Naphthofluorescein (BioDeep_00000392396)
代谢物信息卡片
化学式: C28H16O5 (432.0997686)
中文名称: 萘荧光素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C2C(=C1)C(=O)OC23C4=C(C5=C(C=C4)C=C(C=C5)O)OC6=C3C=CC7=C6C=CC(=C7)O
InChI: InChI=1S/C28H16O5/c29-17-7-9-19-15(13-17)5-11-23-25(19)32-26-20-10-8-18(30)14-16(20)6-12-24(26)28(23)22-4-2-1-3-21(22)27(31)33-28/h1-14,29-30H
描述信息
D004396 - Coloring Agents > D005456 - Fluorescent Dyes > D005452 - Fluoresceins
Naphthofluorescein inhibits the interaction between HIF-1 and Mint3. Naphthofluorescein suppresses Mint3-dependent HIF-1 activity and glycolysis in cancer cells and macrophages without cytotoxicity in vitro and adverse effect in vivo[1]. Naphthofluorescein is also a fluorescent pH-sensitive probe that can be used for functional Cerenkov imaging[2].
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:187610
- PubChem: 3124834
- Metlin: METLIN45440
- CAS: 61419-02-1
- PMhub: MS000242659
- medchemexpress: HY-124473
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xingwei Chen, Jiajia Xu, Fengtai Suo, Changmin Yu, Duoteng Zhang, Jian Chen, Qiong Wu, Su Jing, Lin Li, Wei Huang. A novel naphthofluorescein-based probe for ultrasensitive point-of-care testing of zinc(II) ions and its bioimaging in living cells and zebrafishes.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2020 Mar; 229(?):117949. doi:
10.1016/j.saa.2019.117949. [PMID: 31864152] - Vanesa Román-Pizarro, Manuel Ramírez-Gutiérrez, Agustina Gómez-Hens, Juan Manuel Fernández-Romero. Usefulness of magnetically-controlled MNPs-enzymes microreactors for the fluorimetric determination of total cholesterol in serum.
Talanta.
2020 Feb; 208(?):120426. doi:
10.1016/j.talanta.2019.120426. [PMID: 31816686] - Jianxi Wang, Cheng Zhou, Wei Liu, Jianjian Zhang, Xinyue Zhu, Xiaoyan Liu, Qin Wang, Haixia Zhang. A near-infrared fluorescent probe based on chloroacetate modified naphthofluorescein for selectively detecting cysteine/homocysteine and its application in living cells.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.
2016 Nov; 15(11):1393-1399. doi:
10.1039/c6pp00219f. [PMID: 27714261]