Vismodegib (BioDeep_00000392555)
代谢物信息卡片
化学式: C19H14Cl2N2O3S (420.0102154)
中文名称: 维莫地尼
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
InChI: InChI=1S/C19H14Cl2N2O3S/c1-27(25,26)13-6-7-14(17(21)11-13)19(24)23-12-5-8-16(20)15(10-12)18-4-2-3-9-22-18/h2-11H,1H3,(H,23,24)
描述信息
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01X - Other antineoplastic agents > L01XJ - Hedgehog pathway inhibitors
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C188731 - Hedgehog Pathway Inhibitor
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor
同义名列表
2 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:66903
- KEGGdrug: D09992
- PubChem: 24776445
- Metlin: METLIN85191
- DrugBank: DB08828
- ChEMBL: CHEMBL473417
- CAS: 879085-55-9
- PMhub: MS000242829
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Yuting Zhang, Weijuan Xin, Xiaozhi Hu, Hanqi Wang, Xiaomiao Ye, Caili Xu, Yanyang Nan, Zhengyu Wu, Dianwen Ju, Jiajun Fan. Inhibition of Hedgehog signaling ameliorates foam cell formation by promoting autophagy in early atherosclerosis.
Cell death & disease.
2023 Nov; 14(11):740. doi:
10.1038/s41419-023-06270-5
. [PMID: 37963874] - Yixing Yao, Tianyuan Li, Tingting Yu, Xin Yang, Yue Wang, Jing Cai, Steven Y Cheng, Chen Liu, Shen Yue. Hedgehog signal activates AMPK via Smoothened to promote autophagy and lipid degradation in hepatocytes.
Biochemistry and cell biology = Biochimie et biologie cellulaire.
2023 08; 101(4):284-293. doi:
10.1139/bcb-2022-0345
. [PMID: 36821837] - Huanxian Wu, Lishun Zhang, Boyu Chen, Baofang Ou, Jiahuan Xu, Nannan Tian, Danni Yang, Yangcheng Ai, Qianqing Chen, Dongling Quan, Tingting Zhang, Lin Lv, Yuanxin Tian, Jiajie Zhang, Shaoyu Wu. B13, a well-tolerated inhibitor of hedgehog pathway, exhibited potent anti-tumor effects against colorectal carcinoma in vitro and in vivo.
Bioorganic chemistry.
2023 Mar; 135(?):106488. doi:
10.1016/j.bioorg.2023.106488
. [PMID: 36989734] - Mrinal M Gounder, Evan Rosenbaum, Nian Wu, Mark A Dickson, Tahir N Sheikh, Sandra P D'Angelo, Ping Chi, Mary Lou Keohan, Joseph P Erinjeri, Cristina R Antonescu, Narasimhan Agaram, Meera R Hameed, Moriah Martindale, Robert A Lefkowitz, Aimee M Crago, Sam Singer, William D Tap, Naoko Takebe, Li-Xuan Qin, Gary K Schwartz. A Phase Ib/II Randomized Study of RO4929097, a Gamma-Secretase or Notch Inhibitor with or without Vismodegib, a Hedgehog Inhibitor, in Advanced Sarcoma.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2022 04; 28(8):1586-1594. doi:
10.1158/1078-0432.ccr-21-3874
. [PMID: 35110418] - Michael Migden, Aaron S Farberg, Reinhard Dummer, Nicholas Squittieri, C William Hanke. A Review of Hedgehog Inhibitors Sonidegib and Vismodegib for Treatment of Advanced Basal Cell Carcinoma.
Journal of drugs in dermatology : JDD.
2021 02; 20(2):156-165. doi:
10.36849/jdd.5657
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Nanomedicine : nanotechnology, biology, and medicine.
2021 02; 32(?):102345. doi:
10.1016/j.nano.2020.102345
. [PMID: 33259959] - Uffe Høgh Olesen, Gael Clergeaud, Kristoffer Kjærgaard Hendel, Kelvin Yeung, Catharina Margrethe Lerche, Thomas Lars Andresen, Merete Haedersdal. Enhanced and Sustained Cutaneous Delivery of Vismodegib by Ablative Fractional Laser and Microemulsion Formulation.
The Journal of investigative dermatology.
2020 10; 140(10):2051-2059. doi:
10.1016/j.jid.2020.01.032
. [PMID: 32135181] - Michael J Dolton, Po-Chang Chiang, Fang Ma, Jin Y Jin, Yuan Chen. A Physiologically Based Pharmacokinetic Model of Vismodegib: Deconvoluting the Impact of Saturable Plasma Protein Binding, pH-Dependent Solubility and Nonsink Permeation.
The AAPS journal.
2020 09; 22(5):117. doi:
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. [PMID: 32875428] - Alessia Villani, Gabriella Fabbrocini, Claudia Costa, Massimiliano Scalvenzi. Patients with advanced basal cell carcinomas in treatment with sonic hedgehog inhibitors during the coronavirus disease 2019 (COVID-19) period: Management and adherence to treatment.
Journal of the American Academy of Dermatology.
2020 06; 82(6):e205. doi:
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. [PMID: 32244017] - Bonan Zhang, Hong Xu, Yi Zhang, Xue Yi, Guizhen Zhang, Xin Zhang, Dingjie Xu, Xuemin Gao, Shifeng Li, Ying Zhu, Hui Zhang, Zhongqiu Wei, Shumin Li, Lijuan Zhang, Ruimin Wang, Fang Yang. Targeting the RAS axis alleviates silicotic fibrosis and Ang II-induced myofibroblast differentiation via inhibition of the hedgehog signaling pathway.
Toxicology letters.
2019 Oct; 313(?):30-41. doi:
10.1016/j.toxlet.2019.05.023
. [PMID: 31181250] - Jennifer C. Tang, Larry Buckel, C. William Hanke. Histopathology of Basal Cell Carcinoma After Treatment With Vismogedib.
Journal of drugs in dermatology : JDD.
2019 Feb; 18(2):136-138. doi:
NULL
. [PMID: 30794363] - Uffe H Olesen, Gael Clergeaud, Catharina M Lerche, Thomas L Andresen, Merete Haedersdal. Topical delivery of vismodegib using ablative fractional laser and micro-emulsion formulation in vitro.
Lasers in surgery and medicine.
2019 01; 51(1):79-87. doi:
10.1002/lsm.23013
. [PMID: 30152536] - Andrea Sbrana, Andrea Antonuzzo, Luca Galli, Elisa Biasco, Gianna Musettini, Federico Paolieri, Sergio Ricci. A case of a patient with severe renal failure on hemodialysis treated with vismodegib for relapsing basal cell carcinoma.
Tumori.
2018 Dec; 104(6):NP2-NP4. doi:
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Therapeutic drug monitoring.
2018 06; 40(3):337-343. doi:
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Journal of the European Academy of Dermatology and Venereology : JEADV.
2018 Jan; 32(1):e7-e8. doi:
10.1111/jdv.14430
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Cardiovascular research.
2017 Nov; 113(13):1653-1663. doi:
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Thorax.
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Cancer chemotherapy and pharmacology.
2017 Jul; 80(1):29-36. doi:
10.1007/s00280-017-3315-8
. [PMID: 28523596] - Rinku Dutta, Virender Kumar, Yang Peng, Ruby E Evande, Jean L Grem, Ram I Mahato. Pharmacokinetics and Biodistribution of GDC-0449 Loaded Micelles in Normal and Liver Fibrotic Mice.
Pharmaceutical research.
2017 03; 34(3):564-578. doi:
10.1007/s11095-016-2081-3
. [PMID: 27995525] - Douglas Fife, Marko A Laitinen, David J Myers, Pamela B Landsteiner. Vismodegib Therapy for Basal Cell Carcinoma in an 8-Year-Old Chinese Boy with Xeroderma Pigmentosum.
Pediatric dermatology.
2017 Mar; 34(2):163-165. doi:
10.1111/pde.13080
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. [PMID: 27736063] - Melek Karaca, Rinku Dutta, Yildiz Ozsoy, Ram I Mahato. Micelle Mixtures for Coadministration of Gemcitabine and GDC-0449 To Treat Pancreatic Cancer.
Molecular pharmaceutics.
2016 06; 13(6):1822-32. doi:
10.1021/acs.molpharmaceut.5b00971
. [PMID: 26981724] - Chuanqing Wu, Ji Cheng, Shaobo Hu, Rui Deng, Yamba Willy Muangu, Liang Shi, Ke Wu, Peng Zhang, Weilong Chang, Guobin Wang, Kaixiong Tao. Reduced proliferation and increased apoptosis of the SGC‑7901 gastric cancer cell line on exposure to GDC‑0449.
Molecular medicine reports.
2016 Feb; 13(2):1434-40. doi:
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. [PMID: 26676867] - Wanyun Zhao, Xiaoqi Pan, Tao Li, Changchun Zhang, Nian Shi. Lycium barbarum Polysaccharides Protect against Trimethyltin Chloride-Induced Apoptosis via Sonic Hedgehog and PI3K/Akt Signaling Pathways in Mouse Neuro-2a Cells.
Oxidative medicine and cellular longevity.
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. [PMID: 27143997] - Daniel V T Catenacci, Melissa R Junttila, Theodore Karrison, Nathan Bahary, Margit N Horiba, Sreenivasa R Nattam, Robert Marsh, James Wallace, Mark Kozloff, Lakshmi Rajdev, Deirdre Cohen, James Wade, Bethany Sleckman, Heinz-Josef Lenz, Patrick Stiff, Pankaj Kumar, Peng Xu, Les Henderson, Naoko Takebe, Ravi Salgia, Xi Wang, Walter M Stadler, Frederic J de Sauvage, Hedy L Kindler. Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer.
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2015 Dec; 33(36):4284-92. doi:
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Clinical cancer research : an official journal of the American Association for Cancer Research.
2013 Nov; 19(22):6305-12. doi:
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Clinical cancer research : an official journal of the American Association for Cancer Research.
2013 Jun; 19(11):3059-67. doi:
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PloS one.
2013; 8(7):e70599. doi:
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. [PMID: 23894677] - Patricia M LoRusso, Sarina A Piha-Paul, Monica Mita, A Dimitrios Colevas, Vikram Malhi, Dawn Colburn, Ming Yin, Jennifer A Low, Richard A Graham. Co-administration of vismodegib with rosiglitazone or combined oral contraceptive in patients with locally advanced or metastatic solid tumors: a pharmacokinetic assessment of drug-drug interaction potential.
Cancer chemotherapy and pharmacology.
2013 Jan; 71(1):193-202. doi:
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British journal of clinical pharmacology.
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International journal of cancer.
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Clinical cancer research : an official journal of the American Association for Cancer Research.
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2011 Sep; 17(17):5774-82. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2011 Aug; 39(8):1460-7. doi:
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Clinical cancer research : an official journal of the American Association for Cancer Research.
2011 Jul; 17(14):4682-92. doi:
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. [PMID: 21610148] - Yuzhong Deng, Harvey Wong, Richard A Graham, Wenbin Liu, Heuy-shin Shen, Yao Shi, Laixin Wang, Min Meng, Vikram Malhi, Xiao Ding, Brian Dean. Determination of unbound vismodegib (GDC-0449) concentration in human plasma using rapid equilibrium dialysis followed by solid phase extraction and high-performance liquid chromatography coupled to mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Jul; 879(22):2119-26. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2011 Jun; 39(6):952-65. doi:
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Journal of medicinal chemistry.
2011 Apr; 54(8):2592-601. doi:
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Clinical cancer research : an official journal of the American Association for Cancer Research.
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Drug metabolism and disposition: the biological fate of chemicals.
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
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Xenobiotica; the fate of foreign compounds in biological systems.
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The Journal of pharmacology and experimental therapeutics.
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