Pentoxyverine (BioDeep_00000392142)
Volatile Flavor Compounds
代谢物信息卡片
化学式: C20H31NO3 (333.2303816)
中文名称: Carβpentane, 卡贝戊烷
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCC1
InChI: InChI=1S/C20H31NO3/c1-3-21(4-2)14-15-23-16-17-24-19(22)20(12-8-9-13-20)18-10-6-5-7-11-18/h5-7,10-11H,3-4,8-9,12-17H2,1-2H3
描述信息
R - Respiratory system > R05 - Cough and cold preparations > R05D - Cough suppressants, excl. combinations with expectorants
C78273 - Agent Affecting Respiratory System > C66917 - Antitussive Agent
D019141 - Respiratory System Agents > D000996 - Antitussive Agents
D002491 - Central Nervous System Agents
Pentoxyverine (Carbetapentane) is an orally active sigma-1 receptor agonist, with Kis of 41 nM, 894 nM and 75 nM for σ1, σ2 and guinea-pig brain membran σ1, respectively. Pentoxyverine is a muscarinic antagonist. Pentoxyverine is a potent antitussive, anticonvulsant, and spasmolytic agent. Pentoxyverine can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance[1][2][3][4].
同义名列表
3 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:94484
- KEGGdrug: D08334
- PubChem: 2562
- DrugBank: DB11186
- ChEMBL: CHEMBL73234
- CAS: 77-23-6
- PMhub: MS000242389
- medchemexpress: HY-134004
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Ahmed S Abo Dena, Alaa M Ali, Ibrahim M El-Sherbiny. Carbetapentane citrate.
Profiles of drug substances, excipients, and related methodology.
2020; 45(?):41-53. doi:
10.1016/bs.podrm.2019.10.002. [PMID: 32164969] - Sabrein H Mohamed, Yousry M Issa, Shaimaa A Elfeky. Extraction-free spectrophotometric assay of the antitussive drug pentoxyverine citrate using sulfonephthalein dyes.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2019 Nov; 222(?):117186. doi:
10.1016/j.saa.2019.117186. [PMID: 31176152] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - F Westphal, Th Junge, L Radünz, J Stegk, G Rochholz. Characterization of pentoxyverine metabolites in urine using GC/MS after intoxication with Silomat cough drops.
Forensic science international.
2012 Feb; 215(1-3):124-35. doi:
10.1016/j.forsciint.2011.03.002. [PMID: 21450423] - Ming-qin Lin, Ying Cai, Wei Zhang, Xiu-qiong Wu, Jin-jun Rao, Shu-wen Liu. [Bioequivalence evaluation of orally disintegrating tablet of pentoxyverine citrate].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2010 Jul; 30(7):1621-3. doi:
NULL. [PMID: 20650784] - Jinhua Wen, Hong Zhang, Chunhua Xia, Xiao Hu, Wenwei Xu, Xiaohua Cheng, Jun Gao, Yuqing Xiong. A sensitive liquid chromatography-electrospray ionization-mass spectrometry method for the simultaneous determination of pentoxyverine citrate and guaifenesin in human plasma---application to pharmacokinetic and bioequivalence studies.
Biomedical chromatography : BMC.
2010 Apr; 24(4):351-7. doi:
10.1002/bmc.1298. [PMID: 19634120] - Ke-Hua Yu, Jin-Hua Wen, Fu-Gen Nie, Yu-Qing Xiong. [Quantification of pentoxyverine citrate in human plasma by LC-ESI/MS method and its application].
Yao xue xue bao = Acta pharmaceutica Sinica.
2009 Dec; 44(12):1402-5. doi:
NULL. [PMID: 21351477] - Heike Deisemann, Nadine Ahrens, Irene Schlobohm, Christian Kirchhoff, Rainer Netzer, Clemens Möller. Effects of common antitussive drugs on the hERG potassium channel current.
Journal of cardiovascular pharmacology.
2008 Dec; 52(6):494-9. doi:
10.1097/fjc.0b013e31818eec8d. [PMID: 19034038] - Jianjing Cao, Santosh S Kulkarni, Stephen M Husbands, Wayne D Bowen, Wanda Williams, Theresa Kopajtic, Jonathan L Katz, Clifford George, Amy Hauck Newman. Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents.
Journal of medicinal chemistry.
2003 Jun; 46(13):2589-98. doi:
10.1021/jm030008u. [PMID: 12801223] - B T Hoffman, T Kopajtic, J L Katz, A H Newman. 2D QSAR modeling and preliminary database searching for dopamine transporter inhibitors using genetic algorithm variable selection of Molconn Z descriptors.
Journal of medicinal chemistry.
2000 Nov; 43(22):4151-9. doi:
10.1021/jm990472s. [PMID: 11063611] - B J Stier, L Sieverding, H Moeller. [Pentoxyverine poisoning via maternal milk in a fully breast-fed newborn infant].
Deutsche medizinische Wochenschrift (1946).
1988 Jun; 113(22):898-900. doi:
10.1055/s-2008-1067740. [PMID: 3371222] - M O Farber, J J Szwed, A R Dowell, R A Strawbridge. The acute effects of respiratory and metabolic acidosis on renal function in the dog.
Clinical science and molecular medicine.
1976 Mar; 50(3):165-9. doi:
10.1042/cs0500165. [PMID: 3305] - . .
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. [PMID: 32353859]