Anhydrovinblastine (BioDeep_00000395854)

Main id: BioDeep_00000008773

 

PANOMIX_OTCML-2023 Chemicals and Drugs


代谢物信息卡片


methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R)-17-ethyl-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9,16-pentaen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate

化学式: C46H56N4O8 (792.4097936000001)
中文名称: 脱水长春碱
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC1=CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC
InChI: InChI=1S/C46H56N4O8/c1-8-28-21-29-24-45(41(52)56-6,37-31(15-19-49(25-28)26-29)30-13-10-11-14-34(30)47-37)33-22-32-35(23-36(33)55-5)48(4)39-44(32)17-20-50-18-12-16-43(9-2,38(44)50)40(58-27(3)51)46(39,54)42(53)57-7/h10-14,16,21-23,29,38-40,47,54H,8-9,15,17-20,24-26H2,1-7H3/t29-,38-,39+,40+,43+,44+,45-,46-/m0/s1

描述信息

Anhydrovinblastine has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific.
Anhydrovinblastine is a semisynthetic derivative of the vinca alkaloid vinblastine, with potential antineoplastic activity. Like vinblastine, anhydrovinblastine targets and binds to tubulin and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and causing tumor cell cycle arrest in the M phase.
C274 - Antineoplastic Agent > C1931 - Antineoplastic Plant Product > C932 - Vinca Alkaloid Compound
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C273 - Antimitotic Agent
D000970 - Antineoplastic Agents > D014748 - Vinca Alkaloids
C1907 - Drug, Natural Product

同义名列表

13 个代谢物同义名

methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R)-17-ethyl-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9,16-pentaen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate; Vincaleukoblastine, 3,4-didehydro-4-deoxy-; 3,4-anhydrovinblastine, (18alpha)-isomer; 3,4-Didehydro-4-deoxuvincaleukoblastine; 3,4-Didehydroisoleurosine; Anhydrovincaleukoblastine; 3,4-Didehydrovinblastine; 3,4-Dehydroisoleurosine; 3,4-Anhydrovinblastine; (+)-ANHYDROVINBLASTINE; Anhydrovinblastine; UNII-5B622U08B3; 5B622U08B3



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Mamiko Asano, Kazuo Harada, Akiko Umeno, IKazutnasa Hirata. Optimization of 3', 4'-Anhydrovinblastine Synthesis in vitro Using Crude Extracts of Catharanthus roseus Irradiated with Near- Ultraviolet Light. Natural product communications. 2016 Aug; 11(8):1089-1092. doi: . [PMID: 30725564]
  • Inês Carqueijeiro, Henrique Noronha, Patrícia Duarte, Hernâni Gerós, Mariana Sottomayor. Vacuolar transport of the medicinal alkaloids from Catharanthus roseus is mediated by a proton-driven antiport. Plant physiology. 2013 Jul; 162(3):1486-96. doi: 10.1104/pp.113.220558. [PMID: 23686419]
  • Han-Kun Zhang, Yong Shao, Hong Ding, Li-Hong Hu. Synthesis and structure-activity relationship studies of cytotoxic ester and ether anhydrovinblastine derivatives. Journal of natural products. 2008 Oct; 71(10):1669-76. doi: 10.1021/np800284h. [PMID: 18771244]
  • Arvind Verma, Kari Hartonen, Marja-Liisa Riekkola. Optimisation of supercritical fluid extraction of indole alkaloids from Catharanthus roseus using experimental design methodology--comparison with other extraction techniques. Phytochemical analysis : PCA. 2008 Jan; 19(1):52-63. doi: 10.1002/pca.1015. [PMID: 17654538]
  • M Sottomayor, A Ros Barceló. Peroxidase from Catharanthus roseus (L.) G. Don and the biosynthesis of alpha-3',4'-anhydrovinblastine: a specific role for a multifunctional enzyme. Protoplasma. 2003 Sep; 222(1-2):97-105. doi: 10.1007/s00709-003-0003-9. [PMID: 14513315]