Fenclonine (BioDeep_00000392936)
代谢物信息卡片
4-Chloro-L-phenylalanine
化学式: C9H10ClNO2 (199.040003)
中文名称: 4-氯-L-苯基丙氨酸, (S)-2-氨基-3-(4-氯苯基)丙酸, DL-4-氯苯基丙氨酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=CC=C1CC(C(=O)O)N)Cl
InChI: InChI=1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)
描述信息
A non-proteinogenic L-alpha-amino acid that is L-phenylalanine in which the meta-hydrogen of the phenyl group has been replaced by a chlorine.
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
D004791 - Enzyme Inhibitors
C471 - Enzyme Inhibitor
同义名列表
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:47069
- ChEBI: CHEBI:110187
- KEGGdrug: D04143
- PubChem: 736190
- PubChem: 4652
- ChEMBL: CHEMBL412813
- ChEMBL: CHEMBL1256351
- MeSH: Fenclonine
- CAS: 14173-39-8
- CAS: 1991-78-2
- CAS: 7424-00-2
- PMhub: MS000243249
- MetaboLights: MTBLC47069
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yingxin Chu, Yinjie Zhang, Jiaxing Liu, Chenhui Du, Yan Yan. An integrated liver, hippocampus and serum metabolomics based on UPLC-Q-TOF-MS revealed the therapeutical mechanism of Ziziphi Spinosae Semen in p-chlorophenylalanine-induced insomnia rats.
Biomedical chromatography : BMC.
2024 Mar; 38(3):e5796. doi:
10.1002/bmc.5796. [PMID: 38009807] - Xinye Li, Chao He, Min Shen, Mingyun Wang, Jingwen Zhou, Dongying Chen, Tong Zhang, Yiqiong Pu. Effects of aqueous extracts and volatile oils prepared from Huaxiang Anshen decoction on p-chlorophenylalanine-induced insomnia mice.
Journal of ethnopharmacology.
2023 Oct; 319(Pt 3):117331. doi:
10.1016/j.jep.2023.117331. [PMID: 37858748] - Qiao Lina, Shi Yinan, Tan Lianhong, Jiang Yanshu, Yang Yongsheng. Efficacy of electroacupuncture stimulating Shenmen (HT7), Baihui (GV20), Sanyinjiao (SP6) on spatial learning and memory deficits in rats with insomnia induced by para-chlorophenylalanine: a single acupoint combined acupoints.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2023 Aug; 43(4):704-714. doi:
10.19852/j.cnki.jtcm.20230308.001. [PMID: 37454255] - Yanpo Si, Wenjun Wei, Xiaohui Chen, Xiaolong Xie, Tao Guo, Yohei Sasaki, Youbo Zhang, Lili Wang, Fei Zhang, Shuying Feng. A comprehensive study on the relieving effect of Lilium brownii on the intestinal flora and metabolic disorder in p-chlorphenylalanine induced insomnia rats.
Pharmaceutical biology.
2022 Dec; 60(1):131-143. doi:
10.1080/13880209.2021.2019283. [PMID: 34978949] - Canhong Wang, Yunyun Wang, Bao Gong, Yulan Wu, Xiqin Chen, Yangyang Liu, Jianhe Wei. Effective Components and Molecular Mechanism of Agarwood Essential Oil Inhalation and the Sedative and Hypnotic Effects Based on GC-MS-Qtof and Molecular Docking.
Molecules (Basel, Switzerland).
2022 May; 27(11):. doi:
10.3390/molecules27113483. [PMID: 35684421] - Yanpo Si, Xiaohui Chen, Tao Guo, Wenjun Wei, Lili Wang, Fei Zhang, Xiaoya Sun, Mengqi Liu. Comprehensive 16S rDNA Sequencing and LC-MS/MS-Based Metabolomics to Investigate Intestinal Flora and Metabolic Profiles of the Serum, Hypothalamus and Hippocampus in p‑Chlorophenylalanine-Induced Insomnia Rats Treated with Lilium brownie.
Neurochemical research.
2022 Mar; 47(3):574-589. doi:
10.1007/s11064-021-03466-z. [PMID: 34661797] - Lan Yao, Jianhua Lv, Chao Duan, Xiaoya An, Chen Zhang, Dan Li, Changtian Li, Shuyan Liu. Armillaria mellea fermentation liquor ameliorates p-chlorophenylalanine-induced insomnia associated with the modulation of serotonergic system and gut microbiota in rats.
Journal of food biochemistry.
2022 02; 46(2):e14075. doi:
10.1111/jfbc.14075. [PMID: 34984694] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Eun Jung Bae, Won Gun Choi, Haushabhau S Pagire, Suvarna H Pagire, Saravanan Parameswaran, Jun-Ho Choi, Jihyeon Yoon, Won-Il Choi, Ji Hun Lee, Jin Sook Song, Myung Ae Bae, Mijin Kim, Jae-Han Jeon, In-Kyu Lee, Hail Kim, Jin Hee Ahn. Peripheral Selective Oxadiazolylphenyl Alanine Derivatives as Tryptophan Hydroxylase 1 Inhibitors for Obesity and Fatty Liver Disease.
Journal of medicinal chemistry.
2021 01; 64(2):1037-1053. doi:
10.1021/acs.jmedchem.0c01560. [PMID: 33417443] - Huafu Wang, Xianjin Qin, Zhihong Gui, Weihua Chu. The effect of Bailemian on neurotransmitters and gut microbiota in p-chlorophenylalanine induced insomnia mice.
Microbial pathogenesis.
2020 Nov; 148(?):104474. doi:
10.1016/j.micpath.2020.104474. [PMID: 32910986] - Małgorzata Gumułka, Anna Hrabia, Nataly Avital-Cohen, Krzysztof Andres, Israel Rozenboim. The effect of parachlorophenylalanine treatment on the activity of gonadal and lactotrophic axes in native Polish crested chickens stimulated to broodiness.
Poultry science.
2020 May; 99(5):2708-2717. doi:
10.1016/j.psj.2019.12.015. [PMID: 32359608] - Yujie Sun, Na Zhang, Yuxia Qu, Yijia Cao, Jianhao Li, Yuwei Yang, Tiange Yang, Yikun Sun. Shuangxia decoction alleviates p-chlorophenylalanine induced insomnia through the modification of serotonergic and immune system.
Metabolic brain disease.
2020 02; 35(2):315-325. doi:
10.1007/s11011-019-00499-w. [PMID: 31786727] - Kevin M Cheung, Kyung-Ae Yang, Nako Nakatsuka, Chuanzhen Zhao, Mao Ye, Michael E Jung, Hongyan Yang, Paul S Weiss, Milan N Stojanović, Anne M Andrews. Phenylalanine Monitoring via Aptamer-Field-Effect Transistor Sensors.
ACS sensors.
2019 12; 4(12):3308-3317. doi:
10.1021/acssensors.9b01963. [PMID: 31631652] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Yan Yan, Qiang Li, Hui-Zhi DU, Chen-Xi Shen, Ai-Ping Li, Xiang-Ping Pei, Chen-Hui DU, Xue-Mei Qin. Determination of five neurotransmitters in the rat brain for the study of the hypnotic effects of Ziziphi Spinosae Semen aqueous extract on insomnia rat model by UPLC-MS/MS.
Chinese journal of natural medicines.
2019 Jul; 17(7):551-560. doi:
10.1016/s1875-5364(19)30077-9. [PMID: 31514987] - Aruna Sharma, Rudy J Castellani, Mark A Smith, Dafin Fior Muresanu, Prasanta Kumar Dey, Hari Shanker Sharma. 5-Hydroxytryptophan: A precursor of serotonin influences regional blood-brain barrier breakdown, cerebral blood flow, brain edema formation, and neuropathology.
International review of neurobiology.
2019; 146(?):1-44. doi:
10.1016/bs.irn.2019.06.005. [PMID: 31349924] - Patrick Amoateng, Kennedy Kwami Edem Kukuia, Jeffrey Amoako Mensah, Dorcas Osei-Safo, Samuel Adjei, Audrey Akyea Eklemet, Emmanuel Atsu Vinyo, Thomas K Karikari. An extract of Synedrella nodiflora (L) Gaertn exhibits antidepressant properties through monoaminergic mechanisms.
Metabolic brain disease.
2018 08; 33(4):1359-1368. doi:
10.1007/s11011-018-0244-0. [PMID: 29754167] - Yu-Fei Ni, Hao Wang, Qiu-Yan Gu, Fei-Ying Wang, Ying-Jie Wang, Jin-Liang Wang, Bo Jiang. Gemfibrozil has antidepressant effects in mice: Involvement of the hippocampal brain-derived neurotrophic factor system.
Journal of psychopharmacology (Oxford, England).
2018 04; 32(4):469-481. doi:
10.1177/0269881118762072. [PMID: 29534628] - Solomon Umukoro, Somtochukwu I Ogboh, Osarume Omorogbe, Abdul-Lateef A Adekeye, Matthew O Olatunde. Evidence for the Involvement of Monoaminergic Pathways in the Antidepressant-Like Activity of Cymbopogon citratus in Mice.
Drug research.
2017 Jul; 67(7):419-424. doi:
10.1055/s-0043-106586. [PMID: 28499312] - Kimio Sugaya, Saori Nishijima, Katsumi Kadekawa, Katsuhiro Ashitomi, Tomoyuki Ueda, Hideyuki Yamamoto, Tsuyoshi Hattori. Action of naftopidil on spinal serotonergic neurotransmission for inhibition of the micturition reflex in rats.
Neurourology and urodynamics.
2017 03; 36(3):604-609. doi:
10.1002/nau.23028. [PMID: 27128660] - Sachie Sasaki-Hamada, Azusa Suzuki, Yudai Ueda, Kinzo Matsumoto, Jun-Ichiro Oka. Serotonergic and dopaminergic systems are implicated in antidepressant-like effects of chotosan, a Kampo formula, in mice.
Journal of pharmacological sciences.
2017 Feb; 133(2):110-113. doi:
10.1016/j.jphs.2017.01.002. [PMID: 28233634] - Chaoyang Zhou, Lingling Shi, Bin Ye, Haichao Feng, Ji Zhang, Ruifu Zhang, Xin Yan. pheS * , an effective host-genotype-independent counter-selectable marker for marker-free chromosome deletion in Bacillus amyloliquefaciens.
Applied microbiology and biotechnology.
2017 Jan; 101(1):217-227. doi:
10.1007/s00253-016-7906-9. [PMID: 27730334] - Franciane Bobinski, Tamara A A Ferreira, Marina M Córdova, Patrícia A Dombrowski, Cláudio da Cunha, Caroline C do Espírito Santo, Anicleto Poli, Rita G W Pires, Cristina Martins-Silva, Kathleen A Sluka, Adair R S Santos. Role of brainstem serotonin in analgesia produced by low-intensity exercise on neuropathic pain after sciatic nerve injury in mice.
Pain.
2015 Dec; 156(12):2595-2606. doi:
10.1097/j.pain.0000000000000372. [PMID: 26447701] - Rui Weng, Sensen Shen, Li Yang, Min Li, Yonglu Tian, Yu Bai, Huwei Liu. Lipidomic analysis of p-chlorophenylalanine-treated mice using continuous-flow two-dimensional liquid chromatography/quadrupole time-of-flight mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2015 Aug; 29(16):1491-500. doi:
10.1002/rcm.7241. [PMID: 26212164] - Yun-Yun Shao, Jing Huang, Yan-Rong Ma, Miao Han, Kang Ma, Hong-Yan Qin, Zhi Rao, Xin-An Wu. Serum serotonin reduced the expression of hepatic transporter Mrp2 and P-gp via regulating nuclear receptor CAR in PI-IBS rats.
Canadian journal of physiology and pharmacology.
2015 Aug; 93(8):633-9. doi:
10.1139/cjpp-2015-0039. [PMID: 26053941] - Rui Weng, Sensen Shen, Yonglu Tian, Casey Burton, Xinyuan Xu, Yi Liu, Cuilan Chang, Yu Bai, Huwei Liu. Metabolomics Approach Reveals Integrated Metabolic Network Associated with Serotonin Deficiency.
Scientific reports.
2015 Jul; 5(?):11864. doi:
10.1038/srep11864. [PMID: 26154191] - Katarzyna Młyniec, Magdalena Gaweł, Tadeusz Librowski, Witold Reczyński, Beata Bystrowska, Birgitte Holst. Investigation of the GPR39 zinc receptor following inhibition of monoaminergic neurotransmission and potentialization of glutamatergic neurotransmission.
Brain research bulletin.
2015 Jun; 115(?):23-9. doi:
10.1016/j.brainresbull.2015.04.005. [PMID: 25917396] - Ying-I Chen, Chung-Yuh Tzeng, Yu-Wen Cheng, Tai-Hao Hsu, Wai Jane Ho, Zeng-Chin Liang, Chang-Wei Hsieh, Jason T C Tzen, Shih-Liang Chang. The Involvement of Serotonin in the Hypoglycemic Effects Produced by Administration of the Aqueous Extract of Xylaria nigripes with Steroid-Induced Insulin-Resistant Rats.
Phytotherapy research : PTR.
2015 May; 29(5):770-6. doi:
10.1002/ptr.5314. [PMID: 25712886] - Yaxin Zheng, Jiming Wu, Xuesong Feng, Ying Jia, Jian Huang, Zhihui Hao, Songyan Zhao, Jinhui Wang. In silico Analysis and Experimental Validation of Lignan Extracts from Kadsura longipedunculata for Potential 5-HT1AR Agonists.
PloS one.
2015; 10(6):e0130055. doi:
10.1371/journal.pone.0130055. [PMID: 26076134] - Tan Wee Nie, Mohamed Saleem Abdul Shukkoor, Rajesh Sreedharan Nair, Fatimah Khursiah Binti Amiruddin, Shamala Ramasamy. Involvement of opioidergic and serotonergic systems in the analgesic activity of Cissus quadrangularis L. stem extract in mice.
Journal of basic and clinical physiology and pharmacology.
2015 Jan; 26(1):35-41. doi:
10.1515/jbcpp-2014-0035. [PMID: 24810560] - James Oluwagbamigbe Fajemiroye, Pablinny Moreira Galdino, Joelma Abadia Marciano De Paula, Fagundes Fabio Rocha, Moses A Akanmu, Frederico Argollo Vanderlinde, Jordan K Zjawiony, Elson Alves Costa. Anxiolytic and antidepressant like effects of natural food flavour (E)-methyl isoeugenol.
Food & function.
2014 Aug; 5(8):1819-28. doi:
10.1039/c4fo00109e. [PMID: 24920211] - Wei He, Guanghui Liu, Hao Cai, Xiuman Sun, Waner Hou, Peiting Zhang, Zhiyong Xie, Qiongfeng Liao. Integrated pharmacokinetics of five protoberberine-type alkaloids in normal and insomnic rats after single and multiple oral administration of Jiao-Tai-Wan.
Journal of ethnopharmacology.
2014 Jul; 154(3):635-44. doi:
10.1016/j.jep.2014.04.040. [PMID: 24815220] - Aarti Khulbe, Savita Pandey, Sangeeta Pilkhwal Sah. Antidepressant-like action of the hydromethanolic flower extract of Tagetes erecta L. in mice and its possible mechanism of action.
Indian journal of pharmacology.
2013 Jul; 45(4):386-90. doi:
10.4103/0253-7613.115026. [PMID: 24014916] - Hongchao Wang, Haiqin Chen, Guangfei Hao, Bo Yang, Yun Feng, Yu Wang, Lu Feng, Jianxin Zhao, Yuanda Song, Hao Zhang, Yong Q Chen, Lei Wang, Wei Chen. Role of the phenylalanine-hydroxylating system in aromatic substance degradation and lipid metabolism in the oleaginous fungus Mortierella alpina.
Applied and environmental microbiology.
2013 May; 79(10):3225-33. doi:
10.1128/aem.00238-13. [PMID: 23503309] - Nader Mobarkey, Natalie Avital, Rachel Heiblum, Israel Rozenboim. The effect of parachlorophenylalanine and active immunization against vasoactive intestinal peptide on reproductive activities of broiler breeder hens photostimulated with green light.
Biology of reproduction.
2013 Apr; 88(4):83. doi:
10.1095/biolreprod.112.103697. [PMID: 23325814] - Tapan Audhya, James B Adams, Leah Johansen. Correlation of serotonin levels in CSF, platelets, plasma, and urine.
Biochimica et biophysica acta.
2012 Oct; 1820(10):1496-501. doi:
10.1016/j.bbagen.2012.05.012. [PMID: 22664303] - Yue Tu, Shi-xiang Cheng, Hong-tao Sun, Tie-zhu Ma, Sai Zhang. Ferulic acid potentiates pentobarbital-induced sleep via the serotonergic system.
Neuroscience letters.
2012 Sep; 525(2):95-9. doi:
10.1016/j.neulet.2012.07.068. [PMID: 22897877] - Katie Ann Jennings, Cecilie Löe Licht, Aynsley Bruce, Klaus-Peter Lesch, Gitte Moos Knudsen, Trevor Sharp. Genetic variation in 5-hydroxytryptamine transporter expression causes adaptive changes in 5-HT₄ receptor levels.
The international journal of neuropsychopharmacology.
2012 Sep; 15(8):1099-107. doi:
10.1017/s1461145711001258. [PMID: 21846421] - Pallavi B Shewale, Rupali A Patil, Yogesh A Hiray. Antidepressant-like activity of anthocyanidins from Hibiscus rosa-sinensis flowers in tail suspension test and forced swim test.
Indian journal of pharmacology.
2012 Jul; 44(4):454-7. doi:
10.4103/0253-7613.99303. [PMID: 23087504] - Klaus Pönicke, Ulrich Gergs, Igor B Buchwalow, Steffen Hauptmann, Joachim Neumann. On the presence of serotonin in mammalian cardiomyocytes.
Molecular and cellular biochemistry.
2012 Jun; 365(1-2):301-12. doi:
10.1007/s11010-012-1270-6. [PMID: 22367115] - Ryan E O'Leary, Jean C Shih, Keith Hyland, Nancy Kramer, Y Jane Tavyev Asher, John M Graham. De novo microdeletion of Xp11.3 exclusively encompassing the monoamine oxidase A and B genes in a male infant with episodic hypotonia: a genomics approach to personalized medicine.
European journal of medical genetics.
2012 May; 55(5):349-53. doi:
10.1016/j.ejmg.2012.01.007. [PMID: 22365943] - Ana C Stein, Alice F Viana, Liz G Müller, Jéssica M Nunes, Eveline D Stolz, Jean-Claude Do Rego, Jean Costentin, Gilsane L von Poser, Stela M K Rates. Uliginosin B, a phloroglucinol derivative from Hypericum polyanthemum: a promising new molecular pattern for the development of antidepressant drugs.
Behavioural brain research.
2012 Mar; 228(1):66-73. doi:
10.1016/j.bbr.2011.11.031. [PMID: 22155486] - Zdeněk Svagera, Dagmar Hanzlíková, Petr Simek, Petr Hušek. Study of disulfide reduction and alkyl chloroformate derivatization of plasma sulfur amino acids using gas chromatography-mass spectrometry.
Analytical and bioanalytical chemistry.
2012 Mar; 402(9):2953-63. doi:
10.1007/s00216-012-5727-y. [PMID: 22349320] - Ana Elisa Gonçalves, Cristiani Bürger, Solomon K S Amoah, Rogério Tolardo, Maique W Biavatti, Márcia M de Souza. The antidepressant-like effect of Hedyosmum brasiliense and its sesquiterpene lactone, podoandin in mice: evidence for the involvement of adrenergic, dopaminergic and serotonergic systems.
European journal of pharmacology.
2012 Jan; 674(2-3):307-14. doi:
10.1016/j.ejphar.2011.11.009. [PMID: 22115892] - Sanjay Mandhane, Prasanta Nayak, Durgesh Soni, Shakti Jain, John C Ashton, Thennati Rajamannar. Induction of glucose intolerance by acute administration of rimonabant.
Pharmacology.
2012; 89(5-6):339-47. doi:
10.1159/000337731. [PMID: 22678147] - Mark J Airhart, Deborah H Lee, Tracy D Wilson, Barney E Miller, Merry N Miller, Richard G Skalko, Paul J Monaco. Adverse effects of serotonin depletion in developing zebrafish.
Neurotoxicology and teratology.
2012 Jan; 34(1):152-60. doi:
10.1016/j.ntt.2011.08.008. [PMID: 21893190] - Dinesh Dhingra, Ritu Chhillar. Antidepressant-like activity of ellagic acid in unstressed and acute immobilization-induced stressed mice.
Pharmacological reports : PR.
2012; 64(4):796-807. doi:
10.1016/s1734-1140(12)70875-7. [PMID: 23087132] - Hiroshi Onogi, Osamu Nakagawasai, Atsushi Sato, Satoru Mitazaki, Kota Nakaya, Kenya Watanabe, Fukie Niijima-Yaoita, Koichi Tan-No, Yuichiro Arai, Tsuneaki Kikuchi, Takeshi Tadano. p-Hydroxyamphetamine causes prepulse inhibition disruption in mice: contribution of serotonin neurotransmission.
Behavioural brain research.
2011 Oct; 224(1):159-65. doi:
10.1016/j.bbr.2011.06.002. [PMID: 21689684] - Kevin White, Yvonne Dempsie, Margaret Nilsen, Audrey F Wright, Lynn Loughlin, Margaret R MacLean. The serotonin transporter, gender, and 17β oestradiol in the development of pulmonary arterial hypertension.
Cardiovascular research.
2011 May; 90(2):373-82. doi:
10.1093/cvr/cvq408. [PMID: 21177701] - Yong Chen, Florian Palm, Klaus-Peter Lesch, Manfred Gerlach, Rainald Moessner, Claudia Sommer. 5-hydroxyindolacetic acid (5-HIAA), a main metabolite of serotonin, is responsible for complete Freund's adjuvant-induced thermal hyperalgesia in mice.
Molecular pain.
2011 Mar; 7(?):21. doi:
10.1186/1744-8069-7-21. [PMID: 21447193] - Nikolaos Psychogios, David D Hau, Jun Peng, An Chi Guo, Rupasri Mandal, Souhaila Bouatra, Igor Sinelnikov, Ramanarayan Krishnamurthy, Roman Eisner, Bijaya Gautam, Nelson Young, Jianguo Xia, Craig Knox, Edison Dong, Paul Huang, Zsuzsanna Hollander, Theresa L Pedersen, Steven R Smith, Fiona Bamforth, Russ Greiner, Bruce McManus, John W Newman, Theodore Goodfriend, David S Wishart. The human serum metabolome.
PloS one.
2011 Feb; 6(2):e16957. doi:
10.1371/journal.pone.0016957. [PMID: 21359215] - Ashok Agrawal, Mahalaxmi Mohan, Sanjay Kasture, Caterina Foddis, Maria Assunta Frau, Maria Cecilia Loi, Andrea Maxia. Antidepressant activity of Ceratonia siliqua L. fruit extract, a source of polyphenols.
Natural product research.
2011 Feb; 25(4):450-6. doi:
10.1080/14786419.2010.527447. [PMID: 21328139] - Gislaine Z Réus, Roberto B Stringari, Bruna de Souza, Fabrícia Petronilho, Felipe Dal-Pizzol, Jaime E Hallak, Antônio W Zuardi, José A Crippa, João Quevedo. Harmine and imipramine promote antioxidant activities in prefrontal cortex and hippocampus.
Oxidative medicine and cellular longevity.
2010 Sep; 3(5):325-31. doi:
10.4161/oxim.3.5.13109. [PMID: 21150338] - Jonathan L Brigman, Poonam Mathur, Judith Harvey-White, Alicia Izquierdo, Lisa M Saksida, Timothy J Bussey, Stephanie Fox, Evan Deneris, Dennis L Murphy, Andrew Holmes. Pharmacological or genetic inactivation of the serotonin transporter improves reversal learning in mice.
Cerebral cortex (New York, N.Y. : 1991).
2010 Aug; 20(8):1955-63. doi:
10.1093/cercor/bhp266. [PMID: 20032063] - Shikha Girdhar, Manish M Wanjari, Sunil K Prajapati, Amit Girdhar. Evaluation of anti-compulsive effect of methanolic extract of Benincasa hispida Cogn. fruit in mice.
Acta poloniae pharmaceutica.
2010 Jul; 67(4):417-21. doi:
". [PMID: 20635538] - Myrna Déciga-Campos, María Yolanda Rios, A Berenice Aguilar-Guadarrama. Antinociceptive effect of Heliopsis longipes extract and affinin in mice.
Planta medica.
2010 May; 76(7):665-70. doi:
10.1055/s-0029-1240658. [PMID: 19950048] - Sunoh Kwon, Bombi Lee, Myunghwan Kim, Hyejung Lee, Hi-Joon Park, Dae-Hyun Hahm. Antidepressant-like effect of the methanolic extract from Bupleurum falcatum in the tail suspension test.
Progress in neuro-psychopharmacology & biological psychiatry.
2010 Mar; 34(2):265-70. doi:
10.1016/j.pnpbp.2009.11.015. [PMID: 19932727] - Jens Benninghoff, Angela Gritti, Matteo Rizzi, Giuseppe Lamorte, Robert J Schloesser, Angelika Schmitt, Stefanie Robel, Just Genius, Rainald Moessner, Peter Riederer, Husseini K Manji, Heinz Grunze, Dan Rujescu, Hans-Juergen Moeller, Klaus-Peter Lesch, Angelo Luigi Vescovi. Serotonin depletion hampers survival and proliferation in neurospheres derived from adult neural stem cells.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2010 Mar; 35(4):893-903. doi:
10.1038/npp.2009.181. [PMID: 20010549] - Meredith A Fox, Alison R Stein, Helen T French, Dennis L Murphy. Functional interactions between 5-HT2A and presynaptic 5-HT1A receptor-based responses in mice genetically deficient in the serotonin 5-HT transporter (SERT).
British journal of pharmacology.
2010 Feb; 159(4):879-87. doi:
10.1111/j.1476-5381.2009.00578.x. [PMID: 20128812] - Marwa A Aboukhatwa, Ashiwel S Undieh. Antidepressant stimulation of CDP-diacylglycerol synthesis does not require monoamine reuptake inhibition.
BMC neuroscience.
2010 Jan; 11(?):10. doi:
10.1186/1471-2202-11-10. [PMID: 20105322] - Sarai Hess, Cristina Padoani, Laiana Carla Scorteganha, Iandra Holzmann, Angela Malheiros, Rosendo Augusto Yunes, Franco Delle Monache, Márcia Maria de Souza. Assessment of mechanisms involved in antinociception caused by myrsinoic acid B.
Biological & pharmaceutical bulletin.
2010; 33(2):209-15. doi:
10.1248/bpb.33.209. [PMID: 20118542] - Akula Ramakrishna, Parvatam Giridhar, G A Ravishankar. Indoleamines and calcium channels influence morphogenesis in in vitro cultures of Mimosa pudica L.
Plant signaling & behavior.
2009 Dec; 4(12):1136-41. doi:
10.4161/psb.4.12.10101. [PMID: 20514228] - O O Masalova, N S Sapronov. The role of the serotoninergic system in the regulation of thyroid function in old rats.
Bulletin of experimental biology and medicine.
2009 Nov; 148(5):815-8. doi:
10.1007/s10517-010-0824-4. [PMID: 20396800] - Maria Carrillo, Lesley A Ricci, Glen A Coppersmith, Richard H Melloni. The effect of increased serotonergic neurotransmission on aggression: a critical meta-analytical review of preclinical studies.
Psychopharmacology.
2009 Aug; 205(3):349-68. doi:
10.1007/s00213-009-1543-2. [PMID: 19404614] - Daniele G Machado, Luis E B Bettio, Mauricio P Cunha, Juliano C Capra, Juliana B Dalmarco, Moacir G Pizzolatti, Ana Lúcia S Rodrigues. Antidepressant-like effect of the extract of Rosmarinus officinalis in mice: involvement of the monoaminergic system.
Progress in neuro-psychopharmacology & biological psychiatry.
2009 Jun; 33(4):642-50. doi:
10.1016/j.pnpbp.2009.03.004. [PMID: 19286446] - Cecilie L Licht, Anders B Marcussen, Gregers Wegener, David H Overstreet, Susana Aznar, Gitte M Knudsen. The brain 5-HT4 receptor binding is down-regulated in the Flinders Sensitive Line depression model and in response to paroxetine administration.
Journal of neurochemistry.
2009 Jun; 109(5):1363-74. doi:
10.1111/j.1471-4159.2009.06050.x. [PMID: 19476548] - Mireille Basselin, Meredith A Fox, Lisa Chang, Jane M Bell, Dede Greenstein, Mei Chen, Dennis L Murphy, Stanley I Rapoport. Imaging elevated brain arachidonic acid signaling in unanesthetized serotonin transporter (5-HTT)-deficient mice.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2009 Jun; 34(7):1695-709. doi:
10.1038/npp.2008.227. [PMID: 19145225] - Zaorui Zhao, Han-Ting Zhang, Elianna Bootzin, Mark J Millan, James M O'Donnell. Association of changes in norepinephrine and serotonin transporter expression with the long-term behavioral effects of antidepressant drugs.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2009 May; 34(6):1467-81. doi:
10.1038/npp.2008.183. [PMID: 18923402] - Silvia Laura Guzmán-Gutiérrez, Andrés Navarrete. Pharmacological exploration of the sedative mechanism of hesperidin identified as the active principle of Citrus sinensis flowers.
Planta medica.
2009 Mar; 75(4):295-301. doi:
10.1055/s-0029-1185306. [PMID: 19219759] - D I Nasyrova, N A Urtikova, A Ia Sapronova, M V Ugriumov. [Brain is a source of blood serotonin in rats during perinatal development].
Ontogenez.
2009 Jan; 40(1):55-64. doi:
NULL. [PMID: 19326844] - Joanna Solich, Paulina Pałach, Bogusława Budziszewska, Marta Dziedzicka-Wasylewska. Effect of two behavioral tests on corticosterone level in plasma of mice lacking the noradrenaline transporter.
Pharmacological reports : PR.
2008 Nov; 60(6):1008-13. doi:
NULL. [PMID: 19211997] - Prem Prakash Tripathi, Luca Giovanni Di Giovannantonio, Alessandro Viegi, Wolfgang Wurst, Antonio Simeone, Yuri Bozzi. Serotonin hyperinnervation abolishes seizure susceptibility in Otx2 conditional mutant mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2008 Sep; 28(37):9271-6. doi:
10.1523/jneurosci.2208-08.2008. [PMID: 18784307] - Daniele G Machado, Luis E B Bettio, Mauricio P Cunha, Adair R S Santos, Moacir G Pizzolatti, Inês M C Brighente, Ana Lúcia S Rodrigues. Antidepressant-like effect of rutin isolated from the ethanolic extract from Schinus molle L. in mice: evidence for the involvement of the serotonergic and noradrenergic systems.
European journal of pharmacology.
2008 Jun; 587(1-3):163-8. doi:
10.1016/j.ejphar.2008.03.021. [PMID: 18457827] - Lei An, You-Zhi Zhang, Neng-Jiang Yu, Xin-Min Liu, Nan Zhao, Li Yuan, Yun-Feng Li. Role for serotonin in the antidepressant-like effect of a flavonoid extract of Xiaobuxin-Tang.
Pharmacology, biochemistry, and behavior.
2008 Jun; 89(4):572-80. doi:
10.1016/j.pbb.2008.02.014. [PMID: 18367239] - Yasuhito Nakatomi, Chihiro Yokoyama, Seijiro Kinoshita, Daiki Masaki, Hideto Tsuchida, Hirotaka Onoe, Kanji Yoshimoto, Kenji Fukui. Serotonergic mediation of the antidepressant-like effect of the green leaves odor in mice.
Neuroscience letters.
2008 May; 436(2):167-70. doi:
10.1016/j.neulet.2008.03.013. [PMID: 18378079] - Boris Mlinar, Simona Mascalchi, Raffaella Morini, Filippo Giachi, Renato Corradetti. MDMA induces EPSP-Spike potentiation in rat ventral hippocampus in vitro via serotonin and noradrenaline release and coactivation of 5-HT4 and beta1 receptors.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2008 May; 33(6):1464-75. doi:
10.1038/sj.npp.1301512. [PMID: 17653110] - L L Hernandez, C M Stiening, J B Wheelock, L H Baumgard, A M Parkhurst, R J Collier. Evaluation of serotonin as a feedback inhibitor of lactation in the bovine.
Journal of dairy science.
2008 May; 91(5):1834-44. doi:
10.3168/jds.2007-0766. [PMID: 18420614] - K A Jennings, W J Sheward, A J Harmar, T Sharp. Evidence that genetic variation in 5-HT transporter expression is linked to changes in 5-HT2A receptor function.
Neuropharmacology.
2008 Apr; 54(5):776-83. doi:
10.1016/j.neuropharm.2007.12.001. [PMID: 18241894] - Rui Wang, Ying Xu, Hong-Li Wu, Ying-Bo Li, Yu-Hua Li, Jia-Bin Guo, Xue-Jun Li. The antidepressant effects of curcumin in the forced swimming test involve 5-HT1 and 5-HT2 receptors.
European journal of pharmacology.
2008 Jan; 578(1):43-50. doi:
10.1016/j.ejphar.2007.08.045. [PMID: 17942093] - Simone M Smits, Cornelle W Noorlander, Martien J H Kas, Geert M J Ramakers, Marten P Smidt. Alterations in serotonin signalling are involved in the hyperactivity of Pitx3-deficient mice.
The European journal of neuroscience.
2008 Jan; 27(2):388-95. doi:
10.1111/j.1460-9568.2008.06032.x. [PMID: 18215235] - Judith R Homberg, Olga J G Schiepers, Anton N M Schoffelmeer, Edwin Cuppen, Louk J M J Vanderschuren. Acute and constitutive increases in central serotonin levels reduce social play behaviour in peri-adolescent rats.
Psychopharmacology.
2007 Dec; 195(2):175-82. doi:
10.1007/s00213-007-0895-8. [PMID: 17661017] - Dinesh Dhingra, Rekha Valecha. Evaluation of antidepressant-like activity of aqueous and ethanolic extracts of Terminalia bellirica Roxb. fruits in mice.
Indian journal of experimental biology.
2007 Jul; 45(7):610-6. doi:
". [PMID: 17821856] - Dinesh Dhingra, Rekha Valecha. Evaluation of the antidepressant-like activity of Convolvulus pluricaulis choisy in the mouse forced swim and tail suspension tests.
Medical science monitor : international medical journal of experimental and clinical research.
2007 Jul; 13(7):BR155-61. doi:
". [PMID: 17599020] - Guo-Xiang Xie, Yun-Ping Qiu, Ming-Feng Qiu, Xian-Fu Gao, Yu-Min Liu, Wei Jia. Analysis of dencichine in Panax notoginseng by gas chromatography-mass spectrometry with ethyl chloroformate derivatization.
Journal of pharmaceutical and biomedical analysis.
2007 Feb; 43(3):920-5. doi:
10.1016/j.jpba.2006.09.009. [PMID: 17029672] - Arturo Zazpe, Inés Artaiz, Ana Innerárity, Elena Del Olmo, Elena Castro, Luis Labeaga, Angel Pazos, Aurelio Orjales. In vitro and in vivo characterization of F-97013-GD, a partial 5-HT1A agonist with antipsychotic- and antiparkinsonian-like properties.
Neuropharmacology.
2006 Jul; 51(1):129-40. doi:
10.1016/j.neuropharm.2006.03.008. [PMID: 16643965] - Chloé Alexandre, Daniela Popa, Véronique Fabre, Saoussen Bouali, Patrice Venault, Klaus-Peter Lesch, Michel Hamon, Joëlle Adrien. Early life blockade of 5-hydroxytryptamine 1A receptors normalizes sleep and depression-like behavior in adult knock-out mice lacking the serotonin transporter.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2006 May; 26(20):5554-64. doi:
10.1523/jneurosci.5156-05.2006. [PMID: 16707806] - Dinesh Dhingra, Amandeep Sharma. Antidepressant-like activity of Glycyrrhiza glabra L. in mouse models of immobility tests.
Progress in neuro-psychopharmacology & biological psychiatry.
2006 May; 30(3):449-54. doi:
10.1016/j.pnpbp.2005.11.019. [PMID: 16443316] - Saadia Eddahibi, Christophe Guignabert, Anne-Marie Barlier-Mur, Laurence Dewachter, Elie Fadel, Philippe Dartevelle, Marc Humbert, Gerald Simonneau, Naïma Hanoun, Françoise Saurini, Michel Hamon, Serge Adnot. Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: critical role for serotonin-induced smooth muscle hyperplasia.
Circulation.
2006 Apr; 113(15):1857-64. doi:
10.1161/circulationaha.105.591321. [PMID: 16606791] - Juan R Muñoz-Castañeda, Pedro Montilla, Francisco J Padillo, Inmaculada Bujalance, Maria C Muñoz, Jordi Muntané, Isaac Túnez. Role of serotonin in cerebral oxidative stress in rats.
Acta neurobiologiae experimentalis.
2006; 66(1):1-6. doi:
. [PMID: 16617671] - Dinesh Dhingra, Amandeep Sharma. Antidepressant-like activity of n-hexane extract of nutmeg (Myristica fragrans) seeds in mice.
Journal of medicinal food.
2006; 9(1):84-9. doi:
10.1089/jmf.2006.9.84. [PMID: 16579733] - Maria M Campos, Elizabeth S Fernandes, Juliano Ferreira, Adair R S Santos, João B Calixto. Antidepressant-like effects of Trichilia catigua (Catuaba) extract: evidence for dopaminergic-mediated mechanisms.
Psychopharmacology.
2005 Oct; 182(1):45-53. doi:
10.1007/s00213-005-0052-1. [PMID: 15991001] - Juan R Muñoz-Castañeda, Pedro Montilla, Maria C Muñoz, Immaculada Bujalance, Jordi Muntané, Isaac Túnez. Parachlorophenylalanine exacerbates oxidative stress induced by gentamicin in rats.
Basic & clinical pharmacology & toxicology.
2005 Sep; 97(3):174-8. doi:
10.1111/j.1742-7843.2005.pto_973141.x. [PMID: 16128912] - Shih-Liang Chang, Chin-Chuan Tsai, Jaung-Geng Lin, Ching-Liang Hsieh, Rong-Tsung Lin, Juei-Tang Cheng. Involvement of serotonin in the hypoglycemic response to 2 Hz electroacupuncture of zusanli acupoint (ST36) in rats.
Neuroscience letters.
2005 Apr; 379(1):69-73. doi:
10.1016/j.neulet.2004.12.057. [PMID: 15814202] - Takanori Esaki, Michelle Cook, Kazuaki Shimoji, Dennis L Murphy, Louis Sokoloff, Andrew Holmes. Developmental disruption of serotonin transporter function impairs cerebral responses to whisker stimulation in mice.
Proceedings of the National Academy of Sciences of the United States of America.
2005 Apr; 102(15):5582-7. doi:
10.1073/pnas.0501509102. [PMID: 15809439] - María Elena Avale, Sergio Iván Nemirovsky, Rita Raisman-Vozari, Marcelo Rubinstein. Elevated serotonin is involved in hyperactivity but not in the paradoxical effect of amphetamine in mice neonatally lesioned with 6-hydroxydopamine.
Journal of neuroscience research.
2004 Oct; 78(2):289-96. doi:
10.1002/jnr.20245. [PMID: 15378510] - Sylvie Chalon, Cécile Bronquard, Johnny Vercouillie, Ercem Kodas, Lucette Garreau, Sylvie Bodard, Patrick Emond, Jean-Claude Besnard, Denis Guilloteau. ADAM is an effective tool for in vivo study of serotonergic function: validation in rat models.
Synapse (New York, N.Y.).
2004 May; 52(2):136-42. doi:
10.1002/syn.20012. [PMID: 15034919] - Antonio Carrillo-Vico, Juan R Calvo, Pedro Abreu, Patricia J Lardone, Sofía García-Mauriño, Russel J Reiter, Juan M Guerrero. Evidence of melatonin synthesis by human lymphocytes and its physiological significance: possible role as intracrine, autocrine, and/or paracrine substance.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2004 Mar; 18(3):537-9. doi:
10.1096/fj.03-0694fje. [PMID: 14715696] - A Heinz, D W Jones, K Zajicek, J G Gorey, G Juckel, J D Higley, D R Weinberger. Depletion and restoration of endogenous monoamines affects beta-CIT binding to serotonin but not dopamine transporters in non-human primates.
Journal of neural transmission. Supplementum.
2004; ?(68):29-38. doi:
10.1007/978-3-7091-0579-5_4. [PMID: 15354387] - C I Gutiérrez, M Urbina, F Obregion, J Glykys, L Lima. Characterization of tryptophan high affinity transport system in pinealocytes of the rat. Day-night modulation.
Amino acids.
2003 Jul; 25(1):95-105. doi:
10.1007/s00726-002-0353-1. [PMID: 12836064]