SRT 1720 (BioDeep_00000391566)
代谢物信息卡片
N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide
化学式: C25H23N7OS (469.1684708)
中文名称: SRT 1720
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CN(CCN1)CC2=CSC3=NC(=CN23)C4=CC=CC=C4NC(=O)C5=NC6=CC=CC=C6N=C5
InChI: InChI=1S/C25H23N7OS/c33-24(22-13-27-20-7-3-4-8-21(20)28-22)29-19-6-2-1-5-18(19)23-15-32-17(16-34-25(32)30-23)14-31-11-9-26-10-12-31/h1-8,13,15-16,26H,9-12,14H2,(H,29,33)
描述信息
SRT 1720 is a selective activator of human SIRT1 with an EC1.5 of 0.16 μM, and shows less potent activities for SIRT2 and SIRT3 with EC1.5s of 37 μM and > 300 μM, respectively.
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- PubChem: 24180125
- Metlin: METLIN64711
- ChEMBL: CHEMBL257991
- CAS: 925434-55-5
- CAS: 925435-64-9
- PMhub: MS000241777
- medchemexpress: HY-10532
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lanlan Li, Shengjun Fu, Jianliang Wang, Jianzhong Lu, Yan Tao, Liangtao Zhao, Beitang Fu, Lanpeng Lu, Caifei Xiang, Xince Sun, Shanhui Liu, Degui Wang, Zhiping Wang. SRT1720 inhibits bladder cancer cell progression by impairing autophagic flux.
Biochemical pharmacology.
2024 Apr; 222(?):116111. doi:
10.1016/j.bcp.2024.116111. [PMID: 38458329] - Jin Young Sung, Seul Gi Kim, Young Jin Kang, So-Young Park, Hyoung Chul Choi. SIRT1-dependent PGC-1α deacetylation by SRT1720 rescues progression of atherosclerosis by enhancing mitochondrial function.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2024 Jan; ?(?):159453. doi:
10.1016/j.bbalip.2024.159453. [PMID: 38244675] - Yanan Zhao, Ankang Mao, Ranran Zhang, Shuang Guan, Jing Lu. SIRT1/mTOR pathway-mediated autophagy dysregulation promotes Pb-induced hepatic lipid accumulation in HepG2 cells.
Environmental toxicology.
2022 Mar; 37(3):549-563. doi:
10.1002/tox.23420. [PMID: 34842334] - Yuanyuan Huang, Jianlin Lu, Li Zhan, Ming Wang, Ronghua Shi, Xiao Yuan, Xinjiao Gao, Xing Liu, Jianye Zang, Wei Liu, Xuebiao Yao. Resveratrol-induced Sirt1 phosphorylation by LKB1 mediates mitochondrial metabolism.
The Journal of biological chemistry.
2021 08; 297(2):100929. doi:
10.1016/j.jbc.2021.100929. [PMID: 34216621] - Chengwei Yang, Xiang Huang, Sheng Wang, Mingming Han, Fang Kang, Zhi Zhang, Juan Li. Intrathecal administration of SRT1720 relieves bone cancer pain by inhibiting the CREB/CRTC1 signalling pathway.
Neuroscience letters.
2020 01; 715(?):134623. doi:
10.1016/j.neulet.2019.134623. [PMID: 31722235] - Long The Nguyen, Hui Chen, Crystal Mak, Amgad Zaky, Carol Pollock, Sonia Saad. SRT1720 attenuates obesity and insulin resistance but not liver damage in the offspring due to maternal and postnatal high-fat diet consumption.
American journal of physiology. Endocrinology and metabolism.
2018 08; 315(2):E196-E203. doi:
10.1152/ajpendo.00472.2017. [PMID: 29533740] - Allah Nawaz, Arshad Mehmood, Yukiko Kanatani, Tomonobu Kado, Yoshiko Igarashi, Akiko Takikawa, Seiji Yamamoto, Keisuke Okabe, Takashi Nakagawa, Kunimasa Yagi, Shiho Fujisaka, Kazuyuki Tobe. Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice.
Scientific reports.
2018 07; 8(1):11370. doi:
10.1038/s41598-018-29773-0. [PMID: 30054532] - Min Jo Kim, Hye Jin An, Dae Hyun Kim, Bonggi Lee, Hye Jin Lee, Sultan Ullah, Su Jeong Kim, Hyoung Oh Jeong, Kyoung Mi Moon, Eun Kyeong Lee, Jungho Yang, Jinia Akter, Pusoon Chun, Hyung Ryong Moon, Hae Young Chung. Novel SIRT1 activator MHY2233 improves glucose tolerance and reduces hepatic lipid accumulation in db/db mice.
Bioorganic & medicinal chemistry letters.
2018 02; 28(4):684-688. doi:
10.1016/j.bmcl.2018.01.021. [PMID: 29402742] - William R Swindell, Xianying Xing, Yi Fritz, Doina Diaconu, Daniel I Simon, Nicole L Ward, Johann E Gudjonsson. Deficiency of myeloid-related proteins 8 and 14 (Mrp8/Mrp14) does not block inflammaging but prevents steatosis.
Oncotarget.
2016 Jun; 7(24):35535-35551. doi:
10.18632/oncotarget.9550. [PMID: 27224926] - M K Kemelo, A Horinek, N K Canová, H Farghali. Comparative effects of Quercetin and SRT1720 against D-galactosamine/lipopolysaccharide-induced hepatotoxicity in rats: biochemical and molecular biological investigations.
European review for medical and pharmacological sciences.
2016; 20(2):363-71. doi:
". [PMID: 26875909] - Kristoffer Svensson, Svenia Schnyder, Verena Albert, Bettina Cardel, Luca Quagliata, Luigi M Terracciano, Christoph Handschin. Resveratrol and SRT1720 Elicit Differential Effects in Metabolic Organs and Modulate Systemic Parameters Independently of Skeletal Muscle Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α).
The Journal of biological chemistry.
2015 Jun; 290(26):16059-76. doi:
10.1074/jbc.m114.590653. [PMID: 25987562] - Naohiro Yamamoto, Takanobu Otsuka, Gen Kuroyanagi, Akira Kondo, Shingo Kainuma, Akira Nakakami, Rie Matsushima-Nishiwaki, Osamu Kozawa, Haruhiko Tokuda. Resveratrol reduces prostaglandin E1-stimulated osteoprotegerin synthesis in osteoblasts: suppression of stress-activated protein kinase/c-Jun N-terminal kinase.
Prostaglandins & other lipid mediators.
2015 Jan; 116-117(?):57-63. doi:
10.1016/j.prostaglandins.2015.01.003. [PMID: 25677506] - Hongwei Yao, Isaac K Sundar, Tanveer Ahmad, Chad Lerner, Janice Gerloff, Alan E Friedman, Richard P Phipps, Patricia J Sime, Michael W McBurney, Leonard Guarente, Irfan Rahman. SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism.
American journal of physiology. Lung cellular and molecular physiology.
2014 May; 306(9):L816-28. doi:
10.1152/ajplung.00323.2013. [PMID: 24633890] - Yu Li, Kimberly Wong, Amber Giles, Jianwei Jiang, Jong Woo Lee, Andrew C Adams, Alexei Kharitonenkov, Qin Yang, Bin Gao, Leonard Guarente, Mengwei Zang. Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21.
Gastroenterology.
2014 Feb; 146(2):539-49.e7. doi:
10.1053/j.gastro.2013.10.059. [PMID: 24184811] - Yechun Wang, Hui Chen, Oliver Yu. Metabolic engineering of resveratrol and other longevity boosting compounds.
BioFactors (Oxford, England).
2010 Sep; 36(5):394-400. doi:
10.1002/biof.126. [PMID: 20848556] - Amy K Walker, Fajun Yang, Karen Jiang, Jun-Yuan Ji, Jennifer L Watts, Aparna Purushotham, Olivier Boss, Michael L Hirsch, Scott Ribich, Jesse J Smith, Kristine Israelian, Christoph H Westphal, Joseph T Rodgers, Toshi Shioda, Sarah L Elson, Peter Mulligan, Hani Najafi-Shoushtari, Josh C Black, Jitendra K Thakur, Lisa C Kadyk, Johnathan R Whetstine, Raul Mostoslavsky, Pere Puigserver, Xiaoling Li, Nicholas J Dyson, Anne C Hart, Anders M Näär. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.
Genes & development.
2010 Jul; 24(13):1403-17. doi:
10.1101/gad.1901210. [PMID: 20595232] - Jason A Funk, Sina Odejinmi, Rick G Schnellmann. SRT1720 induces mitochondrial biogenesis and rescues mitochondrial function after oxidant injury in renal proximal tubule cells.
The Journal of pharmacology and experimental therapeutics.
2010 May; 333(2):593-601. doi:
10.1124/jpet.109.161992. [PMID: 20103585] - Yu Yamazaki, Isao Usui, Yukiko Kanatani, Yuji Matsuya, Koichi Tsuneyama, Shiho Fujisaka, Agussalim Bukhari, Hikari Suzuki, Satoko Senda, Shingo Imanishi, Kazuya Hirata, Manabu Ishiki, Ryuji Hayashi, Masaharu Urakaze, Hideo Nemoto, Masashi Kobayashi, Kazuyuki Tobe. Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice.
American journal of physiology. Endocrinology and metabolism.
2009 Nov; 297(5):E1179-86. doi:
10.1152/ajpendo.90997.2008. [PMID: 19724016] - Jérôme N Feige, Marie Lagouge, Carles Canto, Axelle Strehle, Sander M Houten, Jill C Milne, Philip D Lambert, Chikage Mataki, Peter J Elliott, Johan Auwerx. Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation.
Cell metabolism.
2008 Nov; 8(5):347-58. doi:
10.1016/j.cmet.2008.08.017. [PMID: 19046567] - Jill C Milne, Philip D Lambert, Simon Schenk, David P Carney, Jesse J Smith, David J Gagne, Lei Jin, Olivier Boss, Robert B Perni, Chi B Vu, Jean E Bemis, Roger Xie, Jeremy S Disch, Pui Yee Ng, Joseph J Nunes, Amy V Lynch, Hongying Yang, Heidi Galonek, Kristine Israelian, Wendy Choy, Andre Iffland, Siva Lavu, Oliver Medvedik, David A Sinclair, Jerrold M Olefsky, Michael R Jirousek, Peter J Elliott, Christoph H Westphal. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.
Nature.
2007 Nov; 450(7170):712-6. doi:
10.1038/nature06261. [PMID: 18046409]