Quine (BioDeep_00000395735)
PANOMIX_OTCML-2023 Chemicals and Drugs
代谢物信息卡片
(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol sulfate (2:1)
化学式: C40H50N4O8S (746.334918)
中文名称: 硫酸奎宁, 奎宁硫酸盐
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 2.04%
分子结构信息
SMILES: COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.OS(=O)(=O)O
InChI: /m00./s1
描述信息
Quinine Sulfate is the sulfate salt form of the quinidine alkaloid isolate quinine. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)
An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.
See also: Quinine (has active moiety) ... View More ...
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
同义名列表
61 个代谢物同义名
(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol sulfate (2:1); (R)-(6-Methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methanol hemisulfate; (R)-(6-methoxy-4-quinolyl)-[(2S,4S,5R)-5-vinylquinuclidin-2-yl]methanol; sulfuric acid; (R)-(6-methoxyquinolin-4-yl)((2S,4S,5R)-5-vinylquinuclidin-2-yl)methanol hemisulfate; Cinchonan-9-ol, 6-methoxy-, (8 alpha,9R)-, Sulfate, Hydrate (2:1:2); Cinchonan-9-ol, 6-methoxy-, (8.alpha.,9R)-, sulfate (2:1) (salt); Cinchonan-9-ol, 6-methoxy-, (8alpha,9R)-, sulfate (2:1) (salt); Cinchonan-9-ol, 6-methoxy-, (8.alpha.,9R)-, sulfate (2:1); Cinchonan-9-ol, 6-methoxy-, (8alpha,9R)-, sulfate (2:1); bis((8alpha,9R)-6-methoxycinchonan-9-ol) sulfate; ANHYDROUS QUININE SULFATE [MART.]; ANHYDROUS QUININE SULFATE (MART.); QUININE SULFATE (USP MONOGRAPH); QUININE SULFATE (USP IMPURITY); QUININE SULFATE (EP MONOGRAPH); QUININE SULFATE ANHYDROUS [MI]; Quinine, sulfate (2:1) (salt); Quinine hemisulfate anhydrous; Quinine hydrogen sulphate; Anhydrous quinine sulfate; Quinine sulfate anhydrous; QUININE SULFATE [WHO-DD]; QUININE SULFATE (USP-RS); Quinine hydrogen sulfate; Quinine (sulfate) (2:1); QUININE SULFATE (MART.); Hydrochloride, Quinine; Quinine sulfate (VAN); Quinine sulfate (2:1); Quinine Hydrochloride; Bisulfate, Quinine; Sulphate, Quinine; Quinine bisulfate; Quinine sulphate; Quinine, sulfate; Sulfate, Quinine; Quinine Sulfate; UNII-M4XCR57IWG; UNII-KF7Z0E0Q2B; Quinine Lafran; Coco-Quinine; Quinine-Odan; M4XCR57IWG; Quinoctal; Quinbisan; Quinbisul; Qualaquin; Biquinate; Legatrim; Surquina; Quinimax; Legatrin; Aflukin; Quindan; Quinsul; Quinine; Quinson; Myoquin; Quinamm; Strema; Quine
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:52250
- PubChem: 16051948
- PubChem: 56927704
- MeSH: Quinine
- ChemIDplus: 0000804637
- CAS: 207671-44-1
- CAS: 549-56-4
- CAS: 804-63-7
- medchemexpress: HY-B0433B
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Muhammad Irfan Waris, Yanyuan Lei, Guojun Qi, Ziying Guan, Abdul Rashied, Jie Chen, Lihua Lyu. The temporal-spatial expression and functional analysis of three gustatory receptor genes in Solenopsis invicta using sweet and bitter compounds.
Insect science.
2024 Apr; 31(2):448-468. doi:
10.1111/1744-7917.13301. [PMID: 38010036] - Cécile Ficko, Pierre-Louis Conan. [Malaria in 2022: clinical and therapeutic aspects].
Medecine tropicale et sante internationale.
2023 06; 3(2):. doi:
10.48327/mtsi.v3i2.2023.378. [PMID: 37525671] - Louis H Miller, Jesus Rojas-Jaimes, Leanne M Low, Gilberto Corbellini. What Historical Records Teach Us about the Discovery of Quinine.
The American journal of tropical medicine and hygiene.
2023 01; 108(1):7-11. doi:
10.4269/ajtmh.22-0404. [PMID: 36410328] - Ning Wen, Ping-Shun Song, Lin Ni, Juan Chen. Tannic acid-aminopropyltriethoxysilane co-deposition modified polymer membrane for α-glucosidase immobilization.
Journal of chromatography. A.
2022 Nov; 1683(?):463550. doi:
10.1016/j.chroma.2022.463550. [PMID: 36219969] - Parker Elijah Joshua, Junaidu Yahaya, Daniel Emmanuel Ekpo, Joyce Oloaigbe Ogidigo, Arome Solomon Odiba, Rita Onyekachukwu Asomadu, Samson Ayodeji Oka, Olasupo Stephen Adeniyi. Modulation of immunological responses by aqueous extract of Datura stramonium L. seeds on cyclophosphamide-induced immunosuppression in Wistar rats.
BMC immunology.
2022 10; 23(1):50. doi:
10.1186/s12865-022-00519-y. [PMID: 36261807] - M G Semedo, A L Pereira, J R Pita. Cinchona bark and quinine in the Portuguese official pharmacopoeias (1794-2001).
Die Pharmazie.
2022 09; 77(7):278-285. doi:
10.1691/ph.2022.2034. [PMID: 36199186] - Peyman Rezaie, Vida Bitarafan, Braden D Rose, Kylie Lange, Jens F Rehfeld, Michael Horowitz, Christine Feinle-Bisset. Quinine Effects on Gut and Pancreatic Hormones and Antropyloroduodenal Pressures in Humans-Role of Delivery Site and Sex.
The Journal of clinical endocrinology and metabolism.
2022 06; 107(7):e2870-e2881. doi:
10.1210/clinem/dgac182. [PMID: 35325161] - Nourhan M Abd El-Aziz, Ibrahim Khalifa, Amira M G Darwish, Ahmed N Badr, Huda Aljumayi, El-Sayed Hafez, Mohamed G Shehata. Docking Analysis of Some Bioactive Compounds from Traditional Plants against SARS-CoV-2 Target Proteins.
Molecules (Basel, Switzerland).
2022 Apr; 27(9):. doi:
10.3390/molecules27092662. [PMID: 35566014] - Teerachat Sae-Heng, Rajith Kumar Reddy Rajoli, Marco Siccardi, Juntra Karbwang, Kesara Na-Bangchang. Physiologically based pharmacokinetic modeling for dose optimization of quinine-phenobarbital coadministration in patients with cerebral malaria.
CPT: pharmacometrics & systems pharmacology.
2022 01; 11(1):104-115. doi:
10.1002/psp4.12737. [PMID: 34730282] - Xiuliang Dai, Xiangjiao Yi, Yufeng Wang, Wei Xia, Jianguo Tao, Jun Wu, Dengshun Miao, Li Chen. PQQ Dietary Supplementation Prevents Alkylating Agent-Induced Ovarian Dysfunction in Mice.
Frontiers in endocrinology.
2022; 13(?):781404. doi:
10.3389/fendo.2022.781404. [PMID: 35340329] - Yong-Jia Chen, Kun-Yuan Ma, Sha-Sha Du, Zhi-Jun Zhang, Tian-Lin Wu, Yu Sun, Ying-Qian Liu, Xiao-Dan Yin, Rui Zhou, Yin-Fang Yan, Ren-Xuan Wang, Ying-Hui He, Qing-Ru Chu, Chen Tang. Antifungal Exploration of Quinoline Derivatives against Phytopathogenic Fungi Inspired by Quinine Alkaloids.
Journal of agricultural and food chemistry.
2021 Oct; 69(41):12156-12170. doi:
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Clinics in dermatology.
2021 Sep; 39(5):900-903. doi:
10.1016/j.clindermatol.2021.08.017. [PMID: 34785019] - M G Semedo, A L Pereira, J R Pita. The influence of German science on Cinchona and quinine research in Portugal in the second half of the 19th century.
Die Pharmazie.
2021 08; 76(8):396-402. doi:
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Journal of chemical ecology.
2021 Jul; 47(7):642-652. doi:
10.1007/s10886-021-01290-x. [PMID: 34331170] - Wout Verbeure, Eveline Deloose, Joran Tóth, Jens F Rehfeld, Lukas Van Oudenhove, Inge Depoortere, Jan Tack. The endocrine effects of bitter tastant administration in the gastrointestinal system: intragastric versus intraduodenal administration.
American journal of physiology. Endocrinology and metabolism.
2021 07; 321(1):E1-E10. doi:
10.1152/ajpendo.00636.2020. [PMID: 34029163] - Braden D Rose, Vida Bitarafan, Peyman Rezaie, Penelope C E Fitzgerald, Michael Horowitz, Christine Feinle-Bisset. Comparative Effects of Intragastric and Intraduodenal Administration of Quinine on the Plasma Glucose Response to a Mixed-Nutrient Drink in Healthy Men: Relations with Glucoregulatory Hormones and Gastric Emptying.
The Journal of nutrition.
2021 06; 151(6):1453-1461. doi:
10.1093/jn/nxab020. [PMID: 33704459] - Maximilian Große, Natalia Ruetalo, Mirjam Layer, Dan Hu, Ramona Businger, Sascha Rheber, Christian Setz, Pia Rauch, Janina Auth, Maria Fröba, Ekkehard Brysch, Michael Schindler, Ulrich Schubert. Quinine Inhibits Infection of Human Cell Lines with SARS-CoV-2.
Viruses.
2021 04; 13(4):. doi:
10.3390/v13040647. [PMID: 33918670] - Francesco Trenti, Kotaro Yamamoto, Benke Hong, Christian Paetz, Yoko Nakamura, Sarah E O'Connor. Early and Late Steps of Quinine Biosynthesis.
Organic letters.
2021 03; 23(5):1793-1797. doi:
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International journal of molecular sciences.
2021 Feb; 22(4):. doi:
10.3390/ijms22041992. [PMID: 33671466] - Wei Wei, Xingyue Wu, Chaoyuan Jin, Tong Mu, Guorong Gu, Min Min, Sucheng Mu, Yi Han. Predictive Significance of the Prognostic Nutritional Index (PNI) in Patients with Severe COVID-19.
Journal of immunology research.
2021; 2021(?):9917302. doi:
10.1155/2021/9917302. [PMID: 34337084] - Andrew D S Duncan, Simona Hapca, Nicosha De Souza, Daniel Morales, Samira Bell. Quinine exposure and the risk of acute kidney injury: a population-based observational study of older people.
Age and ageing.
2020 10; 49(6):1042-1047. doi:
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Chemical senses.
2020 10; 45(7):533-539. doi:
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Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsiny.
2020 Oct; 28(Special Issue):1118-1122. doi:
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Journal of the American Society of Nephrology : JASN.
2020 10; 31(10):2475-2489. doi:
10.1681/asn.2020050564. [PMID: 32963091] - Davoud Kianifard, Seyyed Maysam Mousavi Shoar, Ahmed Aly, Leila Kianifard, Farhad Rezaee. Administration of Nicotine Exacerbates the Quinine-induced Structural and Functional Alterations of Testicular Tissue in Adult Rats: An Experimental Study.
Urology journal.
2020 Jul; 18(1):103-110. doi:
10.22037/uj.v16i7.5884. [PMID: 32748385] - Victoria V Golovchenko, Shinen Naranmandakh, Jamsranjav Ganbaatar, Artur Yu Prilepskii, Gennady L Burygin, Alexander O Chizhov, Alexander S Shashkov. Structural investigation and comparative cytotoxic activity of water-soluble polysaccharides from fruit bodies of the medicinal fungus quinine conk.
Phytochemistry.
2020 Jul; 175(?):112313. doi:
10.1016/j.phytochem.2020.112313. [PMID: 32353551] - X J Wang, Y S Yang, K Shen, J Wang, F Han, G F Wu, Y Li, X Z Bai, L Luo, D H Hu. [Effects and mechanism of pyrroloquinoline quinine on mitochondrial function and cell survival of rat bone marrow mesenchymal stem cells under oxidative stress].
Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns.
2020 May; 36(5):378-387. doi:
10.3760/cma.j.cn501120-20190806-00335. [PMID: 32456375] - Nataly Allasi Canales, Tobias Nikolaj Gress Hansen, Claus Cornett, Kim Walker, Felix Driver, Alexandre Antonelli, Carla Maldonado, Mark Nesbitt, Christopher J Barnes, Nina Rønsted. Historical chemical annotations of Cinchona bark collections are comparable to results from current day high-pressure liquid chromatography technologies.
Journal of ethnopharmacology.
2020 Mar; 249(?):112375. doi:
10.1016/j.jep.2019.112375. [PMID: 31698039] - Vida Bitarafan, Penelope C E Fitzgerald, Tanya J Little, Wolfgang Meyerhof, Karen L Jones, Tongzhi Wu, Michael Horowitz, Christine Feinle-Bisset. Intragastric administration of the bitter tastant quinine lowers the glycemic response to a nutrient drink without slowing gastric emptying in healthy men.
American journal of physiology. Regulatory, integrative and comparative physiology.
2020 02; 318(2):R263-R273. doi:
10.1152/ajpregu.00294.2019. [PMID: 31774306] - Franklin Mogo Kom, Martin Paul Baane, Marius Mbody, Moussa Abame Sanda, Bi Ndongo Bilong, Francis Ateba Ndongo, Jean-Marc Mben Ii. COVID-19 mimics endemic tropical diseases at an early stage: a report of two symptomatic COVID-19 patients treated in a polymerase chain reaction void zone in Cameroon.
The Pan African medical journal.
2020; 37(?):212. doi:
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Combinatorial chemistry & high throughput screening.
2020; 23(2):111-118. doi:
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Nutritional neuroscience.
2019 Dec; 22(12):850-862. doi:
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Journal of pharmaceutical and biomedical analysis.
2019 Sep; 174(?):248-255. doi:
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British journal of clinical pharmacology.
2019 08; 85(8):1704-1709. doi:
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Bioelectrochemistry (Amsterdam, Netherlands).
2019 Jun; 127(?):59-67. doi:
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BMC infectious diseases.
2019 Apr; 19(1):354. doi:
10.1186/s12879-019-3921-7. [PMID: 31035938] - Dietrich Mebs, Cora Wunder, Stefan W Toennes. Coping with noxious effects of quinine by praying mantids (Mantodea) and spiders (Araneae).
Toxicon : official journal of the International Society on Toxinology.
2019 Apr; 162(?):57-60. doi:
10.1016/j.toxicon.2019.03.017. [PMID: 30904569] - Shoji Maehara, Andria Agusta, Yoshimi Tokunaga, Hirotaka Shibuya, Toshiyuki Hata. Endophyte composition and Cinchona alkaloid production abilities of Cinchona ledgeriana cultivated in Japan.
Journal of natural medicines.
2019 Mar; 73(2):431-438. doi:
10.1007/s11418-018-1273-z. [PMID: 30552602] - Jinrong Li, Christian H Lemon. Mouse Parabrachial Neurons Signal a Relationship between Bitter Taste and Nociceptive Stimuli.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2019 02; 39(9):1631-1648. doi:
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Chemico-biological interactions.
2019 Feb; 300(?):35-39. doi:
10.1016/j.cbi.2019.01.006. [PMID: 30629953] - Chee Tung Tai, Hong Heng See. Rapid quantification of quinine by multi-stacking in a portable microchip electrophoresis system.
Electrophoresis.
2019 02; 40(3):455-461. doi:
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Drug and alcohol dependence.
2018 10; 191(?):195-202. doi:
10.1016/j.drugalcdep.2018.05.034. [PMID: 30138791] - Mastaneh Sharafi, Shristi Rawal, Maria Luz Fernandez, Tania B Huedo-Medina, Valerie B Duffy. Taste phenotype associates with cardiovascular disease risk factors via diet quality in multivariate modeling.
Physiology & behavior.
2018 10; 194(?):103-112. doi:
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Immunity.
2018 07; 49(1):56-65.e4. doi:
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BMC pharmacology & toxicology.
2018 06; 19(1):33. doi:
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Journal of chromatography. A.
2018 Jun; 1554(?):117-122. doi:
10.1016/j.chroma.2018.04.038. [PMID: 29699870] - Kazuki Harada, Hidekazu Sakaguchi, Shoko Sada, Rika Ishida, Yuki Hayasaka, Takashi Tsuboi. Bitter tastant quinine modulates glucagon-like peptide-1 exocytosis from clonal GLUTag enteroendocrine L cells via actin reorganization.
Biochemical and biophysical research communications.
2018 06; 500(3):723-730. doi:
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BMJ case reports.
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Scientific reports.
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The Pediatric infectious disease journal.
2018 02; 37(2):e43-e45. doi:
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AAPS PharmSciTech.
2018 Feb; 19(2):551-564. doi:
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Neurological research.
2018 Jan; 40(1):26-33. doi:
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Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
2018 Jan; 30(1):. doi:
10.1111/nmo.13171. [PMID: 28776826] - Khan Muhammad Baloch, Khan Usmanghani, Ejaz Mohiuddin, Tasneem Qureshi, Muhammad Daniyal, Muhammad Ibrar Shinwari. A randomized, control and comparative study of polyherbal formulation use for Malaria (Plasmodium falciparum).
Pakistan journal of pharmaceutical sciences.
2018 Jan; 31(1(Suppl.)):291-297. doi:
". [PMID: 29386156] - Zay Myo Htet, Mahzuz Karim. A Catastrophic Consequence of Cramp.
Acute medicine.
2018; 17(1):50-52. doi:
NULL. [PMID: 29589607] - Caitlin McIntyre, Rory McQuillan, Chaim Bell, Marisa Battistella. Targeted Deprescribing in an Outpatient Hemodialysis Unit: A Quality Improvement Study to Decrease Polypharmacy.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2017 Nov; 70(5):611-618. doi:
10.1053/j.ajkd.2017.02.374. [PMID: 28416321] - Evaren E Page, Dustin J Little, Sara K Vesely, James N George. Quinine-Induced Thrombotic Microangiopathy: A Report of 19 Patients.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2017 Nov; 70(5):686-695. doi:
10.1053/j.ajkd.2017.05.023. [PMID: 28780041] - John I Glendinning, Joyce Tang, Ana Paula Morales Allende, Bruce P Bryant, Lisa Youngentob, Steven L Youngentob. Fetal alcohol exposure reduces responsiveness of taste nerves and trigeminal chemosensory neurons to ethanol and its flavor components.
Journal of neurophysiology.
2017 08; 118(2):1198-1209. doi:
10.1152/jn.00108.2017. [PMID: 28490641] - Papa Alioune Ndour, Sébastien Larréché, Oussama Mouri, Nicolas Argy, Frédérick Gay, Camille Roussel, Stéphane Jauréguiberry, Claire Perillaud, Dominique Langui, Sylvestre Biligui, Nathalie Chartrel, Audrey Mérens, Eric Kendjo, Aniruddha Ghose, Md Mahtab Uddin Hassan, Md Amir Hossain, Hugh W F Kingston, Katherine Plewes, Arjen M Dondorp, Martin Danis, Sandrine Houzé, Serge Bonnefoy, Marc Thellier, Charles J Woodrow, Pierre A Buffet. Measuring the Plasmodium falciparum HRP2 protein in blood from artesunate-treated malaria patients predicts post-artesunate delayed hemolysis.
Science translational medicine.
2017 07; 9(397):. doi:
10.1126/scitranslmed.aaf9377. [PMID: 28679662] - Olasupo Stephen Adeniyi, Olubiyi Vincent Makinde, Emmanuel Titus Friday, Samuel Babafemi Olaleye. Effects of quinine on gastric ulcer healing in Wistar rats.
Journal of complementary & integrative medicine.
2017 Jun; 14(4):. doi:
10.1515/jcim-2016-0132. [PMID: 28665790] - Subramanyam J Tantry, Shankar D Markad, Vikas Shinde, Jyothi Bhat, Gayathri Balakrishnan, Amit K Gupta, Anisha Ambady, Anandkumar Raichurkar, Chaitanyakumar Kedari, Sreevalli Sharma, Naina V Mudugal, Ashwini Narayan, C N Naveen Kumar, Robert Nanduri, Sowmya Bharath, Jitendar Reddy, Vijender Panduga, K R Prabhakar, Karthikeyan Kandaswamy, Ramanatha Saralaya, Parvinder Kaur, Neela Dinesh, Supreeth Guptha, Kirsty Rich, David Murray, Helen Plant, Marian Preston, Helen Ashton, Darren Plant, Jarrod Walsh, Peter Alcock, Kathryn Naylor, Matthew Collier, James Whiteaker, Robert E McLaughlin, Meenakshi Mallya, Manoranjan Panda, Suresh Rudrapatna, Vasanthi Ramachandran, Radha Shandil, Vasan K Sambandamurthy, Khisi Mdluli, Christopher B Cooper, Harvey Rubin, Takahiro Yano, Pravin Iyer, Shridhar Narayanan, Stefan Kavanagh, Kakoli Mukherjee, V Balasubramanian, Vinayak P Hosagrahara, Suresh Solapure, Sudha Ravishankar, Shahul Hameed P. Discovery of Imidazo[1,2-a]pyridine Ethers and Squaramides as Selective and Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthesis.
Journal of medicinal chemistry.
2017 02; 60(4):1379-1399. doi:
10.1021/acs.jmedchem.6b01358. [PMID: 28075132] - Margarete do Socorro Mendonça Gomes, José Luiz Fernandes Vieira, Álvaro Augusto Ribeiro D'Almeida Couto, Vanja Suely Calvosa D'Almeida Couto, Michelle Valéria Dias Ferreira Vieira, Francis Christian da Silva Pereira, Ricado Luiz Dantas Machado. Recurrence of Plasmodium falciparum after treatment with quinine and doxycycline in the Amazon basin.
Tropical medicine & international health : TM & IH.
2017 02; 22(2):133-138. doi:
10.1111/tmi.12813. [PMID: 27862676] - G Gachelin, P Garner, E Ferroni, U Tröhler, I Chalmers. Evaluating Cinchona bark and quinine for treating and preventing malaria.
Journal of the Royal Society of Medicine.
2017 Feb; 110(2):73-82. doi:
10.1177/0141076816688411. [PMID: 28169590] - G Gachelin, P Garner, E Ferroni, U Tröhler, I Chalmers. Evaluating Cinchona bark and quinine for treating and preventing malaria.
Journal of the Royal Society of Medicine.
2017 Jan; 110(1):31-40. doi:
10.1177/0141076816681421. [PMID: 28106483] - Atthanee Jeeyapant, Hugh W Kingston, Katherine Plewes, Richard J Maude, Josh Hanson, M Trent Herdman, Stije J Leopold, Thatsanun Ngernseng, Prakaykaew Charunwatthana, Nguyen Hoan Phu, Aniruddha Ghose, M Mahtab Uddin Hasan, Caterina I Fanello, Md Abul Faiz, Tran Tinh Hien, Nicholas P J Day, Nicholas J White, Arjen M Dondorp. Defining Surrogate Endpoints for Clinical Trials in Severe Falciparum Malaria.
PloS one.
2017; 12(1):e0169307. doi:
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Appetite.
2016 12; 107(?):116-125. doi:
10.1016/j.appet.2016.07.026. [PMID: 27457970] - Fabrice Bruneel, Florence Tubach, Jean-Paul Mira, Sandrine Houze, Sebastien Gibot, Marie-Genevieve Huisse, Bruno Megarbane, Christophe Choquet, Philippe Corne, Eric Peytel, Daniel Villers, Christophe Camus, Olivier Bouchaud, Eric Caumes, Pierre-Marie Girard, Fabrice Simon, Antoine Kalloumeh, Carine Roy, Remy Durand, Jacques Le Bras, Sophie Matheron, Michel Wolff. Imported falciparum malaria in adults: host- and parasite-related factors associated with severity. The French prospective multicenter PALUREA cohort study.
Intensive care medicine.
2016 Oct; 42(10):1588-1596. doi:
10.1007/s00134-016-4356-x. [PMID: 27169586] - Felicity Muth, Jacob S Francis, Anne S Leonard. Bees use the taste of pollen to determine which flowers to visit.
Biology letters.
2016 Jul; 12(7):. doi:
10.1098/rsbl.2016.0356. [PMID: 27405383] - Olubunmi B Falade, Adeyinka G Falusi, Ajibola A Olaniyi, Chizoba Ezeasor, David A Kwasi, Chinedum P Babalola. Significant Pharmacokinetic Interactions Between Quinine and Ampicillin-Cloxacillin Combination.
Drugs in R&D.
2016 Jun; 16(2):193-203. doi:
10.1007/s40268-016-0128-x. [PMID: 27020278] - Nathan W Liles, Evaren E Page, Amber L Liles, Sara K Vesely, Gary E Raskob, James N George. Diversity and severity of adverse reactions to quinine: A systematic review.
American journal of hematology.
2016 May; 91(5):461-6. doi:
10.1002/ajh.24314. [PMID: 26822544] - Shengxin Cai, April L Risinger, Shalini Nair, Jiangnan Peng, Timothy J C Anderson, Lin Du, Douglas R Powell, Susan L Mooberry, Robert H Cichewicz. Identification of Compounds with Efficacy against Malaria Parasites from Common North American Plants.
Journal of natural products.
2016 Mar; 79(3):490-8. doi:
10.1021/acs.jnatprod.5b00874. [PMID: 26722868] - Adebanjo J Adegbola, Julius O Soyinka, Babatunde A Adeagbo, Sharon I Igbinoba, Thomas I Nathaniel. Alteration of the Disposition of Quinine in Healthy Volunteers After Concurrent Ciprofloxacin Administration.
American journal of therapeutics.
2016 Mar; 23(2):e398-404. doi:
10.1097/mjt.0000000000000087. [PMID: 25406952] - El Mostafa El Mezouari, Ayoub Belhadj, Mohamed Ziani, Mohamed Boughanem, Redouane Moutaj. [Severe imported malaria in adults: a retrospective study of thirteen cases admitted to the Intensive Care Unit in Marrakech].
The Pan African medical journal.
2016; 25(?):179. doi:
10.11604/pamj.2016.25.179.8558. [PMID: 28292141] - Qin Ma, Jian-Guo Jiang. Functional Components from Nature-Derived Drugs for the Treatment of Rheumatoid Arthritis.
Current drug targets.
2016; 17(14):1673-1686. doi:
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Dansk medicinhistorisk arbog.
2016 ; 44(?):9-30. doi:
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The American journal of tropical medicine and hygiene.
2015 Dec; 93(6):1383-90. doi:
10.4269/ajtmh.15-0453. [PMID: 26416104] - Shanna Babalonis, Aidan J Hampson, Michelle R Lofwall, Paul A Nuzzo, Sharon L Walsh. Quinine as a potential tracer for medication adherence: A pharmacokinetic and pharmacodynamic assessment of quinine alone and in combination with oxycodone in humans.
Journal of clinical pharmacology.
2015 Dec; 55(12):1332-43. doi:
10.1002/jcph.557. [PMID: 26032168] - Johandie Gildenhuys, Chandre J Sammy, Ronel Müller, Victor A Streltsov, Tanya le Roex, David Kuter, Katherine A de Villiers. Alkoxide coordination of iron(III) protoporphyrin IX by antimalarial quinoline methanols: a key interaction observed in the solid-state and solution.
Dalton transactions (Cambridge, England : 2003).
2015 Oct; 44(38):16767-77. doi:
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The American journal of clinical nutrition.
2015 Oct; 102(4):729-35. doi:
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Journal of tropical pediatrics.
2015 Aug; 61(4):272-8. doi:
10.1093/tropej/fmv029. [PMID: 25957436] - Azizath Moussiliou, Maroufou J Alao, Lise Denoeud-Ndam, Rachida Tahar, Sem Ezimegnon, Gratien Sagbo, Annick Amoussou, Adrian J F Luty, Philippe Deloron, Nicaise Tuikue Ndam. High plasma levels of soluble endothelial protein C receptor are associated with increased mortality among children with cerebral malaria in Benin.
The Journal of infectious diseases.
2015 May; 211(9):1484-8. doi:
10.1093/infdis/jiu661. [PMID: 25425698] - Sherif El-Tawil, Tarique Al Musa, Haseeb Valli, Michael P T Lunn, Ruth Brassington, Tariq El-Tawil, Markus Weber. Quinine for muscle cramps.
The Cochrane database of systematic reviews.
2015 Apr; ?(4):CD005044. doi:
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Journal of clinical pharmacology.
2015 Mar; 55(3):348-54. doi:
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Pharmacology, biochemistry, and behavior.
2015 Feb; 129(?):26-33. doi:
10.1016/j.pbb.2014.11.021. [PMID: 25482328] - J Flieger, A Czajkowska-Żelazko. Aqueous two phase system based on ionic liquid for isolation of quinine from human plasma sample.
Food chemistry.
2015 Jan; 166(?):150-157. doi:
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The Pan African medical journal.
2015; 22(?):301. doi:
10.11604/pamj.2015.22.301.8176. [PMID: 26966497] - Frank Kloprogge, Vincent Jullien, Patrice Piola, Mehul Dhorda, Sulaiman Muwanga, François Nosten, Nicholas P J Day, Nicholas J White, Philippe J Guerin, Joel Tarning. Population pharmacokinetics of quinine in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda.
The Journal of antimicrobial chemotherapy.
2014 Nov; 69(11):3033-40. doi:
10.1093/jac/dku228. [PMID: 24970740] - Mariana Angoa-Pérez, Michael J Kane, Denise I Briggs, Nieves Herrera-Mundo, Catherine E Sykes, Dina M Francescutti, Donald M Kuhn. Mice genetically depleted of brain serotonin do not display a depression-like behavioral phenotype.
ACS chemical neuroscience.
2014 Oct; 5(10):908-19. doi:
10.1021/cn500096g. [PMID: 25089765] - Sanna R Rijpma, Jeroen J M W van den Heuvel, Maarten van der Velden, Robert W Sauerwein, Frans G M Russel, Jan B Koenderink. Atovaquone and quinine anti-malarials inhibit ATP binding cassette transporter activity.
Malaria journal.
2014 Sep; 13(?):359. doi:
10.1186/1475-2875-13-359. [PMID: 25218605] - Arjo Roersch van der Hoogte, Toine Pieters. Science in the service of colonial agro-industrialism: the case of cinchona cultivation in the Dutch and British East Indies, 1852-1900.
Studies in history and philosophy of biological and biomedical sciences.
2014 Sep; 47 Pt A(?):12-22. doi:
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Homeopathy : the journal of the Faculty of Homeopathy.
2014 Jul; 103(3):165-71. doi:
10.1016/j.homp.2014.03.002. [PMID: 24931747] - Geneviève Genest, David M P Thomson. Fixed drug eruption to quinine: a case report and review of the literature.
The journal of allergy and clinical immunology. In practice.
2014 Jul; 2(4):469-70. doi:
10.1016/j.jaip.2014.02.013. [PMID: 25017539] - Aida S Badiane, Khadim Diongue, Seydou Diallo, Aliou A Ndongo, Cyrille K Diedhiou, Awa B Deme, Diallo Ma, Mouhamadou Ndiaye, Mame C Seck, Therese Dieng, Omar Ndir, Souleymane Mboup, Daouda Ndiaye. Acute kidney injury associated with Plasmodium malariae infection.
Malaria journal.
2014 Jun; 13(?):226. doi:
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Journal of molecular recognition : JMR.
2014 May; 27(5):239-49. doi:
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The American journal of tropical medicine and hygiene.
2014 Mar; 90(3):530-534. doi:
10.4269/ajtmh.13-0655. [PMID: 24420779] - Eyram Yoan Amekoudi, Kossi Akomola Sabi, Befa Noto Kadou Kaza. [Profound anemia, hemoglobinuria ... where to stop in the etiological investigation?].
Nephrologie & therapeutique.
2014 Feb; 10(1):58-9. doi:
10.1016/j.nephro.2013.07.001. [PMID: 23978630] - Farida Islahudin, Sarah M Tindall, Ian R Mellor, Karen Swift, Hans E M Christensen, Kevin C F Fone, Richard J Pleass, Kang-Nee Ting, Simon V Avery. The antimalarial drug quinine interferes with serotonin biosynthesis and action.
Scientific reports.
2014 Jan; 4(?):3618. doi:
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Drug metabolism and pharmacokinetics.
2014; 29(4):352-5. doi:
10.2133/dmpk.dmpk-13-sh-138. [PMID: 24522201] - Katsuyoshi Saitou, John N Lees, Michael G Tordoff. Taste hedonics influence the disposition of fat by modulating gastric emptying in rats.
PloS one.
2014; 9(3):e90717. doi:
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