Chelerythrine (BioDeep_00000395539)
Main id: BioDeep_00000230885
PANOMIX_OTCML-2023
代谢物信息卡片
1,2-Dimethoxy-12-methyl-[1,3]dioxolo[4,5:4,5]-benzo[1,2-c]phenanthridin-12-ium chloride
化学式: C21H18ClNO4 (383.09242980000005)
中文名称: 白菜屈红碱氯化物, 白屈菜赤碱氯化物, 氯化白屈菜红碱, 盐酸白屈菜红碱
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C[N+]1=C2C(=C3C=CC(=C(C3=C1)OC)OC)C=CC4=CC5=C(C=C42)OCO5.[Cl-]
InChI: /p-1
描述信息
Chelerythrine chloride is a potent, cell-permeable inhibitor of protein kinase C, with an IC50 of 660 nM. Chelerythrine chloride inhibits the Bcl-XL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine chloride induces apoptosis and autophagy.
Chelerythrine chloride is a potent, cell-permeable inhibitor of protein kinase C, with an IC50 of 660 nM. Chelerythrine chloride inhibits the Bcl-XL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine chloride induces apoptosis and autophagy.
同义名列表
28 个代谢物同义名
1,2-Dimethoxy-12-methyl-[1,3]dioxolo[4,5:4,5]-benzo[1,2-c]phenanthridin-12-ium chloride; 1,2-DIMETHOXY-12-METHYL-(1,3)DIOXOLO(4,5:4,5)BENZO(1,2-C)PHENANTHRIDIN-12-IUM CHLORIDE; 1,2-Dimethoxy-12-methyl-[1,3]dioxolo[4,5:4,5]benzo[1,2-c]phenanthridin-12-ium chloride; 1,2-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium;chloride; (1,3)Benzodioxolo(5,6-c)phenanthridinium, 1,2-dimethoxy-12-methyl-, chloride; 1,2-Dimethoxy-12-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium chloride; 1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium chloride; 1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridiniumchloride; [1,6-c]phenanthridinium, 1,2-dimethoxy-12-methyl-, chloride; Chelerythrine, hydroxide, hydrochloride; Chelerythrine, hydrochloride; Chelerythrine hydrochloride; BROUSSONPAPYRINE CHLORIDE; CHELERYTHRINIUM CHLORIDE; Chelerythrine (chloride); Chelerythrine, chloride; chelerythrine hydroxide; Chelerythrine chloride; Chelerythrine cloride; Chelerythrinechloride; chelerythrine sulfate; Toddalin chloride; Chelerythrine HCl; norchelerythrine; UNII-7IC98TZ0PZ; Chelerythrine; Tox21_500241; 7IC98TZ0PZ
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 72311
- MeSH: chelerythrine
- ChemIDplus: 0003895929
- CAS: 3895-92-9
- medchemexpress: HY-12048
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jia Zhou, Yuchen Wang, Yangxin Fu, Zhe Lin, He Lin, Guangfu Lv, Ning Kong, Guo Xin, Fang Zhou, Zhidong Qiu, Xiaowei Huang. Chelerythrine induces apoptosis and ferroptosis through Nrf2 in ovarian cancer cells.
Cellular and molecular biology (Noisy-le-Grand, France).
2024 Mar; 70(3):174-181. doi:
10.14715/cmb/2024.70.3.26. [PMID: 38650145] - Jinjin Cao, Yanhui Zheng, Ting Liu, Jiamiao Liu, Jinze Liu, Jing Wang, Qirui Sun, Wenhong Li, Yongju Wei. Fluorescence, Absorption, Chromatography and Structural Transformation of Chelerythrine and Ethoxychelerythrine in Protic Solvents: A Comparative Study.
Molecules (Basel, Switzerland).
2022 Jul; 27(15):. doi:
10.3390/molecules27154693. [PMID: 35897862] - Hong Li, Mei He, Pengyu Zhao, Ping Liu, Wei Chen, Xuewen Xu. Chelerythrine Chloride Inhibits Stemness of Melanoma Cancer Stem-Like Cells (CSCs) Potentially via Inducing Reactive Oxygen Species and Causing Mitochondria Dysfunction.
Computational and mathematical methods in medicine.
2022; 2022(?):4000733. doi:
10.1155/2022/4000733. [PMID: 35761835] - Mehdi Valipour, Afshin Zarghi, Mohammad Ali Ebrahimzadeh, Hamid Irannejad. Therapeutic potential of chelerythrine as a multi-purpose adjuvant for the treatment of COVID-19.
Cell cycle (Georgetown, Tex.).
2021 11; 20(22):2321-2336. doi:
10.1080/15384101.2021.1982509. [PMID: 34585628] - Na-Jiao Zhao, Li-Li Wang, Zhao-Ying Liu, Qin Wang, Lei Liu, Zhi-Liang Sun, Yong Wu. Pharmacokinetics of chelerythrine and its metabolite after oral and intramuscular administrations in pigs.
Xenobiotica; the fate of foreign compounds in biological systems.
2021 Nov; 51(11):1264-1270. doi:
10.1080/00498254.2021.1882714. [PMID: 33538636] - Ling Peng, Li Wen, Qingfeng Shi, Feng Gao, Bin Huang, Changming Wang. Chelerythrine Ameliorates Pulmonary Fibrosis via Activating the Nrf2/ARE Signaling Pathway.
Cell biochemistry and biophysics.
2021 Jun; 79(2):337-347. doi:
10.1007/s12013-021-00967-0. [PMID: 33580396] - Siu Wah Wong-Deyrup, Xun Song, Tsz-Wai Ng, Xiu-Bin Liu, Jian-Guo Zeng, Zhi-Xing Qing, Stephen T Deyrup, Zhen-Dan He, Hong-Jie Zhang. Plant-derived isoquinoline alkaloids that target ergosterol biosynthesis discovered by using a novel antifungal screening tool.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 May; 137(?):111348. doi:
10.1016/j.biopha.2021.111348. [PMID: 33578237] - Daniela Marasco, Caterina Vicidomini, Pawel Krupa, Federica Cioffi, Pham Dinh Quoc Huy, Mai Suan Li, Daniele Florio, Kerensa Broersen, Maria Francesca De Pandis, Giovanni N Roviello. Plant isoquinoline alkaloids as potential neurodrugs: A comparative study of the effects of benzo[c]phenanthridine and berberine-based compounds on β-amyloid aggregation.
Chemico-biological interactions.
2021 Jan; 334(?):109300. doi:
10.1016/j.cbi.2020.109300. [PMID: 33098838] - Peng Huang, Liqiong Xia, Li Zhou, Wei Liu, Peng Wang, Zhixing Qing, Jianguo Zeng. Influence of different elicitors on BIA production in Macleaya cordata.
Scientific reports.
2021 01; 11(1):619. doi:
10.1038/s41598-020-79802-0. [PMID: 33436669] - Danielle Annette Orozco-Nunnelly, Jeffery Pruet, Clara Patricia Rios-Ibarra, Estefany Lucia Bocangel Gamarra, Theodore Lefeber, Teodora Najdeska. Characterizing the cytotoxic effects and several antimicrobial phytocompounds of Argemone mexicana.
PloS one.
2021; 16(4):e0249704. doi:
10.1371/journal.pone.0249704. [PMID: 33826680] - Mehrdad Ghashghaeinia, Peter Dreischer, Thomas Wieder, Martin Köberle. Coronavirus disease 2019 (COVID-19), human erythrocytes and the PKC-alpha/-beta inhibitor chelerythrine -possible therapeutic implication.
Cell cycle (Georgetown, Tex.).
2020 12; 19(24):3399-3405. doi:
10.1080/15384101.2020.1859197. [PMID: 33305655] - Qiyan Lin, Chao Ma, Huida Guan, Liangni Chen, Qi Xie, Xuemei Cheng, Changhong Wang. Metabolites identification and reversible interconversion of chelerythrine and dihydrochelerythrine in vitro/in vivo in rats using ultra-performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2020 Sep; 189(?):113462. doi:
10.1016/j.jpba.2020.113462. [PMID: 32659571] - Win Sen Heng, Shiau-Chuen Cheah. Chelerythrine Chloride Downregulates β-Catenin and Inhibits Stem Cell Properties of Non-Small Cell Lung Carcinoma.
Molecules (Basel, Switzerland).
2020 Jan; 25(1):. doi:
10.3390/molecules25010224. [PMID: 31935827] - Hongchao He, Ran Zhuo, Jun Dai, Xiaojing Wang, Xin Huang, Haofei Wang, Danfeng Xu. Chelerythrine induces apoptosis via ROS-mediated endoplasmic reticulum stress and STAT3 pathways in human renal cell carcinoma.
Journal of cellular and molecular medicine.
2020 01; 24(1):50-60. doi:
10.1111/jcmm.14295. [PMID: 31568643] - Yizhong Shen, Chunlei Zhu, Yaping Wang, Jingjing Xu, Ruyu Xue, Fuyun Ji, Yiwei Wu, Zeyu Wu, Wencheng Zhang, Zhi Zheng, Yingwang Ye. Evaluation the binding of chelerythrine, a potentially harmful toxin, with bovine serum albumin.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2020 Jan; 135(?):110933. doi:
10.1016/j.fct.2019.110933. [PMID: 31682930] - Lan Gao, Hans-Joachim Schmitz, Karl-Heinz Merz, Dieter Schrenk. Characterization of the cytotoxicity of selected Chelidonium alkaloids in rat hepatocytes.
Toxicology letters.
2019 Sep; 311(?):91-97. doi:
10.1016/j.toxlet.2019.04.031. [PMID: 31054355] - Zhong-Min Zhao, Xiao-Fei Shang, Raymond Kobla Lawoe, Ying-Qian Liu, Rui Zhou, Yu Sun, Yin-Fang Yan, Jun-Cai Li, Guan-Zhou Yang, Cheng-Jie Yang. Anti-phytopathogenic activity and the possible mechanisms of action of isoquinoline alkaloid sanguinarine.
Pesticide biochemistry and physiology.
2019 Sep; 159(?):51-58. doi:
10.1016/j.pestbp.2019.05.015. [PMID: 31400784] - Cuiting Wu, Xin Wang, Ming Xu, Youping Liu, Xin Di. Intracellular Accumulation as an Indicator of Cytotoxicity to Screen Hepatotoxic Components of Chelidonium majus L. by LC-MS/MS.
Molecules (Basel, Switzerland).
2019 Jun; 24(13):. doi:
10.3390/molecules24132410. [PMID: 31261913] - Nan-Xi Hu, Mei Chen, Yi-Song Liu, Qi Shi, Bo Yang, Huan-Cheng Zhang, Pi Cheng, Qi Tang, Zhao-Ying Liu, Jian-Guo Zeng. Pharmacokinetics of sanguinarine, chelerythrine, and their metabolites in broiler chickens following oral and intravenous administration.
Journal of veterinary pharmacology and therapeutics.
2019 Mar; 42(2):197-206. doi:
10.1111/jvp.12729. [PMID: 30350369] - Bo Shi, Shixing Li, Hao Ju, Xin Liu, Dan Li, Ying Li. Protein kinase C inhibitor chelerythrine attenuates partial unilateral ureteral obstruction induced kidney injury in neonatal rats.
Life sciences.
2019 Jan; 216(?):85-91. doi:
10.1016/j.lfs.2018.11.025. [PMID: 30439378] - Basma G Eid, Alaa T Abu-Sharib, Hany M El-Bassossy, Khadijah Balamash, Sergey V Smirnov. Enhanced calcium entry via activation of NOX/PKC underlies increased vasoconstriction induced by methylglyoxal.
Biochemical and biophysical research communications.
2018 12; 506(4):1013-1018. doi:
10.1016/j.bbrc.2018.10.171. [PMID: 30404736] - Nan He, Peiqing Wang, Pengyu Wang, Changyang Ma, Wenyi Kang. Antibacterial mechanism of chelerythrine isolated from root of Toddalia asiatica (Linn) Lam.
BMC complementary and alternative medicine.
2018 Sep; 18(1):261. doi:
10.1186/s12906-018-2317-3. [PMID: 30257662] - Shogo Shimizu, Takahiro Shimizu, Kumiko Nakamura, Youichirou Higashi, Motoaki Saito. Angiotensin II, a stress-related neuropeptide in the CNS, facilitates micturition reflex in rats.
British journal of pharmacology.
2018 09; 175(18):3727-3737. doi:
10.1111/bph.14439. [PMID: 29981238] - Emine Kacar, Zubeyde Ercan, Ihsan Serhatlioglu, Aysegul Sumer, Haluk Kelestimur, Selim Kutlu. The effects of apelin on myometrium contractions in pregnant rats.
Cellular and molecular biology (Noisy-le-Grand, France).
2018 Aug; 64(11):74-79. doi:
10.14715/cmb/2018.64.11.13. [PMID: 30213292] - W Wang, L C Dolan, S von Alvensleben, M Morlacchini, G Fusconi. Safety of standardized Macleaya cordata extract in an eighty-four-day dietary study in dairy cows.
Journal of animal physiology and animal nutrition.
2018 Feb; 102(1):e61-e68. doi:
10.1111/jpn.12702. [PMID: 28247552] - Yuanzhang Zhu, Yingyi Pan, Guibiao Zhang, Yingchun Wu, Weicai Zhong, Chunxiao Chu, Yun Qian, Guofu Zhu. Chelerythrine Inhibits Human Hepatocellular Carcinoma Metastasis in Vitro.
Biological & pharmaceutical bulletin.
2018 Jan; 41(1):36-46. doi:
10.1248/bpb.b17-00451. [PMID: 29093327] - Igor V Almeida, Liliane M Fernandes, Bruna I Biazi, Veronica E P Vicentini. Evaluation of the Anticancer Activities of the Plant Alkaloids Sanguinarine and Chelerythrine in Human Breast Adenocarcinoma Cells.
Anti-cancer agents in medicinal chemistry.
2017 Nov; 17(11):1586-1592. doi:
10.2174/1871520617666170213115132. [PMID: 28270066] - Mahboobeh Yeganeh-Hajahmadi, Hamid Najafipour, Farzaneh Rostamzadeh. The differential effects of low and high doses of apelin through opioid receptors on the blood pressure of rats with renovascular hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension.
2017 Aug; 40(8):732-737. doi:
10.1038/hr.2017.28. [PMID: 28275232] - Xiubin Liu, Yisong Liu, Peng Huang, Yongshuo Ma, Zhixing Qing, Qi Tang, Huifen Cao, Pi Cheng, Yajie Zheng, Zejun Yuan, Yuan Zhou, Jinfeng Liu, Zhaoshan Tang, Yixiu Zhuo, Yancong Zhang, Linlan Yu, Jialu Huang, Peng Yang, Qiong Peng, Jinbo Zhang, Wenkai Jiang, Zhonghua Zhang, Kui Lin, Dae-Kyun Ro, Xiaoya Chen, Xingyao Xiong, Yi Shang, Sanwen Huang, Jianguo Zeng. The Genome of Medicinal Plant Macleaya cordata Provides New Insights into Benzylisoquinoline Alkaloids Metabolism.
Molecular plant.
2017 07; 10(7):975-989. doi:
10.1016/j.molp.2017.05.007. [PMID: 28552780] - Amrita Banerjee, Sulagna Sanyal, Shreyasi Dutta, Payal Chakraborty, Prajna Paramita Das, Kuladip Jana, Madavan Vasudevan, Chandrima Das, Dipak Dasgupta. The plant alkaloid chelerythrine binds to chromatin, alters H3K9Ac and modulates global gene expression.
Journal of biomolecular structure & dynamics.
2017 May; 35(7):1491-1499. doi:
10.1080/07391102.2016.1188154. [PMID: 27494525] - Jagannath Jana, Soma Mondal, Payel Bhattacharjee, Pallabi Sengupta, Tanaya Roychowdhury, Pranay Saha, Pallob Kundu, Subhrangsu Chatterjee. Chelerythrine down regulates expression of VEGFA, BCL2 and KRAS by arresting G-Quadruplex structures at their promoter regions.
Scientific reports.
2017 01; 7(?):40706. doi:
10.1038/srep40706. [PMID: 28102286] - Bo Hu, Guangtao Xu, Yongxia Zheng, Fei Tong, Ping Qian, Xiaoyan Pan, Xinmei Zhou, Ruilin Shen. Chelerythrine Attenuates Renal Ischemia/Reperfusion-induced Myocardial Injury by Activating CSE/H2S via PKC/NF-κB Pathway in Diabetic Rats.
Kidney & blood pressure research.
2017; 42(2):379-388. doi:
10.1159/000477948. [PMID: 28624831] - Fei Yang, Wen Xiao, Xiaohua Ma, Ruixue Huang, Ran Yu, Guiyin Li, Xiao Huang, Cuimei Chen, Ping Ding. Optimization of a novel chelerythrine-loaded magnetic Fe3 O4 /chitosan alpha-ketoglutaric acid system and evaluation of its anti-tumour activities.
The Journal of pharmacy and pharmacology.
2016 Aug; 68(8):1030-40. doi:
10.1111/jphp.12564. [PMID: 27293067] - Elsayed Mickdam, Ratchaneewan Khiaosa-Ard, Barbara U Metzler-Zebeli, Fenja Klevenhusen, Remigius Chizzola, Qendrim Zebeli. Rumen microbial abundance and fermentation profile during severe subacute ruminal acidosis and its modulation by plant derived alkaloids in vitro.
Anaerobe.
2016 Jun; 39(?):4-13. doi:
10.1016/j.anaerobe.2016.02.002. [PMID: 26868619] - Tetsuya Nakamura, Jun Kamishikiryo, Tetsuo Morita. Prazosin-stimulated release of hepatic triacylglyceride lipase from primary cultured rat hepatocytes is involved in the regulation of cAMP-dependent protein kinase through activation of the Ca(2+)/calmodulin-dependent protein kinase-II.
Pharmacological reports : PR.
2016 Jun; 68(3):649-53. doi:
10.1016/j.pharep.2016.02.001. [PMID: 27031052] - Li-Fei Zhu, Zhe Hou, Kun Zhou, Zong-Bo Tong, Qian Kuang, Hui-Ling Geng, Le Zhou. Synthesis, bioactivity and structure-activity relationships of new 2-aryl-8-OR-3,4-dihydroisoquinolin-2-iums salts as potential antifungal agents.
Bioorganic & medicinal chemistry letters.
2016 05; 26(10):2413-2417. doi:
10.1016/j.bmcl.2016.04.001. [PMID: 27072907] - Sutanwi Bhuiya, Ankur Bikash Pradhan, Lucy Haque, Suman Das. Molecular Aspects of the Interaction of Iminium and Alkanolamine Forms of the Anticancer Alkaloid Chelerythrine with Plasma Protein Bovine Serum Albumin.
The journal of physical chemistry. B.
2016 Jan; 120(1):5-17. doi:
10.1021/acs.jpcb.5b07818. [PMID: 26653994] - Mauro C Wesseling, Lisa Wagner-Britz, Duc Bach Nguyen, Salome Asanidze, Judy Mutua, Nagla Mohamed, Benjamin Hanf, Mehrdad Ghashghaeinia, Lars Kaestner, Ingolf Bernhardt. Novel Insights in the Regulation of Phosphatidylserine Exposure in Human Red Blood Cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2016; 39(5):1941-1954. doi:
10.1159/000447891. [PMID: 27771709] - Rica Capistrano I, An Wouters, Filip Lardon, Claudia Gravekamp, Sandra Apers, Luc Pieters. In vitro and in vivo investigations on the antitumour activity of Chelidonium majus.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2015 Dec; 22(14):1279-87. doi:
10.1016/j.phymed.2015.10.013. [PMID: 26626193] - Jette Skov Alstrøm, Daniel Bloch Hansen, Morten Schak Nielsen, Nanna MacAulay. Isoform-specific phosphorylation-dependent regulation of connexin hemichannels.
Journal of neurophysiology.
2015 Nov; 114(5):3014-22. doi:
10.1152/jn.00575.2015. [PMID: 26400258] - Johanna Abrigo, María Gabriela Morales, Felipe Simon, Daniel Cabrera, Gabriella Di Capua, Claudio Cabello-Verrugio. Apocynin inhibits the upregulation of TGF-β1 expression and ROS production induced by TGF-β in skeletal muscle cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2015 Sep; 22(10):885-93. doi:
10.1016/j.phymed.2015.06.011. [PMID: 26321737] - Yue Sun, Yuanyuan Li, Jiajian Zeng, Qixian Lu, Paul C H Li. Microchip electrophoretic separation and fluorescence detection of chelerythrine and sanguinarine in medicinal plants.
Talanta.
2015 Sep; 142(?):90-6. doi:
10.1016/j.talanta.2015.04.008. [PMID: 26003696] - Mercè Garcia-Belinchón, María Sánchez-Osuna, Laura Martínez-Escardó, Carla Granados-Colomina, Sònia Pascual-Guiral, Victoria Iglesias-Guimarais, Elisenda Casanelles, Judit Ribas, Victor J Yuste. An Early and Robust Activation of Caspases Heads Cells for a Regulated Form of Necrotic-like Cell Death.
The Journal of biological chemistry.
2015 Aug; 290(34):20841-20855. doi:
10.1074/jbc.m115.644179. [PMID: 26124276] - Saptaparni Ghosh, Dipak Dasgupta. Quadruplex forming promoter region of c-myc oncogene as a potential target for a telomerase inhibitory plant alkaloid, chelerythrine.
Biochemical and biophysical research communications.
2015 Mar; 459(1):75-80. doi:
10.1016/j.bbrc.2015.02.072. [PMID: 25712523] - Saptaparni Ghosh, Jagannath Jana, Rajiv K Kar, Subhrangsu Chatterjee, Dipak Dasgupta. Plant alkaloid chelerythrine induced aggregation of human telomere sequence--a unique mode of association between a small molecule and a quadruplex.
Biochemistry.
2015 Feb; 54(4):974-86. doi:
10.1021/bi501117x. [PMID: 25566806] - Fang-Jun Cao, Rui Yang, Chao Lv, Qun Ma, Ming Lei, Hui-Ling Geng, Le Zhou. Pseudocyanides of sanguinarine and chelerythrine and their series of structurally simple analogues as new anticancer lead compounds: Cytotoxic activity, structure-activity relationship and apoptosis induction.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2015 Jan; 67(?):45-54. doi:
10.1016/j.ejps.2014.10.020. [PMID: 25444843] - Doug Medvetz, Yang Sun, Chenggang Li, Damir Khabibullin, Murugabaskar Balan, Andrey Parkhitko, Carmen Priolo, John M Asara, Soumitro Pal, Jane Yu, Elizabeth P Henske. High-throughput drug screen identifies chelerythrine as a selective inducer of death in a TSC2-null setting.
Molecular cancer research : MCR.
2015 Jan; 13(1):50-62. doi:
10.1158/1541-7786.mcr-14-0440. [PMID: 25185584] - Pritha Basu, Gopinatha Suresh Kumar. Elucidation of the DNA binding specificity of the natural plant alkaloid chelerythrine: a biophysical approach.
Journal of photochemistry and photobiology. B, Biology.
2014 Sep; 138(?):282-94. doi:
10.1016/j.jphotobiol.2014.06.005. [PMID: 25010289] - Hui-Fang Chiu, Jen-Kun Cheng, Pu-Hua Lin, Jung-Chen Chang, I-Ming Chen, Ching-I Lin, Wei-Pin Chang, Chia-Hsien Lin. A mechanistic study on urine retention in d-amphetamine addicts.
The Chinese journal of physiology.
2014 Aug; 57(4):171-81. doi:
10.4077/cjp.2014.bac198. [PMID: 25246058] - Denis Castillo, Michel Sauvain, Marion Rivaud, Valérie Jullian. In vitro and in vivo activity of benzo[c]phenanthridines against Leishmania amazonensis.
Planta medica.
2014 Jul; 80(11):902-6. doi:
10.1055/s-0034-1382826. [PMID: 25029171] - Kiranj K Chaudagar, Anita A Mehta. Effect of atorvastatin on the angiogenic responsiveness of coronary endothelial cells in normal and streptozotocin (STZ) induced diabetic rats.
Canadian journal of physiology and pharmacology.
2014 Apr; 92(4):338-49. doi:
10.1139/cjpp-2013-0391. [PMID: 24708217] - Chang-Ping Jia, Fang Feng. Optimization of the separation and determination of nitidine and chelerythrine in Zanthoxylum nitidum by high-performance liquid chromatography with fluorescence detection.
Journal of chromatographic science.
2014 Feb; 52(2):164-8. doi:
10.1093/chromsci/bmt003. [PMID: 23390024] - Xiao-feng Shan, Qing-feng Meng, Yuan-huan Kang, Yu Bian, Yun-hang Gao, Wei-li Wang, Ai-dong Qian. Isolation of active compounds from methanol extracts of Toddalia asiatica against Ichthyophthirius multifiliis in goldfish (Carassius auratus).
Veterinary parasitology.
2014 Jan; 199(3-4):250-4. doi:
10.1016/j.vetpar.2013.10.021. [PMID: 24295957] - Jan Vacek, Barbora Papoušková, Pavel Kosina, Adéla Galandáková, Jitka Ulrichová. Mass spectrometric investigation of chelerythrine and dihydrochelerythrine biotransformation patterns in human hepatocytes.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2013 Dec; 941(?):17-24. doi:
10.1016/j.jchromb.2013.09.037. [PMID: 24184831] - Jaione Barrenetxe, Olga Sánchez, Ana Barber, Sonia Gascón, M Jesús Rodríguez-Yoldi, Maria Pilar Lostao. TNFα regulates sugar transporters in the human intestinal epithelial cell line Caco-2.
Cytokine.
2013 Oct; 64(1):181-7. doi:
10.1016/j.cyto.2013.07.004. [PMID: 23910014] - Pei-Qing Wang, Zhen-Hua Yin, Wen-Yi Kang. [Advance in studies on pharmacological activities of chelerythrine].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2013 Sep; 38(17):2745-9. doi:
. [PMID: 24380291] - Tayyab A Mansoor, Pedro M Borralho, Xuan Luo, Silva Mulhovo, Cecília M P Rodrigues, Maria-José U Ferreira. Apoptosis inducing activity of benzophenanthridine-type alkaloids and 2-arylbenzofuran neolignans in HCT116 colon carcinoma cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2013 Jul; 20(10):923-9. doi:
10.1016/j.phymed.2013.03.026. [PMID: 23643093] - Weifeng Li, Wei Xing, Xiaofeng Niu, Ping Zhou, Ting Fan. The pharmacokinetics of chelerythrine solution and chelerythrine liposomes after oral administration to rats.
Planta medica.
2013 May; 79(8):654-60. doi:
10.1055/s-0032-1328540. [PMID: 23670624] - Jia Zhou, Juliy M Perelman, Victor P Kolosov, Xiangdong Zhou. Neutrophil elastase induces MUC5AC secretion via protease-activated receptor 2.
Molecular and cellular biochemistry.
2013 May; 377(1-2):75-85. doi:
10.1007/s11010-013-1572-3. [PMID: 23392769] - Qin Gao, Junfeng Hu, Jie Hu, Ying Yu, Hongwei Ye, Zhenghong Li, Sudong Guan. Calcium activated potassium channel and protein kinase C participate in the cardiac protection of remote post conditioning.
Pakistan journal of pharmaceutical sciences.
2013 Mar; 26(2):285-90. doi:
NULL. [PMID: 23455198] - Qian Zhang, Lin Lin, Yan Lu, Haifeng Liu, Yanhua Duan, Xiaolong Zhu, Chengwei Zou, R Davis Manning, Ruisheng Liu. Interaction between nitric oxide and superoxide in the macula densa in aldosterone-induced alterations of tubuloglomerular feedback.
American journal of physiology. Renal physiology.
2013 Feb; 304(3):F326-32. doi:
10.1152/ajprenal.00501.2012. [PMID: 23220724] - Kevin M Dorney, Ioana E P Sizemore, Tariq Alqahtani, Norma C Adragna, Peter K Lauf. Surface-enhanced Raman spectroscopy (SERS) tracking of chelerythrine, a Na(+)/K(+) pump inhibitor, into cytosol and plasma membrane fractions of human lens epithelial cell cultures.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2013; 32(7):146-56. doi:
10.1159/000356634. [PMID: 24429821] - Sheng Wang, Jiawan Wang, Yaning Sun, Qisheng Song, Sheng Li. PKC-mediated USP phosphorylation at Ser35 modulates 20-hydroxyecdysone signaling in Drosophila.
Journal of proteome research.
2012 Dec; 11(12):6187-96. doi:
10.1021/pr3008804. [PMID: 23136906] - Stefanie Mühlfeld, Olga Domanova, Thomas Berlage, Claudia Stross, Angelika Helmer, Verena Keitel, Dieter Häussinger, Ralf Kubitz. Short-term feedback regulation of bile salt uptake by bile salts in rodent liver.
Hepatology (Baltimore, Md.).
2012 Dec; 56(6):2387-97. doi:
10.1002/hep.25955. [PMID: 22806967] - Weifeng Li, Ting Fan, Yanmin Zhang, Xiaofeng Niu, Wei Xing. Effect of chelerythrine against endotoxic shock in mice and its modulation of inflammatory mediators in peritoneal macrophages through the modulation of mitogen-activated protein kinase (MAPK) pathway.
Inflammation.
2012 Dec; 35(6):1814-24. doi:
10.1007/s10753-012-9502-1. [PMID: 22825879] - Yu-Jun Shen, Shan-Shan Pan, Jun Ge, Zhe Hao. Exercise preconditioning provides early cardioprotection against exhaustive exercise in rats: potential involvement of protein kinase C delta translocation.
Molecular and cellular biochemistry.
2012 Sep; 368(1-2):89-102. doi:
10.1007/s11010-012-1346-3. [PMID: 22648735] - K Pěnčíková, P Kollár, V Müller Závalová, E Táborská, J Urbanová, J Hošek. Investigation of sanguinarine and chelerythrine effects on LPS-induced inflammatory gene expression in THP-1 cell line.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2012 Jul; 19(10):890-5. doi:
10.1016/j.phymed.2012.04.001. [PMID: 22592163] - Yung-Shun Juan, Shu-Mien Chuang, Cheng-Yu Long, Rong-Jyh Lin, Keh-Min Liu, Wen-Jeng Wu, Chun-Hsiung Huang. Protein kinase C inhibitor prevents renal apoptotic and fibrotic changes in response to partial ureteric obstruction.
BJU international.
2012 Jul; 110(2):283-92. doi:
10.1111/j.1464-410x.2011.10805.x. [PMID: 22145940] - Janet D Klein, Christopher F Martin, Kimilia J Kent, Jeff M Sands. Protein kinase C-α mediates hypertonicity-stimulated increase in urea transporter phosphorylation in the inner medullary collecting duct.
American journal of physiology. Renal physiology.
2012 May; 302(9):F1098-103. doi:
10.1152/ajprenal.00664.2011. [PMID: 22301620] - M Artini, R Papa, G Barbato, G L Scoarughi, A Cellini, P Morazzoni, E Bombardelli, L Selan. Bacterial biofilm formation inhibitory activity revealed for plant derived natural compounds.
Bioorganic & medicinal chemistry.
2012 Jan; 20(2):920-6. doi:
10.1016/j.bmc.2011.11.052. [PMID: 22182580] - Nilufar Mohebbi, Chahira Benabbas, Solange Vidal, Arezoo Daryadel, Soline Bourgeois, Ana Velic, Marie-Gabrielle Ludwig, Klaus Seuwen, Carsten A Wagner. The proton-activated G protein coupled receptor OGR1 acutely regulates the activity of epithelial proton transport proteins.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2012; 29(3-4):313-24. doi:
10.1159/000338486. [PMID: 22508039] - Xi-Lian Li, Jia-Yun Yao, Zhi-Ming Zhou, Jin-Yu Shen, Hong-Shun Ru, Xiao-Lin Liu. Activity of the chelerythrine, a quaternary benzo[c]phenanthridine alkaloid from Chelidonium majus L. on Dactylogyrus intermedius.
Parasitology research.
2011 Jul; 109(1):247-52. doi:
10.1007/s00436-011-2320-9. [PMID: 21400114] - F Martín, L Mora, Ml Laorden, Mv Milanés. Protein kinase C phosphorylates the cAMP response element binding protein in the hypothalamic paraventricular nucleus during morphine withdrawal.
British journal of pharmacology.
2011 Jun; 163(4):857-75. doi:
10.1111/j.1476-5381.2011.01287.x. [PMID: 21615389] - Xiao-Feng Niu, Ping Zhou, Wei-Feng Li, Hong-Bo Xu. Effects of chelerythrine, a specific inhibitor of cyclooxygenase-2, on acute inflammation in mice.
Fitoterapia.
2011 Jun; 82(4):620-5. doi:
10.1016/j.fitote.2011.01.020. [PMID: 21291962] - Frantisek Jursky, Martina Baliova. Differential effect of the benzophenanthridine alkaloids sanguinarine and chelerythrine on glycine transporters.
Neurochemistry international.
2011 May; 58(6):641-7. doi:
10.1016/j.neuint.2011.02.001. [PMID: 21315125] - Junchao Liang, Fanli Zeng, Aizhen Guo, Liqiang Liu, Na Guo, Lei Li, Jing Jin, Xiuping Wu, Mingyuan Liu, Dan Zhao, Yang Li, Qi Jin, Lu Yu. Microarray analysis of the chelerythrine-induced transcriptome of Mycobacterium tuberculosis.
Current microbiology.
2011 Apr; 62(4):1200-8. doi:
10.1007/s00284-010-9837-5. [PMID: 21170712] - Violeta Ristoiu, Koji Shibasaki, Kunitoshi Uchida, Yiming Zhou, Bich-Hoai Thi Ton, Maria-Luiza Flonta, Makoto Tominaga. Hypoxia-induced sensitization of transient receptor potential vanilloid 1 involves activation of hypoxia-inducible factor-1 alpha and PKC.
Pain.
2011 Apr; 152(4):936-945. doi:
10.1016/j.pain.2011.02.024. [PMID: 21376466] - Gábor Harmati, Ferenc Papp, Norbert Szentandrássy, László Bárándi, Ferenc Ruzsnavszky, Balázs Horváth, Tamás Bányász, János Magyar, György Panyi, Zoltán Krasznai, Péter P Nánási. Effects of the PKC inhibitors chelerythrine and bisindolylmaleimide I (GF 109203X) on delayed rectifier K+ currents.
Naunyn-Schmiedeberg's archives of pharmacology.
2011 Feb; 383(2):141-8. doi:
10.1007/s00210-010-0584-8. [PMID: 21120453] - Yu-Jun Shen, Shan-Shan Pan, Tao Zhuang, Feng-Juan Wang. Exercise preconditioning initiates late cardioprotection against isoproterenol-induced myocardial injury in rats independent of protein kinase C.
The journal of physiological sciences : JPS.
2011 Jan; 61(1):13-21. doi:
10.1007/s12576-010-0116-9. [PMID: 20941560] - Ing-Marie Jonsson, Jarmo T Juuti, Patrice François, Rana AlMajidi, Milla Pietiäinen, Myriam Girard, Catharina Lindholm, Manfred J Saller, Arnold J M Driessen, Pentti Kuusela, Maria Bokarewa, Jacques Schrenzel, Vesa P Kontinen. Inactivation of the Ecs ABC transporter of Staphylococcus aureus attenuates virulence by altering composition and function of bacterial wall.
PloS one.
2010 Dec; 5(12):e14209. doi:
10.1371/journal.pone.0014209. [PMID: 21151985] - Yanhua Wang, Janet D Klein, Carole M Liedtke, Jeff M Sands. Protein kinase C regulates urea permeability in the rat inner medullary collecting duct.
American journal of physiology. Renal physiology.
2010 Dec; 299(6):F1401-6. doi:
10.1152/ajprenal.00322.2010. [PMID: 20861079] - José Silva, Mariella Pastorello, Jorge Arzola, Lida E Zavala, Sara De Jesús, Maider Varela, María Gabriela Matos, María del Rosario Garrido, Anita Israel. AT₁ receptor and NAD(P)H oxidase mediate angiotensin II-stimulated antioxidant enzymes and mitogen-activated protein kinase activity in the rat hypothalamus.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2010 Dec; 11(4):234-42. doi:
10.1177/1470320310376987. [PMID: 20807796] - Kevin K Schrader. Plant Natural compounds with antibacterial activity towards common pathogens of pond-cultured channel catfish (Ictalurus punctatus).
Toxins.
2010 07; 2(7):1676-89. doi:
10.3390/toxins2071676. [PMID: 22069655] - Pablo M Paez, Daniel J Fulton, Vilma Spreur, Vance Handley, Anthony T Campagnoni. Multiple kinase pathways regulate voltage-dependent Ca2+ influx and migration in oligodendrocyte precursor cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2010 May; 30(18):6422-33. doi:
10.1523/jneurosci.5086-09.2010. [PMID: 20445068] - María C González-Montelongo, Raquel Marín, Tomás Gómez, Jorge Marrero-Alonso, Mario Díaz. Androgens induce nongenomic stimulation of colonic contractile activity through induction of calcium sensitization and phosphorylation of LC20 and CPI-17.
Molecular endocrinology (Baltimore, Md.).
2010 May; 24(5):1007-23. doi:
10.1210/me.2009-0472. [PMID: 20207835] - Shady M Eldaif, Jeremiah A Deneve, Ning-Ping Wang, Rong Jiang, Mario Mosunjac, Christopher J Mutrie, Robert A Guyton, Zhi-Qing Zhao, Jakob Vinten-Johansen. Attenuation of renal ischemia-reperfusion injury by postconditioning involves adenosine receptor and protein kinase C activation.
Transplant international : official journal of the European Society for Organ Transplantation.
2010 Feb; 23(2):217-26. doi:
10.1111/j.1432-2277.2009.00949.x. [PMID: 19725910] - Fanyan Meng, Guoying Zuo, Xiaoyan Hao, Genchun Wang, Haitao Xiao, Jiquan Zhang, Guili Xu. Antifungal activity of the benzo[c]phenanthridine alkaloids from Chelidonium majus Linn against resistant clinical yeast isolates.
Journal of ethnopharmacology.
2009 Sep; 125(3):494-6. doi:
10.1016/j.jep.2009.07.029. [PMID: 19647059] - Grzegorz Chodaczek, Attila Bacsi, Nilesh Dharajiya, Sanjiv Sur, Tapas K Hazra, Istvan Boldogh. Ragweed pollen-mediated IgE-independent release of biogenic amines from mast cells via induction of mitochondrial dysfunction.
Molecular immunology.
2009 Aug; 46(13):2505-14. doi:
10.1016/j.molimm.2009.05.023. [PMID: 19501909] - Jennifer A Easton, Jorgen S Petersen, Patricia E M Martin. The anti-arrhythmic peptide AAP10 remodels Cx43 and Cx40 expression and function.
Naunyn-Schmiedeberg's archives of pharmacology.
2009 Jul; 380(1):11-24. doi:
10.1007/s00210-009-0411-2. [PMID: 19326099] - S Pierno, G M Camerino, V Cippone, J-F Rolland, J-F Desaphy, A De Luca, A Liantonio, G Bianco, J D Kunic, A L George, D Conte Camerino. Statins and fenofibrate affect skeletal muscle chloride conductance in rats by differently impairing ClC-1 channel regulation and expression.
British journal of pharmacology.
2009 Apr; 156(8):1206-15. doi:
10.1111/j.1476-5381.2008.00079.x. [PMID: 19220292] - Ying-Zhuang Chen, Guo-Zhu Liu, Yao Shen, Bo Chen, Jian-Guo Zeng. Analysis of alkaloids in Macleaya cordata (Willd.) R. Br. using high-performance liquid chromatography with diode array detection and electrospray ionization mass spectrometry.
Journal of chromatography. A.
2009 Mar; 1216(11):2104-10. doi:
10.1016/j.chroma.2008.08.066. [PMID: 18774138] - Anita Israel, Jorge Arzola, Sara De Jesús, Maider Varela. Role of oxidative stress in the natriuresis induced by central administration of angiotensin II.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2009 Mar; 10(1):9-14. doi:
10.1177/1470320309102946. [PMID: 19286753] - Edlira Bashari, Yawar J Qadri, Zhen-Hong Zhou, Niren Kapoor, Susan J Anderson, Robert H Meltzer, Catherine M Fuller, Dale J Benos. Two PKC consensus sites on human acid-sensing ion channel 1b differentially regulate its function.
American journal of physiology. Cell physiology.
2009 Feb; 296(2):C372-84. doi:
10.1152/ajpcell.00200.2008. [PMID: 19091960] - Parvaneh Rafiee, Victoria M Nelson, Sharon Manley, Michael Wellner, Martin Floer, David G Binion, Reza Shaker. Effect of curcumin on acidic pH-induced expression of IL-6 and IL-8 in human esophageal epithelial cells (HET-1A): role of PKC, MAPKs, and NF-kappaB.
American journal of physiology. Gastrointestinal and liver physiology.
2009 Feb; 296(2):G388-98. doi:
10.1152/ajpgi.90428.2008. [PMID: 19074641] - Alvaro Yogi, Glaucia E Callera, Rita Tostes, Rhian M Touyz. Bradykinin regulates calpain and proinflammatory signaling through TRPM7-sensitive pathways in vascular smooth muscle cells.
American journal of physiology. Regulatory, integrative and comparative physiology.
2009 Feb; 296(2):R201-7. doi:
10.1152/ajpregu.90602.2008. [PMID: 18799634] - Yudan Liu, Xihua Chen. Cholinergic excitation of dopaminergic cells depends on sequential activation of protein kinase C and the L-type calcium channel in ventral tegmental area slices.
Brain research.
2008 Dec; 1245(?):41-51. doi:
10.1016/j.brainres.2008.09.062. [PMID: 18929546] - Adela Zdarilova, Eva Vrublova, Jitka Vostalova, Borivoj Klejdus, David Stejskal, Jitka Proskova, Pavel Kosina, Alena Svobodova, Rostislav Vecera, Jan Hrbac, Drahomira Cernochova, Jaroslav Vicar, Jitka Ulrichova, Vilim Simanek. Natural feed additive of Macleaya cordata: safety assessment in rats a 90-day feeding experiment.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2008 Dec; 46(12):3721-6. doi:
10.1016/j.fct.2008.09.054. [PMID: 18930108] - Amanda L Tattersall, Robert J Wilkins. Modulation of Na+-H+ exchange isoforms NHE1 and NHE3 by insulin-like growth factor-1 in isolated bovine articular chondrocytes.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
2008 Nov; 26(11):1428-33. doi:
10.1002/jor.20617. [PMID: 18404734] - Beihua Zhong, Donna H Wang. N-oleoyldopamine, a novel endogenous capsaicin-like lipid, protects the heart against ischemia-reperfusion injury via activation of TRPV1.
American journal of physiology. Heart and circulatory physiology.
2008 Aug; 295(2):H728-35. doi:
10.1152/ajpheart.00022.2008. [PMID: 18567714]