Memorosone (BioDeep_00000395553)
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C33H42O4 (502.3083)
中文名称:
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 92.5%
分子结构信息
SMILES: CC(=CCC1CC2(C(=C(C(=O)C(C2=O)(C1(C)C)C(=O)C3=CC=CC=C3)CC=C(C)C)O)CC=C(C)C)C
InChI: InChI=1S/C33H42O4/c1-21(2)14-16-25-20-32(19-18-23(5)6)28(35)26(17-15-22(3)4)29(36)33(30(32)37,31(25,7)8)27(34)24-12-10-9-11-13-24/h9-15,18,25,35H,16-17,19-20H2,1-8H3/t25-,32+,33-/m0/s1
描述信息
Nemorosone is a natural product found in Clusia rosea, Clusia nemorosa, and other organisms with data available.
同义名列表
10 个代谢物同义名
InChI=1/C33H42O4/c1-21(2)14-16-25-20-32(19-18-23(5)6)28(35)26(17-15-22(3)4)29(36)33(30(32)37,31(25,7)8)27(34)24-12-10-9-11-13-24/h9-15,18,25,35H,16-17,19-20H2,1-8H3/t25-,32+,33-/m0/s; (1R,5S,7S)-rel-5-benzoyl-4-hydroxy-6,6-dimethyl-1,3,7-tris(3-methyl-2-buten-1-yl)-bicyclo[3.3.1]non-3-ene-2,9-dione; rel-(1R,5R,7S)-1-benzoyl-4-hydroxy-8,8-dimethyl-3,5,7-tris(3-methylbut-2-en-1-yl)bicyclo[3.3.1]non-3-ene-2,9-dione; bicyclo[3.3.1]non-3-ene-2,9-dione, 1-benzoyl-4-hydroxy-8,8-dimethyl-3,5,7-tris(3-methyl-2-butenyl)-, (1R,5R,7S)-; (1R,5R,7S)-1-benzoyl-4-hydroxy-8,8-dimethyl-3,5,7-tris(3-methylbut-2-enyl)bicyclo[3.3.1]non-3-ene-2,9-dione; 1-Benzoyl-4-hydroxy-8,8-dimethyl-3,5,7-tris-(3-methyl-but-2-enyl)-bicyclo[3.3.1]non-3-ene-2,9-dione; 1-Benzoyl-3,5,7-tri-(3-methyl-2-butenyl)-4-hydroxy-8-dimethyl-bicyclo[3.3.1]-3-nonene-2,9-dione; 7-epi-nemorosone; Memorosone; Nemorosone
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Clarice Noleto-Dias, Mohamed A Farag, Andrea Porzel, Josean F Tavares, Ludger A Wessjohann. A multiplex approach of MS, 1D-, and 2D-NMR metabolomics in plant ontogeny: A case study on Clusia minor L. organs (leaf, flower, fruit, and seed).
Phytochemical analysis : PCA.
2024 Apr; 35(3):445-468. doi:
10.1002/pca.3300. [PMID: 38069552] - Yeelin Phang, Xueying Wang, Yue Lu, Wenwei Fu, Changwu Zheng, Hongxi Xu. Bicyclic polyprenylated acylphloroglucinols and their derivatives: structural modification, structure-activity relationship, biological activity and mechanism of action.
European journal of medicinal chemistry.
2020 Nov; 205(?):112646. doi:
10.1016/j.ejmech.2020.112646. [PMID: 32791400] - A P Anu Aravind, K R T Asha, K B Rameshkumar. Phytochemical analysis and antioxidant potential of the leaves of Garcinia travancorica Bedd.
Natural product research.
2016; 30(2):232-6. doi:
10.1080/14786419.2015.1043551. [PMID: 25982126] - Gilberto L Pardo Andreu, Felippe H Z Reis, Felipe M Dalalio, Yanier Nuñez Figueredo, Osmany Cuesta Rubio, Sergio A Uyemura, Carlos Curti, Luciane C Alberici. The cytotoxic effects of brown Cuban propolis depend on the nemorosone content and may be mediated by mitochondrial uncoupling.
Chemico-biological interactions.
2015 Feb; 228(?):28-34. doi:
10.1016/j.cbi.2015.01.010. [PMID: 25617483] - M S Camargo, M T Oliveira, M M Santoni, F A Resende, A P Oliveira-Höhne, L G Espanha, C H Nogueira, O Cuesta-Rubio, W Vilegas, E A Varanda. Effects of nemorosone, isolated from the plant Clusia rosea, on the cell cycle and gene expression in MCF-7 BUS breast cancer cell lines.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2015 Jan; 22(1):153-7. doi:
10.1016/j.phymed.2014.11.007. [PMID: 25636884] - Mariana S Camargo, Aline M Prieto, Flavia A Resende, Paula K Boldrin, Cassia R P Cardoso, Mariana F Fernández, José Manuel Molina-Molina, Nicolás Olea, Wagner Vilegas, Osmany Cuesta-Rubio, Eliana A Varanda. Evaluation of estrogenic, antiestrogenic and genotoxic activity of nemorosone, the major compound found in brown Cuban propolis.
BMC complementary and alternative medicine.
2013 Jul; 13(?):201. doi:
10.1186/1472-6882-13-201. [PMID: 23902919] - Robert J Wolf, Ralf A Hilger, Jörg D Hoheisel, Jens Werner, Frank Holtrup. In vivo activity and pharmacokinetics of nemorosone on pancreatic cancer xenografts.
PloS one.
2013; 8(9):e74555. doi:
10.1371/journal.pone.0074555. [PMID: 24040280] - David Díaz-Carballo, Sebastian Gustmann, Ali Haydar Acikelli, Walter Bardenheuer, Helmut Buehler, Holger Jastrow, Suleyman Ergun, Dirk Strumberg. 7-epi-nemorosone from Clusia rosea induces apoptosis, androgen receptor down-regulation and dysregulation of PSA levels in LNCaP prostate carcinoma cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2012 Nov; 19(14):1298-306. doi:
10.1016/j.phymed.2012.08.004. [PMID: 22981203] - Ada Popolo, Anna Lisa Piccinelli, Silvana Morello, Rosalinda Sorrentino, Cuesta Rubio Osmany, Luca Rastrelli, Aldo Pinto, Pinto Aldo. Cytotoxic activity of nemorosone in human MCF-7 breast cancer cells.
Canadian journal of physiology and pharmacology.
2011 Jan; 89(1):50-7. doi:
10.1139/y10-100. [PMID: 21186377] - David Díaz-Carballo, Sascha Malak, Walter Bardenheuer, Michael Freistuehler, H Peter Reusch. The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
Bioorganic & medicinal chemistry.
2008 Nov; 16(22):9635-43. doi:
10.1016/j.bmc.2008.10.019. [PMID: 18951805] - Volker Bittrich, Maria do Carmo E Amaral, Samísia M F Machado, Anita J Marsaioli. Floral resin of Tovomitopsis saldanhae (Guttiferae) and 7-epi-nemorosone: structural revision.
Zeitschrift fur Naturforschung. C, Journal of biosciences.
2003 Sep; 58(9-10):643-8. doi:
10.1515/znc-2003-9-1008. [PMID: 14577624]
