STF-62247 (BioDeep_00000393205)
代谢物信息卡片
化学式: C15H13N3S (267.083)
中文名称: STF-62247
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CC(=CC=C1)NC2=NC(=CS2)C3=CC=NC=C3
InChI: InChI=1S/C15H13N3S/c1-11-3-2-4-13(9-11)17-15-18-14(10-19-15)12-5-7-16-8-6-12/h2-10H,1H3,(H,17,18)
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:125656
- PubChem: 704473
- Metlin: METLIN45454
- ChEMBL: CHEMBL565269
- CAS: 315702-99-9
- PMhub: MS000243543
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Nadia Bouhamdani, Dominique Comeau, Alexandre Coholan, Kevin Cormier, Sandra Turcotte. Targeting lysosome function causes selective cytotoxicity in VHL-inactivated renal cell carcinomas.
Carcinogenesis.
2020 07; 41(6):828-840. doi:
10.1093/carcin/bgz161. [PMID: 31556451] - Ayyoub Selka, Jérémie A Doiron, Pierre Lyons, Sonia Dastous, Alison Chiasson, Marc Cormier, Sandra Turcotte, Marc E Surette, Mohamed Touaibia. Discovery of a novel 2,5-dihydroxycinnamic acid-based 5-lipoxygenase inhibitor that induces apoptosis and may impair autophagic flux in RCC4 renal cancer cells.
European journal of medicinal chemistry.
2019 Oct; 179(?):347-357. doi:
10.1016/j.ejmech.2019.06.060. [PMID: 31260889] - Nadia Bouhamdani, Dominique Comeau, Kevin Cormier, Sandra Turcotte. STF-62247 accumulates in lysosomes and blocks late stages of autophagy to selectively target von Hippel-Lindau-inactivated cells.
American journal of physiology. Cell physiology.
2019 05; 316(5):C605-C620. doi:
10.1152/ajpcell.00483.2018. [PMID: 30758995] - Nadia Bouhamdani, Andrew Joy, David Barnett, Kevin Cormier, Daniel Léger, Ian C Chute, Simon Lamarre, Rodney Ouellette, Sandra Turcotte. Quantitative proteomics to study a small molecule targeting the loss of von Hippel-Lindau in renal cell carcinomas.
International journal of cancer.
2017 08; 141(4):778-790. doi:
10.1002/ijc.30774. [PMID: 28486780] - Muriel Bonnet, Jack U Flanagan, Denise A Chan, Amato J Giaccia, Michael P Hay. Identifying novel targets in renal cell carcinoma: design and synthesis of affinity chromatography reagents.
Bioorganic & medicinal chemistry.
2014 Jan; 22(2):711-20. doi:
10.1016/j.bmc.2013.12.028. [PMID: 24387866] - Selvakumar Anbalagan, Isabel M Pires, Christopher Blick, Mark A Hill, David J P Ferguson, Denise A Chan, Ester M Hammond. Radiosensitization of renal cell carcinoma in vitro through the induction of autophagy.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.
2012 Jun; 103(3):388-93. doi:
10.1016/j.radonc.2012.04.001. [PMID: 22551566] - Muriel Bonnet, Jack U Flanagan, Denise A Chan, Edwin W Lai, Phuong Nguyen, Amato J Giaccia, Michael P Hay. SAR studies of 4-pyridyl heterocyclic anilines that selectively induce autophagic cell death in von Hippel-Lindau-deficient renal cell carcinoma cells.
Bioorganic & medicinal chemistry.
2011 Jun; 19(11):3347-56. doi:
10.1016/j.bmc.2011.04.042. [PMID: 21561782] - Sandra Turcotte, Patrick D Sutphin, Amato J Giaccia. Targeted therapy for the loss of von Hippel-Lindau in renal cell carcinoma: a novel molecule that induces autophagic cell death.
Autophagy.
2008 Oct; 4(7):944-6. doi:
10.4161/auto.6785. [PMID: 18769110] - Sandra Turcotte, Denise A Chan, Patrick D Sutphin, Michael P Hay, William A Denny, Amato J Giaccia. A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy.
Cancer cell.
2008 Jul; 14(1):90-102. doi:
10.1016/j.ccr.2008.06.004. [PMID: 18598947]
