5-(N,N-Hexamethylene)amiloride (BioDeep_00000393131)

   


代谢物信息卡片


5-(N,N-Hexamethylene)-amiloride

化学式: C12H18ClN7O (311.1261288)
中文名称: 5-(N,N-六亚甲基)阿米洛利
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CCCN(CC1)C2=NC(=C(N=C2Cl)C(=O)N=C(N)N)N
InChI: InChI=1S/C12H18ClN7O/c13-8-10(20-5-3-1-2-4-6-20)18-9(14)7(17-8)11(21)19-12(15)16/h1-6H2,(H2,14,18)(H4,15,16,19,21)

描述信息

D000970 - Antineoplastic Agents

同义名列表

2 个代谢物同义名

5-(N,N-Hexamethylene)-amiloride; 5-(N,N-Hexamethylene)amiloride



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Noah H Somberg, João Medeiros-Silva, Hyunil Jo, Jun Wang, William F DeGrado, Mei Hong. Hexamethylene amiloride binds the SARS-CoV-2 envelope protein at the protein-lipid interface. Protein science : a publication of the Protein Society. 2023 10; 32(10):e4755. doi: 10.1002/pro.4755. [PMID: 37632140]
  • Kiem Vu, Benjamin J Buckley, Richard S Bujaroski, Eduardo Blumwald, Michael J Kelso, Angie Gelli. Antifungal activity of 6-substituted amiloride and hexamethylene amiloride (HMA) analogs. Frontiers in cellular and infection microbiology. 2023; 13(?):1101568. doi: 10.3389/fcimb.2023.1101568. [PMID: 36923593]
  • Trine Lisberg Toft-Bertelsen, Mads Gravers Jeppesen, Eva Tzortzini, Kai Xue, Karin Giller, Stefan Becker, Amer Mujezinovic, Bo Hjorth Bentzen, Loren B Andreas, Antonios Kolocouris, Thomas Nitschke Kledal, Mette Marie Rosenkilde. Amantadine has potential for the treatment of COVID-19 because it inhibits known and novel ion channels encoded by SARS-CoV-2. Communications biology. 2021 12; 4(1):1347. doi: 10.1038/s42003-021-02866-9. [PMID: 34853399]
  • Benjamin J Buckley, Ashraf Aboelela, Hiwa Majed, Richard S Bujaroski, Karen L White, Andrew K Powell, Wen Wang, Kasiram Katneni, Jessica Saunders, David M Shackleford, Susan A Charman, Gregory M Cook, Michael J Kelso, Marie Ranson. Systematic evaluation of structure-property relationships and pharmacokinetics in 6-(hetero)aryl-substituted matched pair analogs of amiloride and 5-(N,N-hexamethylene)amiloride. Bioorganic & medicinal chemistry. 2021 05; 37(?):116116. doi: 10.1016/j.bmc.2021.116116. [PMID: 33799173]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Venkata S Mandala, Matthew J McKay, Alexander A Shcherbakov, Aurelio J Dregni, Antonios Kolocouris, Mei Hong. Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers. Nature structural & molecular biology. 2020 12; 27(12):1202-1208. doi: 10.1038/s41594-020-00536-8. [PMID: 33177698]
  • Leandro Rocha Silva, Paulo Fernando da Silva Santos-Júnior, Júlia de Andrade Brandão, Letícia Anderson, Ênio José Bassi, João Xavier de Araújo-Júnior, Sílvia Helena Cardoso, Edeildo Ferreira da Silva-Júnior. Druggable targets from coronaviruses for designing new antiviral drugs. Bioorganic & medicinal chemistry. 2020 11; 28(22):115745. doi: 10.1016/j.bmc.2020.115745. [PMID: 33007557]
  • Carmen Aravena, Ana R Beltrán, Marcelo Cornejo, Viviana Torres, Emilce S Díaz, Enrique Guzmán-Gutiérrez, Fabián Pardo, Andrea Leiva, Luis Sobrevia, Marco A Ramírez. Potential role of sodium-proton exchangers in the low concentration arsenic trioxide-increased intracellular pH and cell proliferation. PloS one. 2012; 7(12):e51451. doi: 10.1371/journal.pone.0051451. [PMID: 23236503]
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  • Lauren Wilson, Peter Gage, Gary Ewart. Hexamethylene amiloride blocks E protein ion channels and inhibits coronavirus replication. Virology. 2006 Sep; 353(2):294-306. doi: 10.1016/j.virol.2006.05.028. [PMID: 16815524]
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