N-[(6-oxo-5-prop-2-enyl-1-cyclohexa-2,4-dienylidene)methyl]-2-[4-(phenylmethyl)-1-piperazinyl]acetohydrazide (BioDeep_00000392687)

   


代谢物信息卡片


N-[(6-oxo-5-prop-2-enyl-1-cyclohexa-2,4-dienylidene)methyl]-2-[4-(phenylmethyl)-1-piperazinyl]acetohydrazide

化学式: C23H28N4O2 (392.2212148)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C=CCc1cccc(C=NN=C(O)CN2CCN(Cc3ccccc3)CC2)c1O
InChI:



数据库引用编号

2 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Kurosh Parsi, David E Connor, Anne Pilotelle, Joyce Low, David D F Ma, Joanne E Joseph. Low concentration detergent sclerosants induce platelet activation but inhibit aggregation due to suppression of GPIIb/IIIa activation in vitro. Thrombosis research. 2012 Sep; 130(3):472-8. doi: 10.1016/j.thromres.2012.03.023. [PMID: 22531012]
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  • Ying-Xue Li, Qiang Sun, Hui Zhang, Shu-Ting Ren, Yi-Ran Liao, Ya Wang, Xin-Liang Shen, Bing Wang. A novel anti-platelet peptide (Z4A5) potential for glycoprotein IIb/IIIa inhibits platelet aggregation. Thrombosis research. 2012 May; 129(5):e217-22. doi: 10.1016/j.thromres.2012.02.047. [PMID: 22445430]
  • Yan Yang, Zhenyin Shi, Adili Reheman, Joseph W Jin, Conglei Li, Yiming Wang, Marc C Andrews, Pingguo Chen, Guangheng Zhu, Wenhua Ling, Heyu Ni. Plant food delphinidin-3-glucoside significantly inhibits platelet activation and thrombosis: novel protective roles against cardiovascular diseases. PloS one. 2012; 7(5):e37323. doi: 10.1371/journal.pone.0037323. [PMID: 22624015]
  • Bryan N Kahner, Hisashi Kato, Asoka Banno, Mark H Ginsberg, Sanford J Shattil, Feng Ye. Kindlins, integrin activation and the regulation of talin recruitment to αIIbβ3. PloS one. 2012; 7(3):e34056. doi: 10.1371/journal.pone.0034056. [PMID: 22457811]
  • Kyu Kwang Kim, Ajay P Singh, Rakesh K Singh, Angelica Demartino, Laurent Brard, Nicholi Vorsa, Thilo S Lange, Richard G Moore. Anti-angiogenic activity of cranberry proanthocyanidins and cytotoxic properties in ovarian cancer cells. International journal of oncology. 2012 Jan; 40(1):227-35. doi: 10.3892/ijo.2011.1198. [PMID: 21922132]
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  • Jun Zhou, Changhong Zhang, Jinghan Liu, Lixia Fan, Liangui Yang. Loading solution prevents activation damage of human platelets before lyophilization. Cryobiology. 2011 Dec; 63(3):229-34. doi: 10.1016/j.cryobiol.2011.08.007. [PMID: 21945819]
  • Pamela W Lucas, Joanna M Schmit, Quinn P Peterson, Diana C West, Danny C Hsu, Chris J Novotny, Levent Dirikolu, Mona I Churchwell, Daniel R Doerge, Laura D Garrett, Paul J Hergenrother, Timothy M Fan. Pharmacokinetics and derivation of an anticancer dosing regimen for PAC-1, a preferential small molecule activator of procaspase-3, in healthy dogs. Investigational new drugs. 2011 Oct; 29(5):901-11. doi: 10.1007/s10637-010-9445-z. [PMID: 20499133]
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  • Raffaella Priora, Antonios Margaritis, Simona Frosali, Lucia Coppo, Domenico Summa, Danila Di Giuseppe, Carlo Aldinucci, Gianpaolo Pessina, Anna Di Stefano, Paolo Di Simplicio. In vitro inhibition of human and rat platelets by NO donors, nitrosoglutathione, sodium nitroprusside and SIN-1, through activation of cGMP-independent pathways. Pharmacological research. 2011 Sep; 64(3):289-97. doi: 10.1016/j.phrs.2011.03.014. [PMID: 21539916]
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  • Xin Zhang, Feng Tan, Chuan-zhi Duan. [Effect of electro-needling at acupoints of the yangming meridian on the expression of PAC-1 and lower limb functions in acute cerebral infarction patients]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2011 Apr; 31(4):483-6. doi: ". [PMID: 21608218]
  • Li-Na Fang, Xiao-Hui Chen, Qiu-Di Wang, Di Zhang, Juan-Juan Zhao, Zhi-Min Long, Ping Gong, Kai-Shun Bi. A liquid chromatography-tandem mass spectrometry method for the quantification of PAC-1 in rat plasma. Journal of pharmaceutical and biomedical analysis. 2011 Jan; 54(1):225-9. doi: 10.1016/j.jpba.2010.07.042. [PMID: 20828970]
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  • Anne Fischer-Nielsen, Trine Stissing, Charlotte Maansson, Bent Gymoese Joergensen. Pressure-aided transfusion of platelets: does it affect the platelets?. Transfusion. 2010 Feb; 50(2):361-5. doi: 10.1111/j.1537-2995.2009.02396.x. [PMID: 19788509]
  • Hong-Xia Yao, Li Huang, Li-E Lin, Cong-Ming Wu, Hua Wang, Wen-Ting Chen, Xiang-Jun Fu, Yi-Peng Ding. [The study of relationship between platelet function and thrombus in patients with essential thrombocythaemia]. Zhonghua yi xue za zhi. 2010 Jan; 90(4):253-5. doi: . [PMID: 20356540]
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  • Min Suk Kim, Fang Wang, Prasanth Puthanveetil, Girish Kewalramani, Sheila Innis, Lucy Marzban, Susan F Steinberg, Travis D Webber, Timothy J Kieffer, Ashraf Abrahani, Brian Rodrigues. Cleavage of protein kinase D after acute hypoinsulinemia prevents excessive lipoprotein lipase-mediated cardiac triglyceride accumulation. Diabetes. 2009 Nov; 58(11):2464-75. doi: 10.2337/db09-0681. [PMID: 19875622]
  • Anne-lie Ståhl, Lisa Sartz, Anders Nelsson, Zivile D Békássy, Diana Karpman. Shiga toxin and lipopolysaccharide induce platelet-leukocyte aggregates and tissue factor release, a thrombotic mechanism in hemolytic uremic syndrome. PloS one. 2009 Sep; 4(9):e6990. doi: 10.1371/journal.pone.0006990. [PMID: 19750223]
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  • Osamu Ayukawa, Kazuo Nakamura, Hiroko Kariyazono, Ryuji Ikeda, Junko Arima, Terutoshi Shinkawa, Harunobu Iwase, Ryuzo Sakata, Katsushi Yamada. Enhanced platelet responsiveness due to chilling and its relation to CD40 ligand level and platelet-leukocyte aggregate formation. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. 2009 Apr; 20(3):176-84. doi: 10.1097/mbc.0b013e328322ffd5. [PMID: 19300046]
  • Konstantinos Stellos, Boris Bigalke, Harald Langer, Tobias Geisler, Annika Schad, Andreas Kögel, Florian Pfaff, Dimitrios Stakos, Peter Seizer, Iris Müller, Patrick Htun, Stephan Lindemann, Meinrad Gawaz. Expression of stromal-cell-derived factor-1 on circulating platelets is increased in patients with acute coronary syndrome and correlates with the number of CD34+ progenitor cells. European heart journal. 2009 Mar; 30(5):584-93. doi: 10.1093/eurheartj/ehn566. [PMID: 19109356]
  • Li-Na Fang, Xiao-Hui Chen, Zhen Song, Gang Wang, Xu Zhao, Lei Ren, Ping Gong, Kai-Shun Bi. Development of a high performance liquid chromatography method for quantification of PAC-1 in rat plasma. Journal of pharmaceutical and biomedical analysis. 2009 Feb; 49(2):447-50. doi: 10.1016/j.jpba.2008.11.024. [PMID: 19135329]
  • Dimitris Papapanagiotou, Elena A Nicu, Sergio Bizzarro, Victor E A Gerdes, Joost C Meijers, Rienk Nieuwland, Ubele van der Velden, Bruno G Loos. Periodontitis is associated with platelet activation. Atherosclerosis. 2009 Feb; 202(2):605-11. doi: 10.1016/j.atherosclerosis.2008.05.035. [PMID: 18617175]
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  • A Thijs, P W B Nanayakkara, P M Ter Wee, P C Huijgens, C van Guldener, C D A Stehouwer. Mild-to-moderate renal impairment is associated with platelet activation: a cross-sectional study. Clinical nephrology. 2008 Oct; 70(4):325-31. doi: NULL. [PMID: 18826858]
  • Ronit Mor-Cohen, Nurit Rosenberg, Meytal Landau, Judith Lahav, Uri Seligsohn. Specific cysteines in beta3 are involved in disulfide bond exchange-dependent and -independent activation of alphaIIbbeta3. The Journal of biological chemistry. 2008 Jul; 283(28):19235-44. doi: 10.1074/jbc.m802399200. [PMID: 18458089]
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