Polyphyllin G (BioDeep_00000395870)
Main id: BioDeep_00000230734
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C51H84O22 (1048.5453964)
中文名称: 重楼皂苷VII, 重楼皂苷G
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1C2C(CC3C2(CCC4C3CC=C5C4(CCC(C5)OC6C(C(C(C(O6)CO)OC7C(C(C(O7)CO)O)O)OC8C(C(C(C(O8)C)O)O)O)O)C)C)OC1(CCC(C)COC9C(C(C(C(O9)CO)O)O)O)OC
InChI: InChI=1S/C51H84O22/c1-21(20-65-45-40(61)38(59)35(56)30(17-52)68-45)9-14-51(64-6)22(2)33-29(73-51)16-28-26-8-7-24-15-25(10-12-49(24,4)27(26)11-13-50(28,33)5)67-48-42(63)44(72-46-41(62)37(58)34(55)23(3)66-46)43(32(19-54)70-48)71-47-39(60)36(57)31(18-53)69-47/h7,21-23,25-48,52-63H,8-20H2,1-6H3/t21-,22+,23+,25+,26-,27+,28+,29+,30-,31+,32+,33+,34+,35-,36+,37-,38+,39-,40-,41-,42+,43+,44+,45-,46+,47+,48+,49+,50+,51+/m1/s1
描述信息
同义名列表
3 个代谢物同义名
(2S,3R,4R,5R,6S)-2-[(2S,3S,4S,5S,6S)-3-[(2S,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-5-hydroxy-2-(hydroxymethyl)-6-[[(1S,2S,4S,6S,7S,8R,9S,12S,13R,16S)-6-methoxy-7,9,13-trimethyl-6-[(3R)-3-methyl-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxybutyl]-5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-en-16-yl]oxy]oxan-4-yl]oxy-6-methyloxane-3,4,5-triol; Polyphyllin VII; Polyphyllin G
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Haiqin Wang, Xiaojuan Xiao, Zhenzhen Li, Saiqun Luo, Lei Hu, Hui Yi, Ruohong Xiang, Yu Zhu, Yanpeng Wang, Lin Zhu, Ling Xiao, Chongwen Dai, Abdul Aziz, Lingli Yuan, Yajuan Cui, Ruijuan Li, Fanjie Gong, Xifeng Liu, Long Liang, Hongling Peng, Hui Zhou, Jing Liu. Polyphyllin VII, a novel moesin inhibitor, suppresses cell growth and overcomes bortezomib resistance in multiple myeloma.
Cancer letters.
2022 07; 537(?):215647. doi:
10.1016/j.canlet.2022.215647. [PMID: 35306105] - Genbei Wang, Ruijia Hao, Chen Luo, Yu Wang, Shuli Man, Wenyuan Gao. Pharmacokinetics profiles of polyphyllin II and polyphyllin VII in rats by liquid chromatography with tandem mass spectrometry.
Biomedical chromatography : BMC.
2021 Jun; 35(6):e5083. doi:
10.1002/bmc.5083. [PMID: 33544400] - Shan Peng, Ligai Bai, Laisen Wang, Fanrong Sun, Haiyan Liu, Hongyuan Yan. Fabrication of a cycloalkyl-monolith for on-line solid-phase extraction and determination of four polyphyllins in plasma.
Analytical biochemistry.
2020 02; 591(?):113555. doi:
10.1016/j.ab.2019.113555. [PMID: 31874172] - Hao He, Chang Xu, Lei Zheng, Kaidi Wang, Manfei Jin, Yanping Sun, Zhenggang Yue. Polyphyllin VII induces apoptotic cell death via inhibition of the PI3K/Akt and NF‑κB pathways in A549 human lung cancer cells.
Molecular medicine reports.
2020 02; 21(2):597-606. doi:
10.3892/mmr.2019.10879. [PMID: 31974591] - Benwei Wang, Songgang Ji, Hai Zhang, Liang Zhao, Lei Lv, Yueyue Li, Guichen Zhou, Guoqing Zhang. Liquid chromatography tandem mass spectrometry in study of the pharmacokinetics of six steroidal saponins in rats.
Steroids.
2013 Dec; 78(12-13):1164-70. doi:
10.1016/j.steroids.2013.08.009. [PMID: 24012730]