todralazine (BioDeep_00000391447)

   

Volatile Flavor Compounds


代谢物信息卡片


todralazine

化学式: C11H12N4O2 (232.0960212)
中文名称: Todralazine
谱图信息: 最多检出来源 Viridiplantae(plant) 88.89%

分子结构信息

SMILES: CCOC(=O)NNC1=NN=CC2=CC=CC=C12
InChI: InChI=1S/C11H12N4O2/c1-2-17-11(16)15-14-10-9-6-4-3-5-8(9)7-12-13-10/h3-7H,2H2,1H3,(H,13,14)(H,15,16)

描述信息

C78274 - Agent Affecting Cardiovascular System > C29707 - Vasodilating Agent
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
CONFIDENCE standard compound; INTERNAL_ID 1276; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4755; ORIGINAL_PRECURSOR_SCAN_NO 4753
CONFIDENCE standard compound; INTERNAL_ID 1276; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4752; ORIGINAL_PRECURSOR_SCAN_NO 4751
CONFIDENCE standard compound; INTERNAL_ID 1276; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4779; ORIGINAL_PRECURSOR_SCAN_NO 4778
CONFIDENCE standard compound; INTERNAL_ID 1276; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4772; ORIGINAL_PRECURSOR_SCAN_NO 4769
CONFIDENCE standard compound; INTERNAL_ID 1276; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4779; ORIGINAL_PRECURSOR_SCAN_NO 4777

同义名列表

2 个代谢物同义名

todralazine; Todralazine



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Y Tameda, M Hamada, K Takase, T Nakano, Y Kosaka. Fulminant hepatic failure caused by ecarazine hydrochloride (a hydralazine derivative). Hepatology (Baltimore, Md.). 1996 Mar; 23(3):465-70. doi: 10.1053/jhep.1996.v23.pm0008617425. [PMID: 8617425]
  • Z Gomez de Balugera, M Arantzazu Goicolea, R J Barrio. Joint determination of todralazine and acetazolamide in human serum by differential pulse polarography. Journal of pharmaceutical and biomedical analysis. 1994 Jul; 12(7):883-7. doi: 10.1016/s0731-7085(94)80038-3. [PMID: 7981316]
  • K Olczyk, E J Kucharz, M Drózdz. Influence of long-term treatment with hydrazinophthalazines on the activity of lysosomal exoglycosidases in rat tissues. Acta medica Hungarica. 1988; 45(2):161-9. doi: NULL. [PMID: 3266791]
  • A Jendryczko, M Drozdz, K Magner. Urinary excretions of hydroxylysylglycosides in rats with experimentally induced collagen-like syndrome. Biomedica biochimica acta. 1985; 44(7-8):1133-7. doi: . [PMID: 2417593]
  • Z Fijałek, E Szyszko. [Polarographic studies of hypotensive drugs--hydrazinophthalazine derivatives. III. Determination of binazine in the biological material by sinusoidal alternating-current polarography]. Acta poloniae pharmaceutica. 1982; 39(5-6):403-11. doi: NULL. [PMID: 7171012]
  • M Drózdz, E Kucharz, E Feluś. Antiglobulin antibodies in blood serum of rabbits hyperimmunized with bovine albumin and treated chronically with hydrazinophtalazines. Archivum immunologiae et therapiae experimentalis. 1981; 29(2):167-73. doi: NULL. [PMID: 6975611]
  • M Drózdz, E Kucharz, M Wieczorek. Histopathological changes in rabbits with long-term treatment with hydrazinophtalazines with or without hyperimmunization. Archivum immunologiae et therapiae experimentalis. 1981; 29(2):175-85. doi: NULL. [PMID: 7305630]
  • B Kolber-Postepska, Z Kleinrok, M Markiewicz. [Effect of various hypotensive drugs on the plasma level of kininogen and prekallikrein in hypertension]. Polski tygodnik lekarski (Warsaw, Poland : 1960). 1980 Jul; 35(30):1133-6. doi: NULL. [PMID: 6904036]
  • M Drózdz, E Kucharz, Z Anasz, B Piwowarczyk. Haematological changes in hyperimmunized rabbits treated with hydrazinophthalazines for long time periods. Acta physiologica Polonica. 1979 Sep; 30(5-6):639-47. doi: NULL. [PMID: 93848]
  • M Drózdz, E Kucharz, K Olczyk. Effect of catecholamines on the activity of lysosomal enzymes in the blood serum of rats chronically treated with hydrazinophtalazines. Folia biologica. 1979; 27(1):9-16. doi: NULL. [PMID: 499606]