Evernic_acid (BioDeep_00000395548)

 

Secondary id: BioDeep_00000272696

PANOMIX_OTCML-2023 Antitumor activity


代谢物信息卡片


Benzoic acid, 2-hydroxy-4-[(2-hydroxy-4-methoxy-6-methylbenzoyl)oxy]-6-methyl-

化学式: C17H16O7 (332.0896)
中文名称: 扁枝衣二酸
谱图信息: 最多检出来源 Viridiplantae(plant) 80%

分子结构信息

SMILES: CC1=CC(=CC(=C1C(=O)OC2=CC(=C(C(=C2)C)C(=O)O)O)O)OC
InChI: InChI=1S/C17H16O7/c1-8-5-11(7-12(18)14(8)16(20)21)24-17(22)15-9(2)4-10(23-3)6-13(15)19/h4-7,18-19H,1-3H3,(H,20,21)

描述信息

2-hydroxy-4-[(2-hydroxy-4-methoxy-6-methylphenyl)-oxomethoxy]-6-methylbenzoic acid is a carbonyl compound.
Evernic acid is a natural product found in Ochrolechia parella, Usnea rubicunda, and other organisms with data available.
Evernic Acid is a secondary metabolite generated by lichens, including Ramalina, Evernia, and Hypogymnia, and several studies have described its anticancer, antifungal, and antimicrobial effects. Neuroprotective and anti-inflammatory effects[1].
Evernic Acid is a secondary metabolite generated by lichens, including Ramalina, Evernia, and Hypogymnia, and several studies have described its anticancer, antifungal, and antimicrobial effects. Neuroprotective and anti-inflammatory effects[1].

同义名列表

23 个代谢物同义名

Benzoic acid, 2-hydroxy-4-[(2-hydroxy-4-methoxy-6-methylbenzoyl)oxy]-6-methyl-; Benzoic acid, 2-hydroxy-4-((2-hydroxy-4-methoxy-6-methylbenzoyl)oxy)-6-methyl-; 2,6-CRESOTIC ACID, 4-METHOXY-, 4-ESTER WITH 6-METHYL-.BETA.-RESORCYLIC ACID; 2-hydroxy-4-(2-hydroxy-4-methoxy-6-methyl-benzoyl)oxy-6-methyl-benzoic acid; 2-hydroxy-4-(2-hydroxy-4-methoxy-6-methylbenzoyl)oxy-6-methylbenzoic acid; 2,6-Cresotic acid, 4-methoxy-, 4-ester with 6-methyl-beta-resorcylic acid; 2,6-Cresotic acid, 4-methoxy-, 4-ester with 6-methyl-.beta.-resorcylate; 2,6-CRESOTIC ACID, 4-METHOXY-, 4-ESTER with 6-METHYL-beta-RESORCYLATE; 4-((4-Methoxy-6-methylsalicyloyl)oxy)-6-methylsalicylic acid; 2, 4-methoxy-, 4-ester with 6-methyl-.beta.-resorcylate; 3-10-00-01488 (Beilstein Handbook Reference); evernic acid, monopotassium salt; WLN: QR CQ E1 DVOVR BQ F1 DO1; Evernic acid, pruiss; UNII-2EQ5W5403J; Oprea1_749224; DivK1c_006742; Evernic Acid; KBio1_001686; EVERNICACID; Evernsaure; 2EQ5W5403J; Evernic acid



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Mohsen Vaez, Seyed Javad Davarpanah. New Insights into the Biological Activity of Lichens: Bioavailable Secondary Metabolites of Umbilicaria decussata as Potential Anticoagulants. Chemistry & biodiversity. 2021 May; 18(5):e2100080. doi: 10.1002/cbdv.202100080. [PMID: 33773025]
  • Richard Staples, Robert L LaDuca, Ludmila V Roze, Maris Laivenieks, John E Linz, Randolph Beaudry, Alan Fryday, Anthony L Schilmiller, Anna V Koptina, Benjamin Smith, Frances Trail. Structure and Chemical Analysis of Major Specialized Metabolites Produced by the Lichen Evernia prunastri. Chemistry & biodiversity. 2020 Jan; 17(1):e1900465. doi: 10.1002/cbdv.201900465. [PMID: 31701649]
  • Hanxue Wang, Tao Yang, Xuemei Cheng, Sukfan Kwong, Chenghai Liu, Rui An, Guowen Li, Xinhong Wang, Changhong Wang. Simultaneous determination of usnic, diffractaic, evernic and barbatic acids in rat plasma by ultra-high-performance liquid chromatography-quadrupole exactive Orbitrap mass spectrometry and its application to pharmacokinetic studies. Biomedical chromatography : BMC. 2018 Mar; 32(3):. doi: 10.1002/bmc.4123. [PMID: 29055065]
  • Mengchen Yin, Ni Chen, Quan Huang, Anastasia Sulindro Marla, Junming Ma, Jie Ye, Wen Mo. New and Accurate Predictive Model for the Efficacy of Extracorporeal Shock Wave Therapy in Managing Patients With Chronic Plantar Fasciitis. Archives of physical medicine and rehabilitation. 2017 12; 98(12):2371-2377. doi: 10.1016/j.apmr.2017.05.016. [PMID: 28634056]
  • Carlos Fernández-Moriano, Pradeep Kumar Divakar, Ana Crespo, M Pilar Gómez-Serranillos. Protective effects of lichen metabolites evernic and usnic acids against redox impairment-mediated cytotoxicity in central nervous system-like cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2017 Jul; 105(?):262-277. doi: 10.1016/j.fct.2017.04.030. [PMID: 28450128]
  • Barış Gökalsın, Nüzhet Cenk Sesal. Lichen secondary metabolite evernic acid as potential quorum sensing inhibitor against Pseudomonas aeruginosa. World journal of microbiology & biotechnology. 2016 Sep; 32(9):150. doi: 10.1007/s11274-016-2105-5. [PMID: 27465850]
  • Changlei Sun, Feng Liu, Jie Sun, Jia Li, Xiao Wang. Optimisation and establishment of separation conditions of organic acids from Usnea longissima Ach. by pH-zone-refining counter-current chromatography: Discussion of the eluotropic sequence. Journal of chromatography. A. 2016 Jan; 1427(?):96-101. doi: 10.1016/j.chroma.2015.12.016. [PMID: 26686561]
  • Branislav R Ranković, Marijana M Kosanić, Tatjana P Stanojković. Antioxidant, antimicrobial and anticancer activity of the lichens Cladonia furcata, Lecanora atra and Lecanora muralis. BMC complementary and alternative medicine. 2011 Oct; 11(?):97. doi: 10.1186/1472-6882-11-97. [PMID: 22013953]
  • Tatjana Mitrović, Slaviša Stamenković, Vladimir Cvetković, Svetlana Tošić, Milan Stanković, Ivana Radojević, Olgica Stefanović, Ljiljana Comić, Dragana Dačić, Milena Curčić, Snežana Marković. Antioxidant, antimicrobial and antiproliferative activities of five lichen species. International journal of molecular sciences. 2011; 12(8):5428-48. doi: 10.3390/ijms12085428. [PMID: 21954369]
  • Bruno Burlando, Elia Ranzato, Andrea Volante, Giovanni Appendino, Federica Pollastro, Luisella Verotta. Antiproliferative effects on tumour cells and promotion of keratinocyte wound healing by different lichen compounds. Planta medica. 2009 May; 75(6):607-13. doi: 10.1055/s-0029-1185329. [PMID: 19199230]
  • B Fontaniella, J L Mateos, C Vicente, M E Legaz. Improvement of the analysis of dansylated derivatives of polyamines and their conjugates by high-performance liquid chromatography. Journal of chromatography. A. 2001 Jun; 919(2):283-8. doi: 10.1016/s0021-9673(01)00841-x. [PMID: 11442033]
  • P Labrude, B Teisseire, C Vigneron. Attempts to use carbodiimide (EDCI) to cross-link hemoglobin for transfusions. Experientia. 1979 May; 35(5):682-3. doi: 10.1007/bf01960397. [PMID: 36294]
  • P B Soeters, J E Fischer. Insulin, glucagon, aminoacid imbalance, and hepatic encephalopathy. Lancet (London, England). 1976 Oct; 2(7991):880-2. doi: 10.1016/s0140-6736(76)90541-9. [PMID: 62115]