PIMONIDAZOLE (BioDeep_00000393375)
代谢物信息卡片
PIMONIDAZOLE
化学式: C11H18N4O3 (254.1378838)
中文名称: 哌莫硝唑
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CCN(CC1)CC(CN2C=CN=C2[N+](=O)[O-])O
InChI: InChI=1S/C11H18N4O3/c16-10(8-13-5-2-1-3-6-13)9-14-7-4-12-11(14)15(17)18/h4,7,10,16H,1-3,5-6,8-9H2
描述信息
C274 - Antineoplastic Agent > C798 - Radiosensitizing Agent
D011838 - Radiation-Sensitizing Agents
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- PubChem: 50981
- Metlin: METLIN44852
- DrugBank: DB12485
- ChEMBL: CHEMBL58752
- CAS: 70132-50-2
- PMhub: MS000243723
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lisienny Campoli Tono Rempel, Viviane Dias Faustino, Orestes Foresto-Neto, Camilla Fanelli, Simone Costa Alarcon Arias, Gizely Cristina da Silva Moreira, Thalita Fabiana Nascimento, Victor Ferreira Ávila, Denise Maria Avancini Costa Malheiros, Niels Olsen Saraiva Câmara, Clarice Kazue Fujihara, Roberto Zatz. Chronic exposure to hypoxia attenuates renal injury and innate immunity activation in the remnant kidney model.
American journal of physiology. Renal physiology.
2019 11; 317(5):F1285-F1292. doi:
10.1152/ajprenal.00367.2018. [PMID: 31461352] - Connie P C Ow, Md Mahbub Ullah, Jennifer P Ngo, Adheeshee Sayakkarage, Roger G Evans. Detection of cellular hypoxia by pimonidazole adduct immunohistochemistry in kidney disease: methodological pitfalls and their solution.
American journal of physiology. Renal physiology.
2019 08; 317(2):F322-F332. doi:
10.1152/ajprenal.00219.2019. [PMID: 31188031] - Negar Sadeghi, Robbert Jan Kok, Clemens Bos, Maurice Zandvliet, Willie J C Geerts, Gert Storm, Chrit T W Moonen, Twan Lammers, Roel Deckers. Hyperthermia-triggered release of hypoxic cell radiosensitizers from temperature-sensitive liposomes improves radiotherapy efficacy in vitro.
Nanotechnology.
2019 Jun; 30(26):264001. doi:
10.1088/1361-6528/ab0ce6. [PMID: 30836341] - Alexander A Elias, Yohei Maki, Brad Matushewski, Karen Nygard, Timothy R H Regnault, Bryan S Richardson. Maternal nutrient restriction in guinea pigs leads to fetal growth restriction with evidence for chronic hypoxia.
Pediatric research.
2017 07; 82(1):141-147. doi:
10.1038/pr.2017.92. [PMID: 28376077] - Ségolène Mrozek, Aymeric Luzi, Leslie Gonzalez, Lionel Kerhuel, Olivier Fourcade, Thomas Geeraerts. Cerebral and extracerebral vulnerability to hypoxic insults after diffuse traumatic brain injury in rats.
Brain research.
2016 09; 1646(?):334-341. doi:
10.1016/j.brainres.2016.06.007. [PMID: 27302136] - Nadine E Mascini, Menglin Cheng, Lu Jiang, Asif Rizwan, Helen Podmore, Dhaka R Bhandari, Andreas Römpp, Kristine Glunde, Ron M A Heeren. Mass Spectrometry Imaging of the Hypoxia Marker Pimonidazole in a Breast Tumor Model.
Analytical chemistry.
2016 Mar; 88(6):3107-14. doi:
10.1021/acs.analchem.5b04032. [PMID: 26891127] - Nan Yao, Ke Ren, Cuihua Jiang, Meng Gao, Dejian Huang, Xiao Lu, Bin Lou, Fei Peng, Aizhen Yang, Xiaoning Wang, Yicheng Ni, Jian Zhang. Combretastatin A4 phosphate treatment induces vasculogenic mimicry formation of W256 breast carcinoma tumor in vitro and in vivo.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.
2015 Nov; 36(11):8499-510. doi:
10.1007/s13277-015-3508-x. [PMID: 26026583] - Amany Abdelkader, Julie Ho, Connie P C Ow, Gabriela A Eppel, Niwanthi W Rajapakse, Markus P Schlaich, Roger G Evans. Renal oxygenation in acute renal ischemia-reperfusion injury.
American journal of physiology. Renal physiology.
2014 May; 306(9):F1026-38. doi:
10.1152/ajprenal.00281.2013. [PMID: 24598805] - A Dietrich, S Mathia, H Kaminski, K Mutig, C Rosenberger, R Mrowka, S Bachmann, A Paliege. Chronic activation of vasopressin V2 receptor signalling lowers renal medullary oxygen levels in rats.
Acta physiologica (Oxford, England).
2013 Apr; 207(4):721-31. doi:
10.1111/apha.12067. [PMID: 23347696] - Patrick Lauscher, Harry Kertscho, Olga Schmidt, René Zimmermann, Peter Rosenberger, Kai Zacharowski, Jens Meier. Determination of organ-specific anemia tolerance.
Critical care medicine.
2013 Apr; 41(4):1037-45. doi:
10.1097/ccm.0b013e3182746423. [PMID: 23385097] - Alice Ding, Priyadharshani Kalaignanasundaram, Sharon D Ricardo, Amany Abdelkader, Paul K Witting, Brad R S Broughton, Hyun B Kim, Benjamin F Wyse, Jacqueline K Phillips, Roger G Evans. Chronic treatment with tempol does not significantly ameliorate renal tissue hypoxia or disease progression in a rodent model of polycystic kidney disease.
Clinical and experimental pharmacology & physiology.
2012 Nov; 39(11):917-29. doi:
10.1111/1440-1681.12013. [PMID: 23006058] - Masahiro Murakami, Songji Zhao, Yan Zhao, Nusrat Fatema Chowdhury, Wenwen Yu, Ken-Ichi Nishijima, Mitsuyoshi Takiguchi, Nagara Tamaki, Yuji Kuge. Evaluation of changes in the tumor microenvironment after sorafenib therapy by sequential histology and 18F-fluoromisonidazole hypoxia imaging in renal cell carcinoma.
International journal of oncology.
2012 Nov; 41(5):1593-600. doi:
10.3892/ijo.2012.1624. [PMID: 22965141] - Jake S Burrell, Simon Walker-Samuel, Lauren C J Baker, Jessica K R Boult, Yann Jamin, Anderson J Ryan, John C Waterton, Jane Halliday, Simon P Robinson. Evaluation of novel combined carbogen USPIO (CUSPIO) imaging biomarkers in assessing the antiangiogenic effects of cediranib (AZD2171) in rat C6 gliomas.
International journal of cancer.
2012 Oct; 131(8):1854-62. doi:
10.1002/ijc.27460. [PMID: 22290271] - David J Seiffge, Natalia E Lapina, Charalambos Tsagogiorgas, Bastian Theisinger, Robert H Henning, Lothar Schilling. Improvement of oxygen supply by an artificial carrier in combination with normobaric oxygenation decreases the volume of tissue hypoxia and tissue damage from transient focal cerebral ischemia.
Experimental neurology.
2012 Sep; 237(1):18-25. doi:
10.1016/j.expneurol.2012.06.007. [PMID: 22728375] - Shathiyah Kulandavelu, Kathie J Whiteley, Dawei Qu, Junwu Mu, Shannon A Bainbridge, S Lee Adamson. Endothelial nitric oxide synthase deficiency reduces uterine blood flow, spiral artery elongation, and placental oxygenation in pregnant mice.
Hypertension (Dallas, Tex. : 1979).
2012 Jul; 60(1):231-8. doi:
10.1161/hypertensionaha.111.187559. [PMID: 22615111] - Elisa Conde, Laura Alegre, Ignacio Blanco-Sánchez, David Sáenz-Morales, Elia Aguado-Fraile, Belén Ponte, Edurne Ramos, Ana Sáiz, Carlos Jiménez, Angel Ordoñez, Manuel López-Cabrera, Luis del Peso, Manuel O de Landázuri, Fernando Liaño, Rafael Selgas, Jose Antonio Sanchez-Tomero, María Laura García-Bermejo. Hypoxia inducible factor 1-alpha (HIF-1 alpha) is induced during reperfusion after renal ischemia and is critical for proximal tubule cell survival.
PloS one.
2012; 7(3):e33258. doi:
10.1371/journal.pone.0033258. [PMID: 22432008] - Abbas Shirinifard, James Alexander Glazier, Maciej Swat, J Scott Gens, Fereydoon Family, Yi Jiang, Hans E Grossniklaus. Adhesion failures determine the pattern of choroidal neovascularization in the eye: a computer simulation study.
PLoS computational biology.
2012; 8(5):e1002440. doi:
10.1371/journal.pcbi.1002440. [PMID: 22570603] - Hyung Eun Yim, Ji Hae Kim, Kee Hwan Yoo, In Sun Bae, Young Sook Hong, Joo Won Lee. Spironolactone and enalapril differentially up-regulate the expression of VEGF and heme oxygenase-1 in the neonatal rat kidney.
Pediatric research.
2011 May; 69(5 Pt 1):378-83. doi:
10.1203/pdr.0b013e3182114c38. [PMID: 21263376] - Johanna M U Silvola, Antti Saraste, Sarita Forsback, V Jukka O Laine, Pekka Saukko, Suvi E Heinonen, Seppo Ylä-Herttuala, Anne Roivainen, Juhani Knuuti. Detection of hypoxia by [18F]EF5 in atherosclerotic plaques in mice.
Arteriosclerosis, thrombosis, and vascular biology.
2011 May; 31(5):1011-5. doi:
10.1161/atvbaha.110.221440. [PMID: 21372297] - Liye Shi, Nobuo Terada, Yurika Saitoh, Sei Saitoh, Shinichi Ohno. Immunohistochemical distribution of serum proteins in living mouse heart with In vivo cryotechnique.
Acta histochemica et cytochemica.
2011 Apr; 44(2):61-72. doi:
10.1267/ahc.11007. [PMID: 21614167] - Gert Mayer. Capillary rarefaction, hypoxia, VEGF and angiogenesis in chronic renal disease.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2011 Apr; 26(4):1132-7. doi:
10.1093/ndt/gfq832. [PMID: 21330358] - Yumi Takiyama, Tatsuo Harumi, Jun Watanabe, Yukihiro Fujita, Jun Honjo, Norihiko Shimizu, Yuichi Makino, Masakazu Haneda. Tubular injury in a rat model of type 2 diabetes is prevented by metformin: a possible role of HIF-1α expression and oxygen metabolism.
Diabetes.
2011 Mar; 60(3):981-92. doi:
10.2337/db10-0655. [PMID: 21282369] - Raj Munshi, Christine Hsu, Jonathan Himmelfarb. Advances in understanding ischemic acute kidney injury.
BMC medicine.
2011 Feb; 9(?):11. doi:
10.1186/1741-7015-9-11. [PMID: 21288330] - Vladimir A Valera, Beatriz A Walter, W Marston Linehan, Maria J Merino. Regulatory Effects of microRNA-92 (miR-92) on VHL Gene Expression and the Hypoxic Activation of miR-210 in Clear Cell Renal Cell Carcinoma.
Journal of Cancer.
2011; 2(?):515-26. doi:
10.7150/jca.2.515. [PMID: 22043236] - Pottumarthi Prasad, Lu-Ping Li, Sarah Halter, Joann Cabray, Minghao Ye, Daniel Batlle. Evaluation of renal hypoxia in diabetic mice by BOLD MRI.
Investigative radiology.
2010 Dec; 45(12):819-22. doi:
10.1097/rli.0b013e3181ec9b02. [PMID: 20829708] - Sachiko Matsuzaki, Kris Jardon, Elodie Maleysson, Francis D'Arpiany, Michel Canis, Jean-Etienne Bazin, Gérard Mage. Carbon dioxide pneumoperitoneum, intraperitoneal pressure, and peritoneal tissue hypoxia: a mouse study with controlled respiratory support.
Surgical endoscopy.
2010 Nov; 24(11):2871-80. doi:
10.1007/s00464-010-1069-z. [PMID: 20419320] - Fredrik Palm, Masaomi Nangaku, Angelica Fasching, Tetsuhiro Tanaka, Lina Nordquist, Peter Hansell, Takahisa Kawakami, Fuyuhiko Nishijima, Toshiro Fujita. Uremia induces abnormal oxygen consumption in tubules and aggravates chronic hypoxia of the kidney via oxidative stress.
American journal of physiology. Renal physiology.
2010 Aug; 299(2):F380-6. doi:
10.1152/ajprenal.00175.2010. [PMID: 20519374] - H E Yim, J H Kim, K H Yoo, I S Bae, G Y Jang, Y S Hong, J W Lee. Spironolactone, but not enalapril, potentiates hypoxia-inducible factor-1 alpha and Ets-1 expression in newborn rat kidney.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2010 Feb; 61(1):73-81. doi:
NULL. [PMID: 20228418] - C P Lee, G S Payne, A Oregioni, R Ruddle, S Tan, F I Raynaud, D Eaton, M J Campbell, K Cross, G Halbert, M Tracy, J McNamara, B Seddon, M O Leach, P Workman, I Judson. A phase I study of the nitroimidazole hypoxia marker SR4554 using 19F magnetic resonance spectroscopy.
British journal of cancer.
2009 Dec; 101(11):1860-8. doi:
10.1038/sj.bjc.6605425. [PMID: 19935799] - Josep M Lluis, Laura Llacuna, Claudia von Montfort, Cristina Bárcena, Carlos Enrich, Albert Morales, José C Fernandez-Checa. GD3 synthase overexpression sensitizes hepatocarcinoma cells to hypoxia and reduces tumor growth by suppressing the cSrc/NF-kappaB survival pathway.
PloS one.
2009 Nov; 4(11):e8059. doi:
10.1371/journal.pone.0008059. [PMID: 19956670] - D L Roberts, K J Williams, R L Cowen, M Barathova, A J Eustace, S Brittain-Dissont, M J Tilby, D G Pearson, C J Ottley, I J Stratford, C Dive. Contribution of HIF-1 and drug penetrance to oxaliplatin resistance in hypoxic colorectal cancer cells.
British journal of cancer.
2009 Oct; 101(8):1290-7. doi:
10.1038/sj.bjc.6605311. [PMID: 19755992] - Manuela Bartoli, Mohamed Al-Shabrawey, Mohamed Labazi, M Ali Behzadian, Mohamed Istanboli, Azza B El-Remessy, Robert W Caldwell, Dennis M Marcus, Ruth B Caldwell. HMG-CoA reductase inhibitors (statin) prevents retinal neovascularization in a model of oxygen-induced retinopathy.
Investigative ophthalmology & visual science.
2009 Oct; 50(10):4934-40. doi:
10.1167/iovs.08-2158. [PMID: 19098312] - Jun Du, Yu-Yan Fan, Hirofumi Hitomi, Hideyasu Kiyomoto, Shoji Kimura, Chui-Ze Kong, Takahisa Noma, Masakazu Kohno, Akira Nishiyama, Daisuke Nakano. Mineralocorticoid receptor blockade and calcium channel blockade have different renoprotective effects on glomerular and interstitial injury in rats.
American journal of physiology. Renal physiology.
2009 Sep; 297(3):F802-8. doi:
10.1152/ajprenal.00197.2009. [PMID: 19535572] - Ying-Hsien Kao, Bruno Jawan, Shigeru Goto, Mei-Chun Pan, Yu-Chun Lin, Cheuk-Kwan Sun, Li-Wen Hsu, Ming-Hong Tai, Yu-Fan Cheng, Toshiaki Nakano, Chih-Shien Wang, Chia-Jung Huang, Chao-Long Chen. Serum factors potentiate hypoxia-induced hepatotoxicity in vitro through increasing transforming growth factor-beta1 activation and release.
Cytokine.
2009 Jul; 47(1):11-22. doi:
10.1016/j.cyto.2009.03.004. [PMID: 19457680] - Kate Newbold, Isabel Castellano, Elizabeth Charles-Edwards, Dorothy Mears, Aslam Sohaib, Martin Leach, Peter Rhys-Evans, Peter Clarke, Cyril Fisher, Kevin Harrington, Christopher Nutting. An exploratory study into the role of dynamic contrast-enhanced magnetic resonance imaging or perfusion computed tomography for detection of intratumoral hypoxia in head-and-neck cancer.
International journal of radiation oncology, biology, physics.
2009 May; 74(1):29-37. doi:
10.1016/j.ijrobp.2008.07.039. [PMID: 19036529] - HyungJoon Cho, Ellen Ackerstaff, Sean Carlin, Mihaela E Lupu, Ya Wang, Asif Rizwan, Joseph O'Donoghue, C Clifton Ling, John L Humm, Pat B Zanzonico, Jason A Koutcher. Noninvasive multimodality imaging of the tumor microenvironment: registered dynamic magnetic resonance imaging and positron emission tomography studies of a preclinical tumor model of tumor hypoxia.
Neoplasia (New York, N.Y.).
2009 Mar; 11(3):247-59, 2p following 259. doi:
10.1593/neo.81360. [PMID: 19242606] - Christian Rosenberger, Seymour Rosen, Alexander Paliege, Samuel N Heyman. Pimonidazole adduct immunohistochemistry in the rat kidney: detection of tissue hypoxia.
Methods in molecular biology (Clifton, N.J.).
2009; 466(?):161-74. doi:
10.1007/978-1-59745-352-3_12. [PMID: 19148611] - Kathryn J Wiggins, Victoria Tiauw, Yuan Zhang, Richard E Gilbert, Robyn G Langham, Darren J Kelly. Perindopril attenuates tubular hypoxia and inflammation in an experimental model of diabetic nephropathy in transgenic Ren-2 rats.
Nephrology (Carlton, Vic.).
2008 Dec; 13(8):721-9. doi:
10.1111/j.1440-1797.2008.01008.x. [PMID: 18826488] - Tuula M Kalliomäki, Gordon McCallum, Sarah Jane Lunt, Peter G Wells, Richard P Hill. Analysis of the effects of exposure to acute hypoxia on oxidative lesions and tumour progression in a transgenic mouse breast cancer model.
BMC cancer.
2008 May; 8(?):151. doi:
10.1186/1471-2407-8-151. [PMID: 18507854] - Chien Oh, Yafeng Dong, Christopher Harman, Hugh E Mighty, Jerome Kopelman, Loren P Thompson. Chronic hypoxia differentially increases glutathione content and gamma-glutamyl cysteine synthetase expression in fetal guinea pig organs.
Early human development.
2008 Feb; 84(2):121-7. doi:
10.1016/j.earlhumdev.2007.03.013. [PMID: 17512683] - M Bache, M Kappler, H M Said, A Staab, D Vordermark. Detection and specific targeting of hypoxic regions within solid tumors: current preclinical and clinical strategies.
Current medicinal chemistry.
2008; 15(4):322-38. doi:
10.2174/092986708783497391. [PMID: 18288988] - Samuel N Heyman, Mogher Khamaisi, Seymour Rosen, Christian Rosenberger. Renal parenchymal hypoxia, hypoxia response and the progression of chronic kidney disease.
American journal of nephrology.
2008; 28(6):998-1006. doi:
10.1159/000146075. [PMID: 18635927] - C Rosenberger, M Khamaisi, Z Abassi, V Shilo, S Weksler-Zangen, M Goldfarb, A Shina, F Zibertrest, K-U Eckardt, S Rosen, S N Heyman. Adaptation to hypoxia in the diabetic rat kidney.
Kidney international.
2008 Jan; 73(1):34-42. doi:
10.1038/sj.ki.5002567. [PMID: 17914354] - Miriam Echevarría, Ana M Muñoz-Cabello, Rocío Sánchez-Silva, Juan J Toledo-Aral, José López-Barneo. Development of cytosolic hypoxia and hypoxia-inducible factor stabilization are facilitated by aquaporin-1 expression.
The Journal of biological chemistry.
2007 Oct; 282(41):30207-15. doi:
10.1074/jbc.m702639200. [PMID: 17673462] - Xiaomin Deng, James P Luyendyk, Wei Zou, Jingtao Lu, Ernst Malle, Patricia E Ganey, Robert A Roth. Neutrophil interaction with the hemostatic system contributes to liver injury in rats cotreated with lipopolysaccharide and ranitidine.
The Journal of pharmacology and experimental therapeutics.
2007 Aug; 322(2):852-61. doi:
10.1124/jpet.107.122069. [PMID: 17505017] - Ryoich Imamura, Toshiki Moriyama, Yoshitaka Isaka, Yukiomi Namba, Naotsugu Ichimaru, Shiro Takahara, Akihiko Okuyama. Erythropoietin protects the kidneys against ischemia reperfusion injury by activating hypoxia inducible factor-1alpha.
Transplantation.
2007 May; 83(10):1371-9. doi:
10.1097/01.tp.0000264200.38926.70. [PMID: 17519789] - Wanja Michael Bernhardt, Michael Sean Wiesener, Alexander Weidemann, Roland Schmitt, Wilko Weichert, Philipp Lechler, Valentina Campean, Albert Chee Meng Ong, Carsten Willam, Norbert Gretz, Kai-Uwe Eckardt. Involvement of hypoxia-inducible transcription factors in polycystic kidney disease.
The American journal of pathology.
2007 Mar; 170(3):830-42. doi:
10.2353/ajpath.2007.060455. [PMID: 17322369] - C Rosenberger, S Rosen, A Shina, W Bernhardt, M S Wiesener, U Frei, K-U Eckardt, S N Heyman. Hypoxia-inducible factors and tubular cell survival in isolated perfused kidneys.
Kidney international.
2006 Jul; 70(1):60-70. doi:
10.1038/sj.ki.5000395. [PMID: 16710354] - Sandra Villanueva, Carlos Céspedes, Carlos P Vio. Ischemic acute renal failure induces the expression of a wide range of nephrogenic proteins.
American journal of physiology. Regulatory, integrative and comparative physiology.
2006 Apr; 290(4):R861-70. doi:
10.1152/ajpregu.00384.2005. [PMID: 16284088] - Miriam M Kleiter, Donald E Thrall, David E Malarkey, Xiaoshen Ji, David Y W Lee, Shu-Chuan Chou, James A Raleigh. A comparison of oral and intravenous pimonidazole in canine tumors using intravenous CCI-103F as a control hypoxia marker.
International journal of radiation oncology, biology, physics.
2006 Feb; 64(2):592-602. doi:
10.1016/j.ijrobp.2005.09.010. [PMID: 16289910] - Marina Goldfarb, Christian Rosenberger, Zaid Abassi, Ahuva Shina, Fani Zilbersat, Kai U Eckardt, Seymour Rosen, Samuel N Heyman. Acute-on-chronic renal failure in the rat: functional compensation and hypoxia tolerance.
American journal of nephrology.
2006; 26(1):22-33. doi:
10.1159/000091783. [PMID: 16508244] - Naveen Tirkey, Gaganjit Kaur, Garima Vij, Kanwaljit Chopra. Curcumin, a diferuloylmethane, attenuates cyclosporine-induced renal dysfunction and oxidative stress in rat kidneys.
BMC pharmacology.
2005 Oct; 5(?):15. doi:
10.1186/1471-2210-5-15. [PMID: 16225695] - Steffen P Luntz, Kristina Unnebrink, Monika Seibert-Grafe, Hartwig Bunzendahl, Thomas W Kraus, Markus W Büchler, Ernst Klar, Peter Schemmer. HEGPOL: randomized, placebo controlled, multicenter, double-blind clinical trial to investigate hepatoprotective effects of glycine in the postoperative phase of liver transplantation [ISRCTN69350312].
BMC surgery.
2005 Aug; 5(?):18. doi:
10.1186/1471-2482-5-18. [PMID: 16105183] - J J Ord, E H Streeter, I S D Roberts, D Cranston, A L Harris. Comparison of hypoxia transcriptome in vitro with in vivo gene expression in human bladder cancer.
British journal of cancer.
2005 Aug; 93(3):346-54. doi:
10.1038/sj.bjc.6602666. [PMID: 16052224] - Marisa D Covington, Kayla J Bayless, Robert C Burghardt, George E Davis, Alan R Parrish. Ischemia-induced cleavage of cadherins in NRK cells: evidence for a role of metalloproteinases.
American journal of physiology. Renal physiology.
2005 Aug; 289(2):F280-8. doi:
10.1152/ajprenal.00351.2004. [PMID: 15769936] - A M Shannon, D J Bouchier-Hayes, C M Condron, D Toomey. Correction of anaemia through the use of darbepoetin alfa improves chemotherapeutic outcome in a murine model of Lewis lung carcinoma.
British journal of cancer.
2005 Jul; 93(2):224-32. doi:
10.1038/sj.bjc.6602685. [PMID: 15999100] - Daniel W Nelson, Hongbin Cao, Yonghua Zhu, Bulbin Sunar-Reeder, Clara Y H Choi, James D Faix, J Martin Brown, Albert C Koong, Amato J Giaccia, Quynh-Thu Le. A noninvasive approach for assessing tumor hypoxia in xenografts: developing a urinary marker for hypoxia.
Cancer research.
2005 Jul; 65(14):6151-8. doi:
10.1158/0008-5472.can-04-2602. [PMID: 16024616] - Christian Rosenberger, Samuel N Heyman, Seymour Rosen, Ahuva Shina, Marina Goldfarb, Wanja Griethe, Ulrich Frei, Petra Reinke, Sebastian Bachmann, Kai-Uwe Eckardt. Up-regulation of HIF in experimental acute renal failure: evidence for a protective transcriptional response to hypoxia.
Kidney international.
2005 Feb; 67(2):531-42. doi:
10.1111/j.1523-1755.2005.67110.x. [PMID: 15673301] - Pei-Xuan Wang, Paul W Sanders. Mechanism of hypertensive nephropathy in the Dahl/Rapp rat: a primary disorder of vascular smooth muscle.
American journal of physiology. Renal physiology.
2005 Jan; 288(1):F236-42. doi:
10.1152/ajprenal.00213.2004. [PMID: 15583217] - Jens van Wijngaarden, Karien de Rooij, Ermond van Beek, Hans Bernsen, Ivo Que, Victor W M van Hinsbergh, Clemens Löwik. Identification of differentially expressed genes in a renal cell carcinoma tumor model after endostatin-treatment.
Laboratory investigation; a journal of technical methods and pathology.
2004 Nov; 84(11):1472-83. doi:
10.1038/labinvest.3700157. [PMID: 15273700] - H Barthel, H Wilson, D R Collingridge, G Brown, S Osman, S K Luthra, F Brady, P Workman, P M Price, E O Aboagye. In vivo evaluation of [18F]fluoroetanidazole as a new marker for imaging tumour hypoxia with positron emission tomography.
British journal of cancer.
2004 Jun; 90(11):2232-42. doi:
10.1038/sj.bjc.6601862. [PMID: 15150578] - Michael K Samoszuk, James Walter, Eugene Mechetner. Improved immunohistochemical method for detecting hypoxia gradients in mouse tissues and tumors.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
2004 Jun; 52(6):837-9. doi:
10.1369/jhc.4b6248.2004. [PMID: 15150293] - Makiko Matsumoto, Tetsuhiro Tanaka, Tokunori Yamamoto, Eisei Noiri, Toshio Miyata, Reiko Inagi, Toshiro Fujita, Masaomi Nangaku. Hypoperfusion of peritubular capillaries induces chronic hypoxia before progression of tubulointerstitial injury in a progressive model of rat glomerulonephritis.
Journal of the American Society of Nephrology : JASN.
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