AS-605240 (BioDeep_00000392285)
代谢物信息卡片
5-(6-quinoxalinylmethylene)-2,4-thiazolidinedione
化学式: C12H7N3O2S (257.02589620000003)
中文名称: 5-(6-喹喔啉亚甲基)-2,4-噻唑啉二酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC2=NC=CN=C2C=C1C=C3C(=O)NC(=O)S3
InChI: InChI=1S/C12H7N3O2S/c16-11-10(18-12(17)15-11)6-7-1-2-8-9(5-7)14-4-3-13-8/h1-6H,(H,15,16,17)/b10-6+
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:91356
- ChEBI: CHEBI:45302
- PubChem: 10377751
- PubChem: 5289247
- PubChem: 24906273
- Metlin: METLIN45073
- DrugBank: DB04769
- ChEMBL: CHEMBL2218934
- ChEMBL: CHEMBL568150
- CAS: 648450-29-7
- CAS: 1287651-14-2
- PMhub: MS000242543
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Rong Jin, Wei Zhong, Shan Liu, Min Wang, Guohong Li. Inhibition of PI3Kγ by AS605240 plus low-dose tissue plasminogen activator (tPA) combination improves thrombolytic therapy in a rat model of embolic stroke.
Neuroscience letters.
2020 11; 738(?):135339. doi:
10.1016/j.neulet.2020.135339. [PMID: 32882317] - Yaojie Shi, Qianqian Wang, Juan Rong, Jing Ren, Xuejiao Song, Xiaoli Fan, Mengyi Shen, Yong Xia, Ningyu Wang, Zhihao Liu, Quanfang Hu, Tinghong Ye, Luoting Yu. Synthesis and biological evaluation of (1,2,4)triazole[4,3-a]pyridine derivatives as potential therapeutic agents for concanavalin A-induced hepatitis.
European journal of medicinal chemistry.
2019 Oct; 179(?):182-195. doi:
10.1016/j.ejmech.2019.06.025. [PMID: 31254920] - Igor A Schepetkin, Liliya N Kirpotina, Andrei I Khlebnikov, Narayanaganesh Balasubramanian, Mark T Quinn. Neutrophil Immunomodulatory Activity of Natural Organosulfur Compounds.
Molecules (Basel, Switzerland).
2019 May; 24(9):. doi:
10.3390/molecules24091809. [PMID: 31083328] - Xinyi Yu, Yunfeng Xia, Liyi Zeng, Xi Zhang, Liqun Chen, Shujuan Yan, Ruyi Zhang, Chen Zhao, Zongyue Zeng, Yi Shu, Shifeng Huang, Jiayan Lei, Chengfu Yuan, Linghuan Zhang, Yixiao Feng, Wei Liu, Bo Huang, Bo Zhang, Wenping Luo, Xi Wang, Hongmei Zhang, Rex C Haydon, Hue H Luu, Tong-Chuan He, Hua Gan. A blockade of PI3Kγ signaling effectively mitigates angiotensin II-induced renal injury and fibrosis in a mouse model.
Scientific reports.
2018 Jul; 8(1):10988. doi:
10.1038/s41598-018-29417-3. [PMID: 30030497] - Ting-Ting Fan, Xuan-Yun Feng, Yuan-Zheng Yang, Feng Gao, Qiong Liu. Downregulation of PI3K-γ in a mouse model of sepsis-induced myocardial dysfunction.
Cytokine.
2017 08; 96(?):208-216. doi:
10.1016/j.cyto.2017.04.018. [PMID: 28458167] - Marica Mariano, Rolf W Hartmann, Matthias Engel. Systematic diversification of benzylidene heterocycles yields novel inhibitor scaffolds selective for Dyrk1A, Clk1 and CK2.
European journal of medicinal chemistry.
2016 Apr; 112(?):209-216. doi:
10.1016/j.ejmech.2016.02.017. [PMID: 26896709] - Abel Suárez-Fueyo, José M Rojas, Ariel E Cariaga, Esther García, Bart H Steiner, Domingo F Barber, Kamal D Puri, Ana C Carrera. Inhibition of PI3Kδ reduces kidney infiltration by macrophages and ameliorates systemic lupus in the mouse.
Journal of immunology (Baltimore, Md. : 1950).
2014 Jul; 193(2):544-54. doi:
10.4049/jimmunol.1400350. [PMID: 24935930] - Jamil Azzi, Robert F Moore, Wassim Elyaman, Marwan Mounayar, Najib El Haddad, Sunmi Yang, Mollie Jurewicz, Ayumi Takakura, Alessandra Petrelli, Paolo Fiorina, Thomas Ruckle, Reza Abdi. The novel therapeutic effect of phosphoinositide 3-kinase-γ inhibitor AS605240 in autoimmune diabetes.
Diabetes.
2012 Jun; 61(6):1509-18. doi:
10.2337/db11-0134. [PMID: 22403300] - Giovanna Bergamini, Kathryn Bell, Satoko Shimamura, Thilo Werner, Andrew Cansfield, Katrin Müller, Jessica Perrin, Christina Rau, Katie Ellard, Carsten Hopf, Carola Doce, Daniel Leggate, Raffaella Mangano, Toby Mathieson, Alison O'Mahony, Ivan Plavec, Faiza Rharbaoui, Friedrich Reinhard, Mikhail M Savitski, Nigel Ramsden, Emilio Hirsch, Gerard Drewes, Oliver Rausch, Marcus Bantscheff, Gitte Neubauer. A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation.
Nature chemical biology.
2012 Apr; 8(6):576-82. doi:
10.1038/nchembio.957. [PMID: 22544264] - Daniela Carnevale, Carmine Vecchione, Giada Mascio, Giovanni Esposito, Giuseppe Cifelli, Katiuscia Martinello, Alessandro Landolfi, Giulio Selvetella, Paolo Grieco, Antonio Damato, Elio Franco, Hannelore Haase, Angelo Maffei, Elisa Ciraolo, Sergio Fucile, Giacomo Frati, Orazio Mazzoni, Emilio Hirsch, Giuseppe Lembo. PI3Kγ inhibition reduces blood pressure by a vasorelaxant Akt/L-type calcium channel mechanism.
Cardiovascular research.
2012 Jan; 93(1):200-9. doi:
10.1093/cvr/cvr288. [PMID: 22038741] - Joshua J Anzinger, Janet Chang, Qing Xu, Manoj K Barthwal, Thomas Bohnacker, Matthias P Wymann, Howard S Kruth. Murine bone marrow-derived macrophages differentiated with GM-CSF become foam cells by PI3Kγ-dependent fluid-phase pinocytosis of native LDL.
Journal of lipid research.
2012 Jan; 53(1):34-42. doi:
10.1194/jlr.m018887. [PMID: 22058424] - Youfu Luo, Liang Ma, Hao Zheng, Lijuan Chen, Rui Li, Chunmei He, Shengyong Yang, Xia Ye, Zhizhi Chen, Zicheng Li, Yan Gao, Jing Han, Gu He, Li Yang, Yuquan Wei. Discovery of (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione, a readily available and orally active glitazone for the treatment of concanavalin A-induced acute liver injury of BALB/c mice.
Journal of medicinal chemistry.
2010 Jan; 53(1):273-81. doi:
10.1021/jm901183d. [PMID: 19904929] - Adrian Schreiber, Susanne Rolle, Ludmilla Peripelittchenko, Joerg Rademann, Wolfgang Schneider, Friedrich C Luft, Ralph Kettritz. Phosphoinositol 3-kinase-gamma mediates antineutrophil cytoplasmic autoantibody-induced glomerulonephritis.
Kidney international.
2010 Jan; 77(2):118-28. doi:
10.1038/ki.2009.420. [PMID: 19907415] - Zhen-ling Wang, Xiao-hua Wu, Li-fang Song, Yong-sheng Wang, Xiao-hong Hu, You-fu Luo, Zhi-zhi Chen, Jin Ke, Xiao-dong Peng, Chun-mei He, Wei Zhang, Li-juan Chen, Yu-qua Wei. Phosphoinositide 3-kinase gamma inhibitor ameliorates concanavalin A-induced hepatic injury in mice.
Biochemical and biophysical research communications.
2009 Sep; 386(4):569-74. doi:
10.1016/j.bbrc.2009.06.060. [PMID: 19538942] - Gary M Pigeau, Jelena Kolic, Brandon J Ball, Michael B Hoppa, Ying W Wang, Thomas Rückle, Minna Woo, Jocelyn E Manning Fox, Patrick E MacDonald. Insulin granule recruitment and exocytosis is dependent on p110gamma in insulinoma and human beta-cells.
Diabetes.
2009 Sep; 58(9):2084-92. doi:
10.2337/db08-1371. [PMID: 19549714] - Anne Fougerat, Stéphanie Gayral, Pierre Gourdy, Alexia Schambourg, Thomas Rückle, Matthias K Schwarz, Christian Rommel, Emilio Hirsch, Jean-François Arnal, Jean-Pierre Salles, Bertrand Perret, Monique Breton-Douillon, Matthias P Wymann, Muriel Laffargue. Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes.
Circulation.
2008 Mar; 117(10):1310-7. doi:
10.1161/circulationaha.107.720466. [PMID: 18268153] - Domingo F Barber, Almira Bartolomé, Carmen Hernandez, Juana M Flores, Clara Redondo, Cristina Fernandez-Arias, Montserrat Camps, Thomas Rückle, Matthias K Schwarz, Santiago Rodríguez, Carlos Martinez-A, Dimitrios Balomenos, Christian Rommel, Ana C Carrera. PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus.
Nature medicine.
2005 Sep; 11(9):933-5. doi:
10.1038/nm1291. [PMID: 16127435]