dian III (BioDeep_00000395682)

 

Secondary id: BioDeep_00000180709

PANOMIX_OTCML-2023


代谢物信息卡片


1-Methyl-[3,3 inverted exclamation mark -biindolinylidene]-2,2 inverted exclamation mark -dione

化学式: C17H12N2O2 (276.0899)
中文名称: 甲异靛
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 86.92%

分子结构信息

SMILES: CN1C2=CC=CC=C2C(=C1O)C3=C4C=CC=CC4=NC3=O
InChI: InChI=1S/C17H12N2O2/c1-19-13-9-5-3-7-11(13)15(17(19)21)14-10-6-2-4-8-12(10)18-16(14)20/h2-9,21H,1H3

描述信息

Meisoindigo (Dian III), a derivative of Indirubin (HY-N0117), halts the cell cycle at the G0/G1 phase and induces apoptosis in primary acute myeloid leukemia (AML) cells. Meisoindigo exhibits high antitumor activity[1][2].

同义名列表

28 个代谢物同义名

1-Methyl-[3,3 inverted exclamation mark -biindolinylidene]-2,2 inverted exclamation mark -dione; 2H-Indol-2-one, 3-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)-1,3-dihydro-1-methyl-; 2H-Indol-2-one,3-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)-1,3-dihydro-1-methyl-; 3-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)-1,3-dihydro-1-methyl-2H-indol-2-one; 1-methyl-3-(2-oxo-2,3-dihydro-1H-indol-3-ylidene)-2,3-dihydro-1H-indol-2-one; (E)-1-methyl-1H,1H,2H,2H-[3,3-biindolylidene]-2,2-dione; (3E)-1-methyl-3-(2-oxo-1H-indol-3-ylidene)indol-2-one; (3E)-1-methyl-3-(2-oxoindolin-3-ylidene)indolin-2-one; (E)-1,1-dimethyl-[3,3-biindolinylidene]-2,2-dione; (E)-1-methyl-[3,3-biindolinylidene]-2,2-dione; 3-(2-hydroxy-1-methylindol-3-yl)indol-2-one; Dian III;N-Methylisoindigotin;Natura-alpha; 1-Methyl-[3,3-biindolinylidene]-2,2-dione; Dian III;N-Methylisoindigotin;Natura-; 1-Methyl-3,3-biindole-2,2(1H,1H)dione; 1-Methyl-3,3-biindolenyl-2,2-dione; MEISOINDIGO [WHO-DD]; N-methylisoindigotin; Methylisoindigotin; Biindolene deriv.; UNII-92UIP6405R; NATURA-.ALPHA.; Oprea1_162254; Meisoindigo; 92UIP6405R; dian III; Natura-a; Natura-α



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Jing-Jing Liu, Lu-Mei Shentu, Ning Ma, Li-Ying Wang, Gui-Min Zhang, Ying Sun, Yan Wang, Jun Li, Yan-Ling Mu. Inhibition of NF-κB and Wnt/β-catenin/GSK3β Signaling Pathways Ameliorates Cardiomyocyte Hypertrophy and Fibrosis in Streptozotocin (STZ)-induced Type 1 Diabetic Rats. Current medical science. 2020 Feb; 40(1):35-47. doi: 10.1007/s11596-020-2144-x. [PMID: 32166663]
  • Meng Huang, Hai-Shu Lin, Ying Shiuan Lee, Paul C Ho. Evaluation of meisoindigo, an indirubin derivative: in vitro antileukemic activity and in vivo pharmacokinetics. International journal of oncology. 2014 Oct; 45(4):1724-34. doi: 10.3892/ijo.2014.2548. [PMID: 25050545]
  • Yirong Li, Martin Ligr, James P McCarron, Garrett Daniels, David Zhang, Xin Zhao, Fei Ye, Jinhua Wang, Xiaomei Liu, Iman Osman, Simon K Mencher, Hebert Lepor, Long G Wang, Anna Ferrari, Peng Lee. Natura-alpha targets forkhead box m1 and inhibits androgen-dependent and -independent prostate cancer growth and invasion. Clinical cancer research : an official journal of the American Association for Cancer Research. 2011 Jul; 17(13):4414-24. doi: 10.1158/1078-0432.ccr-11-0431. [PMID: 21606178]
  • Xiu-Ju Wang, Song-Mei Yin, Li-Ping Ma, Da-Nian Nie, Shuang-Feng Xie, Yi-Qing Li. [Immuno-regulatory effect of 3'-meisoindigo in mice of various germlines]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2010 Jul; 33(7):1124-9. doi: ". [PMID: 21137371]
  • Meng Huang, Ying Shiuan Lee, Paul C Ho. Identification of circulatory and excretory metabolites of meisoindigo in rat plasma, urine and feces by high-performance liquid chromatography coupled with positive electrospray ionization tandem mass spectrometry. Rapid communications in mass spectrometry : RCM. 2010 Mar; 24(6):729-41. doi: 10.1002/rcm.4434. [PMID: 20169560]
  • Meng Huang, Lip-Wee Choo, Paul C Ho. Characterization of metabolites of meisoindigo in male and female rat kidney microsomes by high-performance liquid chromatography coupled with positive electrospray ionization tandem mass spectrometry. Rapid communications in mass spectrometry : RCM. 2008 Dec; 22(23):3835-45. doi: 10.1002/rcm.3805. [PMID: 18980268]
  • Zhijian Xiao, Yi Wang, Lin Lu, Zongjin Li, Zhi Peng, Zhongchao Han, Yushu Hao. Anti-angiogenesis effects of meisoindigo on chronic myelogenous leukemia in vitro. Leukemia research. 2006 Jan; 30(1):54-9. doi: 10.1016/j.leukres.2005.05.012. [PMID: 15982734]
  • L Song, L Qian. [Apoptosis inducing effect of meisoindigo on K562 cells]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 1999 Jun; 19(6):353-5. doi: ". [PMID: 11783201]