8-Methoxycanthin-6-one (BioDeep_00000395499)

Main id: BioDeep_00000269366

 

PANOMIX_OTCML-2023 Chemicals and Drugs


代谢物信息卡片


13-METHOXY-1,6-DIAZATETRACYCLO[7.6.1.0?,(1)?.0(1)?,(1)?]HEXADECA-3,5,7,9(16),10(15),11,13-HEPTAEN-2-ONE

化学式: C15H10N2O2 (250.07422400000002)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=CC2=C(C=C1)C3=C4N2C(=O)C=CC4=NC=C3
InChI: InChI=1S/C15H10N2O2/c1-19-9-2-3-10-11-6-7-16-12-4-5-14(18)17(15(11)12)13(10)8-9/h2-8H,1H3

描述信息

9-methoxycanthin-6-one is an indole alkaloid that is the 9-methoxy derivative of canthin-6-one. Isolated from Eurycoma longifolia and Simaba multiflora, it exhibits cytotoxic activity towards human cancer cell lines. It has a role as a metabolite, an antineoplastic agent and an antiplasmodial drug. It is an indole alkaloid, an aromatic ether and an organic heterotetracyclic compound. It is functionally related to a canthin-6-one.
9-Methoxycanthin-6-one is a natural product found in Simarouba glauca, Eurycoma longifolia, and other organisms with data available.
An indole alkaloid that is the 9-methoxy derivative of canthin-6-one. Isolated from Eurycoma longifolia and Simaba multiflora, it exhibits cytotoxic activity towards human cancer cell lines.
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
9-Methoxycanthin-6-one, a canthin-6-one alkaloid, is present in intact plant parts and in callus tissues of different explants. 9-Methoxycanthin-6-one shows anti-tumor activity[1][2].
9-Methoxycanthin-6-one, a canthin-6-one alkaloid, is present in intact plant parts and in callus tissues of different explants. 9-Methoxycanthin-6-one shows anti-tumor activity[1][2].

同义名列表

9 个代谢物同义名

13-METHOXY-1,6-DIAZATETRACYCLO[7.6.1.0?,(1)?.0(1)?,(1)?]HEXADECA-3,5,7,9(16),10(15),11,13-HEPTAEN-2-ONE; 13-methoxy-1,6-diazatetracyclo[7.6.1.0(5,16).0(10,15)]hexadeca-3,5(16),6,8,10,12,14-heptaen-2-one; 13-methoxy-1,6-diazatetracyclo[7.6.1.0?,??.0??,??]hexadeca-3,5(16),6,8,10,12,14-heptaen-2-one; 13-methoxy-1,6-diazatetracyclo[7.6.1.05,16.010,15]hexadeca-3,5(16),6,8,10,12,14-heptaen-2-one; 9-methoxy-6H-indolo[3,2,1-de][1,5]naphthyridin-6-one; 9-methoxy-canthin-6-one; 8-Methoxycanthin-6-one; 9-Methoxycanthin-6-one; C15H10N2O2



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Bo Luo, Xinqiang Song. A comprehensive overview of β-carbolines and its derivatives as anticancer agents. European journal of medicinal chemistry. 2021 Nov; 224(?):113688. doi: 10.1016/j.ejmech.2021.113688. [PMID: 34332400]
  • Pham Bich Ngoc, Thanh Binh Pham, Hai Dang Nguyen, Thu Trang Tran, Hoang Ha Chu, Van Minh Chau, Jeong-Hyung Lee, Tien Dat Nguyen. A new anti-inflammatory β-carboline alkaloid from the hairy-root cultures of Eurycoma longifolia. Natural product research. 2016 Jun; 30(12):1360-5. doi: 10.1080/14786419.2015.1056187. [PMID: 26165243]
  • Thi Van Anh Tran, Clemens Malainer, Stefan Schwaiger, Atanas G Atanasov, Elke H Heiss, Verena M Dirsch, Hermann Stuppner. NF-κB inhibitors from Eurycoma longifolia. Journal of natural products. 2014 Mar; 77(3):483-8. doi: 10.1021/np400701k. [PMID: 24467387]
  • Hui Chen, M A Shuang-Gang, Zhen-Feng Fang, Gui-Jie Zhang, Shi-Shan Yu, Xiao-Guang Chen. [A new indole alkaloid from the stems of Brucea mollis]. Yao xue xue bao = Acta pharmaceutica Sinica. 2014 Feb; 49(2):225-9. doi: . [PMID: 24761613]
  • Mahmood Maziah, Noormi Rosli. The Production of 9-methoxycanthin-6-one from Callus Cultures of (Eurycoma longifolia Jack) Tongkat Ali. Methods in molecular biology (Clifton, N.J.). 2009; 547(?):359-69. doi: 10.1007/978-1-60327-287-2_29. [PMID: 19521859]
  • M Y Nurhanan, L P Azimahtol Hawariah, A Mohd Ilham, M A Mohd Shukri. Cytotoxic effects of the root extracts of Eurycoma longifolia Jack. Phytotherapy research : PTR. 2005 Nov; 19(11):994-6. doi: 10.1002/ptr.1759. [PMID: 16317660]
  • Ping-Chung Kuo, Li-Shian Shi, Amooru G Damu, Chung-Ren Su, Chieh-Hung Huang, Chih-Huang Ke, Jin-Bin Wu, Ai-Jeng Lin, Kenneth F Bastow, Kuo-Hsiung Lee, Tian-Shung Wu. Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia. Journal of natural products. 2003 Oct; 66(10):1324-7. doi: 10.1021/np030277n. [PMID: 14575431]
  • Saadiah Tan, Kah-Hay Yuen, Kit-Lam Chan. HPLC analysis of plasma 9-methoxycanthin-6-one from Eurycoma longifolia and its application in a bioavailability/pharmacokinetic study. Planta medica. 2002 Apr; 68(4):355-8. doi: 10.1055/s-2002-26751. [PMID: 11988862]