopathologia. 1980 Nov; 8(6):637-42. doi: NULL. [PMID: 6971047]
  • R G Wyatt, H B Greenberg, D W Dalgard, W P Allen, D L Sly, T S Thornhill, R M Chanock, A Z Kapikian. Experimental infection of chimpanzees with the Norwalk agent of epidemic viral gastroenteritis. Journal of medical virology. 1978; 2(2):89-96. doi: 10.1002/jmv.1890020203. [PMID: 97364]
  • S Amano. Vascular changes in the brain of spontaneously hypertensive rats: hyaline and fibrinoid degeneration. The Journal of pathology. 1977 Feb; 121(2):119-28. doi: 10.1002/path.1711210209. [PMID: 69020]
  • L B KIRSCHNER, W E STONE. Binding of dihydro-beta-erythroidine by a constituent of blood plasma. The Journal of pharmacology and experimental therapeutics. 1953 Feb; 107(2):188-96. doi: NULL. [PMID: 13035656]