AG-825 (BioDeep_00000393430)

   


代谢物信息卡片


3-[3-[(2-benzothiazolylthio)methyl]-4-hydroxy-5-methoxyphenyl]-2-cyano-2-propenamide

化学式: C19H15N3O3S2 (397.0555)
中文名称: 酪氨酸磷酸化抑制剂 AG 825
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=CC(=CC(=C1O)CSC2=NC3=CC=CC=C3S2)C=C(C#N)C(=O)N
InChI: InChI=1S/C19H15N3O3S2/c1-25-15-8-11(6-12(9-20)18(21)24)7-13(17(15)23)10-26-19-22-14-4-2-3-5-16(14)27-19/h2-8,23H,10H2,1H3,(H2,21,24)/b12-6+

描述信息

D000970 - Antineoplastic Agents > D020032 - Tyrphostins

同义名列表

3 个代谢物同义名

Tyrphostin AG 825; AG-825; 3-[3-[(2-benzothiazolylthio)methyl]-4-hydroxy-5-methoxyphenyl]-2-cyano-2-propenamide



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • JunJun Ling, Shengyou Yang, Yi Huang, Dongfeng Wei, Weidong Cheng. Identifying key genes, pathways and screening therapeutic agents for manganese-induced Alzheimer disease using bioinformatics analysis. Medicine. 2018 Jun; 97(22):e10775. doi: 10.1097/md.0000000000010775. [PMID: 29851783]
  • Ryuichi Matsukawa, Yoshitaka Hirooka, Koji Ito, Kenji Sunagawa. Inhibition of neuregulin-1/ErbB signaling in the rostral ventrolateral medulla leads to hypertension through reduced nitric oxide synthesis. American journal of hypertension. 2013 Jan; 26(1):51-7. doi: 10.1093/ajh/hps005. [PMID: 23382327]
  • Vladislav Levchenko, Nadezhda N Zheleznova, Tengis S Pavlov, Alain Vandewalle, Patricia D Wilson, Alexander Staruschenko. EGF and its related growth factors mediate sodium transport in mpkCCDc14 cells via ErbB2 (neu/HER-2) receptor. Journal of cellular physiology. 2010 Apr; 223(1):252-9. doi: 10.1002/jcp.22033. [PMID: 20049896]
  • Seok Joon Kwon, Moon Il Kim, Bosung Ku, Lydie Coulombel, Jin-Hwan Kim, Joseph H Shawky, Robert J Linhardt, Jonathan S Dordick. Unnatural polyketide analogues selectively target the HER signaling pathway in human breast cancer cells. Chembiochem : a European journal of chemical biology. 2010 Mar; 11(4):573-80. doi: 10.1002/cbic.200900674. [PMID: 20058253]
  • Linlin Wang, Thomas C Schulz, Eric S Sherrer, Derek S Dauphin, Soojung Shin, Angelique M Nelson, Carol B Ware, Mei Zhan, Chao-Zhong Song, Xiaoji Chen, Sandii N Brimble, Amanda McLean, Maria J Galeano, Elizabeth W Uhl, Kevin A D'Amour, Jonathan D Chesnut, Mahendra S Rao, C Anthony Blau, Allan J Robins. Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling. Blood. 2007 Dec; 110(12):4111-9. doi: 10.1182/blood-2007-03-082586. [PMID: 17761519]
  • Cecilia Castillo, Caridad Malavé, Juan Carlos Martínez, Jorge Núñez, Deyanell Hernández, Fabiola Pasquali, Gloria M Villegas, Raimundo Villegas. Neuregulin-1 isoform induces mitogenesis, KCa and Ca2+ currents in PC12 cells. A comparison with sciatic nerve conditioned medium. Brain research. 2006 Sep; 1110(1):64-75. doi: 10.1016/j.brainres.2006.06.058. [PMID: 16859657]
  • Sanjay Kansra, Stefan W Stoll, Jessica L Johnson, James T Elder. Autocrine extracellular signal-regulated kinase (ERK) activation in normal human keratinocytes: metalloproteinase-mediated release of amphiregulin triggers signaling from ErbB1 to ERK. Molecular biology of the cell. 2004 Sep; 15(9):4299-309. doi: 10.1091/mbc.e04-03-0233. [PMID: 15254267]
  • M Párrizas, A Gazit, A Levitzki, E Wertheimer, D LeRoith. Specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins. Endocrinology. 1997 Apr; 138(4):1427-33. doi: 10.1210/endo.138.4.5092. [PMID: 9075698]
  • M Sato, M Urade, N Maeda, T Miyazaki, M Watanabe, T Shibata, N Yamamoto. Isolation and characterization of a new rubella variang with DNA polymerase activity. Archives of virology. 1978; 56(1-2):89-103. doi: 10.1007/bf01317285. [PMID: 75725]
  • K Bozkowa, A Bardoń, H Hofman, M Sielicka. [Ribonuclease activity in the serum of children of various ages (author's transl)]. Problemy medycyny wieku rozwojowego. 1975; 5(?):7-13. doi: NULL. [PMID: 4788]