Stachydrine (BioDeep_00000395864)
PANOMIX_OTCML-2023
代谢物信息卡片
PYRROLIDINIUM, 2-CARBOXY-1,1-DIMETHYL-, CHLORIDE (1:1), (2S)-
化学式: C7H14ClNO2 (179.0713014)
中文名称: 水苏碱盐酸盐, 盐酸水苏碱
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 4%
分子结构信息
SMILES: C[N+]1(CCCC1C(=O)O)C.[Cl-]
InChI: 1H/t6-
描述信息
Stachydrine hydrochloride is the major active constituent of Leonurus artemisia, which is a potential therapy for cardiovascular diseases[2]. Stachydrine can inhibit the NF-κB signal pathway. Anti-hypertrophic activities[1].
Stachydrine hydrochloride is the major active constituent of Leonurus artemisia, which is a potential therapy for cardiovascular diseases[2]. Stachydrine can inhibit the NF-κB signal pathway. Anti-hypertrophic activities[1].
同义名列表
20 个代谢物同义名
PYRROLIDINIUM, 2-CARBOXY-1,1-DIMETHYL-, CHLORIDE (1:1), (2S)-; (2S)-1,1-dimethyl-2-pyrrolidin-1-iumcarboxylic acid chloride; (2S)-1,1-dimethylpyrrolidin-1-ium-2-carboxylic acid chloride; (2S)-1,1-dimethylpyrrolidin-1-ium-2-carboxylic acid;chloride; Pyrrolidinium, 2-carboxy-1,1-dimethyl-, chloride, (S)-; (S)-2-Carboxy-1,1-dimethylpyrrolidin-1-ium chloride; (S)-2-Carboxy-1,1-dimethylpyrrolidinium chloride; stachydrine chloride, (S)-isomer; STACHYDRINE HYDROCHLORIDE [MI]; Stachydrine hydrochloride; stachydrine, (+-)-isomer; CADABINE HYDROCHLORIDE; stachydrine chloride; dimethylproline; Stachydrine HCl; UNII-19Z024IC5E; proline betaine; Stachydrine; 1ST156904A; 19Z024IC5E
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 44150282
- MeSH: stachydrine
- ChemIDplus: 0004136372
- CAS: 4136-37-2
- medchemexpress: HY-N0738
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Minghui Feng, Yuwen Chen, Jingzhi Chen, Wei Guo, Pei Zhao, Chen Zhang, Xiaoli Shan, Huihua Chen, Ming Xu, Rong Lu. Stachydrine hydrochloride protects the ischemic heart by ameliorating endoplasmic reticulum stress through a SERCA2a dependent way and maintaining intracellular Ca2+ homeostasis.
European journal of pharmacology.
2024 Jun; 973(?):176585. doi:
10.1016/j.ejphar.2024.176585. [PMID: 38636799] - Xi Zhu, Yingbiao Wu, Xiaogang Zhang, Wei Gu, Zhongping Ning. Stachydrine ameliorates hypoxia reoxygenation injury of cardiomyocyte via enhancing SIRT1-Nrf2 pathway.
Journal of cardiothoracic surgery.
2023 Sep; 18(1):265. doi:
10.1186/s13019-023-02363-6. [PMID: 37752609] - Shuang Lu, Yueyang Liang, Songru Yang, Mengwei Fu, Xiaoli Shan, Chen Zhang, Huihua Chen, Pei Zhao, Rong Lu. Stachydrine Hydrochloride Regulates the NOX2-ROS-Signaling Axis in Pressure-Overload-Induced Heart Failure.
International journal of molecular sciences.
2023 Sep; 24(18):. doi:
10.3390/ijms241814369. [PMID: 37762672] - Yueyang Liang, Lei Xia, Shuang Lu, Songru Yang, Shuting Guo, Xiaoli Shan, Pei Zhao, Chen Zhang, Wei Guo, Ming Xu, Huihua Chen, Rong Lu. A new mechanism of therapeutic effect of stachydrine on heart failure by inhibiting myocardial ferroptosis.
European journal of pharmacology.
2023 Sep; 954(?):175881. doi:
10.1016/j.ejphar.2023.175881. [PMID: 37385579] - Ruixin Gu, Wei Zhang, Dandan Xu. Stachydrine is effective and selective against blast phase chronic myeloid leukaemia through inhibition of multiple receptor tyrosine kinases.
Pharmaceutical biology.
2022 Dec; 60(1):700-707. doi:
10.1080/13880209.2022.2044862. [PMID: 35348419] - T W Jung, H Kim, S Y Park, W Cho, H Oh, H J Lee, A M Abd El-Aty, A Hacimuftuoglu, J H Jeong. Stachydrine alleviates lipid-induced skeletal muscle insulin resistance via AMPK/HO-1-mediated suppression of inflammation and endoplasmic reticulum stress.
Journal of endocrinological investigation.
2022 Nov; 45(11):2181-2191. doi:
10.1007/s40618-022-01866-8. [PMID: 35834165] - Yan Zhang, Xin-Ping Cui, Wen-Quan Wang, Jun-Ling Hou, Bin-Bin Yan. [Effects of pH value on stachydrine biosynthesis of hydroponic Leonurus japonicus and its physiological mechanism].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Oct; 47(20):5502-5507. doi:
10.19540/j.cnki.cjcmm.20220712.101. [PMID: 36471966] - Eunjung Lee, Sunhee Kang, Ae-Ran Lee, Jae Ho Kim, Tae Wan Kim, Jang Eun Lee, Hye Ryun Kim. Stachydrine derived from fermented rice prevents diet-induced obesity by regulating adipsin and endoplasmic reticulum homeostasis.
The Journal of nutritional biochemistry.
2022 09; 107(?):109036. doi:
10.1016/j.jnutbio.2022.109036. [PMID: 35533898] - Xiaomei Bao, Yiman Liu, Jiayan Huang, Shuangshuang Yin, Hua Sheng, Xiao Han, Qian Chen, Tao Wang, Sibao Chen, Yuling Qiu, Chunze Zhang, Haiyang Yu. Stachydrine hydrochloride inhibits hepatocellular carcinoma progression via LIF/AMPK axis.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Jun; 100(?):154066. doi:
10.1016/j.phymed.2022.154066. [PMID: 35366490] - Xiangni Chen, Ning Yan. Stachydrine inhibits TGF-β1-induced epithelial-mesenchymal transition in hepatocellular carcinoma cells through the TGF-β/Smad and PI3K/Akt/mTOR signaling pathways.
Anti-cancer drugs.
2021 09; 32(8):786-792. doi:
10.1097/cad.0000000000001066. [PMID: 33675608] - Feng Li, Sifeng Zhu, Qihui Jiang, Chenhui Hou, Tao Pang, Liang Zhang, Wenbao Li. Novel Stachydrine-Leonurine Conjugate SL06 as a Potent Neuroprotective Agent for Cerebral Ischemic Stroke.
ACS chemical neuroscience.
2021 07; 12(13):2478-2490. doi:
10.1021/acschemneuro.1c00200. [PMID: 34180238] - Fei Zhou, Fei Liu, Juan Liu, Yu-Lin He, Qin-Mei Zhou, Li Guo, Cheng Peng, Liang Xiong. Stachydrine promotes angiogenesis by regulating the VEGFR2/MEK/ERK and mitochondrial-mediated apoptosis signaling pathways in human umbilical vein endothelial cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Nov; 131(?):110724. doi:
10.1016/j.biopha.2020.110724. [PMID: 32920518] - Jiali Zheng, Jing Tian, Sining Wang, Panwei Hu, Qianfu Wu, Xiaoli Shan, Pei Zhao, Chen Zhang, Wei Guo, Ming Xu, Huihua Chen, Rong Lu. Stachydrine hydrochloride suppresses phenylephrine-induced pathological cardiac hypertrophy by inhibiting the calcineurin/nuclear factor of activated T-cell signalling pathway.
European journal of pharmacology.
2020 Sep; 883(?):173386. doi:
10.1016/j.ejphar.2020.173386. [PMID: 32712088] - Fang Cheng, Yanxi Zhou, Miao Wang, Chuanjie Guo, Zhixing Cao, Ruoqi Zhang, Cheng Peng. A review of pharmacological and pharmacokinetic properties of stachydrine.
Pharmacological research.
2020 05; 155(?):104755. doi:
10.1016/j.phrs.2020.104755. [PMID: 32173585] - Hui-Hua Chen, Si-Ning Wang, Tong-Tong Cao, Jia-Li Zheng, Jing Tian, Xiao-Li Shan, Pei Zhao, Wei Guo, Ming Xu, Chen Zhang, Rong Lu. Stachydrine hydrochloride alleviates pressure overload-induced heart failure and calcium mishandling on mice.
Journal of ethnopharmacology.
2020 Feb; 248(?):112306. doi:
10.1016/j.jep.2019.112306. [PMID: 31626909] - Yan-Qing Wen, Li-Ying Gong, Lin Wang, Nan Zhao, Qi Sun, Mohamed Olounfeh Kamara, Hai-Ying Ma, Fan-Hao Meng. Comparative pharmacokinetics study of leonurine and stachydrine in normal rats and rats with cold-stagnation and blood-stasis primary dysmenorrhoea after the administration of Leonurus japonicus houtt electuary.
Journal of separation science.
2019 May; 42(9):1725-1732. doi:
10.1002/jssc.201801257. [PMID: 30839168] - Amal Al-Tamimi, Mohamad Khatib, Giuseppe Pieraccini, Nadia Mulinacci. Quaternary ammonium compounds in roots and leaves of Capparis spinosa L. from Saudi Arabia and Italy: investigation by HPLC-MS and 1H NMR.
Natural product research.
2019 May; 33(9):1322-1328. doi:
10.1080/14786419.2018.1475376. [PMID: 29781300] - Jinwei Gao, Jinbo Yu, Panpan Xu, Jinmei Chen, Guanghui Gao, Binglong Li, Lixin Sun. Established UPLC-MS/MS procedure for multicomponent quantitative analysis in rat plasma: A contrastive pharmacokinetics study of Qiangshen tablet in normal and kidney yang deficiency syndrome models.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Feb; 1106-1107(?):35-42. doi:
10.1016/j.jchromb.2018.12.031. [PMID: 30639948] - Jinlin Zhang, Aihua Yang, Yu Wu, Wei Guan, Biao Xiong, Xiaoqing Peng, Xiaojin Wei, Chang Chen, Zhaoguo Liu. Stachydrine ameliorates carbon tetrachloride-induced hepatic fibrosis by inhibiting inflammation, oxidative stress and regulating MMPs/TIMPs system in rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Jan; 97(?):1586-1594. doi:
10.1016/j.biopha.2017.11.117. [PMID: 29378386] - Oscar D Rangel-Huerta, Concepcion M Aguilera, Antonio Perez-de-la-Cruz, Fernando Vallejo, Francisco Tomas-Barberan, Angel Gil, Maria D Mesa. A serum metabolomics-driven approach predicts orange juice consumption and its impact on oxidative stress and inflammation in subjects from the BIONAOS study.
Molecular nutrition & food research.
2017 02; 61(2):. doi:
10.1002/mnfr.201600120. [PMID: 27689343] - Tong-Tong Cao, Hui-Hua Chen, Zhiwei Dong, Yan-Wu Xu, Pei Zhao, Wei Guo, Hong-Chang Wei, Chen Zhang, Rong Lu. Stachydrine Protects Against Pressure Overload-Induced Cardiac Hypertrophy by Suppressing Autophagy.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2017; 42(1):103-114. doi:
10.1159/000477119. [PMID: 28494450] - Mohamad Khatib, Giuseppe Pieraccini, Marzia Innocenti, Fabrizio Melani, Nadia Mulinacci. An insight on the alkaloid content of Capparis spinosa L. root by HPLC-DAD-MS, MS/MS and (1)H qNMR.
Journal of pharmaceutical and biomedical analysis.
2016 May; 123(?):53-62. doi:
10.1016/j.jpba.2016.01.063. [PMID: 26874255] - Hans Wilhelm Rauwald, Alex Savtschenko, Alexander Merten, Christian Rusch, Kurt Appel, Kenny Kuchta. GABAA Receptor Binding Assays of Standardized Leonurus cardiaca and Leonurus japonicus Extracts as Well as Their Isolated Constituents.
Planta medica.
2015 Aug; 81(12-13):1103-10. doi:
10.1055/s-0035-1546234. [PMID: 26218338] - Chen Zhang, Xiao-Li Shan, Yue-Ling Liao, Pei Zhao, Wei Guo, Hong-Chang Wei, Rong Lu. Effects of stachydrine on norepinephrine-induced neonatal rat cardiac myocytes hypertrophy and intracellular calcium transients.
BMC complementary and alternative medicine.
2014 Dec; 14(?):474. doi:
10.1186/1472-6882-14-474. [PMID: 25488774] - Abdallah Bashir, Tamara Hoffmann, Bettina Kempf, Xiulan Xie, Sander H J Smits, Erhard Bremer. Plant-derived compatible solutes proline betaine and betonicine confer enhanced osmotic and temperature stress tolerance to Bacillus subtilis.
Microbiology (Reading, England).
2014 Oct; 160(Pt 10):2283-2294. doi:
10.1099/mic.0.079665-0. [PMID: 25012968] - Kenny Kuchta, Jutta Ortwein, Lothar Hennig, Hans Wilhelm Rauwald. ¹H-qNMR for direct quantification of stachydrine in Leonurus japonicus and L. cardiaca.
Fitoterapia.
2014 Jul; 96(?):8-17. doi:
10.1016/j.fitote.2014.03.023. [PMID: 24704554] - Kristina D Rogers, Joseph C Cannistra, James B Gloer, Donald T Wicklow. Diplodiatoxin, chaetoglobosins, and diplonine associated with a field outbreak of Stenocarpella ear rot in Illinois.
Mycotoxin research.
2014 May; 30(2):61-70. doi:
10.1007/s12550-014-0188-0. [PMID: 24504633] - K Kuchta, R B Volk, H W Rauwald. Stachydrine in Leonurus cardiaca, Leonurus japonicus, Leonotis leonurus: detection and quantification by instrumental HPTLC and 1H-qNMR analyses.
Die Pharmazie.
2013 Jul; 68(7):534-40. doi:
. [PMID: 23923634] - Baohong Li, Jindong Wu, Xianglu Li. Simultaneous determination and pharmacokinetic study of stachydrine and leonurine in rat plasma after oral administration of Herba Leonuri extract by LC-MS/MS.
Journal of pharmaceutical and biomedical analysis.
2013 Mar; 76(?):192-9. doi:
10.1016/j.jpba.2012.12.029. [PMID: 23348611] - Xia Li, Bin Wang, Yuzhu Li, Li Wang, Xiangzhong Zhao, Xianbin Zhou, Yuqi Guo, Guosheng Jiang, Chengfang Yao. The Th1/Th2/Th17/Treg paradigm induced by stachydrine hydrochloride reduces uterine bleeding in RU486-induced abortion mice.
Journal of ethnopharmacology.
2013 Jan; 145(1):241-53. doi:
10.1016/j.jep.2012.10.059. [PMID: 23178269] - Luigi Servillo, Alfonso Giovane, Maria Luisa Balestrieri, Giovanna Ferrari, Domenico Cautela, Domenico Castaldo. Occurrence of pipecolic acid and pipecolic acid betaine (homostachydrine) in Citrus genus plants.
Journal of agricultural and food chemistry.
2012 Jan; 60(1):315-21. doi:
10.1021/jf204286r. [PMID: 22208890] - Nilufer Rahmioglu, Gwénaëlle Le Gall, James Heaton, Kristine L Kay, Norman W Smith, Ian J Colquhoun, Kourosh R Ahmadi, E Kate Kemsley. Prediction of variability in CYP3A4 induction using a combined 1H NMR metabonomics and targeted UPLC-MS approach.
Journal of proteome research.
2011 Jun; 10(6):2807-16. doi:
10.1021/pr200077n. [PMID: 21491888] - Laura Sánchez-Hernández, María Castro-Puyana, María Luisa Marina, Antonio L Crego. Determination of betaines in vegetable oils by capillary electrophoresis tandem mass spectrometry--application to the detection of olive oil adulteration with seed oils.
Electrophoresis.
2011 Jun; 32(11):1394-401. doi:
10.1002/elps.201100005. [PMID: 21520150] - Xiaolu Feng, Jincai Lu, Hailiang Xin, Lei Zhang, Yuliang Wang, Kexuan Tang. Anti-arthritic active fraction of Capparis spinosa L. fruits and its chemical constituents.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2011 Mar; 131(3):423-9. doi:
10.1248/yakushi.131.423. [PMID: 21372539] - Silke S Heinzmann, Ian J Brown, Queenie Chan, Magda Bictash, Marc-Emmanuel Dumas, Sunil Kochhar, Jeremiah Stamler, Elaine Holmes, Paul Elliott, Jeremy K Nicholson. Metabolic profiling strategy for discovery of nutritional biomarkers: proline betaine as a marker of citrus consumption.
The American journal of clinical nutrition.
2010 Aug; 92(2):436-43. doi:
10.3945/ajcn.2010.29672. [PMID: 20573794] - Inigo Uriarte-Pueyo, María Goicoechea, Ana Gloria Gil, Adela López de Cerain, Adolfo López de Munain, María Isabel Calvo. Negative evidence for stachydrine or Galeopsis ladanum L. seeds as the causal agents of coturnism after quail meat ingestion.
Journal of agricultural and food chemistry.
2009 Nov; 57(22):11055-9. doi:
10.1021/jf902764n. [PMID: 19860419] - Qian Shi, Ze Liu, Yang Yang, Peng Geng, Yuan-yuan Zhu, Qi Zhang, Fang Bai, Gang Bai. Identification of anti-asthmatic compounds in Pericarpium citri reticulatae and evaluation of their synergistic effects.
Acta pharmacologica Sinica.
2009 May; 30(5):567-75. doi:
10.1038/aps.2009.36. [PMID: 19363516] - Alexandre Boscari, Ghislaine Van de Sype, Daniel Le Rudulier, Karine Mandon. Overexpression of BetS, a Sinorhizobium meliloti high-affinity betaine transporter, in bacteroids from Medicago sativa nodules sustains nitrogen fixation during early salt stress adaptation.
Molecular plant-microbe interactions : MPMI.
2006 Aug; 19(8):896-903. doi:
10.1094/mpmi-19-0896. [PMID: 16903355] - Huai-Xia Chen, Shao-Lin Shen, Feng-Mei Han, Yong Chen. [HPLC-ESI/MS analysis of stachydrine and its metabolites in rat urine].
Yao xue xue bao = Acta pharmaceutica Sinica.
2006 May; 41(5):467-70. doi:
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Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA.
2004 Nov; 24(11):1223-6. doi:
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Plant physiology.
2004 Jul; 135(3):1583-94. doi:
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Proceedings of the National Academy of Sciences of the United States of America.
1994 Jan; 91(1):306-10. doi:
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Molecular plant-microbe interactions : MPMI.
1991 Nov; 4(6):571-8. doi:
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Zhong yao tong bao (Beijing, China : 1981).
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". [PMID: 3157476] - . .
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. [PMID: 10689197]