Palmityl Trifluoromethyl Ketone (BioDeep_00000392239)
代谢物信息卡片
化学式: C17H31F3O (308.2326872)
中文名称: 1,1,1-三氟-2-十七烷酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCCCCCCCCC(=O)C(F)(F)F
InChI: InChI=1S/C17H31F3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(21)17(18,19)20/h2-15H2,1H3
描述信息
PACOCF3 (Palmityltrifluoromet?hylketone) is a selective phospholipase A2 inhibitor with an IC50 of 3.8 μM. PACOCF3 alters Ca2+ signaling in renal tubular cells[1][2].
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:186740
- PubChem: 4670
- Metlin: METLIN63017
- ChEMBL: CHEMBL99344
- CAS: 141022-99-3
- PMhub: MS000242494
- medchemexpress: HY-108607
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040
. [PMID: 33910017] - Timothy J Kopper, Bei Zhang, William M Bailey, Kara E Bethel, John C Gensel. The effects of myelin on macrophage activation are phenotypic specific via cPLA2 in the context of spinal cord injury inflammation.
Scientific reports.
2021 03; 11(1):6341. doi:
10.1038/s41598-021-85863-6
. [PMID: 33737707] - Chinh T Q Nguyen, Vivekananda Shetty, Anthony W Maresso. Global metabolomic analysis of a mammalian host infected with Bacillus anthracis.
Infection and immunity.
2015 Dec; 83(12):4811-25. doi:
10.1128/iai.00947-15
. [PMID: 26438791] - Daniel P O'Connell, Daniel F LeBlanc, Debra Cromley, Jeffrey Billheimer, Daniel J Rader, William W Bachovchin. Design and synthesis of boronic acid inhibitors of endothelial lipase.
Bioorganic & medicinal chemistry letters.
2012 Feb; 22(3):1397-401. doi:
10.1016/j.bmcl.2011.12.043
. [PMID: 22225633] - Evelin L Schaeffer, Wagner F Gattaz. Inhibition of calcium-independent phospholipase A2 activity in rat hippocampus impairs acquisition of short- and long-term memory.
Psychopharmacology.
2005 Sep; 181(2):392-400. doi:
10.1007/s00213-005-2256-9
. [PMID: 15830227] - C R Jan, K J Chou, K C Lee, J L Wang, L L Tseng, J S Cheng, W C Chen. Dual action of palmitoyl trifluoromethyl ketone (PACOCF3) on Ca2+ signaling: activation of extracellular Ca2+ influx and alteration of ATP- and bradykinin-induced Ca2+ responses in Madin Darby canine kidney cells.
Archives of toxicology.
2000 Oct; 74(8):447-51. doi:
10.1007/s002040000130
. [PMID: 11097381]