Moranoline (BioDeep_00000395704)

 

Secondary id: BioDeep_00000839808

PANOMIX_OTCML-2023


代谢物信息卡片


3,4,5-PIPERIDINETRIOL, 2-(HYDROXYMETHYL)-, HYDROCHLORIDE, (2R-(2.ALPHA.,3.BETA.,4.ALPHA.,5.BETA.))-

化学式: C6H14ClNO4 (199.0611314)
中文名称: 去氧野艽霉素盐酸盐, 去氧野艽霉素盐酸盐, 1-脱氧野霉素盐酸盐
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 11.76%

分子结构信息

SMILES: C1C(C(C(C(N1)CO)O)O)O.Cl
InChI: /m1./s1

描述信息

AT2220 is an experimental, oral therapy for the treatment of Pompe disease and belongs to a class of molecules known as pharmacological chaperones. It is a small molecule designed to act as a pharmacological chaperone that specifically binds, stabilizes, and facilitates the proper folding and trafficking of α-glucosidase (GAA). GAA to the lysosome, where it can perform its normal function. AT2220 has been shown to increase GAA activity in cell lines derived from Pompe patients and in transfected cells expressing misfolded forms of GAA.
An alpha-glucosidase inhibitor with antiviral action. Derivatives of deoxynojirimycin may have anti-HIV activity.
1-Deoxynojirimycin hydrochloride (Duvoglustat hydrochloride) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin hydrochloride suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin hydrochloride possesses antihyperglycemic, anti-obesity, and antiviral features[1][2].
1-Deoxynojirimycin hydrochloride (Duvoglustat hydrochloride) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin hydrochloride suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin hydrochloride possesses antihyperglycemic, anti-obesity, and antiviral features[1][2].

同义名列表

31 个代谢物同义名

3,4,5-PIPERIDINETRIOL, 2-(HYDROXYMETHYL)-, HYDROCHLORIDE, (2R-(2.ALPHA.,3.BETA.,4.ALPHA.,5.BETA.))-; 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, hydrochloride (1:1), (2R,3R,4R,5S)-; 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, hydrochloride, (2R,3R,4R,5S)-; (2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol hydrochloride; (2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol;hydrochloride; 1,5-Dideoxy-1,5-imino-D-sorbitol hydrochloride; 1-Deoxy-L-altronojirimycin Hydrochloride; (+)-1-Deoxynojirimycin hydrochloride; 1-Deoxynojirimycin (hydrochloride); 1-Deoxynojirimycin Hydrochloride; Duvoglustat hydrochloride (USAN); Duvoglustat hydrochloride [USAN]; 1,5-Dideoxy-1,5-imino-D-mannitol; 1 Deoxynojirimycin Hydrochloride; 1,5-Deoxy-1,5-imino-D-mannitol; Deoxynojirimycin hydrochloride; Duvoglustat hydrochloride; Moranoline hydrochloride; Moranolin hydrochloride; 1-Deoxymannojirimycin; 1 Deoxymannojirimycin; Deoxynojirimycin HCl; 1-Deoxynojirimycin; 1 Deoxynojirimycin; Duvoglustat HCl; UNII-0RN23C42QR; Moranoline HCl; Moranoline; 0RN23C42QR; DNJ; Duvoglustat (hydrochloride)



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jose A Villalobos, Rebecca E Cahoon, Edgar B Cahoon, Ian S Wallace. Glucosylceramides impact cellulose deposition and cellulose synthase complex motility in Arabidopsis. Glycobiology. 2024 Apr; 34(6):. doi: 10.1093/glycob/cwae035. [PMID: 38690785]
  • Varun Jaiswal, Mi-Jin Lee, Ju Lan Chun, Miey Park, Hae-Jeung Lee. 1-Deoxynojirimycin containing Morus alba leaf-based food modulates the gut microbiome and expression of genes related to obesity. BMC veterinary research. 2024 Apr; 20(1):133. doi: 10.1186/s12917-024-03961-9. [PMID: 38570815]
  • Yangzhen Liao, Wenmin Du, Jingqiong Wan, Jiahe Fan, Jilan Pi, Min Wu, Yuan Wei, Zhen Ouyang. Mining and functional characterization of NADPH-cytochrome P450 reductases of the DNJ biosynthetic pathway in mulberry leaves. BMC plant biology. 2024 Feb; 24(1):133. doi: 10.1186/s12870-024-04815-0. [PMID: 38395770]
  • Lucia Marchetti, Eleonora Truzzi, Maria Cecilia Rossi, Stefania Benvenuti, Silvia Cappellozza, Alessio Saviane, Luca Bogataj, Cristina Siligardi, Davide Bertelli. Alginate-Based Carriers Loaded with Mulberry (Morus alba L.) Leaf Extract: A Promising Strategy for Prolonging 1-Deoxynojirimicyn (DNJ) Systemic Activity for the Nutraceutical Management of Hyperglycemic Conditions. Molecules (Basel, Switzerland). 2024 Feb; 29(4):. doi: 10.3390/molecules29040797. [PMID: 38398549]
  • Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-Yan Du, Yan Jiang. Mulberry leaf multi-components exert hypoglycemic effects through regulation of the PI-3K/Akt insulin signaling pathway in type 2 diabetic rats. Journal of ethnopharmacology. 2024 Jan; 319(Pt 3):117307. doi: 10.1016/j.jep.2023.117307. [PMID: 37939911]
  • Saniye Karabudak, Vildan Güzel, Beril Güler, Bülent Uyanık, Azize Esra Gürsoy. A case report of Tangier disease presents with acute sensorimotor polyneuropathy and its treatment approach. Journal of clinical lipidology. 2023 Dec; ?(?):. doi: 10.1016/j.jacl.2023.11.015. [PMID: 38172008]
  • Xinxiu Ren, Qinfeng Guo, Hui Jiang, Xiao Han, Xiaoshi He, Haodong Liu, Zhilong Xiu, Yuesheng Dong. Combinational application of the natural products 1-deoxynojirimycin and morin ameliorates insulin resistance and lipid accumulation in prediabetic mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Sep; 121(?):155106. doi: 10.1016/j.phymed.2023.155106. [PMID: 37797432]
  • Cécile Freihuber, Bahia Dahmani-Rabehi, Anaïs Brassier, Pierre Broué, Claude Cances, Brigitte Chabrol, Didier Eyer, François Labarthe, Philippe Latour, Thierry Levade, Samia Pichard, Caroline Sevin, Marie T Vanier, Bénédicte Héron. Effects of miglustat therapy on neurological disorder and survival in early-infantile Niemann-Pick disease type C: a national French retrospective study. Orphanet journal of rare diseases. 2023 07; 18(1):204. doi: 10.1186/s13023-023-02804-4. [PMID: 37480097]
  • Lu Yang, Jiuyang Zhao, Shaoli Fan, Jinfa Liao, Yicun Chen, Yangdong Wang. Effect of Frost on the Different Metabolites of Two Mulberry (Morus nigra L. and Morus alba L.) Leaves. Molecules (Basel, Switzerland). 2023 Jun; 28(12):. doi: 10.3390/molecules28124718. [PMID: 37375273]
  • Henryk Straube. Am-aza-ing antidiabetic: Mulberry dehydrogenase MnGUTB1 contributes to the biosynthesis of 1-deoxynojirimycin. Plant physiology. 2023 05; 192(2):700-702. doi: 10.1093/plphys/kiad140. [PMID: 36880315]
  • Zhen Yang, Yiwei Luo, Xiaoyu Xia, Jinzhi He, Jiajia Zhang, Qiwei Zeng, Dong Li, Bi Ma, Shaoyu Zhang, Changxin Zhai, Miao Chen, Ningjia He. Dehydrogenase MnGutB1 catalyzes 1-deoxynojirimycin biosynthesis in mulberry. Plant physiology. 2023 Feb; ?(?):. doi: 10.1093/plphys/kiad065. [PMID: 36800200]
  • Dujun Wang, Li Zhao, Jingqiong Wan, Jia Liu, Yuan Wei, Zhen Ouyang, Xiaohong Yu. Molecular cloning, expression, and functional analysis of copper amine oxidase gene from mulberry (Morus alba L.). Protein expression and purification. 2023 01; 201(?):106166. doi: 10.1016/j.pep.2022.106166. [PMID: 36174814]
  • Veronica Antipova, Lisa-Marie Steinhoff, Carsten Holzmann, Arndt Rolfs, Carlos Junior Hempel, Martin Witt, Andreas Wree. Organ Weights in NPC1 Mutant Mice Partly Normalized by Various Pharmacological Treatment Approaches. International journal of molecular sciences. 2022 Dec; 24(1):. doi: 10.3390/ijms24010573. [PMID: 36614015]
  • Agata Walkowiak-Bródka, Natalia Piekuś-Słomka, Kacper Wnuk, Bogumiła Kupcewicz. Analysis of White Mulberry Leaves and Dietary Supplements, ATR-FTIR Combined with Chemometrics for the Rapid Determination of 1-Deoxynojirimycin. Nutrients. 2022 Dec; 14(24):. doi: 10.3390/nu14245276. [PMID: 36558434]
  • F Wen, P Dai, Z Song, C Jin, X Ji, J Hou, N Liu. Alleviating effect of mulberry leaf 1-deoxynojirimycin on resistin-induced hepatic steatosis and insulin resistance in mice. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2022 Dec; 73(6):. doi: 10.26402/jpp.2022.6.07. [PMID: 37087566]
  • Pin-Jian Xiao, Jia-Cheng Zeng, Ping Lin, Dao-Bang Tang, En Yuan, Yong-Gang Tu, Qing-Feng Zhang, Ji-Guang Chen, Da-Yong Peng, Zhong-Ping Yin. Chalcone-1-Deoxynojirimycin Heterozygote Reduced the Blood Glucose Concentration and Alleviated the Adverse Symptoms and Intestinal Flora Disorder of Diabetes Mellitus Rats. Molecules (Basel, Switzerland). 2022 Nov; 27(21):. doi: 10.3390/molecules27217583. [PMID: 36364410]
  • Kamonpan Fongsodsri, Thanchanit Thaipitakwong, Kitiya Rujimongkon, Tapanee Kanjanapruthipong, Sumate Ampawong, Onrapak Reamtong, Pornanong Aramwit. Mulberry-Derived 1-Deoxynojirimycin Prevents Type 2 Diabetes Mellitus Progression via Modulation of Retinol-Binding Protein 4 and Haptoglobin. Nutrients. 2022 Oct; 14(21):. doi: 10.3390/nu14214538. [PMID: 36364802]
  • Fanshan Feng, Wei Xiang, Han Gao, Yanan Jia, Yuansong Zhang, Lingshu Zeng, Jiaxin Chen, Xianzhi Huang, Li Xu. Rapid Screening of Nonalkaloid α-Glucosidase Inhibitors from a Mulberry Twig Extract Using Enzyme-Functionalized Magnetic Nanoparticles Coupled with UPLC-MS/MS. Journal of agricultural and food chemistry. 2022 Sep; 70(38):11958-11966. doi: 10.1021/acs.jafc.2c03435. [PMID: 36107153]
  • Laura López de Frutos, Francisco Almeida, Jessica Murillo-Saich, Vasco A Conceição, Monica Guma, Oswald Queheberger, Pilar Giraldo, Gabriel Miltenberger-Miltenyi. Serum Phospholipid Profile Changes in Gaucher Disease and Parkinson's Disease. International journal of molecular sciences. 2022 Sep; 23(18):. doi: 10.3390/ijms231810387. [PMID: 36142296]
  • Hamid Momeni, Ashraf Salehi, Abdorrahim Absalan, Mehran Akbari. Hydro-alcoholic extract of Morus nigra reduces fasting blood glucose and HbA1c\% in diabetic patients, probably via competitive and allosteric interaction with alpha-glucosidase enzyme; a clinical trial and in silico analysis. Journal of complementary & integrative medicine. 2022 Sep; 19(3):763-769. doi: 10.1515/jcim-2021-0005. [PMID: 33946137]
  • Tatiane G Hammerschmidt, Bruna Donida, Jéssica L Faverzani, Alana P Moura, Bianca G Dos Reis, Andryele Z Machado, Rejane G Kessler, Fernanda M Sebastião, Luiza S Reinhardt, Dinara J Moura, Carmen R Vargas. Cytokine profile and cholesterol levels in patients with Niemann-Pick type C disease presenting neurological symptoms: in vivo effect of miglustat and in vitro effect of N-acetylcysteine and coenzyme Q10. Experimental cell research. 2022 07; 416(2):113175. doi: 10.1016/j.yexcr.2022.113175. [PMID: 35487270]
  • Xinxiu Ren, Yan Xing, Liangyu He, Zhilong Xiu, Ling Yang, Aizhi Han, Qinhua Jia, Yuesheng Dong. Effect of 1-Deoxynojirimycin on insulin resistance in prediabetic mice based on next-generation sequencing and intestinal microbiota study. Journal of ethnopharmacology. 2022 May; 289(?):115029. doi: 10.1016/j.jep.2022.115029. [PMID: 35077826]
  • Jingqiong Wan, Yangzhen Liao, Jia Liu, Wenmin Du, Chang Liu, Yuan Wei, Zhen Ouyang. Screening, cloning and functional characterization of key methyltransferase genes involved in the methylation step of 1-deoxynojirimycin alkaloids biosynthesis in mulberry leaves. Planta. 2022 May; 255(6):121. doi: 10.1007/s00425-022-03901-7. [PMID: 35538157]
  • Malte Lenders, Peter Nordbeck, Christine Kurschat, Maria Eveslage, Nesrin Karabul, Jessica Kaufeld, Julia B Hennermann, Monica Patten, Markus Cybulla, Jonas Müntze, Nurcan Üçeyler, Dan Liu, Anibh M Das, Claudia Sommer, Christian Pogoda, Stefanie Reiermann, Thomas Duning, Jens Gaedeke, Katharina von Cossel, Daniela Blaschke, Stefan-Martin Brand, W Alexander Mann, Christoph Kampmann, Nicole Muschol, Sima Canaan-Kühl, Eva Brand. Treatment of Fabry Disease management with migalastat-outcome from a prospective 24 months observational multicenter study (FAMOUS). European heart journal. Cardiovascular pharmacotherapy. 2022 05; 8(3):272-281. doi: 10.1093/ehjcvp/pvab025. [PMID: 35512362]
  • Yifang Gao, Wenhui Bian, Yuanyuan Fang, Peng Du, Xueting Liu, Xueru Zhao, Fengjuan Li. α-Glucosidase Inhibitory Activity of Fermented Okara Broth Started with the Strain Bacillus amyloliquefaciens SY07. Molecules (Basel, Switzerland). 2022 Feb; 27(3):. doi: 10.3390/molecules27031127. [PMID: 35164396]
  • Saligrama Viswanath Shreelakshmi, Maria Sheeba Nazareth, Pradeep Matam, Darshan Dorairaj, Nandini P Shetty. Chemometric evaluation of functional components and anti-quorum sensing activity of mulberry leaves from Indian cultivars: a potential contribution to the food industry. Journal of the science of food and agriculture. 2022 Jan; 102(2):567-574. doi: 10.1002/jsfa.11385. [PMID: 34148238]
  • Julien Lamontagne, Eszter Sas, Gilles Vincent, Kankan Shang, Frédéric E Pitre, Michel Labrecque. Valuable alkaloids content is preserved in Camptotheca acuminata and Morus alba grown in trace elements contaminated soil. International journal of phytoremediation. 2022; 24(14):1533-1542. doi: 10.1080/15226514.2022.2043238. [PMID: 35234104]
  • Isabella Supardi Parida, Soo Takasu, Kiyotaka Nakagawa. A comprehensive review on the production, pharmacokinetics and health benefits of mulberry leaf iminosugars: Main focus on 1-deoxynojirimycin, d-fagomine, and 2-O-ɑ-d-galactopyranosyl-DNJ. Critical reviews in food science and nutrition. 2021 Oct; ?(?):1-29. doi: 10.1080/10408398.2021.1989660. [PMID: 34658276]
  • Yasushi Honda, Anna Ozaki, Michihiro Iwaki, Takashi Kobayashi, Asako Nogami, Takaomi Kessoku, Yuji Ogawa, Wataru Tomeno, Kento Imajo, Masato Yoneda, Satoru Saito, Yoji Nagashima, Atsushi Nakajima. Protective effect of SGL5213, a potent intestinal sodium-glucose cotransporter 1 inhibitor, in nonalcoholic fatty liver disease in mice. Journal of pharmacological sciences. 2021 Oct; 147(2):176-183. doi: 10.1016/j.jphs.2021.07.002. [PMID: 34384565]
  • Parsa Bazdar, Ali R Jalalvand, Vali Akbari, Reza Khodarahmi, Hector C Goicoechea. Resolving interactions of miglitol with normal and glycated human serum albumin by multivariate methods. Analytical biochemistry. 2021 10; 630(?):114339. doi: 10.1016/j.ab.2021.114339. [PMID: 34411552]
  • Jia Liu, Jingqiong Wan, Wenmin Du, Dujun Wang, Chongwei Wen, Yuan Wei, Zhen Ouyang. In Vivo Functional Verification of Four Related Genes Involved in the 1-Deoxynojirimycin Biosynthetic Pathway in Mulberry Leaves. Journal of agricultural and food chemistry. 2021 Sep; 69(37):10989-10998. doi: 10.1021/acs.jafc.1c03932. [PMID: 34516110]
  • X He, Z Sun, K Ma, Y Mei. [1-deoxynojirimycin alleviates liver fibrosis induced by type 2 diabetes in mice]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2021 Aug; 41(9):1342-1349. doi: 10.12122/j.issn.1673-4254.2021.09.08. [PMID: 34658348]
  • Juan Yan, Xiao-Min Li, Yan-Xin Zhang, Su-Mei Xu, Wan-Li Liu, Jie Guo, Xiao-Lei Hu, Ting Zou, Yu-Ying Xu, Ping-Sheng Xu. Bioequivalence and Evaluation Parameters Based on the Pharmacodynamics of Miglitol in Healthy Volunteers. Clinical pharmacology in drug development. 2021 06; 10(6):582-587. doi: 10.1002/cpdd.873. [PMID: 33058553]
  • Ichiro Misumi, Zhucui Li, Lu Sun, Anshuman Das, Tomoyuki Shiota, John Cullen, Qibin Zhang, Jason K Whitmire, Stanley M Lemon. Iminosugar Glucosidase Inhibitors Reduce Hepatic Inflammation in Hepatitis A Virus-Infected Ifnar1-/- Mice. Journal of virology. 2021 05; 95(11):e0005821. doi: 10.1128/jvi.00058-21. [PMID: 33692213]
  • Elizabeth C Clarke, Robert A Nofchissey, Chunyan Ye, Steven B Bradfute. The iminosugars celgosivir, castanospermine and UV-4 inhibit SARS-CoV-2 replication. Glycobiology. 2021 05; 31(4):378-384. doi: 10.1093/glycob/cwaa091. [PMID: 32985653]
  • Sreejith Rajasekharan, Rafaela Milan Bonotto, Lais Nascimento Alves, Yvette Kazungu, Monica Poggianella, Pamela Martinez-Orellana, Natasa Skoko, Sulena Polez, Alessandro Marcello. Inhibitors of Protein Glycosylation Are Active against the Coronavirus Severe Acute Respiratory Syndrome Coronavirus SARS-CoV-2. Viruses. 2021 04; 13(5):. doi: 10.3390/v13050808. [PMID: 33946304]
  • Fumitaka Okajima, Hitoshi Sugihara, Naoya Emoto. Efficacy and Safety of Miglitol- or Repaglinide-Based Combination Therapy with Alogliptin for Drug-Naïve Patients with Type 2 Diabetes: An Open-Label, Single-Center, Parallel, Randomized Controlled Pilot Study. Journal of Nippon Medical School = Nippon Ika Daigaku zasshi. 2021 Mar; 88(1):71-79. doi: 10.1272/jnms.jnms.2021_88-205. [PMID: 32475902]
  • Salma Hago, Engy A Mahrous, Mohamed Moawad, Samia Abdel-Wahab, Essam Abdel-Sattar. Evaluation of antidiabetic activity of Morus nigra L. and Bauhinia variegata L. leaves as Egyptian remedies used for the treatment of diabetes. Natural product research. 2021 Mar; 35(5):829-835. doi: 10.1080/14786419.2019.1601094. [PMID: 30968706]
  • Masato Minami, Emiko Mizuma, Mai Nakahara, Yumi Oda, Haruhito Yoshimine, Koki Tokunaga, Akihiko Mitsuke, Yasutoshi Yamada, Hideki Enokida, Kosuke Masutani, Norihiko Goto, Akio Ido. A case of latent heterozygous Fabry disease in a female living kidney donor candidate. CEN case reports. 2021 02; 10(1):30-34. doi: 10.1007/s13730-020-00510-9. [PMID: 32712909]
  • Yuting Wang, Zhongwei Yu, Jun Jiang, Yaxin Li, Shui Yu. Mulberry leaf attenuates atherosclerotic lesions in patients with coronary heart disease possibly via 1-Deoxynojirimycin: A placebo-controlled, double-blind clinical trial. Journal of food biochemistry. 2021 01; 45(1):e13573. doi: 10.1111/jfbc.13573. [PMID: 33277698]
  • Haijun Wang, Yin Shen, Lei Zhao, Youfan Ye. 1-Deoxynojirimycin and its Derivatives: A Mini Review of the Literature. Current medicinal chemistry. 2021; 28(3):628-643. doi: 10.2174/0929867327666200114112728. [PMID: 31942844]
  • Daniel G Bichet, Johannes M Aerts, Christiane Auray-Blais, Hiroki Maruyama, Atul B Mehta, Nina Skuban, Eva Krusinska, Raphael Schiffmann. Assessment of plasma lyso-Gb3 for clinical monitoring of treatment response in migalastat-treated patients with Fabry disease. Genetics in medicine : official journal of the American College of Medical Genetics. 2021 01; 23(1):192-201. doi: 10.1038/s41436-020-00968-z. [PMID: 32994552]
  • Eleonora Riccio, Mario Zanfardino, Lucia Ferreri, Ciro Santoro, Sirio Cocozza, Ivana Capuano, Massimo Imbriaco, Sandro Feriozzi, Antonio Pisani. Switch from enzyme replacement therapy to oral chaperone migalastat for treating fabry disease: real-life data. European journal of human genetics : EJHG. 2020 12; 28(12):1662-1668. doi: 10.1038/s41431-020-0677-x. [PMID: 32647377]
  • Ping Lin, Jia-Cheng Zeng, Ji-Guang Chen, Xu-Liang Nie, En Yuan, Xiao-Qiang Wang, Da-Yong Peng, Zhong-Ping Yin. Synthesis, in vitro inhibitory activity, kinetic study and molecular docking of novel N-alkyl-deoxynojirimycin derivatives as potential α-glucosidase inhibitors. Journal of enzyme inhibition and medicinal chemistry. 2020 Dec; 35(1):1879-1890. doi: 10.1080/14756366.2020.1826941. [PMID: 33003963]
  • Jia Liu, Jingqiong Wan, Dujun Wang, Chongwei Wen, Yuan Wei, Zhen Ouyang. Comparative Transcriptome Analysis of Key Reductase Genes Involved in the 1-Deoxynojirimycin Biosynthetic Pathway in Mulberry Leaves and Cloning, Prokaryotic Expression, and Functional Analysis of MaSDR1 and MaSDR2. Journal of agricultural and food chemistry. 2020 Nov; 68(44):12345-12357. doi: 10.1021/acs.jafc.0c04832. [PMID: 33085468]
  • Qirui Hou, Zhongyao Qian, Ping Wu, Manman Shen, Long Li, Weiguo Zhao. 1-Deoxynojirimycin from mulberry leaves changes gut digestion and microbiota composition in geese. Poultry science. 2020 Nov; 99(11):5858-5866. doi: 10.1016/j.psj.2020.07.048. [PMID: 33142503]
  • Markus S Mueller, Patricia N Sidharta, Christine Voors-Pette, Borje Darpo, Hongqi Xue, Jasper Dingemanse. The effect of the glucosylceramide synthase inhibitor lucerastat on cardiac repolarization: results from a thorough QT study in healthy subjects. Orphanet journal of rare diseases. 2020 10; 15(1):303. doi: 10.1186/s13023-020-01582-7. [PMID: 33109218]
  • Hila Braunstein, Maria Papazian, Gali Maor, Jan Lukas, Arndt Rolfs, Mia Horowitz. Misfolding of Lysosomal α-Galactosidase a in a Fly Model and Its Alleviation by the Pharmacological Chaperone Migalastat. International journal of molecular sciences. 2020 Oct; 21(19):. doi: 10.3390/ijms21197397. [PMID: 33036426]
  • Ulla Feldt-Rasmussen, Derralynn Hughes, Gere Sunder-Plassmann, Suma Shankar, Khan Nedd, Iacopo Olivotto, Damara Ortiz, Toya Ohashi, Takashi Hamazaki, Nina Skuban, Julie Yu, Jay A Barth, Kathleen Nicholls. Long-term efficacy and safety of migalastat treatment in Fabry disease: 30-month results from the open-label extension of the randomized, phase 3 ATTRACT study. Molecular genetics and metabolism. 2020 Sep; 131(1-2):219-228. doi: 10.1016/j.ymgme.2020.07.007. [PMID: 33012654]
  • Yue-Sheng Dong, Na Yu, Xia Li, Bowei Zhang, Yan Xing, Chunlin Zhuang, Zhi-Long Xiu. Dietary 5,6,7-Trihydroxy-flavonoid Aglycones and 1-Deoxynojirimycin Synergistically Inhibit the Recombinant Maltase-Glucoamylase Subunit of α-Glucosidase and Lower Postprandial Blood Glucose. Journal of agricultural and food chemistry. 2020 Aug; 68(33):8774-8787. doi: 10.1021/acs.jafc.0c01668. [PMID: 32806121]
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