capsazepine (BioDeep_00000393586)
代谢物信息卡片
N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide
化学式: C19H21ClN2O2S (376.10121960000004)
中文名称: 辣椒平
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC2=CC(=C(C=C2CN(C1)C(=S)NCCC3=CC=C(C=C3)Cl)O)O
InChI: InChI=1S/C19H21ClN2O2S/c20-16-5-3-13(4-6-16)7-8-21-19(25)22-9-1-2-14-10-17(23)18(24)11-15(14)12-22/h3-6,10-11,23-24H,1-2,7-9,12H2,(H,21,25)
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:70773
- PubChem: 2733484
- Metlin: METLIN45065
- ChEMBL: CHEMBL391997
- CAS: 138977-28-3
- PMhub: MS000243947
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Meihao Peng, Jintao Li, Jie Zhou, Bowen Zhang, Jiaqing Liao, Di Yang, Yu Wang, Yixi Yang, Rui Li, Xue Tang, Qiuxia Lu, Qi Zhao. Total alkaloids of Fritillaria unibracteata var. wabuensis bulbus ameliorate chronic asthma via the TRPV1/Ca2+/NFAT pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Jul; 118(?):154946. doi:
10.1016/j.phymed.2023.154946. [PMID: 37421766] - Henning Hagmann, Naghmeh Hassanzadeh Khayyat, Mahsa Matin, Cem Oezel, He Chen, Astrid Schauss, Christoph Schell, Thomas Benzing, Stuart Dryer, Paul T Brinkkoetter. Capsazepine (CPZ) Inhibits TRPC6 Conductance and Is Protective in Adriamycin-Induced Nephropathy and Diabetic Glomerulopathy.
Cells.
2023 01; 12(2):. doi:
10.3390/cells12020271. [PMID: 36672207] - Rui-Kun Zhang, Kun Yan, Hai-Feng Chen, Yang Zhang, Gui-Jin Li, Xiao-Gang Chen, Lin-Pu Ge, Feng Cheng, Zhi-Neng Chen, Xin-Miao Yao. Anti-osteoporotic drugs affect the pathogenesis of gut microbiota and its metabolites: a clinical study.
Frontiers in cellular and infection microbiology.
2023; 13(?):1091083. doi:
10.3389/fcimb.2023.1091083. [PMID: 37475958] - Gerlânia de Oliveira Leite, Sacha Aubrey Alves Rodrigues Santos, Romério Rodrigues Dos Santos Silva, Claudener Souza Teixeira, Adriana Rolim Campos. Parkia platycephala Lectin (PPL) Inhibits Orofacial Nociception Responses via TRPV1 Modulation.
Molecules (Basel, Switzerland).
2022 Nov; 27(21):. doi:
10.3390/molecules27217506. [PMID: 36364332] - Maki Mizogami, Hironori Tsuchiya. Membrane Interactivity of Capsaicin Antagonized by Capsazepine.
International journal of molecular sciences.
2022 Apr; 23(7):. doi:
10.3390/ijms23073971. [PMID: 35409329] - Mayara Alves Amorim, Janiana Raíza Jentsch Matias de Oliveira, Vitor Hélio Souza Oliveira, Daniela Almeida Cabrini, Michel Fleith Otuki, Eunice André. Role of nitric oxide, bradykinin B2 receptor, and TRPV1 in the airway alterations caused by simvastatin in rats.
European journal of pharmacology.
2021 Dec; 912(?):174591. doi:
10.1016/j.ejphar.2021.174591. [PMID: 34710369] - Suk-Yun Kang, Su Yeon Seo, Se Kyun Bang, Seong Jin Cho, Kwang-Ho Choi, Yeonhee Ryu. Inhibition of Spinal TRPV1 Reduces NMDA Receptor 2B Phosphorylation and Produces Anti-Nociceptive Effects in Mice with Inflammatory Pain.
International journal of molecular sciences.
2021 Oct; 22(20):. doi:
10.3390/ijms222011177. [PMID: 34681836] - Stewart Christie, Vladimir Zagorodnyuk. CB2 cannabinoid receptor agonist selectively inhibits the mechanosensitivity of mucosal afferents in the guinea pig bladder.
American journal of physiology. Renal physiology.
2021 05; 320(5):F859-F865. doi:
10.1152/ajprenal.00065.2021. [PMID: 33749323] - Sara AlMarabeh, Julie O'Neill, Jeremy Cavers, Eric F Lucking, Ken D O'Halloran, Mohammed H Abdulla. Chronic intermittent hypoxia impairs diuretic and natriuretic responses to volume expansion in rats with preserved low-pressure baroreflex control of the kidney.
American journal of physiology. Renal physiology.
2021 01; 320(1):F1-F16. doi:
10.1152/ajprenal.00377.2020. [PMID: 33166181] - Francisca Crislândia Oliveira Silva, Jane Eire Silva Alencar de Menezes, Maria Kueirislene Amâncio Ferreira, Antonio Wlisses da Silva, Carlos Leone Alves Holanda, Joyce Dos Reis Lima, Adriana Rolim Campos, Francisco Flávio Vasconcelos Evaristo, Edson Holanda Teixeira, Francisco Ernani Alves Magalhães, Paulo Nogueira Bandeira, Hélcio Silva Dos Santos. Antinociceptive activity of 3β-6β-16β-trihydroxylup-20 (29)-ene triterpene isolated from Combretum leprosum leaves in adult zebrafish (Danio rerio).
Biochemical and biophysical research communications.
2020 12; 533(3):362-367. doi:
10.1016/j.bbrc.2020.07.107. [PMID: 32962857] - Renata de Souza Sampaio, Emmily Petícia do Nascimento, Irwin Rose Alencar de Menezes, Valterlúcio Dos Santos Sales, Anita Oliveira Brito Pereira, Giovana Mendes de Lacerda, Enaide Soares Santos, Maria Janice Pereira Lopes, Luanna Gomes da Silva, Gyllyandeson de Araújo Delmondes, Nélio Barreto Vieira, Victor Mantoani Zaia, Daniel Souza Bezerra, José Galberto Martins da Costa, Cícero Francisco Bezerra Felipe, Marta Regina Kerntopf. Antinociceptive activity of the Psidium brownianum Mart ex DC. leaf essential oil in mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2020 Jan; 135(?):111053. doi:
10.1016/j.fct.2019.111053. [PMID: 31857126] - Juan Carlos Torres-Narváez, Israel Pérez-Torres, Vicente Castrejón-Téllez, Elvira Varela-López, Víctor Hugo Oidor-Chan, Verónica Guarner-Lans, Álvaro Vargas-González, Raúl Martínez-Memije, Pedro Flores-Chávez, Etzna Zizith Cervantes-Yañez, Claudia Angélica Soto-Peredo, Gustavo Pastelín-Hernández, Leonardo Del Valle-Mondragón. The Role of the Activation of the TRPV1 Receptor and of Nitric Oxide in Changes in Endothelial and Cardiac Function and Biomarker Levels in Hypertensive Rats.
International journal of environmental research and public health.
2019 09; 16(19):. doi:
10.3390/ijerph16193576. [PMID: 31557799] - Vivek Krishnan, Padmamalini Baskaran, Baskaran Thyagarajan. Troglitazone activates TRPV1 and causes deacetylation of PPARγ in 3T3-L1 cells.
Biochimica et biophysica acta. Molecular basis of disease.
2019 02; 1865(2):445-453. doi:
10.1016/j.bbadis.2018.11.004. [PMID: 30496795] - Renata Czekaj, Jolanta Majka, Katarzyna Magierowska, Zbigniew Sliwowski, Marcin Magierowski, Robert Pajdo, Agata Ptak-Belowska, Marcin Surmiak, Slawomir Kwiecien, Tomasz Brzozowski. Mechanisms of curcumin-induced gastroprotection against ethanol-induced gastric mucosal lesions.
Journal of gastroenterology.
2018 May; 53(5):618-630. doi:
10.1007/s00535-017-1385-3. [PMID: 28856444] - Marcin Magierowski, Magdalena Hubalewska-Mazgaj, Katarzyna Magierowska, Dagmara Wojcik, Zbigniew Sliwowski, Slawomir Kwiecien, Tomasz Brzozowski. Nitric oxide, afferent sensory nerves, and antioxidative enzymes in the mechanism of protection mediated by tricarbonyldichlororuthenium(II) dimer and sodium hydrosulfide against aspirin-induced gastric damage.
Journal of gastroenterology.
2018 01; 53(1):52-63. doi:
10.1007/s00535-017-1323-4. [PMID: 28238019] - Yelena Nersesyan, Lusine Demirkhanyan, Deny Cabezas-Bratesco, Victoria Oakes, Ricardo Kusuda, Tyler Dawson, Xiaohui Sun, Chike Cao, Alejandro Martin Cohen, Bharath Chelluboina, Krishna Kumar Veeravalli, Katharina Zimmermann, Carmen Domene, Sebastian Brauchi, Eleonora Zakharian. Oxytocin Modulates Nociception as an Agonist of Pain-Sensing TRPV1.
Cell reports.
2017 Nov; 21(6):1681-1691. doi:
10.1016/j.celrep.2017.10.063. [PMID: 29117570] - Yiseul Kim, Jung Tae Kim, Joonwoo Park, Hee Jin Son, Eun-Young Kim, Young Joo Lee, Mee-Ra Rhyu. 4,5-Di-O-Caffeoylquinic Acid from Ligularia fischeri Suppresses Inflammatory Responses Through TRPV1 Activation.
Phytotherapy research : PTR.
2017 Oct; 31(10):1564-1570. doi:
10.1002/ptr.5885. [PMID: 28782267] - Daniel J Conklin, Petra Haberzettl, Ganapathy Jagatheesan, Maiying Kong, Gary W Hoyle. Role of TRPA1 in acute cardiopulmonary toxicity of inhaled acrolein.
Toxicology and applied pharmacology.
2017 06; 324(?):61-72. doi:
10.1016/j.taap.2016.08.028. [PMID: 27592100] - Yousuf M Al Suleimani, Ahmed S Al Mahruqi. The endogenous lipid N-arachidonoyl glycine is hypotensive and nitric oxide-cGMP-dependent vasorelaxant.
European journal of pharmacology.
2017 Jan; 794(?):209-215. doi:
10.1016/j.ejphar.2016.11.040. [PMID: 27890711] - Luis Jardelino de Lacerda Neto, Andreza Guedes Barbosa Ramos, Valterlucio Santos Sales, Severino Denicio Gonçalves de Souza, Antonia Thassya Lucas Dos Santos, Larissa Rolim de Oliveira, Marta Regina Kerntopf, Thais Rodrigues de Albuquerque, Henrique Douglas Melo Coutinho, Lucindo Jose Quintans-Júnior, Almir Gonçalves Wanderley, Irwin Rose Alencar de Menezes. Gastroprotective and ulcer healing effects of hydroethanolic extract of leaves of Caryocar coriaceum: Mechanisms involved in the gastroprotective activity.
Chemico-biological interactions.
2017 Jan; 261(?):56-62. doi:
10.1016/j.cbi.2016.11.020. [PMID: 27871896] - Janiana Raíza Jentsch Matias de Oliveira, Michel Fleith Otuki, Daniela Almeida Cabrini, Indiara Brusco, Sara Marchesan Oliveira, Juliano Ferreira, Eunice André. Involvement of the TRPV1 receptor in plasma extravasation in airways of rats treated with an angiotensin-converting enzyme inhibitor.
Pulmonary pharmacology & therapeutics.
2016 12; 41(?):25-33. doi:
10.1016/j.pupt.2016.09.001. [PMID: 27614181] - László Pecze, Walter Blum, Thomas Henzi, Beat Schwaller. Endogenous TRPV1 stimulation leads to the activation of the inositol phospholipid pathway necessary for sustained Ca2+ oscillations.
Biochimica et biophysica acta.
2016 12; 1863(12):2905-2915. doi:
10.1016/j.bbamcr.2016.09.013. [PMID: 27663071] - Ümit Sinan Özdemir, Mustafa Nazıroğlu, Nilgün Şenol, Vahid Ghazizadeh. Hypericum perforatum Attenuates Spinal Cord Injury-Induced Oxidative Stress and Apoptosis in the Dorsal Root Ganglion of Rats: Involvement of TRPM2 and TRPV1 Channels.
Molecular neurobiology.
2016 08; 53(6):3540-3551. doi:
10.1007/s12035-015-9292-1. [PMID: 26099309] - Ying Xiao, Xiaoqi Chen, Ping-An Zhang, Qiya Xu, Hang Zheng, Guang-Yin Xu. TRPV1-mediated presynaptic transmission in basolateral amygdala contributes to visceral hypersensitivity in adult rats with neonatal maternal deprivation.
Scientific reports.
2016 07; 6(?):29026. doi:
10.1038/srep29026. [PMID: 27364923] - Katrin Kistner, Norbert Siklosi, Alexandru Babes, Mohammad Khalil, Tudor Selescu, Katharina Zimmermann, Stefan Wirtz, Christoph Becker, Markus F Neurath, Peter W Reeh, Matthias A Engel. Systemic desensitization through TRPA1 channels by capsazepine and mustard oil - a novel strategy against inflammation and pain.
Scientific reports.
2016 06; 6(?):28621. doi:
10.1038/srep28621. [PMID: 27356469] - Katarzyna Socała, Piotr Wlaź. Evaluation of the antidepressant- and anxiolytic-like activity of α-spinasterol, a plant derivative with TRPV1 antagonistic effects, in mice.
Behavioural brain research.
2016 Apr; 303(?):19-25. doi:
10.1016/j.bbr.2016.01.048. [PMID: 26808607] - R Czekaj, J Majka, A Ptak-Belowska, A Szlachcic, A Targosz, K Magierowska, M Strzalka, M Magierowski, T Brzozowski. Role of curcumin in protection of gastric mucosa against stress-induced gastric mucosal damage. Involvement of hypoacidity, vasoactive mediators and sensory neuropeptides.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2016 Apr; 67(2):261-75. doi:
. [PMID: 27226186] - Satoshi Murakami, Yuka Sudo, Kanako Miyano, Hitomi Nishimura, Motohiro Matoba, Seiji Shiraishi, Hiroki Konno, Yasuhito Uezono. Tris-hydroxymethyl-aminomethane enhances capsaicin-induced intracellular Ca(2+) influx through transient receptor potential V1 (TRPV1) channels.
Journal of pharmacological sciences.
2016 Feb; 130(2):72-7. doi:
10.1016/j.jphs.2015.11.009. [PMID: 26738986] - Emiko Iwaoka, Shenglan Wang, Nobuyuki Matsuyoshi, Yoko Kogure, Shunji Aoki, Satoshi Yamamoto, Koichi Noguchi, Yi Dai. Evodiamine suppresses capsaicin-induced thermal hyperalgesia through activation and subsequent desensitization of the transient receptor potential V1 channels.
Journal of natural medicines.
2016 Jan; 70(1):1-7. doi:
10.1007/s11418-015-0929-1. [PMID: 26188960] - Yuanyuan Zhang, Qiang Chen, Zewei Sun, Jie Han, Lihong Wang, Liangrong Zheng. Impaired capsaicin-induced relaxation in diabetic mesenteric arteries.
Journal of diabetes and its complications.
2015 Aug; 29(6):747-54. doi:
10.1016/j.jdiacomp.2015.05.005. [PMID: 26055306] - Qin Kang, Chang-Yu Jiang, Tsugumi Fujita, Eiichi Kumamoto. Spontaneous L-glutamate release enhancement in rat substantia gelatinosa neurons by (-)-carvone and (+)-carvone which activate different types of TRP channel.
Biochemical and biophysical research communications.
2015 Apr; 459(3):498-503. doi:
10.1016/j.bbrc.2015.02.135. [PMID: 25747716] - Viksita Vijayvergiya, Shiv Acharya, Sidney P Wilson, Jacob J Schmidt. Measurement of Ensemble TRPV1 Ion Channel Currents Using Droplet Bilayers.
PloS one.
2015; 10(10):e0141366. doi:
10.1371/journal.pone.0141366. [PMID: 26513481] - Francesca Borrelli, Barbara Romano, Stefania Petrosino, Ester Pagano, Raffaele Capasso, Diana Coppola, Giovanni Battista, Pierangelo Orlando, Vincenzo Di Marzo, Angelo A Izzo. Palmitoylethanolamide, a naturally occurring lipid, is an orally effective intestinal anti-inflammatory agent.
British journal of pharmacology.
2015 Jan; 172(1):142-58. doi:
10.1111/bph.12907. [PMID: 25205418] - Alexey M Petrov, Anastasiya A Yakovleva, Andrey L Zefirov. Role of membrane cholesterol in spontaneous exocytosis at frog neuromuscular synapses: reactive oxygen species-calcium interplay.
The Journal of physiology.
2014 Nov; 592(22):4995-5009. doi:
10.1113/jphysiol.2014.279695. [PMID: 25326454] - Jessica A Fawley, Mackenzie E Hofmann, Michael C Andresen. Cannabinoid 1 and transient receptor potential vanilloid 1 receptors discretely modulate evoked glutamate separately from spontaneous glutamate transmission.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2014 Jun; 34(24):8324-32. doi:
10.1523/jneurosci.0315-14.2014. [PMID: 24920635] - G Chung, S T Im, Y H Kim, S J Jung, M-R Rhyu, S B Oh. Activation of transient receptor potential ankyrin 1 by eugenol.
Neuroscience.
2014 Mar; 261(?):153-60. doi:
10.1016/j.neuroscience.2013.12.047. [PMID: 24384226] - Yeranddy A Alpizar, Brett Boonen, Maarten Gees, Alicia Sanchez, Bernd Nilius, Thomas Voets, Karel Talavera. Allyl isothiocyanate sensitizes TRPV1 to heat stimulation.
Pflugers Archiv : European journal of physiology.
2014 Mar; 466(3):507-15. doi:
10.1007/s00424-013-1334-9. [PMID: 23955021] - Yuko Terada, Syunji Horie, Hiromitsu Takayama, Kunitoshi Uchida, Makoto Tominaga, Tatsuo Watanabe. Activation and inhibition of thermosensitive TRP channels by voacangine, an alkaloid present in Voacanga africana, an African tree.
Journal of natural products.
2014 Feb; 77(2):285-97. doi:
10.1021/np400885u. [PMID: 24484240] - Ritesh K Baboota, Dhirendra P Singh, Siddhartha M Sarma, Jaspreet Kaur, Rajat Sandhir, Ravneet K Boparai, Kanthi K Kondepudi, Mahendra Bishnoi. Capsaicin induces 'brite' phenotype in differentiating 3T3-L1 preadipocytes.
PloS one.
2014; 9(7):e103093. doi:
10.1371/journal.pone.0103093. [PMID: 25072597] - Elizabeth S Fernandes, Carolina X L Brito, Simone A Teixeira, Renato Barboza, Aramys S dos Reis, Ana Paula S Azevedo-Santos, Marcelo Muscará, Soraia K P Costa, Claudio R F Marinho, Susan D Brain, Marcos A G Grisotto. TRPV1 antagonism by capsazepine modulates innate immune response in mice infected with Plasmodium berghei ANKA.
Mediators of inflammation.
2014; 2014(?):506450. doi:
10.1155/2014/506450. [PMID: 25242870] - Lan Chen, Lajos Markó, Mario Kaßmann, Ye Zhu, Kaiyin Wu, Maik Gollasch. Role of TRPV1 channels in ischemia/reperfusion-induced acute kidney injury.
PloS one.
2014; 9(10):e109842. doi:
10.1371/journal.pone.0109842. [PMID: 25330307] - Rodrigo José de Siqueira, Karilane Maria Silvino Rodrigues, Moisés Tolentino Bento da Silva, Carlos Antônio Barros Correia Junior, Gloria Pinto Duarte, Pedro Jorge Caldas Magalhães, Armênio Aguiar dos Santos, José Guilherme Soares Maia, Pergentino José Sousa da Cunha, Saad Lahlou. Linalool-rich rosewood oil induces vago-vagal bradycardic and depressor reflex in rats.
Phytotherapy research : PTR.
2014 Jan; 28(1):42-8. doi:
10.1002/ptr.4953. [PMID: 23447129] - Yasser A Mahmmoud, Michael Shattock, Flemming Cornelius, Davor Pavlovic. Inhibition of K+ transport through Na+, K+-ATPase by capsazepine: role of membrane span 10 of the α-subunit in the modulation of ion gating.
PloS one.
2014; 9(5):e96909. doi:
10.1371/journal.pone.0096909. [PMID: 24816799] - Daisuke Kikuchi, Chikashi Shibata, Hirofumi Imoto, Takeshi Naitoh, Koh Miura, Michiaki Unno. Intragastric Dai-Kenchu-To, a Japanese herbal medicine, stimulates colonic motility via transient receptor potential cation channel subfamily V member 1 in dogs.
The Tohoku journal of experimental medicine.
2013 08; 230(4):197-204. doi:
10.1620/tjem.230.197. [PMID: 23892797] - M Nazıroğlu, B Ciğ, C Ozgül. Neuroprotection induced by N-acetylcysteine against cytosolic glutathione depletion-induced Ca2+ influx in dorsal root ganglion neurons of mice: role of TRPV1 channels.
Neuroscience.
2013 Jul; 242(?):151-60. doi:
10.1016/j.neuroscience.2013.03.032. [PMID: 23545271] - Jin-Feng Zhao, Li-Chieh Ching, Yu Ru Kou, Shing-Jong Lin, Jeng Wei, Song-Kun Shyue, Tzong-Shyuan Lee. Activation of TRPV1 prevents OxLDL-induced lipid accumulation and TNF-α-induced inflammation in macrophages: role of liver X receptor α.
Mediators of inflammation.
2013; 2013(?):925171. doi:
10.1155/2013/925171. [PMID: 23878415] - Zohar Bromberg, Pierre Goloubinoff, Younousse Saidi, Yoram George Weiss. The membrane-associated transient receptor potential vanilloid channel is the central heat shock receptor controlling the cellular heat shock response in epithelial cells.
PloS one.
2013; 8(2):e57149. doi:
10.1371/journal.pone.0057149. [PMID: 23468922] - Shivani Ruparel, Dustin Green, Paul Chen, Kenneth M Hargreaves. The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain.
Molecular pain.
2012 Sep; 8(?):73. doi:
10.1186/1744-8069-8-73. [PMID: 23006841] - Gilberto Santos Cerqueira, Gabriela dos Santos e Silva, Emiliano Rios Vasconcelos, Ana Paula Fragoso de Freitas, Brinell Arcanjo Moura, Danielle Silveira Macedo, Augusto Lopes Souto, José Maria Barbosa Filho, Luzia Kalyne de Almeida Leal, Gerly Anne de Castro Brito, Caden Souccar, Glauce Socorro de Barros Viana. Effects of hecogenin and its possible mechanism of action on experimental models of gastric ulcer in mice.
European journal of pharmacology.
2012 May; 683(1-3):260-9. doi:
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Fitoterapia.
2012 Apr; 83(3):604-8. doi:
10.1016/j.fitote.2012.01.005. [PMID: 22285860] - Chihiro Haruta. [Effects of anandamide on IL-11 production through the TRPV1 of human periodontal ligament cells].
Kokubyo Gakkai zasshi. The Journal of the Stomatological Society, Japan.
2012 Mar; 79(1):7-14. doi:
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Anais da Academia Brasileira de Ciencias.
2012 Mar; 84(1):113-22. doi:
10.1590/s0001-37652012000100011. [PMID: 22441600] - Rita Benko, Lászlo Illényi, Dezsö Kelemen, Robert Papp, András Papp, Loránd Bartho. Use and limitations of three TRPV-1 receptor antagonists on smooth muscles of animals and man: a vote for BCTC.
European journal of pharmacology.
2012 Jan; 674(1):44-50. doi:
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Planta medica.
2012 Jan; 78(1):24-30. doi:
10.1055/s-0031-1280217. [PMID: 21928164] - Yu-Sang Li, Jun-Xian Wang, Mei-Mei Jia, Min Liu, Xiao-Jun Li, He-Bin Tang. Dragon's blood inhibits chronic inflammatory and neuropathic pain responses by blocking the synthesis and release of substance P in rats.
Journal of pharmacological sciences.
2012; 118(1):43-54. doi:
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Islets.
2012 Jan; 4(1):56-63. doi:
10.4161/isl.18915. [PMID: 22274646] - Claudia Osycka-Salut, María Gracia Gervasi, Elba Pereyra, Maximiliano Cella, María Laura Ribeiro, Ana María Franchi, Silvina Perez-Martinez. Anandamide induces sperm release from oviductal epithelia through nitric oxide pathway in bovines.
PloS one.
2012; 7(2):e30671. doi:
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The Journal of physiology.
2011 Dec; 589(Pt 24):6191-204. doi:
10.1113/jphysiol.2011.214429. [PMID: 22025666] - Liqun Ma, Jian Zhong, Zhigang Zhao, Zhidan Luo, Shuangtao Ma, Jing Sun, Hongbo He, Tianqi Zhu, Daoyan Liu, Zhiming Zhu, Martin Tepel. Activation of TRPV1 reduces vascular lipid accumulation and attenuates atherosclerosis.
Cardiovascular research.
2011 Dec; 92(3):504-13. doi:
10.1093/cvr/cvr245. [PMID: 21908651] - Bárbara Frias, Tiago Lopes, Rui Pinto, Francisco Cruz, Célia Duarte Cruz. Neurotrophins in the lower urinary tract: becoming of age.
Current neuropharmacology.
2011 Dec; 9(4):553-8. doi:
10.2174/157015911798376253. [PMID: 22654715] - K Weller, P W Reeh, S K Sauer. TRPV1, TRPA1, and CB1 in the isolated vagus nerve--axonal chemosensitivity and control of neuropeptide release.
Neuropeptides.
2011 Dec; 45(6):391-400. doi:
10.1016/j.npep.2011.07.011. [PMID: 21868092] - Suaib Luqman, Abha Meena, Laura E Marler, Tamara P Kondratyuk, John M Pezzuto. Suppression of tumor necrosis factor-α-induced nuclear factor κB activation and aromatase activity by capsaicin and its analog capsazepine.
Journal of medicinal food.
2011 Nov; 14(11):1344-51. doi:
10.1089/jmf.2010.0236. [PMID: 21663483] - Amr A Fouad, Mohamed T Yacoubi. Mechanisms underlying the protective effect of eugenol in rats with acute doxorubicin cardiotoxicity.
Archives of pharmacal research.
2011 May; 34(5):821-8. doi:
10.1007/s12272-011-0516-2. [PMID: 21656368] - Sarah R Wilson, Kristin A Gerhold, Amber Bifolck-Fisher, Qin Liu, Kush N Patel, Xinzhong Dong, Diana M Bautista. TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch.
Nature neuroscience.
2011 May; 14(5):595-602. doi:
10.1038/nn.2789. [PMID: 21460831] - Raffaele Capasso, Gabriella Aviello, Francesca Borrelli, Barbara Romano, Matteo Ferro, Luigi Castaldo, Vittorino Montanaro, Vincenzo Altieri, Angelo A Izzo. Inhibitory effect of standardized cannabis sativa extract and its ingredient cannabidiol on rat and human bladder contractility.
Urology.
2011 Apr; 77(4):1006.e9-1006.e15. doi:
10.1016/j.urology.2010.12.006. [PMID: 21310467] - Jennifer Douat, Pascal Vachon, Francis Beaudry. Characterization of in vitro metabolism of capsazepine, a vanilloid transient receptor potential channel antagonist, by liquid chromatography quadrupole ion trap mass spectrometry.
Biomedical chromatography : BMC.
2011 Apr; 25(4):479-92. doi:
10.1002/bmc.1471. [PMID: 20586106] - Anoland Garateix, Emilio Salceda, Roberto Menéndez, Erik L Regalado, Omar López, Teidy García, Ruth A Morales, Abilio Laguna, Olivier P Thomas, Enrique Soto. Antinociception produced by Thalassia testudinum extract BM-21 is mediated by the inhibition of acid sensing ionic channels by the phenolic compound thalassiolin B.
Molecular pain.
2011 Jan; 7(?):10. doi:
10.1186/1744-8069-7-10. [PMID: 21261973] - Eva M Marco, María S García-Gutiérrez, Francisco-Javier Bermúdez-Silva, Fabricio A Moreira, Francisco Guimarães, Jorge Manzanares, María-Paz Viveros. Endocannabinoid system and psychiatry: in search of a neurobiological basis for detrimental and potential therapeutic effects.
Frontiers in behavioral neuroscience.
2011; 5(?):63. doi:
10.3389/fnbeh.2011.00063. [PMID: 22007164] - Phillip Edward Kunkler, Carrie Jo Ballard, Gerry Stephen Oxford, Joyce Harts Hurley. TRPA1 receptors mediate environmental irritant-induced meningeal vasodilatation.
Pain.
2011 Jan; 152(1):38-44. doi:
10.1016/j.pain.2010.08.021. [PMID: 21075522] - Laurie Hamtiaux, Laurie Hansoulle, Nicolas Dauguet, Giulio G Muccioli, Bernard Gallez, Didier M Lambert. Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism.
PloS one.
2011; 6(10):e26823. doi:
10.1371/journal.pone.0026823. [PMID: 22046372] - Seah-Fang Ang, Shabbir M Moochhala, Paul A MacAry, Madhav Bhatia. Hydrogen sulfide and neurogenic inflammation in polymicrobial sepsis: involvement of substance P and ERK-NF-κB signaling.
PloS one.
2011; 6(9):e24535. doi:
10.1371/journal.pone.0024535. [PMID: 21931742] - Mauro Leonelli, Daniel O Martins, Luiz R G Britto. TRPV1 receptors are involved in protein nitration and Müller cell reaction in the acutely axotomized rat retina.
Experimental eye research.
2010 Nov; 91(5):755-68. doi:
10.1016/j.exer.2010.08.026. [PMID: 20826152] - Emiliano Ricardo Vasconcelos Rios, Nayrton Flávio Moura Rocha, Edith Teles Venâncio, Brinell Arcanjo Moura, Mariana Lima Feitosa, Gilberto Santos Cerqueira, Pedro Marcos Gomes Soares, David John Woods, Francisca Cléa Florenço de Sousa, Luzia Kalyne Almeida Moreira Leal, Marta Maria de França Fonteles. Mechanisms involved in the gastroprotective activity of esculin on acute gastric lesions in mice.
Chemico-biological interactions.
2010 Oct; 188(1):246-54. doi:
10.1016/j.cbi.2010.07.020. [PMID: 20678495] - Jens A Lundbaek, Roger E Koeppe, Olaf S Andersen. Amphiphile regulation of ion channel function by changes in the bilayer spring constant.
Proceedings of the National Academy of Sciences of the United States of America.
2010 Aug; 107(35):15427-30. doi:
10.1073/pnas.1007455107. [PMID: 20713738] - Q W Ding, Y Zhang, Y Wang, Y N Wang, L Zhang, C Ding, L L Wu, G Y Yu. Functional vanilloid receptor-1 in human submandibular glands.
Journal of dental research.
2010 Jul; 89(7):711-6. doi:
10.1177/0022034510366841. [PMID: 20371865] - Zhi Zhou, Jun Peng, Chen-Jing Wang, Dai Li, Ting-Ting Li, Chang-Ping Hu, Xiao-Ping Chen, Yuan-Jian Li. Accelerated senescence of endothelial progenitor cells in hypertension is related to the reduction of calcitonin gene-related peptide.
Journal of hypertension.
2010 May; 28(5):931-9. doi:
10.1097/hjh.0b013e3283399326. [PMID: 20375903] - Zhen-Zhong Xu, Ling Zhang, Tong Liu, Jong Yeon Park, Temugin Berta, Rong Yang, Charles N Serhan, Ru-Rong Ji. Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions.
Nature medicine.
2010 May; 16(5):592-7, 1p following 597. doi:
10.1038/nm.2123. [PMID: 20383154] - Zhiqian Tong, Wenhong Luo, Yanqing Wang, Fei Yang, Ying Han, Hui Li, Hongjun Luo, Bo Duan, Tianle Xu, Qiliang Maoying, Huangying Tan, Jun Wang, Hongmei Zhao, Fengyu Liu, You Wan. Tumor tissue-derived formaldehyde and acidic microenvironment synergistically induce bone cancer pain.
PloS one.
2010 Apr; 5(4):e10234. doi:
10.1371/journal.pone.0010234. [PMID: 20422007] - Ji-Hye Kang, Tsuyoshi Goto, In-Seob Han, Teruo Kawada, Young Min Kim, Rina Yu. Dietary capsaicin reduces obesity-induced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet.
Obesity (Silver Spring, Md.).
2010 Apr; 18(4):780-7. doi:
10.1038/oby.2009.301. [PMID: 19798065] - Patrícia de Araújo Rodrigues, Selene Maia de Morais, Carolina Melo de Souza, Ana Raquel Araújo Silva, Geanne Matos de Andrade, Maria Goretti Vasconcelos Silva, Roberto Lima Albuquerque, Vietla Satyanarayana Rao, Flávia Almeida Santos. Gastroprotective effect of barbatusin and 3-beta-hydroxy-3-deoxibarbatusin, quinonoid diterpenes isolated from Plectranthus grandis, in ethanol-induced gastric lesions in mice.
Journal of ethnopharmacology.
2010 Feb; 127(3):725-30. doi:
10.1016/j.jep.2009.11.031. [PMID: 20025953] - Linda Chularojmontri, Maneewan Suwatronnakorn, Suvara K Wattanapitayakul. Influence of capsicum extract and capsaicin on endothelial health.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet.
2010 Feb; 93 Suppl 2(?):S92-101. doi:
". [PMID: 21302401] - Seah-Fang Ang, Shabbir M Moochhala, Madhav Bhatia. Hydrogen sulfide promotes transient receptor potential vanilloid 1-mediated neurogenic inflammation in polymicrobial sepsis.
Critical care medicine.
2010 Feb; 38(2):619-28. doi:
10.1097/ccm.0b013e3181c0df00. [PMID: 19851090] - Maria Teresa Cencioni, Valerio Chiurchiù, Giuseppina Catanzaro, Giovanna Borsellino, Giorgio Bernardi, Luca Battistini, Mauro Maccarrone. Anandamide suppresses proliferation and cytokine release from primary human T-lymphocytes mainly via CB2 receptors.
PloS one.
2010 Jan; 5(1):e8688. doi:
10.1371/journal.pone.0008688. [PMID: 20098669] - Humberto M Spindola, Leila Servat, Carina Denny, Rodney A F Rodrigues, Marcos N Eberlin, Elaine Cabral, Ilza M O Sousa, Jorge Y Tamashiro, João E Carvalho, Mary A Foglio. Antinociceptive effect of geranylgeraniol and 6alpha,7beta-dihydroxyvouacapan-17beta-oate methyl ester isolated from Pterodon pubescens Benth.
BMC pharmacology.
2010 Jan; 10(?):1. doi:
10.1186/1471-2210-10-1. [PMID: 20055987] - Cristian Neacsu, Alexandru Babes. The M-channel blocker linopirdine is an agonist of the capsaicin receptor TRPV1.
Journal of pharmacological sciences.
2010; 114(3):332-40. doi:
10.1254/jphs.10172fp. [PMID: 21099148] - Feng Sui, Hai-Ru Huo, Chang-Bin Zhang, Na Yang, Jian-You Guo, Xin-Liang Du, Bao-Sheng Zhao, Hong-Bin Liu, Lan-Fang Li, Shu-Ying Guo, Ting-Liang Jiang. Emodin down-regulates expression of TRPV1 mRNA and its function in DRG neurons in vitro.
The American journal of Chinese medicine.
2010; 38(4):789-800. doi:
10.1142/s0192415x1000824x. [PMID: 20626063] - Nuria Olea-Herrero, Diana Vara, Sophie Malagarie-Cazenave, Inés Díaz-Laviada. The cannabinoid R+ methanandamide induces IL-6 secretion by prostate cancer PC3 cells.
Journal of immunotoxicology.
2009 Dec; 6(4):249-56. doi:
10.3109/15476910903241696. [PMID: 19908944] - Ting Wang, Youxue Wang, Hitoshi Yamashita. Evodiamine inhibits adipogenesis via the EGFR-PKCalpha-ERK signaling pathway.
FEBS letters.
2009 Nov; 583(22):3655-9. doi:
10.1016/j.febslet.2009.10.046. [PMID: 19854188] - Tilmann Ditting, Gisa Tiegs, Kristina Rodionova, Peter W Reeh, Winfried Neuhuber, Wolfgang Freisinger, Roland Veelken. Do distinct populations of dorsal root ganglion neurons account for the sensory peptidergic innervation of the kidney?.
American journal of physiology. Renal physiology.
2009 Nov; 297(5):F1427-34. doi:
10.1152/ajprenal.90599.2008. [PMID: 19692481] - Tom Schilling, Claudia Eder. Non-selective cation channel activity is required for lysophosphatidylcholine-induced monocyte migration.
Journal of cellular physiology.
2009 Nov; 221(2):325-34. doi:
10.1002/jcp.21857. [PMID: 19562685] - Naoaki Harada, Nobuhiko Shimozawa, Kenji Okajima. AT(1) receptor blockers increase insulin-like growth factor-I production by stimulating sensory neurons in spontaneously hypertensive rats.
Translational research : the journal of laboratory and clinical medicine.
2009 Sep; 154(3):142-52. doi:
10.1016/j.trsl.2009.06.004. [PMID: 19665690] - R M van den Wijngaard, O Welting, D C Bulmer, M M Wouters, K Lee, W J de Jonge, G E Boeckxstaens. Possible role for TRPV1 in neomycin-induced inhibition of visceral hypersensitivity in rat.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
2009 Aug; 21(8):863-e60. doi:
10.1111/j.1365-2982.2009.01287.x. [PMID: 19298229] - Jin Y Ro, Jong-Seok Lee, Youping Zhang. Activation of TRPV1 and TRPA1 leads to muscle nociception and mechanical hyperalgesia.
Pain.
2009 Aug; 144(3):270-277. doi:
10.1016/j.pain.2009.04.021. [PMID: 19464796] - Akio Mizutani, Kenji Okajima, Kazunori Murakami, Sachiko Mizutani, Kyosuke Kudo, Tetsuya Uchino, Yuji Kadoi, Takayuki Noguchi. Activation of sensory neurons reduces ischemia/reperfusion-induced acute renal injury in rats.
Anesthesiology.
2009 Feb; 110(2):361-9. doi:
10.1097/aln.0b013e3181942f3c. [PMID: 19194162] - Feng Gao, Dexin Sui, R Michael Garavito, R Mark Worden, Donna H Wang. Salt intake augments hypotensive effects of transient receptor potential vanilloid 4: functional significance and implication.
Hypertension (Dallas, Tex. : 1979).
2009 Feb; 53(2):228-35. doi:
10.1161/hypertensionaha.108.117499. [PMID: 19075100] - Debashree Mukherjea, Sarvesh Jajoo, Craig Whitworth, Jennifer R Bunch, Jeremy G Turner, Leonard P Rybak, Vickram Ramkumar. Short interfering RNA against transient receptor potential vanilloid 1 attenuates cisplatin-induced hearing loss in the rat.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2008 Dec; 28(49):13056-65. doi:
10.1523/jneurosci.1307-08.2008. [PMID: 19052196] - Dai Li, Jun Peng, Hong-Ya Xin, Dan Luo, Yi-Shuai Zhang, Zhi Zhou, De-Jian Jiang, Han-Wu Deng, Yuan-Jian Li. Calcitonin gene-related peptide-mediated antihypertensive and anti-platelet effects by rutaecarpine in spontaneously hypertensive rats.
Peptides.
2008 Oct; 29(10):1781-8. doi:
10.1016/j.peptides.2008.06.010. [PMID: 18625276] - Wei Huang, Hui Wang, James J Galligan, Donna H Wang. Transient receptor potential vanilloid subtype 1 channel mediated neuropeptide secretion and depressor effects: role of endoplasmic reticulum associated Ca2+ release receptors in rat dorsal root ganglion neurons.
Journal of hypertension.
2008 Oct; 26(10):1966-75. doi:
10.1097/hjh.0b013e328309eff9. [PMID: 18806620] - Otilia Obreja, Andreas Klusch, Norbert Ponelies, Martin Schmelz, Marlen Petersen. A subpopulation of capsaicin-sensitive porcine dorsal root ganglion neurons is lacking hyperpolarization-activated cyclic nucleotide-gated channels.
European journal of pain (London, England).
2008 Aug; 12(6):775-89. doi:
10.1016/j.ejpain.2007.11.010. [PMID: 18218331]