Vadilex (BioDeep_00000395641)

   

PANOMIX_OTCML-2023


代谢物信息卡片


1-Piperidineethanol, .alpha.-(4-hydroxyphenyl)-.beta.-methyl-4-(phenylmethyl)-, 2,3-dihydroxybutanedioate (1:1) (salt)

化学式: C25H33NO8 (475.22060580000004)
中文名称: 酒石酸艾芬地尔, 苄哌酚胺
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 3.25%

分子结构信息

SMILES: CC(C(C1=CC=C(C=C1)O)O)N2CCC(CC2)CC3=CC=CC=C3.C(C(C(=O)O)O)(C(=O)O)O
InChI: 1-2,5-6H,(H,7,8)(H,9,10)



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Hiroko Kotajima-Murakami, Ayumi Takano, Shinya Hirakawa, Yasukazu Ogai, Daisuke Funada, Yuko Tanibuchi, Eriko Ban, Minako Kikuchi, Hisateru Tachimori, Kazushi Maruo, Takahiro Kawashima, Yui Tomo, Tsuyoshi Sasaki, Hideki Oi, Toshihiko Matsumoto, Kazutaka Ikeda. Ifenprodil for the treatment of methamphetamine use disorder: An exploratory, randomized, double-blind, placebo-controlled trial. Neuropsychopharmacology reports. 2022 03; 42(1):92-104. doi: 10.1002/npr2.12232. [PMID: 35068087]
  • Elena Bechthold, Julian A Schreiber, Kirstin Lehmkuhl, Bastian Frehland, Dirk Schepmann, Freddy A Bernal, Constantin Daniliuc, Inés Álvarez, Cristina Val Garcia, Thomas J Schmidt, Guiscard Seebohm, Bernhard Wünsch. Ifenprodil Stereoisomers: Synthesis, Absolute Configuration, and Correlation with Biological Activity. Journal of medicinal chemistry. 2021 01; 64(2):1170-1179. doi: 10.1021/acs.jmedchem.0c01912. [PMID: 33426889]
  • Yamin Yao, Peijun Ju, Hongmei Liu, Xiaohui Wu, Zhiang Niu, Yuncheng Zhu, Chen Zhang, Yiru Fang. Ifenprodil rapidly ameliorates depressive-like behaviors, activates mTOR signaling and modulates proinflammatory cytokines in the hippocampus of CUMS rats. Psychopharmacology. 2020 May; 237(5):1421-1433. doi: 10.1007/s00213-020-05469-0. [PMID: 32130432]
  • Frederik Börgel, Fabian Galla, Kirstin Lehmkuhl, Dirk Schepmann, Simon M Ametamey, Bernhard Wünsch. Pharmacokinetic properties of enantiomerically pure GluN2B selective NMDA receptor antagonists with 3-benzazepine scaffold. Journal of pharmaceutical and biomedical analysis. 2019 Aug; 172(?):214-222. doi: 10.1016/j.jpba.2019.04.032. [PMID: 31060034]
  • Hiroko Kotajima-Murakami, Ayumi Takano, Yasukazu Ogai, Shotaro Tsukamoto, Maki Murakami, Daisuke Funada, Yuko Tanibuchi, Hisateru Tachimori, Kazushi Maruo, Tsuyoshi Sasaki, Toshihiko Matsumoto, Kazutaka Ikeda. Study of effects of ifenprodil in patients with methamphetamine dependence: Protocol for an exploratory, randomized, double-blind, placebo-controlled trial. Neuropsychopharmacology reports. 2019 06; 39(2):90-99. doi: 10.1002/npr2.12050. [PMID: 30756527]
  • Kenji Hashimoto. Activation of sigma-1 receptor chaperone in the treatment of neuropsychiatric diseases and its clinical implication. Journal of pharmacological sciences. 2015 Jan; 127(1):6-9. doi: 10.1016/j.jphs.2014.11.010. [PMID: 25704012]
  • Evamaria Falck, Frank Begrow, Eugen J Verspohl, Bernhard Wünsch. In vitro and in vivo biotransformation of WMS-1410, a potent GluN2B selective NMDA receptor antagonist. Journal of pharmaceutical and biomedical analysis. 2014 Jun; 94(?):36-44. doi: 10.1016/j.jpba.2014.01.017. [PMID: 24534302]
  • Evamaria Falck, Frank Begrow, Eugen Verspohl, Bernhard Wünsch. Metabolism studies of ifenprodil, a potent GluN2B receptor antagonist. Journal of pharmaceutical and biomedical analysis. 2014 Jan; 88(?):96-105. doi: 10.1016/j.jpba.2013.08.014. [PMID: 24042122]
  • Veronica Musante, Maria Summa, Rodrigo A Cunha, Maurizio Raiteri, Anna Pittaluga. Pre-synaptic glycine GlyT1 transporter--NMDA receptor interaction: relevance to NMDA autoreceptor activation in the presence of Mg2+ ions. Journal of neurochemistry. 2011 May; 117(3):516-27. doi: 10.1111/j.1471-4159.2011.07223.x. [PMID: 21348870]
  • M Korinek, M Sedlacek, O Cais, I Dittert, L Vyklicky. Temperature dependence of N-methyl-D-aspartate receptor channels and N-methyl-D-aspartate receptor excitatory postsynaptic currents. Neuroscience. 2010 Feb; 165(3):736-48. doi: 10.1016/j.neuroscience.2009.10.058. [PMID: 19883737]
  • Zhenyu Sheng, Zhong Liang, James H Geiger, Mary Prorok, Francis J Castellino. The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino acid residues in the S2 region of NR2B. Neuropharmacology. 2009 Aug; 57(2):127-36. doi: 10.1016/j.neuropharm.2009.04.014. [PMID: 19427876]
  • Bo Yang, Yongchuan Chen, Rongfeng Xiang, Dan Yang, Peiyuan Xia, Songqing Liu. [Determination of ifenprodil in human plasma using liquid chromatography with electrospray tandem mass spectrometry]. Se pu = Chinese journal of chromatography. 2008 May; 26(3):322-6. doi: 10.1016/s1872-2059(08)60019-x. [PMID: 18724668]
  • A S Bale, Y Tu, E P Carpenter-Hyland, L J Chandler, J J Woodward. Alterations in glutamatergic and gabaergic ion channel activity in hippocampal neurons following exposure to the abused inhalant toluene. Neuroscience. 2005; 130(1):197-206. doi: 10.1016/j.neuroscience.2004.08.040. [PMID: 15561435]
  • Rudi D'Hooge, Gerda Van de Vijver, Pierre-Paul Van Bogaert, Bart Marescau, Raymond Vanholder, Peter P De Deyn. Involvement of voltage- and ligand-gated Ca2+ channels in the neuroexcitatory and synergistic effects of putative uremic neurotoxins. Kidney international. 2003 May; 63(5):1764-75. doi: 10.1046/j.1523-1755.2003.00912.x. [PMID: 12675852]
  • Erik Harvey-Girard, Robert J Dunn. Excitatory amino acid receptors of the electrosensory system: the NR1/NR2B N-methyl-D-aspartate receptor. Journal of neurophysiology. 2003 Feb; 89(2):822-32. doi: 10.1152/jn.00629.2002. [PMID: 12574460]
  • József Nagy, Sándor Kolok, Péter Dezso, András Boros, Zsolt Szombathelyi. Differential alterations in the expression of NMDA receptor subunits following chronic ethanol treatment in primary cultures of rat cortical and hippocampal neurones. Neurochemistry international. 2003 Jan; 42(1):35-43. doi: 10.1016/s0197-0186(02)00062-1. [PMID: 12441166]
  • M Brüss, G J Molderings, H Bönisch, M Göthert. Pharmacological differences and similarities between the native mouse 5-HT3 receptor in N1E-115 cells and a cloned short splice variant of the mouse 5-HT3 receptor expressed in HEK 293 cells. Naunyn-Schmiedeberg's archives of pharmacology. 1999 Sep; 360(3):225-33. doi: 10.1007/s002109900088. [PMID: 10543422]
  • D L Anders, T Blevins, G Sutton, L J Chandler, J J Woodward. Effects of c-Src tyrosine kinase on ethanol sensitivity of recombinant NMDA receptors expressed in HEK 293 cells. Alcoholism, clinical and experimental research. 1999 Feb; 23(2):357-62. doi: 10.1111/j.1530-0277.1999.tb04122.x. [PMID: 10069568]
  • S J Kendrick, M A Dichter, K S Wilcox. Characterization of desensitization in recombinant N-methyl-D-aspartate receptors: comparison with native receptors in cultured hippocampal neurons. Brain research. Molecular brain research. 1998 Jun; 57(1):10-20. doi: 10.1016/s0169-328x(98)00054-0. [PMID: 9630479]
  • S D Hess, L P Daggett, C Deal, C C Lu, E C Johnson, G Veliçelebi. Functional characterization of human N-methyl-D-aspartate subtype 1A/2D receptors. Journal of neurochemistry. 1998 Mar; 70(3):1269-79. doi: 10.1046/j.1471-4159.1998.70031269.x. [PMID: 9489750]
  • T Blevins, T Mirshahi, L J Chandler, J J Woodward. Effects of acute and chronic ethanol exposure on heteromeric N-methyl-D-aspartate receptors expressed in HEK 293 cells. Journal of neurochemistry. 1997 Dec; 69(6):2345-54. doi: 10.1046/j.1471-4159.1997.69062345.x. [PMID: 9375665]
  • A S Basile, J M Huang, C Xie, D Webster, C Berlin, P Skolnick. N-methyl-D-aspartate antagonists limit aminoglycoside antibiotic-induced hearing loss. Nature medicine. 1996 Dec; 2(12):1338-43. doi: 10.1038/nm1296-1338. [PMID: 8946832]
  • M J Gallagher, H Huang, D B Pritchett, D R Lynch. Interactions between ifenprodil and the NR2B subunit of the N-methyl-D-aspartate receptor. The Journal of biological chemistry. 1996 Apr; 271(16):9603-11. doi: 10.1074/jbc.271.16.9603. [PMID: 8621635]
  • D M Lovinger. Developmental decrease in ethanol inhibition of N-methyl-D-aspartate receptors in rat neocortical neurons: relation to the actions of ifenprodil. The Journal of pharmacology and experimental therapeutics. 1995 Jul; 274(1):164-72. doi: NULL. [PMID: 7616394]
  • T Zarnowski, Z Kleinrok, W A Turski, S J Czuczwar. The NMDA antagonist procyclidine, but not ifenprodil, enhances the protective efficacy of common antiepileptics against maximal electroshock-induced seizures in mice. Journal of neural transmission. General section. 1994; 97(1):1-12. doi: 10.1007/bf01277958. [PMID: 7888145]
  • K Goto, M Suekawa, E Hosoya. [Pharmacological study of TJ-8007 (tsumura-zokumeito) (II): Protective effect of TJ-8007 against cerebral ischemia]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1989 Apr; 93(4):255-60. doi: 10.1254/fpj.93.255. [PMID: 2744655]
  • K Saitoh, T Manabe, O Irino. [The mode for the manifestation of the inhibitory effects of ifenprodil tartrate on platelet aggregation in vivo and ex vivo]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1988 Feb; 91(2):105-9. doi: 10.1254/fpj.91.105. [PMID: 3371793]
  • K Saitoh, T Manabe, H Honda, O Irino. Effects of ifenprodil glucuronide derivative on platelet aggregation and vasocontraction. Japanese journal of pharmacology. 1987 Jul; 44(3):355-7. doi: 10.1254/jjp.44.355. [PMID: 3656787]
  • K Goto, M Suekawa, M Aburada, E Hosoya. [Pharmacological study of TJ-8007 (Tsumura-Zokumeito) (I): Protective effects of TJ-8007 against anoxic brain damage]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1987 Jun; 89(6):355-63. doi: 10.1254/fpj.89.355. [PMID: 3623336]
  • O Irino, K Saitoh, K Bando, M Uchida, H Honda. [Effects of ifenprodil tartrate on erythrocyte deformability and cerebral blood flow]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1987 Apr; 89(4):197-202. doi: 10.1254/fpj.89.197. [PMID: 3609967]
  • O Irino, K Saitoh, T Hayashi, K Ohkubo. [Inhibitory mechanism of ifenprodil tartrate on rabbit platelet aggregation]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1985 May; 85(5):379-85. doi: 10.1254/fpj.85.379. [PMID: 3896987]