SEW2871 (BioDeep_00000392992)

   


代谢物信息卡片


5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole

化学式: C20H10F6N2OS (440.0418002)
中文名称: 5-[4-苯基-5-(三氟甲基)-2-噻吩基]-3-[3-(三氟甲基)苯基]-1,2,4-恶二唑
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C=C1)C2=C(SC(=C2)C3=NC(=NO3)C4=CC(=CC=C4)C(F)(F)F)C(F)(F)F
InChI: InChI=1S/C20H10F6N2OS/c21-19(22,23)13-8-4-7-12(9-13)17-27-18(29-28-17)15-10-14(11-5-2-1-3-6-11)16(30-15)20(24,25)26/h1-10H

描述信息

D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents > D000081243 - Sphingosine 1 Phosphate Receptor Modulators
SEW2871 is an orally active, potent, highly selective S1P1 (sphingosine-1-phosphate type 1 receptor) agonist, with an EC50 of 13.8 nM. SEW2871 activates ERK, Akt, and Rac signaling pathways and induces S1P1 internalization and recycling. SEW2871 reduces lymphocyte numbers in blood. SEW2871 can be used for the research of diabetes, Alzheimer’s disease, liver fibrosis, and inflammatory responses[1][2].

同义名列表

3 个代谢物同义名

5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole; SEW2871; SEW?2871



数据库引用编号

7 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Christine Bassila, George E G Kluck, Narmadaa Thyagarajan, Kevin M Chathely, Leticia Gonzalez, Bernardo L Trigatti. Ligand-dependent interactions between SR-B1 and S1PR1 in macrophages and atherosclerotic plaques. Journal of lipid research. 2024 May; 65(5):100541. doi: 10.1016/j.jlr.2024.100541. [PMID: 38583587]
  • Wanyi Liu, Jieyi Huang, Lixia Zhu, Die Pei, Yingfeng Zhang. Study on the action mechanism of Buyang Huanwu Decoction against ischemic stroke based on S1P/S1PR1/PI3K/Akt signaling pathway. Journal of ethnopharmacology. 2023 Apr; ?(?):116471. doi: 10.1016/j.jep.2023.116471. [PMID: 37030556]
  • Tingting Yang, Xue Wang, Zihang Yuan, Yingying Miao, Ziteng Wu, Yuanyuan Chai, Qiongna Yu, Haiyan Wang, Lixin Sun, Xin Huang, Luyong Zhang, Zhenzhou Jiang. Sphingosine 1-phosphate receptor-1 specific agonist SEW2871 ameliorates ANIT-induced dysregulation of bile acid homeostasis in mice plasma and liver. Toxicology letters. 2020 Oct; 331(?):242-253. doi: 10.1016/j.toxlet.2020.06.018. [PMID: 32579994]
  • Ruth R Magaye, Feby Savira, Yue Hua, Xin Xiong, Li Huang, Christopher Reid, Bernard Flynn, David Kaye, Danny Liew, Bing H Wang. Exogenous dihydrosphingosine 1 phosphate mediates collagen synthesis in cardiac fibroblasts through JAK/STAT signalling and regulation of TIMP1. Cellular signalling. 2020 08; 72(?):109629. doi: 10.1016/j.cellsig.2020.109629. [PMID: 32278008]
  • Nathalie Burg, Steven Swendeman, Stefan Worgall, Timothy Hla, Jane E Salmon. Sphingosine 1-Phosphate Receptor 1 Signaling Maintains Endothelial Cell Barrier Function and Protects Against Immune Complex-Induced Vascular Injury. Arthritis & rheumatology (Hoboken, N.J.). 2018 11; 70(11):1879-1889. doi: 10.1002/art.40558. [PMID: 29781582]
  • Takahiro Ito, Naohisa Kuriyama, Hiroyuki Kato, Akitoshi Matsuda, Shugo Mizuno, Masanobu Usui, Hiroyuki Sakurai, Shuji Isaji. Sinusoidal protection by sphingosine-1-phosphate receptor 1 agonist in liver ischemia-reperfusion injury. The Journal of surgical research. 2018 02; 222(?):139-152. doi: 10.1016/j.jss.2017.09.048. [PMID: 29273365]
  • Qian Ni, Baohong Yuan, Tao Liu, Fang Lan, Xiaochun Luo, Xiaoyan Lu, Ping Huang, Liangcheng Dai, Xiaobao Jin, Hui Yin. Sphingosine-1-phosphate receptor 1 agonist SEW2871 prolongs heterotopic heart allograft survival in mice. International immunopharmacology. 2015 May; 26(1):37-42. doi: 10.1016/j.intimp.2015.03.004. [PMID: 25776899]
  • Lei Zou, Lu Ke, Congye Wu, Zhihui Tong, Weiqin Li, Ning Li, Jieshou Li. SEW2871 Alleviates the Severity of Caerulein-Induced Acute Pancreatitis in Mice. Biological & pharmaceutical bulletin. 2015; 38(7):1012-9. doi: 10.1248/bpb.b15-00043. [PMID: 25948069]
  • Zhen Wang, Clark R Sims, Naeem K Patil, Neriman Gokden, Philip R Mayeux. Pharmacologic targeting of sphingosine-1-phosphate receptor 1 improves the renal microcirculation during sepsis in the mouse. The Journal of pharmacology and experimental therapeutics. 2015 Jan; 352(1):61-6. doi: 10.1124/jpet.114.219394. [PMID: 25355645]
  • J Dong, H Wang, G Wu, J Zhao, L Zhang, L Zuo, W Zhu, J Gong, Y Li, L Gu, J Li. Oral treatment with SEW2871, a sphingosine-1-phosphate type 1 receptor agonist, ameliorates experimental colitis in interleukin-10 gene deficient mice. Clinical and experimental immunology. 2014 Jul; 177(1):94-101. doi: 10.1111/cei.12304. [PMID: 24611843]
  • Aishah Al-Jarallah, Xing Chen, Leticia González, Bernardo L Trigatti. High density lipoprotein stimulated migration of macrophages depends on the scavenger receptor class B, type I, PDZK1 and Akt1 and is blocked by sphingosine 1 phosphate receptor antagonists. PloS one. 2014; 9(9):e106487. doi: 10.1371/journal.pone.0106487. [PMID: 25188469]
  • Naveen Sharma, Ajay Suresh Akhade, Ayub Qadri. Sphingosine-1-phosphate suppresses TLR-induced CXCL8 secretion from human T cells. Journal of leukocyte biology. 2013 Apr; 93(4):521-8. doi: 10.1189/jlb.0712328. [PMID: 23345392]
  • F E Curry, J F Clark, R H Adamson. Erythrocyte-derived sphingosine-1-phosphate stabilizes basal hydraulic conductivity and solute permeability in rat microvessels. American journal of physiology. Heart and circulatory physiology. 2012 Oct; 303(7):H825-34. doi: 10.1152/ajpheart.00181.2012. [PMID: 22865384]
  • Alaa S Awad, Michael D Rouse, Konstantine Khutsishvili, Liping Huang, W Kline Bolton, Kevin R Lynch, Mark D Okusa. Chronic sphingosine 1-phosphate 1 receptor activation attenuates early-stage diabetic nephropathy independent of lymphocytes. Kidney international. 2011 May; 79(10):1090-8. doi: 10.1038/ki.2010.544. [PMID: 21289599]
  • Sang Won Park, Mihwa Kim, Sean W C Chen, Kevin M Brown, Vivette D D'Agati, H Thomas Lee. Sphinganine-1-phosphate protects kidney and liver after hepatic ischemia and reperfusion in mice through S1P1 receptor activation. Laboratory investigation; a journal of technical methods and pathology. 2010 Aug; 90(8):1209-24. doi: 10.1038/labinvest.2010.102. [PMID: 20458275]
  • Amandeep Bajwa, Sang-Kyung Jo, Hong Ye, Liping Huang, Krishna R Dondeti, Diane L Rosin, Volker H Haase, Timothy L Macdonald, Kevin R Lynch, Mark D Okusa. Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury. Journal of the American Society of Nephrology : JASN. 2010 Jun; 21(6):955-65. doi: 10.1681/asn.2009060662. [PMID: 20338995]
  • Scott Crousillac, Jeremy Colonna, Emily McMains, Jill Sayes Dewey, Evanna Gleason. Sphingosine-1-phosphate elicits receptor-dependent calcium signaling in retinal amacrine cells. Journal of neurophysiology. 2009 Dec; 102(6):3295-309. doi: 10.1152/jn.00119.2009. [PMID: 19776367]
  • L-W Lai, K-C Yong, S Igarashi, Y-Hh Lien. A sphingosine-1-phosphate type 1 receptor agonist inhibits the early T-cell transient following renal ischemia-reperfusion injury. Kidney international. 2007 Jun; 71(12):1223-31. doi: 10.1038/sj.ki.5002203. [PMID: 17377506]
  • Alaa S Awad, Hong Ye, Liping Huang, Li Li, Frank W Foss, Timothy L Macdonald, Kevin R Lynch, Mark D Okusa. Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney. American journal of physiology. Renal physiology. 2006 Jun; 290(6):F1516-24. doi: 10.1152/ajprenal.00311.2005. [PMID: 16403835]
  • Y-Hh Lien, K-C Yong, C Cho, S Igarashi, L-W Lai. S1P(1)-selective agonist, SEW2871, ameliorates ischemic acute renal failure. Kidney international. 2006 May; 69(9):1601-8. doi: 10.1038/sj.ki.5000360. [PMID: 16572108]
  • M Germana Sanna, Jiayu Liao, Euijung Jo, Christopher Alfonso, Min-Young Ahn, Melissa S Peterson, Bill Webb, Sophie Lefebvre, Jerold Chun, Nathanael Gray, Hugh Rosen. Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. The Journal of biological chemistry. 2004 Apr; 279(14):13839-48. doi: 10.1074/jbc.m311743200. [PMID: 14732717]