Roscovitine (CYC202) (BioDeep_00000393823)
代谢物信息卡片
2-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol
化学式: C19H26N6O (354.2168)
中文名称: 塞利西利, 2-[[9-(1-甲基乙基)-6-[(苯基甲基)氨基]-9H-嘌呤-2-基]氨基]-1-丁醇
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(CO)N=c1nc2c(ncn2C(C)C)c(NCc2ccccc2)[nH]1
InChI: InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)
描述信息
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C2185 - Cyclin-Dependent Kinase Inhibitor
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor
D004791 - Enzyme Inhibitors > D047428 - Protein Kinase Inhibitors
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
D000970 - Antineoplastic Agents
同义名列表
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:45307
- PubChem: 160355
- PubChem: 5097
- DrugBank: DB06195
- ChEMBL: CHEMBL14762
- ChEMBL: CHEMBL52387
- MeSH: Roscovitine
- CAS: 186692-46-6
- CAS: 186692-44-4
- PMhub: MS000244208
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Nabil Rabhi, Kathleen Desevin, Briana Noel Cortez, Ryan Hekman, Jean Z Lin, Andrew Emili, Stephen R Farmer. The cyclin dependent kinase inhibitor Roscovitine prevents diet-induced metabolic disruption in obese mice.
Scientific reports.
2021 10; 11(1):20365. doi:
10.1038/s41598-021-99871-z. [PMID: 34645915] - Pinar Obakan Yerlikaya, Elif Damla Arısan, Ajda Coker Gurkan, Osman Orcun Okumus, Tugba Yenigun, Utku Ozbey, Melissa Kara, Narcin Palavan Unsal. Epibrassinolide prevents tau hyperphosphorylation via GSK3β inhibition in vitro and improves Caenorhabditis elegans lifespan and motor deficits in combination with roscovitine.
Amino acids.
2021 Sep; 53(9):1373-1389. doi:
10.1007/s00726-021-03027-2. [PMID: 34386848] - Stephanie Kim, Eric Reed, Stefano Monti, Jennifer J Schlezinger. A Data-Driven Transcriptional Taxonomy of Adipogenic Chemicals to Identify White and Brite Adipogens.
Environmental health perspectives.
2021 07; 129(7):77006. doi:
10.1289/ehp6886. [PMID: 34323617] - Alessandra Ghigo, Giulia Prono, Elisa Riccardi, Virginia De Rose. Dysfunctional Inflammation in Cystic Fibrosis Airways: From Mechanisms to Novel Therapeutic Approaches.
International journal of molecular sciences.
2021 Feb; 22(4):. doi:
10.3390/ijms22041952. [PMID: 33669352] - Qi Huang, Yingyuan Zhong, Jingyan Li, Yilu Ye, Wenjiao Wu, Lizhu Chen, Mingkai Feng, Jie Yang, Shuwen Liu. Kinase inhibitor roscovitine as a PB2 cap-binding inhibitor against influenza a virus replication.
Biochemical and biophysical research communications.
2020 06; 526(4):1143-1149. doi:
10.1016/j.bbrc.2020.04.034. [PMID: 32327257] - Rosiára Rosária Dias Maziero, Carlos Renato de Freitas Guaitolini, Daniela Martins Paschoal, André Maciel Crespilho, Danielle Andressa Oliveira Sestari, Margot Alves Nunes Dode, Fernanda da Cruz Landim-Alvarenga. Effects of the addition of oocyte meiosis-inhibiting drugs on the expression of maturation-promoting factor components and organization of cytoplasmic organelles.
Reproductive biology.
2020 Mar; 20(1):48-62. doi:
10.1016/j.repbio.2019.12.005. [PMID: 31889629] - Rannar Airik, Merlin Airik, Markus Schueler, Carlton M Bates, Friedhelm Hildebrandt. Roscovitine blocks collecting duct cyst growth in Cep164-deficient kidneys.
Kidney international.
2019 08; 96(2):320-326. doi:
10.1016/j.kint.2019.04.014. [PMID: 31248650] - Shuo Wang, Yi Zhou, Yue Zhang, Xingyu He, Xiangning Zhao, Hairong Zhao, Wei Liu. Roscovitine attenuates renal interstitial fibrosis in diabetic mice through the TGF-β1/p38 MAPK pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Jul; 115(?):108895. doi:
10.1016/j.biopha.2019.108895. [PMID: 31029000] - Virginie Vauthier, Amel Ben Saad, Jonathan Elie, Nassima Oumata, Anne-Marie Durand-Schneider, Alix Bruneau, Jean-Louis Delaunay, Chantal Housset, Tounsia Aït-Slimane, Laurent Meijer, Thomas Falguières. Structural analogues of roscovitine rescue the intracellular traffic and the function of ER-retained ABCB4 variants in cell models.
Scientific reports.
2019 04; 9(1):6653. doi:
10.1038/s41598-019-43111-y. [PMID: 31040306] - Richard A Feelders, John Newell-Price, Rosario Pivonello, Lynnette K Nieman, Leo J Hofland, Andre Lacroix. Advances in the medical treatment of Cushing's syndrome.
The lancet. Diabetes & endocrinology.
2019 04; 7(4):300-312. doi:
10.1016/s2213-8587(18)30155-4. [PMID: 30033041] - Guillaume Compain, Nassima Oumata, Jonathan Clarhaut, Elodie Péraudeau, Brigitte Renoux, Hervé Galons, Sébastien Papot. A β-glucuronidase-responsive albumin-binding prodrug for potential selective kinase inhibitor-based cancer chemotherapy.
European journal of medicinal chemistry.
2018 Oct; 158(?):1-6. doi:
10.1016/j.ejmech.2018.08.100. [PMID: 30199702] - Katy Billot, Charlène Coquil, Benoit Villiers, Béatrice Josselin-Foll, Nathalie Desban, Claire Delehouzé, Nassima Oumata, Yannick Le Meur, Alessandra Boletta, Thomas Weimbs, Melanie Grosch, Ralph Witzgall, Sophie Saunier, Evelyne Fischer, Marco Pontoglio, Alain Fautrel, Michal Mrug, Darren Wallace, Pamela V Tran, Marie Trudel, Nikolay Bukanov, Oxana Ibraghimov-Beskrovnaya, Laurent Meijer. Casein kinase 1ε and 1α as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8.
American journal of physiology. Renal physiology.
2018 07; 315(1):F57-F73. doi:
10.1152/ajprenal.00489.2017. [PMID: 29537311] - Kazuki Motomura, Tomokazu Kawashima, Frédéric Berger, Tetsu Kinoshita, Tetsuya Higashiyama, Daisuke Maruyama. A pharmacological study of Arabidopsis cell fusion between the persistent synergid and endosperm.
Journal of cell science.
2018 01; 131(2):. doi:
10.1242/jcs.204123. [PMID: 28808086] - Shalabh Srivastava, Simon A Ramsbottom, Elisa Molinari, Sumaya Alkanderi, Andrew Filby, Kathryn White, Charline Henry, Sophie Saunier, Colin G Miles, John A Sayer. A human patient-derived cellular model of Joubert syndrome reveals ciliary defects which can be rescued with targeted therapies.
Human molecular genetics.
2017 12; 26(23):4657-4667. doi:
10.1093/hmg/ddx347. [PMID: 28973549] - Ming He, Chao Wang, Jia-Huan Sun, Yu Liu, Hong Wang, Jing-Shan Zhao, Yun-Feng Li, Hong Chang, Jian-Ming Hou, Jun-Na Song, Ai-Ying Li, En-Sheng Ji. Roscovitine attenuates intimal hyperplasia via inhibiting NF-κB and STAT3 activation induced by TNF-α in vascular smooth muscle cells.
Biochemical pharmacology.
2017 08; 137(?):51-60. doi:
10.1016/j.bcp.2017.04.018. [PMID: 28433552] - Xiaoyan Bai, Xiaoyan Hou, Jianwei Tian, Jian Geng, Xiao Li. CDK5 promotes renal tubulointerstitial fibrosis in diabetic nephropathy via ERK1/2/PPARγ pathway.
Oncotarget.
2016 Jun; 7(24):36510-36528. doi:
10.18632/oncotarget.9058. [PMID: 27145370] - Hervé Husson, Sarah Moreno, Laurie A Smith, Mandy M Smith, Ryan J Russo, Rose Pitstick, Mikhail Sergeev, Steven R Ledbetter, Nikolay O Bukanov, Monica Lane, Kate Zhang, Katy Billot, George Carlson, Jagesh Shah, Laurent Meijer, David R Beier, Oxana Ibraghimov-Beskrovnaya. Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis.
Human molecular genetics.
2016 06; 25(11):2245-2255. doi:
10.1093/hmg/ddw093. [PMID: 27053712] - Laurent Meijer, Deborah J Nelson, Vladimir Riazanski, Aida G Gabdoulkhakova, Geneviève Hery-Arnaud, Rozenn Le Berre, Nadège Loaëc, Nassima Oumata, Hervé Galons, Emmanuel Nowak, Laetitia Gueganton, Guillaume Dorothée, Michaela Prochazkova, Bradford Hall, Ashok B Kulkarni, Robert D Gray, Adriano G Rossi, Véronique Witko-Sarsat, Caroline Norez, Frédéric Becq, Denis Ravel, Dominique Mottier, Gilles Rault. Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis.
Journal of innate immunity.
2016; 8(4):330-49. doi:
10.1159/000444256. [PMID: 26987072] - Vladimir Riazanski, Aida G Gabdoulkhakova, Lin S Boynton, Raphael R Eguchi, Ludmila V Deriy, D Kyle Hogarth, Nadège Loaëc, Nassima Oumata, Hervé Galons, Mary E Brown, Pavel Shevchenko, Alexander J Gallan, Sang Gune Yoo, Anjaparavanda P Naren, Mitchel L Villereal, Daniel W Beacham, Vytautas P Bindokas, Lutz Birnbaumer, Laurent Meijer, Deborah J Nelson. TRPC6 channel translocation into phagosomal membrane augments phagosomal function.
Proceedings of the National Academy of Sciences of the United States of America.
2015 Nov; 112(47):E6486-95. doi:
10.1073/pnas.1518966112. [PMID: 26604306] - Chun-Tang Chiou, Wei-Chun Lee, Jiahn-Haur Liao, Jing-Jy Cheng, Lie-Chwen Lin, Chih-Yu Chen, Jen-Shin Song, Ming-Hsien Wu, Kak-Shan Shia, Wen-Tai Li. Synthesis and evaluation of 3-ylideneoxindole acetamides as potent anticancer agents.
European journal of medicinal chemistry.
2015 Jun; 98(?):1-12. doi:
10.1016/j.ejmech.2015.04.062. [PMID: 25988923] - Hatem Sallam, Ahmed T El-Serafi, Elisabeth Filipski, Ylva Terelius, Francis Lévi, Moustapha Hassan. The effect of circadian rhythm on pharmacokinetics and metabolism of the Cdk inhibitor, roscovitine, in tumor mice model.
Chronobiology international.
2015 Jun; 32(5):608-14. doi:
10.3109/07420528.2015.1022782. [PMID: 25938685] - Grazia Tamma, Domenica Lasorsa, Christiane Trimpert, Marianna Ranieri, Annarita Di Mise, Maria Grazia Mola, Lisa Mastrofrancesco, Olivier Devuyst, Maria Svelto, Peter M T Deen, Giovanna Valenti. A protein kinase A-independent pathway controlling aquaporin 2 trafficking as a possible cause for the syndrome of inappropriate antidiuresis associated with polycystic kidney disease 1 haploinsufficiency.
Journal of the American Society of Nephrology : JASN.
2014 Oct; 25(10):2241-53. doi:
10.1681/asn.2013111234. [PMID: 24700872] - Hiroki Yasuhara, Kazuki Kitamoto. Aphidicolin-induced nuclear elongation in tobacco BY-2 cells.
Plant & cell physiology.
2014 May; 55(5):913-27. doi:
10.1093/pcp/pcu026. [PMID: 24492257] - Jitka Holcakova, Petr Muller, Peter Tomasec, Roman Hrstka, Marta Nekulova, Vladimir Krystof, Miroslav Strnad, Gavin W G Wilkinson, Borivoj Vojtesek. Inhibition of post-transcriptional RNA processing by CDK inhibitors and its implication in anti-viral therapy.
PloS one.
2014; 9(2):e89228. doi:
10.1371/journal.pone.0089228. [PMID: 24586613] - Grazia Tamma, Marianna Ranieri, Annarita Di Mise, Alessia Spirlì, Annamaria Russo, Maria Svelto, Giovanna Valenti. Effect of roscovitine on intracellular calcium dynamics: differential enantioselective responses.
Molecular pharmaceutics.
2013 Dec; 10(12):4620-8. doi:
10.1021/mp400430t. [PMID: 24168213] - Wei Liu, Yue Zhang, Shuxia Liu, Qingjuan Liu, Jun Hao, Yonghong Shi, Song Zhao, Huijun Duan. The expression of intermediate filament protein nestin and its association with cyclin-dependent kinase 5 in the glomeruli of rats with diabetic nephropathy.
The American journal of the medical sciences.
2013 Jun; 345(6):470-7. doi:
10.1097/maj.0b013e3182648459. [PMID: 23000950] - M Wittayarat, A Thongphakdee, K Saikhun, K Chatdarong, T Otoi, M Techakumphu. Cell cycle synchronization of skin fibroblast cells in four species of family Felidae.
Reproduction in domestic animals = Zuchthygiene.
2013 Apr; 48(2):305-10. doi:
10.1111/j.1439-0531.2012.02149.x. [PMID: 22834557] - Adeyemi O Aremu, Michael W Bairu, Ondřej Novák, Lenka Plačková, Marek Zatloukal, Karel Doležal, Jeffrey F Finnie, Miroslav Strnad, Johannes Van Staden. Physiological responses and endogenous cytokinin profiles of tissue-cultured 'Williams' bananas in relation to roscovitine and an inhibitor of cytokinin oxidase/dehydrogenase (INCYDE) treatments.
Planta.
2012 Dec; 236(6):1775-90. doi:
10.1007/s00425-012-1721-z. [PMID: 22886380] - Nikolay O Bukanov, Sarah E Moreno, Thomas A Natoli, Kelly A Rogers, Laurie A Smith, Steven R Ledbetter, Nassima Oumata, Hervé Galons, Laurent Meijer, Oxana Ibraghimov-Beskrovnaya. CDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD.
Cell cycle (Georgetown, Tex.).
2012 Nov; 11(21):4040-6. doi:
10.4161/cc.22375. [PMID: 23032260] - Ming Ji, Shuping Yang, Yuanhong Chen, Ling Xiao, Lin Zhang, Jixin Dong. Phospho-regulation of KIBRA by CDK1 and CDC14 phosphatase controls cell-cycle progression.
The Biochemical journal.
2012 Oct; 447(1):93-102. doi:
10.1042/bj20120751. [PMID: 22784093] - Christine K Cheng, W Clay Gustafson, Elizabeth Charron, Benjamin T Houseman, Eli Zunder, Andrei Goga, Nathanael S Gray, Brian Pollok, Scott A Oakes, C David James, Kevan M Shokat, William A Weiss, Qi-Wen Fan. Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma.
Proceedings of the National Academy of Sciences of the United States of America.
2012 Jul; 109(31):12722-7. doi:
10.1073/pnas.1202492109. [PMID: 22802621] - Naresh L Selokar, Monika Saini, Mushariffa Muzaffer, G Krishnakanth, Ambika P Saha, Manmohan S Chauhan, Radheysham Manik, Prabhat Palta, Pavneesh Madan, Suresh K Singla. Roscovitine treatment improves synchronization of donor cell cycle in G0/G1 stage and in vitro development of handmade cloned buffalo (Bubalus bubalis) embryos.
Cellular reprogramming.
2012 Apr; 14(2):146-54. doi:
10.1089/cell.2011.0076. [PMID: 22372577] - Ayelet Orenbuch, Lee Shalev, Vincenzo Marra, Isaac Sinai, Yotam Lavy, Joy Kahn, Jemima J Burden, Kevin Staras, Daniel Gitler. Synapsin selectively controls the mobility of resting pool vesicles at hippocampal terminals.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2012 Mar; 32(12):3969-80. doi:
10.1523/jneurosci.5058-11.2012. [PMID: 22442064] - Viktor Yarotskyy, Keith S Elmslie. Roscovitine inhibits CaV3.1 (T-type) channels by preferentially affecting closed-state inactivation.
The Journal of pharmacology and experimental therapeutics.
2012 Feb; 340(2):463-72. doi:
10.1124/jpet.111.187104. [PMID: 22088954] - Robert C Jackson. Pharmacodynamic modelling of biomarker data in oncology.
ISRN pharmacology.
2012; 2012(?):590626. doi:
10.5402/2012/590626. [PMID: 22523699] - Liat Josefsberg Ben-Yehoshua, Katia Beider, Avichai Shimoni, Olga Ostrovsky, Michal Samookh, Amnon Peled, Arnon Nagler. Characterization of cyclin E expression in multiple myeloma and its functional role in seliciclib-induced apoptotic cell death.
PloS one.
2012; 7(4):e33856. doi:
10.1371/journal.pone.0033856. [PMID: 22558078] - F Nutter, A Khwaja, J Haylor. Seliciclib inhibits renal hypertrophy but not fibrosis in the rat following subtotal nephrectomy.
Nephron. Experimental nephrology.
2012; 122(3-4):114-22. doi:
10.1159/000350248. [PMID: 23689642] - Ming-Yang Chang, Albert C M Ong. Mechanism-based therapeutics for autosomal dominant polycystic kidney disease: recent progress and future prospects.
Nephron. Clinical practice.
2012; 120(1):c25-34; discussion c35. doi:
10.1159/000334166. [PMID: 22205396] - Letícia Siqueira Sá Barretto, Viviane Sgobbi Dias Caiado Castro, Joaquim Mansano Garcia, Gisele Zoccal Mingoti. Meiotic inhibition of bovine oocytes in medium supplemented with a serum replacer and hormones: effects on meiosis progression and developmental capacity.
Zygote (Cambridge, England).
2011 May; 19(2):107-16. doi:
10.1017/s096719941000016x. [PMID: 20569512] - Y S Akshey, D Malakar, A Kumar De, M Kumar Jena, S Kumar Pawar, R Dutta, S Sahu. Effect of roscovitine treated donor cells and different activation methods on development of handmade cloned goat (Capra hircus) embryos.
Theriogenology.
2011 May; 75(8):1516-24. doi:
10.1016/j.theriogenology.2010.12.015. [PMID: 21320722] - Abdulmunem M Sheryanna, Jennifer Smith, Gurjeet Bhangal, Anna Barnett, Steven McClue, Frederick W K Tam, Terence Cook, Charles D Pusey. Treatment with a cyclin-dependent kinase inhibitor, seliciclib, is effective in reducing glomerular macrophage numbers and the severity of established experimental glomerulonephritis.
Nephrology (Carlton, Vic.).
2011 May; 16(4):410-6. doi:
10.1111/j.1440-1797.2010.01416.x. [PMID: 21518118] - Edit Abrahám, Pál Miskolczi, Ferhan Ayaydin, Ping Yu, Edit Kotogány, László Bakó, Krisztina Otvös, Gábor V Horváth, Dénes Dudits. Immunodetection of retinoblastoma-related protein and its phosphorylated form in interphase and mitotic alfalfa cells.
Journal of experimental botany.
2011 Mar; 62(6):2155-68. doi:
10.1093/jxb/erq413. [PMID: 21196474] - Wei Guo, Shuhong Wu, Li Wang, Xiaoli Wei, Xiaoying Liu, Ji Wang, Zhimin Lu, Melinda Hollingshead, Bingliang Fang. Antitumor activity of a novel oncrasin analogue is mediated by JNK activation and STAT3 inhibition.
PloS one.
2011; 6(12):e28487. doi:
10.1371/journal.pone.0028487. [PMID: 22174819] - H J Park, O J Koo, D K Kwon, J T Kang, G Jang, B C Lee. Effect of roscovitine-treated donor cells on development of porcine cloned embryos.
Reproduction in domestic animals = Zuchthygiene.
2010 Dec; 45(6):1082-8. doi:
10.1111/j.1439-0531.2009.01499.x. [PMID: 19602177] - Christophe Le Tourneau, Sandrine Faivre, Valérie Laurence, Catherine Delbaldo, Karina Vera, Veronique Girre, Judy Chiao, Sian Armour, Sheelagh Frame, Simon R Green, Athos Gianella-Borradori, Veronique Diéras, Eric Raymond. Phase I evaluation of seliciclib (R-roscovitine), a novel oral cyclin-dependent kinase inhibitor, in patients with advanced malignancies.
European journal of cancer (Oxford, England : 1990).
2010 Dec; 46(18):3243-50. doi:
10.1016/j.ejca.2010.08.001. [PMID: 20822897] - Tatsuto Ishimaru, Jasmine Lau, Amy L Jackson, Jaime F Modiano, Robert H Weiss. Pharmacological inhibition of cyclin dependent kinases causes p53 dependent apoptosis in renal cell carcinoma.
The Journal of urology.
2010 Nov; 184(5):2143-9. doi:
10.1016/j.juro.2010.06.088. [PMID: 20850841] - Ashley Hinther, Dominik Domanski, Saadia Vawda, Caren C Helbing. C-fin: a cultured frog tadpole tail fin biopsy approach for detection of thyroid hormone-disrupting chemicals.
Environmental toxicology and chemistry.
2010 Feb; 29(2):380-388. doi:
10.1002/etc.44. [PMID: 20821457] - Ho Sook Choi, Sul-Hee Chung. Roscovitine increases intracellular calcium release and capacitative calcium entry in PC12 cells.
Neuroscience letters.
2010 Jan; 469(1):141-4. doi:
10.1016/j.neulet.2009.11.061. [PMID: 19944738] - Małgorzata Rogalińska, Jerzy Z Błoński, Oxana Komina, Paweł Góralski, Jolanta D Zołnierczyk, Henryk Piekarski, Tadeusz Robak, Zofia M Kiliańska, Józefa Wesierska-Gadek. R-roscovitine (Seliciclib) affects CLL cells more strongly than combinations of fludarabine or cladribine with cyclophosphamide: Inhibition of CDK7 sensitizes leukemic cells to caspase-dependent apoptosis.
Journal of cellular biochemistry.
2010 Jan; 109(1):217-35. doi:
10.1002/jcb.22400. [PMID: 19911397] - David A Price, Alexander Sorkin, Nancy R Zahniser. Cyclin-dependent kinase 5 inhibitors: inhibition of dopamine transporter activity.
Molecular pharmacology.
2009 Oct; 76(4):812-23. doi:
10.1124/mol.109.056978. [PMID: 19628755] - Ida Iurisci, Elisabeth Filipski, Hatem Sallam, Francis Harper, Catherine Guettier, Irène Maire, Moustapha Hassan, Stefano Iacobelli, Francis Lévi. Liver circadian clock, a pharmacologic target of cyclin-dependent kinase inhibitor seliciclib.
Chronobiology international.
2009 Aug; 26(6):1169-88. doi:
10.3109/07420520903209942. [PMID: 19731111] - Margarita Maurer, Oxana Komina, Józefa Wesierska-Gadek. Roscovitine differentially affects asynchronously growing and synchronized human MCF-7 breast cancer cells.
Annals of the New York Academy of Sciences.
2009 Aug; 1171(?):250-6. doi:
10.1111/j.1749-6632.2009.04717.x. [PMID: 19723062] - Gemma Muruáis, Vassiliki Lalioti, Ignacio V Sandoval. The Cdk5 inhibitor roscovitine strongly inhibits glucose uptake in 3T3-L1 adipocytes without altering GLUT4 translocation from internal pools to the cell surface.
Journal of cellular physiology.
2009 Jul; 220(1):238-44. doi:
10.1002/jcp.21758. [PMID: 19326393] - Józefa Wesierska-Gadek, Andreea Borza, Eva Walzi, Vladimir Krystof, Margarita Maurer, Oxana Komina, Stefanie Wandl. Outcome of treatment of human HeLa cervical cancer cells with roscovitine strongly depends on the dosage and cell cycle status prior to the treatment.
Journal of cellular biochemistry.
2009 Apr; 106(5):937-55. doi:
10.1002/jcb.22074. [PMID: 19180585] - Sindura B Ganapathi, Mark Kester, Keith S Elmslie. State-dependent block of HERG potassium channels by R-roscovitine: implications for cancer therapy.
American journal of physiology. Cell physiology.
2009 Apr; 296(4):C701-10. doi:
10.1152/ajpcell.00633.2008. [PMID: 19244476] - Vishal Patel, Renuka Chowdhury, Peter Igarashi. Advances in the pathogenesis and treatment of polycystic kidney disease.
Current opinion in nephrology and hypertension.
2009 Mar; 18(2):99-106. doi:
10.1097/mnh.0b013e3283262ab0. [PMID: 19430332] - Hsien-Yu Peng, Gin-Den Chen, Kwong-Chung Tung, Cheng-Yuan Lai, Ming-Chun Hsien, Chun-Hsien Chiu, Hsiao-Ting Lu, Jiuan-Miaw Liao, Shin-Da Lee, Tzer-Bin Lin. Colon mustard oil instillation induced cross-organ reflex sensitization on the pelvic-urethra reflex activity in rats.
Pain.
2009 Mar; 142(1-2):75-88. doi:
10.1016/j.pain.2008.11.017. [PMID: 19167822] - Wen-Son Hsieh, Ross Soo, Bee-Keow Peh, Thomas Loh, Difeng Dong, Donny Soh, Lim-Soon Wong, Simon Green, Judy Chiao, Chun-Ying Cui, Yoke-Fong Lai, Soo-Chin Lee, Benjamin Mow, Richie Soong, Manuel Salto-Tellez, Boon-Cher Goh. Pharmacodynamic effects of seliciclib, an orally administered cell cycle modulator, in undifferentiated nasopharyngeal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2009 Feb; 15(4):1435-42. doi:
10.1158/1078-0432.ccr-08-1748. [PMID: 19228744] - Ran An, Yuichiro Hagiya, Ai Tamura, Shanshan Li, Hikaru Saito, Daisuke Tokushima, Toshihisa Ishikawa. Cellular phototoxicity evoked through the inhibition of human ABC transporter ABCG2 by cyclin-dependent kinase inhibitors in vitro.
Pharmaceutical research.
2009 Feb; 26(2):449-58. doi:
10.1007/s11095-008-9738-5. [PMID: 18841444] - Ok Jae Koo, Mohammad Shamim Hossein, So Gun Hong, Jose A Martinez-Conejero, Byeong Chun Lee. Cell cycle synchronization of canine ear fibroblasts for somatic cell nuclear transfer.
Zygote (Cambridge, England).
2009 Feb; 17(1):37-43. doi:
10.1017/s096719940800498x. [PMID: 19032801] - Casiano H Choresca, Ok Jae Koo, Hyun Ju Oh, So Gun Hong, Dennis K Gomez, Ji Hyung Kim, Byeong Chun Lee, Se Chang Park. Different culture conditions used for arresting the G0/G1 phase of the cell cycle in goldfish (Carassius auratus) caudal fin-derived fibroblasts.
Cell biology international.
2009 Jan; 33(1):65-70. doi:
10.1016/j.cellbi.2008.09.015. [PMID: 18977451] - Jin-Young Park, See-Hyoung Park, Robert H Weiss. Disparate effects of roscovitine on renal tubular epithelial cell apoptosis and senescence: implications for autosomal dominant polycystic kidney disease.
American journal of nephrology.
2009; 29(6):509-15. doi:
10.1159/000184590. [PMID: 19066425] - Paula Hernandez, Gloria Lee, Marcela Sjoberg, Ricardo B Maccioni. Tau phosphorylation by cdk5 and Fyn in response to amyloid peptide Abeta (25-35): involvement of lipid rafts.
Journal of Alzheimer's disease : JAD.
2009; 16(1):149-56. doi:
10.3233/jad-2009-0933. [PMID: 19158430] - Jonathan L Tobin, Philip L Beales. Restoration of renal function in zebrafish models of ciliopathies.
Pediatric nephrology (Berlin, Germany).
2008 Nov; 23(11):2095-9. doi:
10.1007/s00467-008-0898-7. [PMID: 18604564] - Hatem Sallam, Patricia Jimenez, Hairong Song, Marina Vita, Angel Cedazo-Minguez, Moustapha Hassan. Age-dependent pharmacokinetics and effect of roscovitine on Cdk5 and Erk1/2 in the rat brain.
Pharmacological research.
2008 Jul; 58(1):32-7. doi:
10.1016/j.phrs.2008.05.010. [PMID: 18588979] - R Khammanit, S Chantakru, Y Kitiyanant, J Saikhun. Effect of serum starvation and chemical inhibitors on cell cycle synchronization of canine dermal fibroblasts.
Theriogenology.
2008 Jul; 70(1):27-34. doi:
10.1016/j.theriogenology.2008.02.015. [PMID: 18423836] - Sarah Moreno, Oxana Ibraghimov-Beskrovnaya, Nikolay O Bukanov. Serum and urinary biomarker signatures for rapid preclinical in vivo assessment of CDK inhibition as a therapeutic approach for PKD.
Cell cycle (Georgetown, Tex.).
2008 Jun; 7(12):1856-64. doi:
10.4161/cc.7.12.6055. [PMID: 18583937] - Anna Pezzotta, Marilena Mister, Giuseppe Monteferrante, Linda Cassis, Nadia Azzollini, Sistiana Aiello, Maddalena Satta, Ariela Benigni, Giuseppe Remuzzi, Marina Noris. Effect of seliciclib (CYC202, R-roscovitine) on lymphocyte alloreactivity and acute kidney allograft rejection in rat.
Transplantation.
2008 May; 85(10):1476-82. doi:
10.1097/tp.0b013e31816f240c. [PMID: 18497689] - Xiuzhu Sun, Shuhui Wang, Yunhai Zhang, Haiping Wang, Lili Wang, Liu Ying, Rong Li, Ning Li. Cell-cycle synchronization of fibroblasts derived from transgenic cloned cattle ear skin: effects of serum starvation, roscovitine and contact inhibition.
Zygote (Cambridge, England).
2008 May; 16(2):111-6. doi:
10.1017/s0967199407004522. [PMID: 18405431] - Steven J McClue, Iain Stuart. Metabolism of the trisubstituted purine cyclin-dependent kinase inhibitor seliciclib (R-roscovitine) in vitro and in vivo.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Mar; 36(3):561-70. doi:
10.1124/dmd.107.019232. [PMID: 18048486] - Esther Meijer, Paul E de Jong, Dorien J Peters, Ronald T Gansevoort. Better understanding of ADPKD results in potential new treatment options: ready for the cure?.
Journal of nephrology.
2008 Mar; 21(2):133-8. doi:
NULL. [PMID: 18446706] - O Ibraghimov-Beskrovnaya, N Bukanov. Polycystic kidney diseases: from molecular discoveries to targeted therapeutic strategies.
Cellular and molecular life sciences : CMLS.
2008 Feb; 65(4):605-19. doi:
10.1007/s00018-007-7362-x. [PMID: 17975706] - Jodi M Carter, Laurent Demizieux, Robert B Campenot, Dennis E Vance, Jean E Vance. Phosphatidylcholine biosynthesis via CTP:phosphocholine cytidylyltransferase 2 facilitates neurite outgrowth and branching.
The Journal of biological chemistry.
2008 Jan; 283(1):202-212. doi:
10.1074/jbc.m706531200. [PMID: 17981805] - Thomas A Natoli, Tiffany C Gareski, William R Dackowski, Laurie Smith, Nikolay O Bukanov, Ryan J Russo, Hervé Husson, Douglas Matthews, Peter Piepenhagen, Oxana Ibraghimov-Beskrovnaya. Pkd1 and Nek8 mutations affect cell-cell adhesion and cilia in cysts formed in kidney organ cultures.
American journal of physiology. Renal physiology.
2008 Jan; 294(1):F73-83. doi:
10.1152/ajprenal.00362.2007. [PMID: 17928412] - Junjie Lu, David M Gilbert. Proliferation-dependent and cell cycle regulated transcription of mouse pericentric heterochromatin.
The Journal of cell biology.
2007 Nov; 179(3):411-21. doi:
10.1083/jcb.200706176. [PMID: 17984319] - Józefa Wesierska-Gadek, Margarita Maurer, Gerald Schmid. Inhibition of farnesyl protein transferase sensitizes human MCF-7 breast cancer cells to roscovitine-mediated cell cycle arrest.
Journal of cellular biochemistry.
2007 Oct; 102(3):736-47. doi:
10.1002/jcb.21325. [PMID: 17415788] - M Serova, C M Galmarini, A Ghoul, K Benhadji, S R Green, J Chiao, S Faivre, E Cvitkovic, C Le Tourneau, F Calvo, E Raymond. Antiproliferative effects of sapacitabine (CYC682), a novel 2'-deoxycytidine-derivative, in human cancer cells.
British journal of cancer.
2007 Sep; 97(5):628-36. doi:
10.1038/sj.bjc.6603896. [PMID: 17637678] - Shuang Liang, Fan-Yan Wei, Yu-Mei Wu, Kenji Tanabe, Tadashi Abe, Yoshiya Oda, Yumi Yoshida, Hiroshi Yamada, Hideki Matsui, Kazuhito Tomizawa, Kohji Takei. Major Cdk5-dependent phosphorylation sites of amphiphysin 1 are implicated in the regulation of the membrane binding and endocytosis.
Journal of neurochemistry.
2007 Sep; 102(5):1466-1476. doi:
10.1111/j.1471-4159.2007.04507.x. [PMID: 17419807] - Jin-Young Park, William E Schutzer, Jessie N Lindsley, Susan P Bagby, Terry T Oyama, Sharon Anderson, Robert H Weiss. p21 is decreased in polycystic kidney disease and leads to increased epithelial cell cycle progression: roscovitine augments p21 levels.
BMC nephrology.
2007 Aug; 8(?):12. doi:
10.1186/1471-2369-8-12. [PMID: 17714589] - E Wolfgang Kuehn, Gerd Walz. Prime time for polycystic kidney disease: does one shot of roscovitine bring the cure?.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2007 Aug; 22(8):2133-5. doi:
10.1093/ndt/gfm178. [PMID: 17412700] - Ariela Benigni, Cristina Caroli, Lorena Longaretti, Elena Gagliardini, Carla Zoja, Miriam Galbusera, Daniela Moioli, Paola Romagnani, Angela Tincani, Laura Andreoli, Giuseppe Remuzzi. Involvement of renal tubular Toll-like receptor 9 in the development of tubulointerstitial injury in systemic lupus.
Arthritis and rheumatism.
2007 May; 56(5):1569-78. doi:
10.1002/art.22524. [PMID: 17469139] - Carla Zoja, Federica Casiraghi, Sara Conti, Daniela Corna, Daniela Rottoli, Regiane A Cavinato, Giuseppe Remuzzi, Ariela Benigni. Cyclin-dependent kinase inhibition limits glomerulonephritis and extends lifespan of mice with systemic lupus.
Arthritis and rheumatism.
2007 May; 56(5):1629-37. doi:
10.1002/art.22593. [PMID: 17469145] - Shu-Fen Kan, Ching-Han Yu, Hsiao-Fung Pu, Jong-Ming Hsu, Ming-Jen Chen, Paulus S Wang. Anti-proliferative effects of evodiamine on human prostate cancer cell lines DU145 and PC3.
Journal of cellular biochemistry.
2007 May; 101(1):44-56. doi:
10.1002/jcb.21036. [PMID: 17340628] - Oxana Ibraghimov-Beskrovnaya. Targeting dysregulated cell cycle and apoptosis for polycystic kidney disease therapy.
Cell cycle (Georgetown, Tex.).
2007 Apr; 6(7):776-9. doi:
10.4161/cc.6.7.4047. [PMID: 17377490] - C Benson, J White, J De Bono, A O'Donnell, F Raynaud, C Cruickshank, H McGrath, M Walton, P Workman, S Kaye, J Cassidy, A Gianella-Borradori, I Judson, C Twelves. A phase I trial of the selective oral cyclin-dependent kinase inhibitor seliciclib (CYC202; R-Roscovitine), administered twice daily for 7 days every 21 days.
British journal of cancer.
2007 Jan; 96(1):29-37. doi:
10.1038/sj.bjc.6603509. [PMID: 17179992] - Nikolay O Bukanov, Laurie A Smith, Katherine W Klinger, Steven R Ledbetter, Oxana Ibraghimov-Beskrovnaya. Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine.
Nature.
2006 Dec; 444(7121):949-52. doi:
10.1038/nature05348. [PMID: 17122773] - Kazuchika Miyoshi, Sezen Arat, Steven L Stice. Production of cloned calves using roscovitine-treated adult somatic cells as donors.
Methods in molecular biology (Clifton, N.J.).
2006; 348(?):125-34. doi:
10.1007/978-1-59745-154-3_8. [PMID: 16988376] - Jason D Coombes, Ellein Mreich, Christopher Liddle, Gopala K Rangan. Rapamycin worsens renal function and intratubular cast formation in protein overload nephropathy.
Kidney international.
2005 Dec; 68(6):2599-607. doi:
10.1111/j.1523-1755.2005.00732.x. [PMID: 16316336] - Matthew R Hass, Bruce A Yankner. A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein.
The Journal of biological chemistry.
2005 Nov; 280(44):36895-904. doi:
10.1074/jbc.m502861200. [PMID: 16103124] - Adam Tripp, Prabal Banerjee, Michelle Sieburg, Vicente Planelles, Fengzhi Li, Gerold Feuer. Induction of cell cycle arrest by human T-cell lymphotropic virus type 1 Tax in hematopoietic progenitor (CD34+) cells: modulation of p21cip1/waf1 and p27kip1 expression.
Journal of virology.
2005 Nov; 79(22):14069-78. doi:
10.1128/jvi.79.22.14069-14078.2005. [PMID: 16254341] - Taeko Nakagawa, Natumi Sawada, Masayoshi Yamaguchi. Overexpression of regucalcin suppresses cell proliferation of cloned normal rat kidney proximal tubular epithelial NRK52E cells.
International journal of molecular medicine.
2005 Oct; 16(4):637-43. doi:
. [PMID: 16142398] - Marina Vita, Mohamed Abdel-Rehim, Christina Nilsson, Zuzana Hassan, Patrik Skansen, Hong Wan, Lennart Meurling, Moustapha Hassan. Stability, pKa and plasma protein binding of roscovitine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Jul; 821(1):75-80. doi:
10.1016/j.jchromb.2005.04.014. [PMID: 15894521] - Florence I Raynaud, Steven R Whittaker, Peter M Fischer, Steven McClue, Michael I Walton, S Elaine Barrie, Michelle D Garrett, Paul Rogers, Simon J Clarke, Lloyd R Kelland, Melanie Valenti, Lisa Brunton, Suzanne Eccles, David P Lane, Paul Workman. In vitro and in vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine and CYC202.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2005 Jul; 11(13):4875-87. doi:
10.1158/1078-0432.ccr-04-2264. [PMID: 16000586] - Marina Vita, Mohamed Abdel-Rehim, Susanne Olofsson, Zuzana Hassan, Lennart Meurling, Ake Sidén, Mabel Sidén, Tommy Pettersson, Moustapha Hassan. Tissue distribution, pharmacokinetics and identification of roscovitine metabolites in rat.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2005 May; 25(1):91-103. doi:
10.1016/j.ejps.2005.02.001. [PMID: 15854805] - S R Cho, S A Ock, J G Yoo, B Mohana Kumar, S Y Choe, G J Rho. Effects of confluent, roscovitine treatment and serum starvation on the cell-cycle synchronization of bovine foetal fibroblasts.
Reproduction in domestic animals = Zuchthygiene.
2005 Apr; 40(2):171-6. doi:
10.1111/j.1439-0531.2005.00577.x. [PMID: 15819970] - Maja Milovanceva-Popovska, Uta Kunter, Tammo Ostendorf, Arndt Petermann, Song Rong, Frank Eitner, Dontscho Kerjaschki, Anna Barnett, Jürgen Floege. R-roscovitine (CYC202) alleviates renal cell proliferation in nephritis without aggravating podocyte injury.
Kidney international.
2005 Apr; 67(4):1362-70. doi:
10.1111/j.1523-1755.2005.00213.x. [PMID: 15780088] - Marina Vita, Patrik Skansen, Moustapha Hassan, Mohamed Abdel-Rehim. Development and validation of a liquid chromatography and tandem mass spectrometry method for determination of roscovitine in plasma and urine samples utilizing on-line sample preparation.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Mar; 817(2):303-7. doi:
10.1016/j.jchromb.2004.12.022. [PMID: 15686999] - Siân V Griffin, Ronald D Krofft, Jeffrey W Pippin, Stuart J Shankland. Limitation of podocyte proliferation improves renal function in experimental crescentic glomerulonephritis.
Kidney international.
2005 Mar; 67(3):977-86. doi:
10.1111/j.1523-1755.2005.00161.x. [PMID: 15698436] - Bernard P Nutley, Florence I Raynaud, Stuart C Wilson, Peter M Fischer, Angela Hayes, Phyllis M Goddard, Steven J McClue, Michael Jarman, David P Lane, Paul Workman. Metabolism and pharmacokinetics of the cyclin-dependent kinase inhibitor R-roscovitine in the mouse.
Molecular cancer therapeutics.
2005 Jan; 4(1):125-39. doi:
NULL. [PMID: 15657360]
