anisodamine (BioDeep_00000395841)
PANOMIX_OTCML-2023
代谢物信息卡片
BENZENEACETIC ACID, .ALPHA.-(HYDROXYMETHYL)-, 6-HYDROXY-8-METHYL-8-AZABICYCLO(3.2.1)OCT-3-YL ESTER, HYDROBROMIDE, (1R-(1.ALPHA.,3.BETA.(S*),5.ALPHA.,6.ALPHA.))-
化学式: C17H24BrNO4 (385.08886040000004)
中文名称: 氢溴酸山莨菪碱
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 7.14%
分子结构信息
SMILES: CN1C2CC(CC1C(C2)O)OC(=O)C(CO)C3=CC=CC=C3.Br
InChI: /m0./s1
描述信息
Anisodamine hydrobromide (6-Hydroxyhyoscyamine hydrobromide), a belladonna alkaloid, is a non-subtype-selective muscarinic and a nicotinic cholinoceptor antagonist. Anisodamine hydrobromide shows antioxidant, anti-inflammatory properties[1][2].
Anisodamine hydrobromide (6-Hydroxyhyoscyamine hydrobromide), a belladonna alkaloid, is a non-subtype-selective muscarinic and a nicotinic cholinoceptor antagonist. Anisodamine hydrobromide shows antioxidant, anti-inflammatory properties[1][2].
同义名列表
21 个代谢物同义名
BENZENEACETIC ACID, .ALPHA.-(HYDROXYMETHYL)-, 6-HYDROXY-8-METHYL-8-AZABICYCLO(3.2.1)OCT-3-YL ESTER, HYDROBROMIDE, (1R-(1.ALPHA.,3.BETA.(S*),5.ALPHA.,6.ALPHA.))-; Benzeneacetic acid, alpha-(hydroxymethyl)-, 6-hydroxy-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, hydrobromide, (1R-(1alpha,3beta(S*),5alpha,6alpha))-; BENZENEACETIC ACID, .ALPHA.-(HYDROXYMETHYL)-, (1R,3S,5R,6S)-6-HYDROXY-8-METHYL-8-AZABICYCLO(3.2.1)OCT-3-YL ESTER, HYDROBROMIDE (1:1), (.ALPHA.S)-; Benzeneacetic acid, alpha-(hydroxymethyl)-, (1R,3S,5R,6S)-6-hydroxy-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, hydrobromide (1:1), (alphaS)-; BENZENEACETIC ACID, .ALPHA.-(HYDROXYMETHYL)-, (1R,3S,5R,6S)-6-HYDROXY-8-METHYL-8-AZABICYCLO(3.2.1)OCT-3-YL ESTER, HYDROBROMIDE, (.ALPHA.S)-; Benzeneacetic acid, alpha-(hydroxymethyl)-, (1R,3S,5R,6S)-6-hydroxy-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, hydrobromide, (alphaS)-; [(1R,3S,5R,6S)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] (2S)-3-hydroxy-2-phenylpropanoate;hydrobromide; L-TROPIC ACID, 6.BETA.-HYDROXY-3.ALPHA.-TROPANYL ESTER, HYDROBROMIDE; L-Tropic acid, 6beta-hydroxy-3alpha-tropanyl ester, hydrobromide; Hyoscyamine, 6-hydroxy-, hydrobromide; (-)-6-Hydroxyhyoscyamine hydrobromide; Anisodamine hydrobromide [WHO-DD]; Anisodamine (hydrobromide); anisodamine hydrobromide; 6-hydroxyhyoscyamine; Anisodamine HBr; UNII-4RKP5CSA1O; Racanisodamine; anisodamine; 4RKP5CSA1O; 6-Hydroxyhyoscyamine (hydrobromide)
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 118856046
- MeSH: anisodamine
- ChemIDplus: 0055449495
- CAS: 55449-49-5
- medchemexpress: HY-N0584A
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Fei Tang, Dong Liu, Feng Wan, Li Zhang, Li-Yue Xu, Jing-Nan Zhang, Xiao-Lan Zhao, Hui Ao, Cheng Peng. Ameliorative effect of anisodamine (654-1/654-2) against myocardial dysfunction induced by septic shock via the NF-κB/NLRP-3 or the PI3K-AKT/NF-κB pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jan; 123(?):155277. doi:
10.1016/j.phymed.2023.155277. [PMID: 38128396] - Yuan Zhang, Jiayu Zou, Feng Wan, Fu Peng, Cheng Peng. Update on the sources, pharmacokinetics, pharmacological action, and clinical application of anisodamine.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 May; 161(?):114522. doi:
10.1016/j.biopha.2023.114522. [PMID: 37002581] - Juan M Minoia, María E Villanueva, Guillermo J Copello, Julián Rodríguez Talou, Alejandra B Cardillo. Recycling of hyoscyamine 6β-hydroxylase for the in vitro production of anisodamine and scopolamine.
Applied microbiology and biotechnology.
2023 Apr; ?(?):. doi:
10.1007/s00253-023-12537-w. [PMID: 37099059] - Yan Qiu, Zhi Ouyang, Jian Zhong, Junyi Shen, Wenli Jiang, Yan Liu, Feng Wan, Ye Zeng. Anisodamine hydrobromide attenuates oxidative stress and proinflammatory cytokines in septic rats induced by cecal ligation and puncture.
Cellular and molecular biology (Noisy-le-Grand, France).
2022 Dec; 68(12):54-60. doi:
10.14715/cmb/2022.68.12.11. [PMID: 37130180] - Wei Wei, Ni Kong, Meng-Zhen Liu, Ting Han, Jun-Feng Xu, Chong Liu. Anisodamine potently inhibits SARS-CoV-2 infection in vitro and targets its main protease.
Biochemical and biophysical research communications.
2022 08; 616(?):8-13. doi:
10.1016/j.bbrc.2022.05.024. [PMID: 35636257] - Yuetian Yu, Cheng Zhu, Yucai Hong, Lin Chen, Zhiping Huang, Jiancang Zhou, Xin Tian, Dadong Liu, Bo Ren, Cao Zhang, Caibao Hu, Xinan Wang, Rui Yin, Yuan Gao, Zhongheng Zhang. Effectiveness of anisodamine for the treatment of critically ill patients with septic shock: a multicentre randomized controlled trial.
Critical care (London, England).
2021 09; 25(1):349. doi:
10.1186/s13054-021-03774-4. [PMID: 34579741] - Shu Zhang, Xianzhi Xu, Yuanhong Huang, Siyuan Sun, Chengqi Jin, Hao Ji, Dong Sun, Anzhou Xia. Anisodamine ameliorates ischemia/reperfusion-induced renal injury in rats through activation of the extracellular signal-regulated kinase (ERK) pathway and anti-apoptotic effect.
Die Pharmazie.
2021 05; 76(5):220-224. doi:
10.1691/ph.2021.1302. [PMID: 33964996] - Lingjiang Zeng, Qiaozhuo Zhang, Chunxue Jiang, Yueyue Zheng, Youwei Zuo, Jianbo Qin, Zhihua Liao, Hongping Deng. Development of Atropa belladonna L. Plants with High-Yield Hyoscyamine and without Its Derivatives Using the CRISPR/Cas9 System.
International journal of molecular sciences.
2021 Feb; 22(4):. doi:
10.3390/ijms22041731. [PMID: 33572199] - Zile Wang, Pimiao Zheng, Jianyi Wang, Shuang He, Zhenhui Ren, Yanfang Zhang, Jincheng Xiong, Haiyang Jiang. Indirect competitive enzyme-linked immunosorbent assay based on a broad-spectrum monoclonal antibody for tropane alkaloids detection in pig urine, pork and cereal flours.
Food chemistry.
2021 Feb; 337(?):127617. doi:
10.1016/j.foodchem.2020.127617. [PMID: 32799156] - Feng Wan, Xiaoqiang Du, Huan Liu, Xueling He, Ye Zeng. Protective effect of anisodamine hydrobromide on lipopolysaccharide-induced acute kidney injury.
Bioscience reports.
2020 07; 40(7):. doi:
10.1042/bsr20201812. [PMID: 32573678] - Zhiwei Xu, Tong Wang, Liang Chen, Ying Lou, Xiaoyan Sun, Jinqi Jiang. Treatment of dilated cardiomyopathy caused by coronary microvascular dysfunction with anisodamine: a report of 5 cases.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2020 04; 40(2):340-342. doi:
. [PMID: 32242401] - Yiyi Yan, Xingchen Huo, Taoshan Ai, Jianguo Su. β-glucan and anisodamine can enhance the immersion immune efficacy of inactivated cyprinid herpesvirus 2 vaccine in Carassius auratus gibelio.
Fish & shellfish immunology.
2020 Mar; 98(?):285-295. doi:
10.1016/j.fsi.2020.01.025. [PMID: 31962149] - Tengfei Zhao, Siqi Li, Jing Wang, Qi Zhou, Chunxian Yang, Feng Bai, Xiaozhong Lan, Min Chen, Zhihua Liao. Engineering Tropane Alkaloid Production Based on Metabolic Characterization of Ornithine Decarboxylase in Atropa belladonna.
ACS synthetic biology.
2020 02; 9(2):437-448. doi:
10.1021/acssynbio.9b00461. [PMID: 31935324] - Zhen Qin, Kefa Xiang, Ding-Feng Su, Yang Sun, Xia Liu. Activation of the Cholinergic Anti-Inflammatory Pathway as a Novel Therapeutic Strategy for COVID-19.
Frontiers in immunology.
2020; 11(?):595342. doi:
10.3389/fimmu.2020.595342. [PMID: 33633726] - Tianxiang Lei, Huan Wang, Songling Li, Xiaojian Cai, Shilong Chen, Tingfeng Cheng, Jianwei Shen, Shengbo Shi, Dangwei Zhou. Comparison of Profiling of Hairy Root of Two Tibetan Medicinal Plants Przewalskia tangutica Maxim. and Anisodus tanguticus Maxim.
Current pharmaceutical biotechnology.
2020; 21(6):516-527. doi:
10.2174/1389201020666191127125842. [PMID: 31775597] - Yun-Feng Li, Bing-Yuan Xu, Ran An, Xin-Fang Du, Kun Yu, Jia-Hua Sun, Guo-Hong Zhang, Wei Wang, Li-Ping An, Guang-Li Wu. Protective effect of anisodamine in rats with glycerol-induced acute kidney injury.
BMC nephrology.
2019 06; 20(1):223. doi:
10.1186/s12882-019-1394-y. [PMID: 31208365] - Daniel Schlesinger, Rachel Davidovich Rikanati, Sergei Volis, Adi Faigenboim, Vera Vendramin, Federica Cattonaro, Matthew Hooper, Elad Oren, Mark Taylor, Yaron Sitrit, Moshe Inbar, Efraim Lewinsohn. Alkaloid chemodiversity in Mandragora spp. is associated with loss-of-functionality of MoH6H, a hyoscyamine 6β-hydroxylase gene.
Plant science : an international journal of experimental plant biology.
2019 Jun; 283(?):301-310. doi:
10.1016/j.plantsci.2019.03.013. [PMID: 31128700] - Jiacheng Zhang, Xiaozhe Fu, Yanqi Zhang, Wentao Zhu, Yong Zhou, Gailing Yuan, Xiaoling Liu, Taoshan Ai, Lingbing Zeng, Jianguo Su. Chitosan and anisodamine improve the immune efficacy of inactivated infectious spleen and kidney necrosis virus vaccine in Siniperca chuatsi.
Fish & shellfish immunology.
2019 Jun; 89(?):52-60. doi:
10.1016/j.fsi.2019.03.040. [PMID: 30904683] - Kathrin Laura Kohnen, Selahaddin Sezgin, Michael Spiteller, Hansjörg Hagels, Oliver Kayser. Localization and Organization of Scopolamine Biosynthesis in Duboisia myoporoides R. Br.
Plant & cell physiology.
2018 Jan; 59(1):107-118. doi:
10.1093/pcp/pcx165. [PMID: 29095998] - Xiaopeng Yuan, Yitao Zheng, Chuanbao Chen, Changxi Wang. Anisodamine inhibits endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in rhabdomyolysis-induced acute kidney injury.
Apoptosis : an international journal on programmed cell death.
2017 Dec; 22(12):1524-1531. doi:
10.1007/s10495-017-1414-y. [PMID: 28918467] - Xiao Li, Wei Qiang, Fei Qiu, Min Chen, Xiao-zhong Lan, Zhi-hua Liao, Xiao-qiang Liu. [Cloning and characterization of an aromatic amino acid aminotransferase(ArAT) gene involved in tropane alkaloid biosynthesis from Hyoscyamus niger].
Yao xue xue bao = Acta pharmaceutica Sinica.
2017 Jan; 52(1):172-9. doi:
. [PMID: 29911833] - Zhe-Qi Xu, Bo-Zong Shao, Ping Ke, Jian-Guo Liu, Guo-Ku Liu, Xiong-Wen Chen, Ding-Feng Su, Chong Liu. Combined administration of anisodamine and neostigmine rescued acute lethal crush syndrome through α7nAChR-dependent JAK2-STAT3 signaling.
Scientific reports.
2016 11; 6(?):37709. doi:
10.1038/srep37709. [PMID: 27874086] - Arik Eisenkraft, Avshalom Falk. Possible role for anisodamine in organophosphate poisoning.
British journal of pharmacology.
2016 06; 173(11):1719-27. doi:
10.1111/bph.13486. [PMID: 27010563] - Yue-De Cao, Yu-Cai He, Hao Li, Guo-Yin Kai, Jian-He Xu, Hui-Lei Yu. Efficient biosynthesis of rare natural product scopolamine using E. coli cells expressing a S14P/K97A mutant of hyoscyamine 6β-hydroxylase AaH6H.
Journal of biotechnology.
2015 Oct; 211(?):123-9. doi:
10.1016/j.jbiotec.2015.07.019. [PMID: 26239231] - Szymon Dziomba, Teresa Łepek, Zbigniew Jaremicz, Maria Łuczkiewicz, Adam Prahl, Piotr Kowalski. Simultaneous determination of scopolamine, hyoscyamine and anisodamine in in vitro growth media of selected Solanaceae hairy roots by CE method.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Sep; 1001(?):17-21. doi:
10.1016/j.jchromb.2015.06.029. [PMID: 26253806] - Fengjie Tian, Cuiyun Li, Xin Wang, Shuangxia Ren, Ning Li, Qi Liu, Sufeng Zhou, Yang Lu, Di Zhao, Xijing Chen. Comparative study on pharmacokinetics of a series of anticholinergics, atropine, anisodamine, anisodine, scopolamine and tiotropium in rats.
European journal of drug metabolism and pharmacokinetics.
2015 Sep; 40(3):245-53. doi:
10.1007/s13318-014-0192-y. [PMID: 24748278] - Yun-bin Jiang, Yan Gou, Mao-hua Yuan, Yu-ying Ma, Juan Zhou, Pi-e Wu. [HPLC Fingerprint of Anisodus tanguticus Root].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2015 May; 38(5):957-61. doi:
. [PMID: 26767288] - Peiting Zhang, Yemeng Li, Guanghui Liu, Xiuman Sun, Yuting Zhou, Xuejiao Deng, Qiongfeng Liao, Zhiyong Xie. Simultaneous determination of atropine, scopolamine, and anisodamine from Hyoscyamus niger L. in rat plasma by high-performance liquid chromatography with tandem mass spectrometry and its application to a pharmacokinetics study.
Journal of separation science.
2014 Oct; 37(19):2664-74. doi:
10.1002/jssc.201400534. [PMID: 25044356] - Qing-hai You, Dan Zhang, Cheng-cheng Niu, Zhong-ming Zhu, Nan Wang, Yang Yue, Geng-yun Sun. Expression of IL-17A and IL-17F in lipopolysaccharide-induced acute lung injury and the counteraction of anisodamine or methylprednisolone.
Cytokine.
2014 Mar; 66(1):78-86. doi:
10.1016/j.cyto.2013.12.019. [PMID: 24548428] - Meng Ning, Jing-Hui Huang, Yan-Fang Zhang, Wen-Yu Cui, Hai Wang. [Novel drug composition ameliorating thrombosis and its molecular mechanisms].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2014 Mar; 30(2):184-8. doi:
. [PMID: 25016879] - Xudong Deng, Chong Shen, Qin Meng. Screening of herbal components for attenuating amiodarone-induced hepatotoxicity on gel-entrapped rat hepatocytes.
Drug and chemical toxicology.
2014 Jan; 37(1):100-6. doi:
10.3109/01480545.2013.834347. [PMID: 24274456] - Chong-Hui Li, Xuan Zhang, Xin-Lan Ge, Xin Huang, Ai-Qun Zhang, Wan-Qing Gu. Effects of combined anisodamine and neostigmine treatment on the inflammatory response and liver regeneration of obstructive jaundice rats after hepatectomy.
BioMed research international.
2014; 2014(?):362024. doi:
10.1155/2014/362024. [PMID: 25478569] - Zbigniew Jaremicz, Maria Luczkiewicz, Mariusz Kisiel, Rafael Zárate, Nabil El Jaber-Vazdekis, Piotr Migas. Multi-development-HPTLC method for quantitation of hyoscyamine, scopolamine and their biosynthetic precursors in selected solanaceae plants grown in natural conditions and as in vitro cultures.
Phytochemical analysis : PCA.
2014 Jan; 25(1):29-35. doi:
10.1002/pca.2455. [PMID: 23839972] - Wen Peng Guo, Zhi Bin Rong, Ying Hong Li, Ying Sing Fung, Guo Quan Gao, Zhi Ming Cai. Microfluidic chip capillary electrophoresis coupled with electrochemiluminescence for enantioseparation of racemic drugs using central composite design optimization.
Electrophoresis.
2013 Nov; 34(20-21):2962-9. doi:
10.1002/elps.201300238. [PMID: 24037989] - Wenxue Li, Jun Wen, Jingyu He, Di Cao, Fanlu Sun, Jinying Li, Guorong Fan. Development and validation of a rapid and sensitive assay for the determination of anisodamine in 50 μL of beagle dog plasma by LC-MS/MS.
Journal of separation science.
2013 Oct; 36(19):3184-90. doi:
10.1002/jssc.201300451. [PMID: 23897549] - Nengsheng Ye, Jian Li, Chong Gao, Yali Xie. Simultaneous determination of atropine, scopolamine, and anisodamine in Flos daturae by capillary electrophoresis using a capillary coated by graphene oxide.
Journal of separation science.
2013 Aug; 36(16):2698-702. doi:
10.1002/jssc.201300304. [PMID: 23868645] - Ya-hua Liu, Jie Zhang, Zheng Dai, Man-hong Zhou, Yu-hua Li, Xue-lian Yin, Wei Zhang, Hong Shen. [Protection of anisodamine on the mitochondrial injury induced by oxidative stress in swine with cardiac arrest].
Zhonghua wei zhong bing ji jiu yi xue.
2013 May; 25(5):290-3. doi:
10.3760/cma.j.issn.2095-4352.2013.05.013. [PMID: 23663580] - Ya-hua Liu, Man-hong Zhou, Zheng Dai, Jie Zhang, Hai-yan Zhu, Yu-hua Li, Xue-lian Yin, Wei Zhang, Hong Shen. [Protective effect of anisodamine against myocardial cell apoptosis through mitochondria impairment in cardiac arrest in pigs].
Zhonghua wei zhong bing ji jiu yi xue.
2013 Feb; 25(2):88-91. doi:
10.3760/cma.j.issn.2095-4352.2013.02.009. [PMID: 23648158] - Wei Geng, Xiang-Hua Fu, Xin-Shun Gu, Yan-Bo Wang, Xue-Chao Wang, Wei Li, Yun-Fa Jiang, Guo-Zhen Hao, Wei-Ze Fan, Ling Xue. Preventive effects of anisodamine against contrast-induced nephropathy in type 2 diabetics with renal insufficiency undergoing coronary angiography or angioplasty.
Chinese medical journal.
2012 Oct; 125(19):3368-72. doi:
. [PMID: 23044290] - Li Sun, Gu-fang Zhang, Xin Zhang, Qing Liu, Jian-guo Liu, Ding-feng Su, Chong Liu. Combined administration of anisodamine and neostigmine produces anti-shock effects: involvement of α7 nicotinic acetylcholine receptors.
Acta pharmacologica Sinica.
2012 Jun; 33(6):761-6. doi:
10.1038/aps.2012.26. [PMID: 22580739] - Hui Wu, Zhefeng Fan. Mn-doped ZnS quantum dots for the room-temperature phosphorescence detection of raceanisodamine hydrochloride and atropine sulfate in biological fluids.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2012 May; 90(?):131-4. doi:
10.1016/j.saa.2012.01.041. [PMID: 22336044] - Yan-bo Wang, Xiang-hua Fu, Xin-shun Gu, Xue-chao Wang, Yu-jun Zhao, Guo-zhen Hao, Yun-fa Jiang, Wei-ze Fan, Wei-li Wu, Shi-qiang Li, Ling Xue. Safety and efficacy of anisodamine on prevention of contrast induced nephropathy in patients with acute coronary syndrome.
Chinese medical journal.
2012 Mar; 125(6):1063-7. doi:
NULL. [PMID: 22613532] - Yanbo Wang, Xianghua Fu, Xuechao Wang, Xinwei Jia, Xinshun Gu, Jing Zhang, Jianling Su, Guozhen Hao, Yunfa Jiang, Weize Fan, Weili Wu, Shiqiang Li. Protective effects of anisodamine on renal function in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention.
The Tohoku journal of experimental medicine.
2011 06; 224(2):91-7. doi:
10.1620/tjem.224.91. [PMID: 21597242] - Alejandra Beatriz Cardillo, Angela María Otalvaro Alvarez, Ariel Calabró Lopez, Mario Enrique Velásquez Lozano, Julián Rodríguez Talou, Ana María Giulietti. Anisodamine production from natural sources: seedlings and hairy root cultures of Argentinean and Colombian Brugmansia candida plants.
Planta medica.
2010 Mar; 76(4):402-5. doi:
10.1055/s-0029-1186164. [PMID: 19790035] - Baiqing Yuan, Chunying Zheng, Hong Teng, Tianyan You. Simultaneous determination of atropine, anisodamine, and scopolamine in plant extract by nonaqueous capillary electrophoresis coupled with electrochemiluminescence and electrochemistry dual detection.
Journal of chromatography. A.
2010 Jan; 1217(1):171-4. doi:
10.1016/j.chroma.2009.11.008. [PMID: 19931863] - You-Ling Jing, Yan-Lei Wang, Ying Sun, Chun-Xiu Zhao, Hong-Jie Li, Xiao-Yan Kong. [Experimental research of prevention and therapy effect of anisodamine on acute respiratory distress syndrome (ARDS)].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2009 Nov; 25(4):557-60. doi:
. [PMID: 21158057] - Lin Luo, Ailing Zhou. Antifibrotic activity of anisodamine in vivo is associated with changed intrahepatic levels of matrix metalloproteinase-2 and its inhibitor tissue inhibitors of metalloproteinases-2 and transforming growth factor beta1 in rats with carbon tetrachloride-induced liver injury.
Journal of gastroenterology and hepatology.
2009 Jun; 24(6):1070-6. doi:
10.1111/j.1440-1746.2008.05756.x. [PMID: 19220677] - Yong-Yun Wei, Xiang-Hua Fu, Jun Liu. [Effect of intra-coronary injection of anisodamine on the slow-reflow phenomenon in patients with acute myocardial infarction after percutaneous coronary intervention].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2008 Apr; 28(4):295-9. doi:
". [PMID: 18543478] - Ping Gong, Yu Zhang, Hui Liu, Guang-kuo Zhao, Hong Jiang. [Effects of penehyclidine hydrochloride on the splanchnic perfusion of patients with septic shock].
Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue.
2008 Mar; 20(3):183-6. doi:
". [PMID: 18328136] - Li Zhang, Rong Wang, Yurong Zhang, Yunqiu Yu. Application of high performance capillary electrophoresis on toxic alkaloids analysis.
Journal of separation science.
2007 Jun; 30(9):1357-63. doi:
10.1002/jssc.200600363. [PMID: 17623479] - Jay M Poupko, Steven I Baskin, Eric Moore. The pharmacological properties of anisodamine.
Journal of applied toxicology : JAT.
2007 Mar; 27(2):116-21. doi:
10.1002/jat.1154. [PMID: 17186568] - Huai-Xia Chen, Peng Du, Feng-Mei Han, Yong Chen. [Detection of anisodamine and its metabolites in rat feces by tandem mass spectrometry].
Yao xue xue bao = Acta pharmaceutica Sinica.
2006 Dec; 41(12):1166-9. doi:
. [PMID: 17290614] - László Kursinszki, Hajnalka Hank, Imre László, Eva Szoke. Simultaneous analysis of hyoscyamine, scopolamine, 6beta-hydroxyhyoscyamine and apoatropine in Solanaceous hairy roots by reversed-phase high-performance liquid chromatography.
Journal of chromatography. A.
2005 Oct; 1091(1-2):32-9. doi:
10.1016/j.chroma.2005.07.016. [PMID: 16395790] - Huaixia Chen, Hong Wang, Yong Chen, Huashan Zhang. Liquid chromatography-tandem mass spectrometry analysis of anisodamine and its phase I and II metabolites in rat urine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Sep; 824(1-2):21-9. doi:
10.1016/j.jchromb.2005.07.036. [PMID: 16095983] - Saori Nakagawa, Koji Kushiya, Ikue Taneike, Ken'ichi Imanishi, Takehiko Uchiyama, Tatsuo Yamamoto. Specific inhibitory action of anisodamine against a staphylococcal superantigenic toxin, toxic shock syndrome toxin 1 (TSST-1), leading to down-regulation of cytokine production and blocking of TSST-1 toxicity in mice.
Clinical and diagnostic laboratory immunology.
2005 Mar; 12(3):399-408. doi:
10.1128/cdli.12.3.399-408.2005. [PMID: 15753253] - G R Fan, Z Y Hong, M Lin, X P Yin, Y T Wu. Study of stereoselective pharmacokinetics of anisodamine enantiomers in rabbits by capillary electrophoresis.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2004 Oct; 809(2):265-71. doi:
10.1016/j.jchromb.2004.06.030. [PMID: 15315775] - Qiu-rong Ruan, Jian-xin Song, Zhong-duan Deng. [Study on effect of anisodamine on expressions of tissue factor and plasminogen activator-1 inhibitor in vascular endothelial cells and its mechanisms].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2004 May; 24(5):422-6. doi:
. [PMID: 15199627] - Lucy B Esberg, Jun Ren. The oxygen radical generator pyrogallol impairs cardiomyocyte contractile function via a superoxide and p38 MAP kinase-dependent pathway: protection by anisodamine and tetramethylpyrazine.
Cardiovascular toxicology.
2004; 4(4):375-84. doi:
10.1385/ct:4:4:375. [PMID: 15531780] - Hongzhi Yang, Kangshou Guo, Weisheng Shen, Yongwei Li, Min Dai. [Clinical observation of the treatment of 654-2 injection and 'ganxian tui huang recipe' on liver cirrhosis with intractable jaundice].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2003 May; 26(5):385-7. doi:
NULL. [PMID: 14535021] - Ling Xie, Lin Zhao, Ming Li. Zusanli point injection for treating leukopenia induced by radio-chemotherapy.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2003 Mar; 23(1):59-61. doi:
". [PMID: 12747206] - Y H Liu, Y F Liu, X X Guo. Current studies on anti-endotoxic chemical components of traditional Chinese medicine in China.
Acta pharmacologica Sinica.
2001 Dec; 22(12):1071-7. doi:
. [PMID: 11749802] - K Ma, Y Yu, X M Bu, Y J Li, X W Dai, L Wang, Y Dai, H Y Zhao, X H Yang. Prevention of grafted liver from reperfusive injury.
World journal of gastroenterology.
2001 Aug; 7(4):572-4. doi:
10.3748/wjg.v7.i4.572. [PMID: 11819833] - X Yin, D Yin, X Liu, X Ding. Treatment of 104 cases of chemotherapy-induced leukopenia by injection of drugs into Zusanli.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2001 Mar; 21(1):27-8. doi:
". [PMID: 11360532] - J Chai, H Yang, Z Sheng, Z Guo, L Diao, C Shen, F Li, X Jia, L Li, M Xu, L He, D Hao, Y Yu. [Anisodamine in prevention and treatment of sepsis of severely burned patients].
Zhonghua wai ke za zhi [Chinese journal of surgery].
2000 Sep; 38(9):686-9. doi:
. [PMID: 11832140] - S Y Pan, Y F Han. Learning deficits induced by 4 belladonna alkaloids are preferentially attenuated by tacrine.
Acta pharmacologica Sinica.
2000 Feb; 21(2):124-30. doi:
. [PMID: 11263258] - Q B Li, R Pan, G F Wang, S X Tang. Anisodamine as an effective drug to treat snakebites.
Journal of natural toxins.
1999 Oct; 8(3):327-30. doi:
. [PMID: 10591035] - L Z Wang, Y Q Liu, Y H Cui, F H Zhu, B S Wang, N Lun. Effects of dexamethasone, cyproheptadine, anisodamine, and dinoprostone on TNF alpha production in endotoxic shock.
Zhongguo yao li xue bao = Acta pharmacologica Sinica.
1999 Feb; 20(2):171-4. doi:
NULL. [PMID: 10437167] - X Wei, Z Zhang, L Han, Y Wei. Protective effect of anisodamine on reperfusion injury of skeletal muscles in rabbit.
Acta orthopaedica Scandinavica.
1998 Dec; 69(6):633-7. doi:
10.3109/17453679808999270. [PMID: 9930112] - S Y Pan, Y F Han, Q P Xu, M Y Liu, H Z Ma, W J Ding, R L Zhu. Belladonna alkaloids-induced behavioral changes and amnesia on open-field and step-through in 18-, 28-, and 38-day-old mice.
Zhongguo yao li xue bao = Acta pharmacologica Sinica.
1998 Mar; 19(2):112-6. doi:
. [PMID: 10374631] - X Liu, J Zhang. An experimental study on the mechanism of anisodamini hydrobromidum in treating acute ischemic renal failure.
Journal of Tongji Medical University = Tong ji yi ke da xue xue bao.
1998; 18(3):187-9. doi:
. [PMID: 10806823] - C Huang, Y Zhang, Z Zhang. [The significance of use of anti-intrarenal artery spasm in renal allografts with HAR like manifestation].
Zhonghua wai ke za zhi [Chinese journal of surgery].
1997 Sep; 35(9):530-2. doi:
NULL. [PMID: 10678024] - M Yue, C Li, E Zhao, X Li. [The effect of anisodaminum and dexamethasone on microcirculation, TNF, LPO and pathology in MODS].
Zhonghua wai ke za zhi [Chinese journal of surgery].
1997 Jul; 35(7):392-4. doi:
NULL. [PMID: 10677970] - C Y Sheng, W Y Gao, Z R Guo, L X He. Anisodamine restores bowel circulation in burn shock.
Burns : journal of the International Society for Burn Injuries.
1997 Mar; 23(2):142-6. doi:
10.1016/s0305-4179(96)00086-1. [PMID: 9177881] - X Wang, X Tang, T Xie, X Sun. The beneficial effects of anisodamine for CyA hepatotoxicity in the rat and in renal-transplant recipients.
Transplantation proceedings.
1997 Feb; 29(1-2):286-7. doi:
10.1016/s0041-1345(96)00096-6. [PMID: 9122998] - J Liu, H Lin, Z Sun. [Effect of anisodamine in prevention and treatment of visceral complications in serious burns].
Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns.
1996 Jul; 12(4):282-4. doi:
. [PMID: 9387472] - X Zhang, J Yan, S Hong. [An experimental study on the treatment of fetal rabbits with intrauterine growth retardation].
Zhonghua fu chan ke za zhi.
1996 Feb; 31(2):97-9. doi:
NULL. [PMID: 8758803] - X J Yao, Y H Tan, Z C Xu, X Y Li, S Y Chen. Effects of anisodamine against myocardial ischemia-reperfused injuries and antilipid peroxidation.
Zhongguo yao li xue bao = Acta pharmacologica Sinica.
1995 Mar; 16(2):152-5. doi:
. [PMID: 7597918] - Z H Liu, Z H Song, N Q Du. [Study of treatment on acquired infantile mental retardation with traditional Chinese and Western medicine].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
1994 Dec; 14(12):730-2. doi:
". [PMID: 7719108] - J X Li, D R Kelly, J R Oliver, K D Grantham, J B Philips. Effects of cholinergic blockade on hemodynamic disturbances and intestinal lesions in endotoxic shock in newborn piglets.
Shock (Augusta, Ga.).
1994 Aug; 2(2):98-105. doi:
10.1097/00024382-199408000-00004. [PMID: 7728588] - S Wang, X Shen, X Li, N Huang, X He. [Effect of hemorheological factors on coronary flow during myocardial ischemia].
Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao.
1994 Jun; 25(2):127-30. doi:
NULL. [PMID: 7806186] - S Dai, J Cheng, R Sun, J Duan, Q Yuan, Y Sun, Y Yan, Q Xue. Hemodynamic and nonhemodynamic mechanisms of experimental pulmonary edema in rats and the effects of anisodamine and tetramethylpyrazine--estimation of blood gas analysis, RBC superoxide dismutase and prostaglandin E2 in plasma and bronchoalveolar lavage (Part 3).
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih.
1993 Dec; 8(4):210-4. doi:
. [PMID: 8032066] - P Y Wang, J W Chen, F Hwang. Anisodamine causes acyl chain interdigitation in phosphatidylglycerol.
FEBS letters.
1993 Oct; 332(1-2):193-6. doi:
10.1016/0014-5793(93)80511-r. [PMID: 8405441] - Z Y Luo, Y Tang, J I You, H Luo. Protective effect of anisodamine on cultured bovine pulmonary endothelial cell injury induced by oxygen-free radicals.
Archives of surgery (Chicago, Ill. : 1960).
1992 Oct; 127(10):1204-8; discussion 1209. doi:
10.1001/archsurg.1992.01420100062010. [PMID: 1417486] - S L Dai. [Experimental study of anisodamine on therapeutic effect of pulmonary edema in rats].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
1992 Jun; 12(6):359-61, 326. doi:
. [PMID: 1421980] - P Ma, C Y Wu. [Studies on the determination of plasma level and pharmacokinetic parameters of anisodamine by micellar liquid chromatography].
Yao xue xue bao = Acta pharmaceutica Sinica.
1992; 27(10):763-7. doi:
. [PMID: 1293924] - J X Li, B M Gray, J R Oliver, C Y Lu, J B Philips. Delayed thromboxane synthesis inhibition, but not cholinergic blockade, reverses group B streptococcus-induced pulmonary hypertension.
Developmental pharmacology and therapeutics.
1992; 19(1):40-9. doi:
10.1159/000457461. [PMID: 1307345] - Y J Gu, Y S Wang, B Y Chiang, X D Gao, C X Ye, C R Wildevuur. Reduction of granulocyte-mediated lung injury in canine cardiopulmonary bypass by anisodamine infusion.
The Thoracic and cardiovascular surgeon.
1991 Jun; 39(3):154-7. doi:
10.1055/s-2007-1013953. [PMID: 1882379] - A P Zou, N Parekh, M Steinhausen. [Dopaminergic effect of anisodamine on the microcirculation of the hydronephrotic kidney of rats].
Journal of Tongji Medical University = Tong ji yi ke da xue xue bao.
1991; 11(2):65-72. doi:
10.1007/bf02888091. [PMID: 1687750] - R B Chao, C Y Wu. [Study on separation and determination of four tropane alkaloids in crude drugs by micellar HPLC].
Yao xue xue bao = Acta pharmaceutica Sinica.
1991; 26(7):519-26. doi:
". [PMID: 1805510] - S L Zhang, D Lax, Y Li, E Stejskal, R V Lucas, S Einzig. Anisodamine increases blood flow to the retina-choroid and protects retinal and pancreatic cells against lipid peroxidation.
Journal of ethnopharmacology.
1990 Sep; 30(2):121-34. doi:
10.1016/0378-8741(90)90001-a. [PMID: 2123954] - Y S Huang, A Li, Z C Yang. Roles of thromboxane and its inhibitor anisodamine in burn shock.
Burns : journal of the International Society for Burn Injuries.
1990 Aug; 16(4):249-53. doi:
10.1016/0305-4179(90)90133-h. [PMID: 2257065] - S Xu. [A preliminary study of the inhibiting mechanism of anisodamine on rabbit platelets activated by E. coli endotoxin].
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae.
1990 Aug; 12(4):306-10. doi:
. [PMID: 2174747] - A P Zou, N Parekh, M Steinhausen. Effect of anisodamine on the microcirculation of the hydronephrotic kidney of rats.
International journal of microcirculation, clinical and experimental.
1990 Aug; 9(3):285-96. doi:
NULL. [PMID: 2394549] - Z T Chen. [Comprehensive observation of a canine model of respiratory distress syndrome induced with bone marrow].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases.
1990 Feb; 13(1):18-21, 61. doi:
". [PMID: 2379250] - G F Leskova, L B Su, V I Udovichenko. [The effect of anisodamine on lipoprotein metabolism in the liver and the plasma membrane phospholipids of the hepatocytes in hemorrhagic shock].
Patologicheskaia fiziologiia i eksperimental'naia terapiia.
1990 Jan; ?(1):15-7. doi:
. [PMID: 2352771] - Q Y Xu, W X Liu, C M Chen, W L Di. [Effects of anisodamine on blood coagulation, fibrin and thrombosis in rabbits].
Zhongguo yao li xue bao = Acta pharmacologica Sinica.
1990 Jan; 11(1):44-7. doi:
. [PMID: 2403014] - J F Zhang, C D Yan, Y Q Zhang, W Z Gao, X M Zhai. [Effect of scopolia drugs on the gastric mucosal lesion in rats].
Yao xue xue bao = Acta pharmaceutica Sinica.
1990; 25(2):90-4. doi:
. [PMID: 2239328] - G Yang. [Modern concepts of Chinese medicinal herb (henbane) therapy].
Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine.
1990 Jan; 10(1):59-61. doi:
". [PMID: 2190701] - S S Zheng. [Protective effects of Salviae miltiorrhizae and anisodamine (654-2) against early lung injury in acute hemorrhagic necrotizing pancreatitis in the dog].
Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine.
1989 Mar; 9(3):158-60, 134. doi:
. [PMID: 2736701]