KT5823 (BioDeep_00000393752)
代谢物信息卡片
9,12-Epoxy-1H-diindolo[1,2,3-fg:3,2,1-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-methoxy-2,9-dimethyl-1-oxo-, methyl ester, (9S,10R,12R)-
化学式: C29H25N3O5 (495.179412)
中文名称: 蛋白激酶仰制剂KT5823
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CN(C6=O)C)(C(=O)OC)OC
InChI: InChI=1S/C29H25N3O5/c1-28-29(36-4,27(34)35-3)13-20(37-28)31-18-11-7-5-9-15(18)22-23-17(14-30(2)26(23)33)21-16-10-6-8-12-19(16)32(28)25(21)24(22)31/h5-12,20H,13-14H2,1-4H3/t20-,28+,29+/m1/s1
描述信息
D004791 - Enzyme Inhibitors > D047428 - Protein Kinase Inhibitors
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yen-Chuan Ou, Jian-Ri Li, Chih-Cheng Wu, Tung-Min Yu, Wen-Ying Chen, Su-Lan Liao, Yu-Hsiang Kuan, Yu-Fan Chen, Chun-Jung Chen. Cadmium induces the expression of Interleukin-6 through Heme Oxygenase-1 in HK-2 cells and Sprague-Dawley rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2022 Mar; 161(?):112846. doi:
10.1016/j.fct.2022.112846. [PMID: 35122928] - Carolin Torregroza, Chiara O Glashoerster, Katharina Feige, Martin Stroethoff, Annika Raupach, André Heinen, Markus W Hollmann, Ragnar Huhn. Mediation of the Cardioprotective Effects of Mannitol Discovered, with Refutation of Common Protein Kinases.
International journal of molecular sciences.
2021 Nov; 22(22):. doi:
10.3390/ijms222212471. [PMID: 34830353] - Andrea de la Fuente-Alonso, Marta Toral, Alvaro Alfayate, María Jesús Ruiz-Rodríguez, Elena Bonzón-Kulichenko, Gisela Teixido-Tura, Sara Martínez-Martínez, María José Méndez-Olivares, Dolores López-Maderuelo, Ileana González-Valdés, Eusebio Garcia-Izquierdo, Susana Mingo, Carlos E Martín, Laura Muiño-Mosquera, Julie De Backer, J Francisco Nistal, Alberto Forteza, Arturo Evangelista, Jesús Vázquez, Miguel R Campanero, Juan Miguel Redondo. Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO.
Nature communications.
2021 05; 12(1):2628. doi:
10.1038/s41467-021-22933-3. [PMID: 33976159] - Pallavi Bhargava, Jaroslav Janda, Rick G Schnellmann. Elucidation of cGMP-dependent induction of mitochondrial biogenesis through PKG and p38 MAPK in the kidney.
American journal of physiology. Renal physiology.
2020 02; 318(2):F322-F328. doi:
10.1152/ajprenal.00533.2019. [PMID: 31841384] - Hongliang Li, Mi Seon Seo, Jin Ryeol An, Hee Seok Jung, Kwon-Soo Ha, Eun-Taek Han, Seok-Ho Hong, Young Min Bae, Sung Hun Na, Won Sun Park. Dipeptidyl peptidase-4 inhibitor sitagliptin induces vasorelaxation via the activation of Kv channels and PKA.
Toxicology and applied pharmacology.
2019 12; 384(?):114799. doi:
10.1016/j.taap.2019.114799. [PMID: 31678606] - Hae Jin Kim, Ji Hyun Jang, Yin Hua Zhang, Hae Young Yoo, Sung Joon Kim. Fast relaxation and desensitization of angiotensin II contraction in the pulmonary artery via AT1R and Akt-mediated phosphorylation of muscular eNOS.
Pflugers Archiv : European journal of physiology.
2019 10; 471(10):1317-1330. doi:
10.1007/s00424-019-02305-z. [PMID: 31468138] - Juan Gu, Xin Tian, Wei Wang, Qin Yang, Peijia Lin, Yuanlin Ma, Yan Xiong, Demei Xu, Yanke Zhang, Yong Yang, Shanshan Lu, Zijun Lin, Jing Luo, Fei Xiao, Xuefeng Wang. Inhibition of Cgkii Suppresses Seizure Activity and Hippocampal Excitation by Regulating the Postsynaptic Delivery of Glua1.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2018; 46(1):160-177. doi:
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American journal of physiology. Heart and circulatory physiology.
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Cellular signalling.
2013 Mar; 25(3):630-8. doi:
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American journal of physiology. Renal physiology.
2012 Nov; 303(10):F1399-408. doi:
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Endocrinology.
2011 Mar; 152(3):782-92. doi:
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Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie.
2009 Oct; 247(10):1353-60. doi:
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2008 Aug; 456(5):897-915. doi:
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Biochimica et biophysica acta.
2008 Jun; 1781(6-7):299-305. doi:
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The European journal of neuroscience.
2007 Nov; 26(10):2931-9. doi:
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American journal of physiology. Cell physiology.
2007 Jun; 292(6):C2239-58. doi:
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Journal of immunology (Baltimore, Md. : 1950).
2007 Jan; 178(1):416-27. doi:
10.4049/jimmunol.178.1.416. [PMID: 17182580] - Bahjat Al-Ani, Peter W Hewett, Suborna Ahmed, Melissa Cudmore, Takeshi Fujisawa, Shakil Ahmad, Asif Ahmed. The release of nitric oxide from S-nitrosothiols promotes angiogenesis.
PloS one.
2006 Dec; 1(?):e25. doi:
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The Journal of surgical research.
2006 Sep; 135(1):38-44. doi:
10.1016/j.jss.2006.01.012. [PMID: 16600302] - Binnaz Ay, Adeyemi Iyanoye, Gary C Sieck, Y S Prakash, Christina M Pabelick. Cyclic nucleotide regulation of store-operated Ca2+ influx in airway smooth muscle.
American journal of physiology. Lung cellular and molecular physiology.
2006 Feb; 290(2):L278-83. doi:
10.1152/ajplung.00188.2005. [PMID: 16155088] - Sandhya Sanghi, Rajesh Kumar, Manuela Smith, Kenneth M Baker, David E Dostal. Activation of protein kinase A by atrial natriuretic peptide in neonatal rat cardiac fibroblasts: role in regulation of the local renin-angiotensin system.
Regulatory peptides.
2005 Dec; 132(1-3):1-8. doi:
10.1016/j.regpep.2005.06.007. [PMID: 16194576] - Bing Zhu, Lakshmi Vemavarapu, W Joseph Thompson, Samuel J Strada. Suppression of cyclic GMP-specific phosphodiesterase 5 promotes apoptosis and inhibits growth in HT29 cells.
Journal of cellular biochemistry.
2005 Feb; 94(2):336-50. doi:
10.1002/jcb.20286. [PMID: 15526282] - Hirokazu Mukuno, Makoto Nakamura, Akiyasu Kanamori, Azusa Nagai, Akira Negi, Gail Seigel. Unoprostone isopropyl rescues retinal progenitor cells from apoptosis in vitro.
Current eye research.
2004 Dec; 29(6):457-64. doi:
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Pflugers Archiv : European journal of physiology.
2004 May; 448(2):197-203. doi:
10.1007/s00424-003-1233-6. [PMID: 14722776] - Lionel Valenti, Jacques Mathieu, Yves Chancerelle, Maryse Levacher, Brigitte Chanaud, Martine De Sousa, Suzanne Strzalko, Anh Tuan Dinh-Xuan, Jean-Paul Giroud, Irène Florentin. Nitric oxide inhibits spleen cell proliferative response after burn injury by inducing cytostasis, apoptosis, and necrosis of activated T lymphocytes: role of the guanylate cyclase.
Cellular immunology.
2003 Jan; 221(1):50-63. doi:
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American journal of physiology. Renal physiology.
2002 Oct; 283(4):F784-91. doi:
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Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2002 Jun; 53(2):211-31. doi:
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The Journal of biological chemistry.
2001 Jun; 276(24):21046-52. doi:
10.1074/jbc.m100901200. [PMID: 11274213] - P A Ortiz, J L Garvin. NO Inhibits NaCl absorption by rat thick ascending limb through activation of cGMP-stimulated phosphodiesterase.
Hypertension (Dallas, Tex. : 1979).
2001 Feb; 37(2 Pt 2):467-71. doi:
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Cardiovascular research.
2001 Feb; 49(2):408-16. doi:
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2000 Nov; 58(5):2069-74. doi:
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The Journal of general physiology.
2000 Aug; 116(2):299-310. doi:
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American journal of physiology. Cell physiology.
2000 Jun; 278(6):C1212-7. doi:
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The American journal of physiology.
1999 12; 277(6):F859-65. doi:
10.1152/ajprenal.1999.277.6.f859. [PMID: 10600932] - M Straznicka, G Gong, L Yan, P M Scholz, H R Weiss. Cyclic GMP protein kinase mediates negative metabolic and functional effects of cyclic GMP in control and hypertrophied rabbit cardiac myocytes.
Journal of cardiovascular pharmacology.
1999 Aug; 34(2):229-36. doi:
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1999 Aug; 73(2):532-7. doi:
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The Japanese journal of physiology.
1998 Dec; 48(6):467-76. doi:
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