LFM-A13 (BioDeep_00000393614)

   


代谢物信息卡片


(Z)-2-cyano-N-(2,5-dibromophenyl)-3-hydroxybut-2-enamide

化学式: C11H8Br2N2O2 (357.89524679999994)
中文名称: 2-氰基-N-(2,5-二溴苯基)-3-羟基-2-丁烯酰胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=C(C#N)C(=O)NC1=C(C=CC(=C1)Br)Br)O
InChI: InChI=1S/C11H8Br2N2O2/c1-6(16)8(5-14)11(17)15-10-4-7(12)2-3-9(10)13/h2-4,16H,1H3,(H,15,17)/b8-6-

描述信息

同义名列表

3 个代谢物同义名

(Z)-2-cyano-N-(2,5-dibromophenyl)-3-hydroxybut-2-enamide; LFM-A13; 2Z-cyano-N-(2,5-dibromophenyl)3-hydroxy-2-butenamide



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Simantini Ghosh, Zaidan Mohammed, Itender Singh. Bruton's tyrosine kinase drives neuroinflammation and anxiogenic behavior in mouse models of stress. Journal of neuroinflammation. 2021 Dec; 18(1):289. doi: 10.1186/s12974-021-02322-9. [PMID: 34895246]
  • Wei Zhang, Ping Zhou, Xiao Jiang, Zhe Fan, Xingxin Xu, Fei Wang. Negative Regulation of Tec Kinase Alleviates LPS-Induced Acute Kidney Injury in Mice via theTLR4/NF-κB Signaling Pathway. BioMed research international. 2020; 2020(?):3152043. doi: 10.1155/2020/3152043. [PMID: 32685466]
  • Yiteng Meng, Shuo Sha, Jing Yang, Hongbo Ren. Effects of Tec Tyrosine Kinase Inhibition on the Inflammatory Response of Severe Acute Pancreatitis-Associated Acute Lung Injury in Mice. Digestive diseases and sciences. 2019 08; 64(8):2167-2176. doi: 10.1007/s10620-019-05524-7. [PMID: 30761473]
  • Irene Guendel, Sergey Iordanskiy, Gavin C Sampey, Rachel Van Duyne, Valerie Calvert, Emanuel Petricoin, Mohammed Saifuddin, Kylene Kehn-Hall, Fatah Kashanchi. Role of Bruton's tyrosine kinase inhibitors in HIV-1-infected cells. Journal of neurovirology. 2015 Jun; 21(3):257-75. doi: 10.1007/s13365-015-0323-5. [PMID: 25672887]
  • Rakesh Bam, Wen Ling, Sharmin Khan, Angela Pennisi, Sathisha Upparahalli Venkateshaiah, Xin Li, Frits van Rhee, Saad Usmani, Bart Barlogie, John Shaughnessy, Joshua Epstein, Shmuel Yaccoby. Role of Bruton's tyrosine kinase in myeloma cell migration and induction of bone disease. American journal of hematology. 2013 Jun; 88(6):463-71. doi: 10.1002/ajh.23433. [PMID: 23456977]
  • Stuart A Rushworth, Kristian M Bowles, Lawrence N Barrera, Megan Y Murray, Lyubov Zaitseva, David J MacEwan. BTK inhibitor ibrutinib is cytotoxic to myeloma and potently enhances bortezomib and lenalidomide activities through NF-κB. Cellular signalling. 2013 Jan; 25(1):106-12. doi: 10.1016/j.cellsig.2012.09.008. [PMID: 22975686]
  • Fatih M Uckun, Ilker Dibirdik, Sanjive Qazi, Alexei Vassilev, Hong Ma, Chen Mao, Alexey Benyumov, Katayoon H Emami. Anti-breast cancer activity of LFM-A13, a potent inhibitor of Polo-like kinase (PLK). Bioorganic & medicinal chemistry. 2007 Jan; 15(2):800-14. doi: 10.1016/j.bmc.2006.10.050. [PMID: 17098432]
  • Fatih M Uckun, Heather Tibbles, Taracad Venkatachalam, Darin DuMez, Douglas Erbeck. Preclinical toxicity and pharmacokinetics of the Bruton's tyrosine kinase-targeting anti-leukemic drug candidate, alpha-cyano-beta-hydroxy-beta-methyl-N- (2,5-dibromophenyl) propenamide (LFM-A13). Arzneimittel-Forschung. 2007; 57(1):31-46. doi: 10.1055/s-0031-1296583. [PMID: 17341007]
  • Pedro C Redondo, Matthew T Harper, Juan A Rosado, Stewart O Sage. A role for cofilin in the activation of store-operated calcium entry by de novo conformational coupling in human platelets. Blood. 2006 Feb; 107(3):973-9. doi: 10.1182/blood-2005-05-2015. [PMID: 16234361]
  • Maria J G Fernandes, Geneviève Lachance, Guillaume Paré, Emmanuelle Rollet-Labelle, Paul H Naccache. Signaling through CD16b in human neutrophils involves the Tec family of tyrosine kinases. Journal of leukocyte biology. 2005 Aug; 78(2):524-32. doi: 10.1189/jlb.0804479. [PMID: 15899983]
  • Caroline Gilbert, Sylvain Levasseur, Philippe Desaulniers, Andrée-Anne Dusseault, Nathalie Thibault, Sylvain G Bourgoin, Paul H Naccache. Chemotactic factor-induced recruitment and activation of Tec family kinases in human neutrophils. II. Effects of LFM-A13, a specific Btk inhibitor. Journal of immunology (Baltimore, Md. : 1950). 2003 May; 170(10):5235-43. doi: 10.4049/jimmunol.170.10.5235. [PMID: 12734372]
  • Fatih M Uckun, Yaguo Zheng, Marina Cetkovic-Cvrlje, Alexei Vassilev, Elizabeth Lisowski, Barbara Waurzyniak, Hao Chen, Randy Carpenter, Chun-Lin Chen. In vivo pharmacokinetic features, toxicity profile, and chemosensitizing activity of alpha-cyano-beta-hydroxy-beta- methyl-N-(2,5-dibromophenyl)propenamide (LFM-A13), a novel antileukemic agent targeting Bruton's tyrosine kinase. Clinical cancer research : an official journal of the American Association for Cancer Research. 2002 May; 8(5):1224-33. doi: NULL. [PMID: 12006542]