Lithospermate B (BioDeep_00000395627)
PANOMIX_OTCML-2023
代谢物信息卡片
Magnesium;2-[(E)-3-[3-[1-carboxylato-2-(3,4-dihydroxyphenyl)ethoxy]carbonyl-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-4-yl]prop-2-enoyl]oxy-3-(3,4-dihydroxyphenyl)propanoate
化学式: C36H28MgO16 (740.1227788)
中文名称: 丹参酸 B 镁, 丹酚酸B镁盐, 丹參酸B鎂
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 28.57%
分子结构信息
SMILES: C1=CC(=C(C=C1CC(C(=O)[O-])OC(=O)C=CC2=C3C(C(OC3=C(C=C2)O)C4=CC(=C(C=C4)O)O)C(=O)OC(CC5=CC(=C(C=C5)O)O)C(=O)[O-])O)O.[Mg+2]
InChI: /q
描述信息
Magnesium Lithospermate B, a derivative of caffeic acid tetramer, and is extracted from Salviae miltiorrhizae. Magnesium Lithospermate B is widely used for the research of cardiovascular diseases, and it can protect against glucose-induced intracellular oxidative damage. Magnesium Lithospermate B also suppresses neuroin?ammation and attenuates neurodegeneration[1][2][3].
Magnesium Lithospermate B, a derivative of caffeic acid tetramer, and is extracted from Salviae miltiorrhizae. Magnesium Lithospermate B is widely used for the research of cardiovascular diseases, and it can protect against glucose-induced intracellular oxidative damage. Magnesium Lithospermate B also suppresses neuroin?ammation and attenuates neurodegeneration[1][2][3].
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代谢反应
0 个相关的代谢反应过程信息。
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2 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tsun-Li Cheng, Zi-Yun Lin, Keng-Ying Liao, Wei-Chi Huang, Cian-Fen Jhuo, Pin-Ho Pan, Chun-Jung Chen, Yu-Hsiang Kuan, Wen-Ying Chen. Magnesium Lithospermate B Attenuates High-Fat Diet-Induced Muscle Atrophy in C57BL/6J Mice.
Nutrients.
2021 Dec; 14(1):. doi:
10.3390/nu14010104. [PMID: 35010979] - Wei-Chi Huang, Keng-Ying Liao, Sheng-Kuo Hsieh, Ping-Ho Pan, Yu-Hsiang Kuan, Su-Lan Liao, Chun-Jung Chen, Wen-Ying Chen. Magnesium lithospermate B supplementation improved prenatal Bisphenol A exposure-induced metabolic abnormalities in male offspring.
Environmental toxicology.
2021 Sep; 36(9):1932-1943. doi:
10.1002/tox.23313. [PMID: 34165232] - Sheng-Kuo Hsieh, Nan-Hei Lin, Ying-Jie Chen, Maw-Rong Lee, Wen-Ying Chen, Jason T C Tzen. Therapeutic Effects of Lithospermate B Complexed with Mg2+ or Zn2+ on Metabolic Syndrome Induced in Rats Fed with High-Fat Diet.
Molecules (Basel, Switzerland).
2020 Feb; 25(4):. doi:
10.3390/molecules25040983. [PMID: 32098371] - Meng Wang, Liuyi Yang, Jing Yang, Yuan Zhou, Chen Wang. Magnesium lithospermate B attenuates renal injury in 5/6 renal ablation/infarction rats by mitochondrial pathway of apoptosis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Oct; 118(?):109316. doi:
10.1016/j.biopha.2019.109316. [PMID: 31387002] - Ying-Luo Liu, Xiao-Yu Zhou, Li-Jiang Xuan. Magnesium lithospermate B ameliorates microcirculation perfusion in rats by promoting vascular NO production via activating the PI3K/AKT pathway.
Acta pharmacologica Sinica.
2019 Aug; 40(8):1010-1018. doi:
10.1038/s41401-018-0203-7. [PMID: 30760835] - Jing Zhao, Qing-Li Zhang, Jian-Hua Shen, Kai Wang, Jia Liu. Magnesium lithospermate B improves the gut microbiome and bile acid metabolic profiles in a mouse model of diabetic nephropathy.
Acta pharmacologica Sinica.
2019 Apr; 40(4):507-513. doi:
10.1038/s41401-018-0029-3. [PMID: 29941869] - Pinglan Lin, Ming Wu, Junyan Qin, Jing Yang, Chaoyang Ye, Chen Wang. Magnesium lithospermate B improves renal hemodynamics and reduces renal oxygen consumption in 5/6th renal ablation/infarction rats.
BMC nephrology.
2019 02; 20(1):49. doi:
10.1186/s12882-019-1221-5. [PMID: 30755161] - Pradeep Paudel, Su Hui Seong, Yajuan Zhou, Chan Hum Park, Takako Yokozawa, Hyun Ah Jung, Jae Sue Choi. Rosmarinic Acid Derivatives' Inhibition of Glycogen Synthase Kinase-3β Is the Pharmacological Basis of Kangen-Karyu in Alzheimer's Disease.
Molecules (Basel, Switzerland).
2018 Nov; 23(11):. doi:
10.3390/molecules23112919. [PMID: 30413117] - Yucong Peng, Pingyou He, Linfeng Fan, Hangzhe Xu, Jianru Li, Ting Chen, Wu Ruan, Zhangqi Dou, Gao Chen. Neuroprotective Effects of Magnesium Lithospermate B against Subarachnoid Hemorrhage in Rats.
The American journal of Chinese medicine.
2018; 46(6):1225-1241. doi:
10.1142/s0192415x18500647. [PMID: 30149758] - Xuqi Kang, Hui Chen, Shujuan Li, Liyong Jie, Jingbo Hu, Xiaojuan Wang, Jing Qi, Xiaoying Ying, Yongzhong Du. Magnesium lithospermate B loaded PEGylated solid lipid nanoparticles for improved oral bioavailability.
Colloids and surfaces. B, Biointerfaces.
2018 Jan; 161(?):597-605. doi:
10.1016/j.colsurfb.2017.11.008. [PMID: 29156336] - Tse-Yu Chung, Nan-Hei Lin, Yue-Chiun Li, Tzu-Yin Chen, Ping-Chung Kuo, Wen-Ying Chen, Jason T C Tzen. Detection of lithospermate B in rat plasma at the nanogram level by LC/MS in multi reaction monitoring mode.
Journal of food and drug analysis.
2018 01; 26(1):353-361. doi:
10.1016/j.jfda.2017.06.003. [PMID: 29389574] - Chan Hum Park, Sung Ho Shin, Eun Kyeong Lee, Dae Hyun Kim, Min-Jo Kim, Seong-Soo Roh, Takako Yokozawa, Hae Young Chung. Magnesium Lithospermate B from Salvia miltiorrhiza Bunge Ameliorates Aging-Induced Renal Inflammation and Senescence via NADPH Oxidase-Mediated Reactive Oxygen Generation.
Phytotherapy research : PTR.
2017 May; 31(5):721-728. doi:
10.1002/ptr.5789. [PMID: 28211114] - Zheng Lou, Kai-Di Ren, Bin Tan, Jing-Jie Peng, Xian Ren, Zhong-Bao Yang, Bin Liu, Jie Yang, Qi-Lin Ma, Xiu-Ju Luo, Jun Peng. Salviaolate Protects Rat Brain from Ischemia-Reperfusion Injury through Inhibition of NADPH Oxidase.
Planta medica.
2015 Oct; 81(15):1361-9. doi:
10.1055/s-0035-1557774. [PMID: 26252829] - Feng Jiang, Yongqiang Mao, Huixiang Liu, Ping Xu, Li Zhang, Xiaobo Qian, Xiaofeng Sun. Magnesium Lithospermate B Protects Neurons Against Amyloid β (1-42)-Induced Neurotoxicity Through the NF-κB Pathway.
Neurochemical research.
2015 Sep; 40(9):1954-65. doi:
10.1007/s11064-015-1691-1. [PMID: 26285901] - Wei Quan, Feihu Liu, Yan Zhang, Congmin Xie, Bin Wu, Jipeng Yin, Lei Wang, Wei Zhang, Xiaohong Zhang, Qiangju Wu. Antidepressant-like effects of magnesium lithospermate B in a rat model of chronic unpredictable stress.
Pharmaceutical biology.
2015 Aug; 53(8):1168-75. doi:
10.3109/13880209.2014.967783. [PMID: 25857699] - Yi-Ching Chung, Feng-Chia Hsieh, Ying-Ju Lin, Tzong-Yuan Wu, Cheng-Wen Lin, Ching-Ting Lin, Nou-Ying Tang, Tzyy-Rong Jinn. Magnesium lithospermate B and rosmarinic acid, two compounds present in Salvia miltiorrhiza, have potent antiviral activity against enterovirus 71 infections.
European journal of pharmacology.
2015 May; 755(?):127-33. doi:
10.1016/j.ejphar.2015.02.046. [PMID: 25773498] - Zhi-qiang Cao, Wei Quan, Shuang-xing Hou, Chao Guo, Shan-bo Ma, Wei Zhang, Xin Li. The natural therapeutic magnesium lithospermate B potently provides neuroprotective effects on cerebral ischemia/reperfusion injury in rats.
Journal of ethnopharmacology.
2015 Mar; 162(?):191-8. doi:
10.1016/j.jep.2014.12.048. [PMID: 25560670] - Ying-Jie Chen, Tse-Yu Chung, Wen-Ying Chen, Chung-Yu Chen, Maw-Rong Lee, Tzyy-Rong Jinn, Jason Tc Tzen. Detecting metabolites of different transition metal-lithospermate B complexes after intravenous injection in rats.
Acta pharmacologica Sinica.
2014 Jul; 35(7):937-44. doi:
10.1038/aps.2014.37. [PMID: 24989253] - Guodong Xiao, Weidong Hu, Xuesong Chen. Magnesium lithospermate B protects neurons from N-methyl-D-aspartic acid injury and attenuates kainic acid-induced neurodegeration in FVB mice.
Journal of molecular neuroscience : MN.
2013 Oct; 51(2):550-7. doi:
10.1007/s12031-013-0023-7. [PMID: 23640537] - Xiaoyun Jiang, Yibin Jiang, Dayu Sun, Lan Rong. Protective effect of magnesium lithospermate B against dextran sodiumsulfate induced ulcerative colitis in mice.
Environmental toxicology and pharmacology.
2013 Jul; 36(1):97-102. doi:
10.1016/j.etap.2013.03.010. [PMID: 23603461] - Wei Quan, Ying Yin, Miaomiao Xi, Dan Zhou, Yanrong Zhu, Yue Guan, Chao Guo, Yanhua Wang, Jialin Duan, Aidong Wen. Antioxidant properties of magnesium lithospermate B contribute to the cardioprotection against myocardial ischemia/reperfusion injury in vivo and in vitro.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2013 Feb; 33(1):85-91. doi:
10.1016/s0254-6272(13)60106-5. [PMID: 23596818] - Cheng-Chung Cheng, Shih-Ping Yang, Wei-Shiang Lin, Ling-Jun Ho, Jenn-Haung Lai, Shu-Meng Cheng, Wen-Yu Lin. Magnesium lithospermate B mediates anti-inflammation targeting activator protein-1 and nuclear factor-kappa B signaling pathways in human peripheral T lymphocytes.
International immunopharmacology.
2012 Jul; 13(3):354-61. doi:
10.1016/j.intimp.2012.04.011. [PMID: 22569344] - Chih-Zen Chang, Shu-Chuan Wu, Aij-Lie Kwan, Shi-Lin Hwang, Shen-Long Howng. Magnesium lithospermate B alleviates the production of endothelin-1 through an NO-dependent mechanism and reduces experimental vasospasm in rats.
Acta neurochirurgica.
2011 Nov; 153(11):2211-7. doi:
10.1007/s00701-011-1082-6. [PMID: 21833783] - Yong Han Paik, Young Joon Yoon, Hyun Chul Lee, Man Kil Jung, So Hee Kang, Sook In Chung, Ja Kyung Kim, Jae Yong Cho, Kwan Sik Lee, Kwang Hyub Han. Antifibrotic effects of magnesium lithospermate B on hepatic stellate cells and thioacetamide-induced cirrhotic rats.
Experimental & molecular medicine.
2011 Jun; 43(6):341-9. doi:
10.3858/emm.2011.43.6.037. [PMID: 21499011] - So Hun Kim, Soo Hyun Kim, Minah Choi, Yongho Lee, Young Ook Kim, Duck Sun Ahn, Young Ho Kim, Eun Seok Kang, Eun Jig Lee, Mankil Jung, Jin Won Cho, Darren R Williams, Hyun Chul Lee. Natural therapeutic magnesium lithospermate B potently protects the endothelium from hyperglycaemia-induced dysfunction.
Cardiovascular research.
2010 Sep; 87(4):713-22. doi:
10.1093/cvr/cvq089. [PMID: 20299332] - Li Chen, Li-Jiang Xuan, Yi-Ping Wang. Effects of magnesium lithospermate B and its analogues on Ca(2+) homeostasis in cultured rat thoracic aorta vascular smooth muscle cells.
Planta medica.
2009 Dec; 75(15):1573-9. doi:
10.1055/s-0029-1185905. [PMID: 19598080] - Xiaoyu Liu, Ruohua Chen, Yanjun Shang, Binghua Jiao, Caiguo Huang. Superoxide radicals scavenging and xanthine oxidase inhibitory activity of magnesium lithospermate B from Salvia miltiorrhiza.
Journal of enzyme inhibition and medicinal chemistry.
2009 Jun; 24(3):663-8. doi:
10.1080/14756360802323829. [PMID: 18686136] - Kyu Yeon Hur, Hye Jun Seo, Eun Seok Kang, Soo Hyun Kim, Seungjeong Song, Eun Hee Kim, Soyeon Lim, Chulhee Choi, Ji Hoe Heo, Ki Chul Hwang, Chul Woo Ahn, Bong Soo Cha, Mankil Jung, Hyun Chul Lee. Therapeutic effect of magnesium lithospermate B on neointimal formation after balloon-induced vascular injury.
European journal of pharmacology.
2008 May; 586(1-3):226-33. doi:
10.1016/j.ejphar.2008.02.072. [PMID: 18387604] - Xiao-yan Lü, Ming Li, Meng-wu Weng. [Inhibition effects of constituents of Radix Salviae Miltiorrhizae on proliferation and procollagen transcription of dermal fibroblasts in systemic sclerosis].
Zhonghua yi xue za zhi.
2007 Sep; 87(34):2426-8. doi:
". [PMID: 18036324] - Zheng-Fu Zhang, Hong-Shan Chen, Jian-Rui Li, Jian-Dong Jiang, Zhuo-Rong Li. [Studies on polyphenolic chemical constitutents from root of Salvia yunnansis].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2007 Sep; 32(18):1886-90. doi:
. [PMID: 18051897] - Jason Tc Tzen, Tzyy-Rong Jinn, Yi-Ching Chen, Feng-Yin Li, Fu-Chou Cheng, Li-Shian Shi, Hank Kh She, Balance Cm Chen, Vic Hsieh, Mu-Lin Tu. Magnesium lithospermate B possesses inhibitory activity on Na+,K+-ATPase and neuroprotective effects against ischemic stroke.
Acta pharmacologica Sinica.
2007 May; 28(5):609-15. doi:
10.1111/j.1745-7254.2007.00544.x. [PMID: 17439716] - Wei Wang, Guo-Yuan Hu, Yi-Ping Wang. Selective modulation of L-type calcium current by magnesium lithospermate B in guinea-pig ventricular myocytes.
Life sciences.
2006 May; 78(26):2989-97. doi:
10.1016/j.lfs.2005.11.024. [PMID: 16376948] - Chun-guang Chen, Yi-ping Wang. Magnesium lithospermate B ameliorates renal cortical microperfusion in rats.
Acta pharmacologica Sinica.
2006 Feb; 27(2):217-22. doi:
10.1111/j.1745-7254.2006.00225.x. [PMID: 16412272] - Xiaochuan Li, Chen Yu, Yongbao Cai, Gangyi Liu, Jingying Jia, Yiping Wang. Simultaneous determination of six phenolic constituents of danshen in human serum using liquid chromatography/tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Jun; 820(1):41-7. doi:
10.1016/j.jchromb.2005.03.005. [PMID: 15866491] - Xiaochuan Li, Chen Yu, Weikang Sun, Jie Lu, Lijiang Xuan, Yiping Wang. Liquid chromatography/tandem mass spectrometry for the determination of magnesium lithospermate B in beagle dog serum.
Journal of pharmaceutical and biomedical analysis.
2005 Jun; 38(1):107-11. doi:
10.1016/j.jpba.2004.11.054. [PMID: 15907627] - Xiao-chuan Li, Chen Yu, Wei-kang Sun, Gang-yi Liu, Jing-ying Jia, Yi-ping Wang. Pharmacokinetics of magnesium lithospermate B after intravenous administration in beagle dogs.
Acta pharmacologica Sinica.
2004 Nov; 25(11):1402-7. doi:
NULL. [PMID: 15525459] - Jin-Young Yoon, Sung-Hun Ahn, Hyuncheol Oh, Young-Sup Kim, Shi Yong Ryu, Won-Kyung Ho, Suk-Ho Lee. A novel Na+ channel agonist, dimethyl lithospermate B, slows Na+ current inactivation and increases action potential duration in isolated rat ventricular myocytes.
British journal of pharmacology.
2004 Nov; 143(6):765-73. doi:
10.1038/sj.bjp.0705969. [PMID: 15504759] - Zhi-xin Zhang, Fu-yun Gao, Ke-ming Li. [Effect of magnesium lithospermate B on endothelial cells in human aorta after free radical injury].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2004 Jun; 24(6):521-4. doi:
". [PMID: 15250206] - Ying Zhang, Teruaki Akao, Norio Nakamura, Chang-Ling Duan, Masao Hattori, Xiu-Wei Yang, Jian-Xun Liu. Extremely low bioavailability of magnesium lithospermate B, an active component from Salvia miltiorrhiza, in rat.
Planta medica.
2004 Feb; 70(2):138-42. doi:
10.1055/s-2004-815490. [PMID: 14994191] - Xiaochuan Li, Chen Yu, Weikang Sun, Gangyi Liu, Jingying Jia, Yiping Wang. Simultaneous determination of magnesium lithospermate B, rosmarinic acid, and lithospermic acid in beagle dog serum by liquid chromatography/tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2004; 18(23):2878-82. doi:
10.1002/rcm.1703. [PMID: 15517529] - Do You Soung, Sook Hee Rhee, Jung Sun Kim, Ji Young Lee, Hee-Sun Yang, Jae Sue Choi, Takako Yokozawa, Yong Nam Han, Hae Young Chung. Peroxynitrite scavenging activity of lithospermate B from Salvia miltiorrhiza.
The Journal of pharmacy and pharmacology.
2003 Oct; 55(10):1427-32. doi:
10.1211/0022357021891. [PMID: 14607026] - Geun Taek Lee, Hunjoo Ha, Mankil Jung, Hari Li, Soon Won Hong, Bong Soo Cha, Hyun Chul Lee, Young Dong Cho. Delayed treatment with lithospermate B attenuates experimental diabetic renal injury.
Journal of the American Society of Nephrology : JASN.
2003 Mar; 14(3):709-20. doi:
10.1097/01.asn.0000051660.82593.19. [PMID: 12595507] - Mankil Jung, Hyun Chul Lee, Chul Woo Ahn, Whuijung Park, Sunhee Choi, Hanjo Kim, Donghak Cho, Geun Taek Lee, Hai-Ri Li. Effective isolation of magnesium lithospermate B and its inhibition of aldose reductase and fibronectin on mesangial cell line.
Chemical & pharmaceutical bulletin.
2002 Aug; 50(8):1135-6. doi:
10.1248/cpb.50.1135. [PMID: 12192155] - W B Luo, Y P Wang. Magnesium lithospermate B inhibits hypoxia-induced calcium influx and nitric oxide release in endothelial cells.
Acta pharmacologica Sinica.
2001 Dec; 22(12):1135-42. doi:
". [PMID: 11749815] - X J Wu, Y P Wang, W Wang, W K Sun, Y M Xu, L J Xuan. Free radical scavenging and inhibition of lipid peroxidation by magnesium lithospermate B.
Acta pharmacologica Sinica.
2000 Sep; 21(9):855-8. doi:
NULL. [PMID: 11501171] - T Yokozawa, E Dong, Z W Liu, T Shibata, M Hasegawa, H Watanabe, H Oura. Magnesium lithospermate B ameliorates cephaloridine-induced renal injury.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
1997 Dec; 49(5):337-41. doi:
10.1016/s0940-2993(97)80100-5. [PMID: 9455678] - T Yokozawa, E Dong, H Oura, G Nonaka, I Nishioka. Magnesium lithospermate B ameliorates cisplatin-induced injury in cultured renal epithelial cells.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
1997 Dec; 49(5):343-6. doi:
10.1016/s0940-2993(97)80104-2. [PMID: 9455679] - Y Nomura, T Arima, T Namba, M Hattori, S Kadota. [Ameliorating effects of dan-shen and its major ingredient calcium/magnesium lithospermate B on cognitive deficiencies in senescence-accelerated mouse].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1997 Oct; 110 Suppl 1(?):142P-147P. doi:
10.1254/fpj.110.supplement_142. [PMID: 9503422] - K Hase, R Kasimu, P Basnet, S Kadota, T Namba. Preventive effect of lithospermate B from Salvia miltiorhiza on experimental hepatitis induced by carbon tetrachloride or D-galactosamine/lipopolysaccharide.
Planta medica.
1997 Feb; 63(1):22-6. doi:
10.1055/s-2006-957596. [PMID: 9063092] - T Yokozawa, E Dong, H Oura, H Kashiwagi, G Nonaka, I Nishioka. Magnesium lithospermate B suppresses the increase of active oxygen in rats after subtotal nephrectomy.
Nephron.
1997; 75(1):88-93. doi:
10.1159/000189505. [PMID: 9031276] - T Yokozawa, H Y Chung, E Dong, H Oura. Confirmation that magnesium lithospermate B has a hydroxyl radical-scavenging action.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
1995 Nov; 47(5):341-4. doi:
10.1016/s0940-2993(11)80344-1. [PMID: 8871065] - H Y Chung, J S Kim, H Y Chung, T Yokozawa, H Oura. The promoting action of magnesium lithospermate B on the kinin-prostaglandin E2 system in the kidney.
Pharmacology & toxicology.
1995 Apr; 76(4):240-4. doi:
10.1111/j.1600-0773.1995.tb00136.x. [PMID: 7617552] - T Yokozawa, J J Zhou, M Hattori, S Inaba, T Okada, H Oura, G Nonaka, I Nishioka. Effects of a Dan Shen component, magnesium lithospermate B, in nephrectomized rats.
Nihon Jinzo Gakkai shi.
1995 Feb; 37(2):105-11. doi:
. [PMID: 7752501] - T Shigematsu, S Tajima, T Nishikawa, S Murad, S R Pinnell, I Nishioka. Inhibition of collagen hydroxylation by lithospermic acid magnesium salt, a novel compound isolated from Salviae miltiorrhizae Radix.
Biochimica et biophysica acta.
1994 May; 1200(1):79-83. doi:
10.1016/0304-4165(94)90030-2. [PMID: 8186237] - P Liu, N Kawada, Y Mizoguchi, S Morisawa. [Effects of magnesium lithospermate B on cyclooxygenase activity in rat liver, adherent cells and enzyme's product].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
1994 Feb; 19(2):110-3, 128. doi:
". [PMID: 8011133] - K Kamata, M Noguchi, M Nagai. Hypotensive effects of lithospermic acid B isolated from the extract of Salviae miltiorrhizae Radix in the rat.
General pharmacology.
1994 Jan; 25(1):69-73. doi:
10.1016/0306-3623(94)90011-6. [PMID: 8026714] - K Kamata, T Iizuka, M Nagai, Y Kasuya. Endothelium-dependent vasodilator effects of the extract from Salviae Miltiorrhizae radix. A study on the identification of lithospermic acid B in the extracts.
General pharmacology.
1993 Jul; 24(4):977-81. doi:
10.1016/0306-3623(93)90176-x. [PMID: 8224751] - P Liu, Y Mizoguchi, S Morisawa. [Effects of magnesium lithospermate B on D-galactosamine induced rat liver injury].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
1993 Jun; 13(6):352-3, 326. doi:
. [PMID: 8257841] - T Yokozawa, H Oura, M Iwano, K Dohi, M Hattori. Inhibitory effects of crude drug components on the proliferation of cultured human mesangial cells.
Nihon Jinzo Gakkai shi.
1993 Apr; 35(4):321-7. doi:
". [PMID: 8341007] - T Yokozawa, T W Lee, H Oura, G Nonaka, I Nishioka, M Hattori. Effect of magnesium lithospermate B on the renal and urinary kallikrein activities in rats with adenine-induced renal failure.
Nihon Jinzo Gakkai shi.
1993 Apr; 35(4):337-42. doi:
NULL. [PMID: 8341009] - T Yokozawa, T W Lee, H Oura, G Nonaka, I Nishioka. Effect of magnesium lithospermate B in rats with sodium-induced hypertension and renal failure.
Nephron.
1992; 60(4):460-5. doi:
10.1159/000186809. [PMID: 1584322] - T Yokozawa, H Y Chung, T W Lee, H Oura, G Nonaka, I Nishioka. Potentiating effect of converting enzyme inhibitor captopril to the renal responses of magnesium lithospermate B in rats with adenine-induced renal failure.
Chemical & pharmaceutical bulletin.
1991 Mar; 39(3):732-6. doi:
10.1248/cpb.39.732. [PMID: 2070457] - T Yokozawa, H Oura, T W Lee, G Nonaka, I Nishioka. Augmentation of renal response by magnesium lithospermate B.
Nephron.
1991; 57(1):78-83. doi:
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The Journal of pharmacy and pharmacology.
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