Litorin (BioDeep_00000395456)

   

PANOMIX_OTCML-2023


代谢物信息卡片


(S)-N1-((5S,8S,11S,17S,20S,23S)-11-((1H-imidazol-5-yl)methyl)-8-benzyl-5-carbamoyl-24-(1H-indol-3-yl)-17-isopropyl-20-methyl-7,10,13,16,19,22-hexaoxo-2-thia-6,9,12,15,18,21-hexaazatetracosan-23-yl)-2-((S)-5-oxopyrrolidine-2-carboxamido)pentanediamide

化学式: C51H68N14O11S (1084.4912458000001)
中文名称: GLP-GLN-TRP-ALA-VAL-GLY-HIS-PHE-MET-NH2, 雨滨蛙肽
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)C(C(=O)NCC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCSC)C(=O)N)NC(=O)C(C)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CCC(=O)N)NC(=O)C5CCC(=O)N5
InChI: InChI=1S/C51H68N14O11S/c1-27(2)43(51(76)56-25-42(68)60-39(22-31-24-54-26-57-31)50(75)63-37(20-29-10-6-5-7-11-29)49(74)61-34(44(53)69)18-19-77-4)65-45(70)28(3)58-48(73)38(21-30-23-55-33-13-9-8-12-32(30)33)64-47(72)36(14-16-40(52)66)62-46(71)35-15-17-41(67)59-35/h5-13,23-24,26-28,34-39,43,55H,14-22,25H2,1-4H3,(H2,52,66)(H2,53,69)(H,54,57)(H,56,76)(H,58,73)(H,59,67)(H,60,68)(H,61,74)(H,62,71)(H,63,75)(H,64,72)(H,65,70)/t28-,34-,35-,36-,37-,38-,39-,43-/m0/s1

描述信息

Litorin, an amphibian bombesin peptide derivative, is an bombesin receptor agonist. Litorin stimulates the contraction of smooth muscle, stimulates gastrin, gastric acid, and pancreatic secretion, and suppresses the nutriment in vivo[1][2].
Litorin, an amphibian bombesin peptide derivative, is an bombesin receptor agonist. Litorin stimulates the contraction of smooth muscle, stimulates gastrin, gastric acid, and pancreatic secretion, and suppresses the nutriment in vivo[1][2].
Litorin, an amphibian bombesin peptide derivative, is an bombesin receptor agonist. Litorin stimulates the contraction of smooth muscle, stimulates gastrin, gastric acid, and pancreatic secretion, and suppresses the nutriment in vivo[1][2].

同义名列表

6 个代谢物同义名

(S)-N1-((5S,8S,11S,17S,20S,23S)-11-((1H-imidazol-5-yl)methyl)-8-benzyl-5-carbamoyl-24-(1H-indol-3-yl)-17-isopropyl-20-methyl-7,10,13,16,19,22-hexaoxo-2-thia-6,9,12,15,18,21-hexaazatetracosan-23-yl)-2-((S)-5-oxopyrrolidine-2-carboxamido)pentanediamide; Ranatesin, 2-de-L-valine-3-de-L-proline-; Litorin (trifluoroacetate salt); Litorin (peptide); litorine; Litorin



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kubra Durkan, Fatma Yurt Lambrecht, Perihan Unak. Radiolabeling of bombesin-like peptide with 99mTc: 99mTc-litorin and biodistribution in rats. Bioconjugate chemistry. 2007 Sep; 18(5):1516-20. doi: 10.1021/bc060400x. [PMID: 17760415]
  • A I Esakov, I P Ashmarin, O N Serova, M F Obukhova, Z I Storozheva, V P Golubovich, N V Kuznetsova. Litorin and litorin-albumin conjugate as effective regulators of body temperature in rats. Biomedical science. 1990; 1(6):610-2. doi: NULL. [PMID: 2132946]
  • P A Ishanov, I P Ashmarin, A I Esakov, M F Obukhova, Z I Storozheva, V P Golubovich, K V Golubtsov, N V Kuznetsova. [Intake of water and sodium chloride solution by the rats after central administration of litorin and immunization with litorin-bovine serum albumin conjugate]. Biulleten' eksperimental'noi biologii i meditsiny. 1989 Oct; 108(10):389-91. doi: NULL. [PMID: 2597746]
  • O N Serova, M F Obukhova, A I Esakov, I P Ashmarin, Z I Storozheva. [Specific changes in the sodium chloride intake and activity of the taste receptor apparatus of rats administered the peptide litorin and its albumin conjugate]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. 1989 Jul; 39(4):699-703. doi: NULL. [PMID: 2816056]
  • T Mitsuma, T Nogimori, D H Sun, M Chaya. Litorin (bombesin family) inhibits thyrotropin secretion in rats. Experimental and clinical endocrinology. 1986 Jul; 87(2):162-8. doi: 10.1055/s-0029-1210538. [PMID: 3093255]
  • I M Modlin, C B Lamers, J H Walsh. Stimulation of canine pancreatic polypeptide, gastrin, and gastric acid secretion by ranatensin, litorin, bombesin nonapeptide and substance P. Regulatory peptides. 1981 Jan; 1(4):279-88. doi: 10.1016/0167-0115(81)90051-3. [PMID: 6166964]
  • R T Jensen, T Moody, C Pert, J E Rivier, J D Gardner. Interaction of bombesin and litorin with specific membrane receptors on pancreatic acinar cells. Proceedings of the National Academy of Sciences of the United States of America. 1978 Dec; 75(12):6139-43. doi: 10.1073/pnas.75.12.6139. [PMID: 216015]
  • M Deschodt-Lanckman, P Robberecht, P De Neef, M Lammens, J Christophe. In vitro action of bombesin and bombesin-like peptides on amylase secretion, calcium efflux, and adenylate cyclase activity in the rat pancreas: a comparison with other secretagogues. The Journal of clinical investigation. 1976 Oct; 58(4):891-8. doi: 10.1172/jci108542. [PMID: 184111]
  • R Endean, V Erspamer, G Falconieri Erspamer, G Improta, P Melchiorri, L Negri, N Sopranzi. Parallel bioassay of bombesin and litorin, a bombesin-like peptide from the skin of Litoria aurea. British journal of pharmacology. 1975 Oct; 55(2):213-9. doi: 10.1111/j.1476-5381.1975.tb07630.x. [PMID: 1201379]