KT5720 (BioDeep_00000391229)
代谢物信息卡片
化学式: C32H31N3O5 (537.2263596)
中文名称: 蛋白激酶仰制剂KT5720
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCOC(=O)C1(CC2N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N(C7=C53)C1(O2)C)CNC6=O)O
InChI: InChI=1S/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,33,36)/t23-,31+,32+/m0/s1
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
D004791 - Enzyme Inhibitors
同义名列表
1 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040
. [PMID: 33910017] - Ali Khorasani, Mehdi Abbasnejad, Saeed Esmaeili-Mahani. Phytohormone abscisic acid ameliorates cognitive impairments in streptozotocin-induced rat model of Alzheimer's disease through PPARβ/δ and PKA signaling.
The International journal of neuroscience.
2019 Nov; 129(11):1053-1065. doi:
10.1080/00207454.2019.1634067
. [PMID: 31215291] - Shyamsundar Pal China, Subhashis Pal, Sourav Chattopadhyay, Konica Porwal, Monika Mittal, Sabyasachi Sanyal, Naibedya Chattopadhyay. The wakefulness promoting drug Modafinil causes adenosine receptor-mediated upregulation of receptor activator of nuclear factor κB ligand in osteoblasts: Negative impact of the drug on peak bone accrual in rats.
Toxicology and applied pharmacology.
2018 06; 348(?):22-31. doi:
10.1016/j.taap.2018.04.006
. [PMID: 29649498] - Guillermo Nicolás Tocchetti, Agostina Arias, Maite Rocío Arana, Juan Pablo Rigalli, Camila Juliana Domínguez, Felipe Zecchinati, María Laura Ruiz, Silvina Stella Maris Villanueva, Aldo Domingo Mottino. Acute regulation of multidrug resistance-associated protein 2 localization and activity by cAMP and estradiol-17β-D-glucuronide in rat intestine and Caco-2 cells.
Archives of toxicology.
2018 Feb; 92(2):777-788. doi:
10.1007/s00204-017-2092-9
. [PMID: 29052767] - María Tamayo, Esmeralda Manzanares, Manuel Bas, Laura Martín-Nunes, Almudena Val-Blasco, María Jesús Larriba, María Fernández-Velasco, Carmen Delgado. Calcitriol (1,25-dihydroxyvitamin D3) increases L-type calcium current via protein kinase A signaling and modulates calcium cycling and contractility in isolated mouse ventricular myocytes.
Heart rhythm.
2017 03; 14(3):432-439. doi:
10.1016/j.hrthm.2016.12.013
. [PMID: 27989685] - Jia Deng, Dao-Xin Wang, Ai-Ling Liang, Jing Tang, Da-Kai Xiang. Effects of baicalin on alveolar fluid clearance and α-ENaC expression in rats with LPS-induced acute lung injury.
Canadian journal of physiology and pharmacology.
2017 Feb; 95(2):122-128. doi:
10.1139/cjpp-2016-0212
. [PMID: 27992235] - Lucie Clarysse, Maxime Guéguinou, Marie Potier-Cartereau, Grégoire Vandecasteele, Philippe Bougnoux, Stephan Chevalier, Aurélie Chantôme, Christophe Vandier. cAMP-PKA inhibition of SK3 channel reduced both Ca2+ entry and cancer cell migration by regulation of SK3-Orai1 complex.
Pflugers Archiv : European journal of physiology.
2014 Oct; 466(10):1921-32. doi:
10.1007/s00424-013-1435-5
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Biology of reproduction.
2014 Aug; 91(2):31. doi:
10.1095/biolreprod.113.116848
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Andrology.
2014 May; 2(3):474-80. doi:
10.1111/j.2047-2927.2014.00189.x
. [PMID: 24711244] - Hye Rin Lee, Hwa Kyoung Shin, So Youn Park, Hye Young Kim, Won Suk Lee, Byung Yong Rhim, Ki Whan Hong, Chi Dae Kim. Attenuation of β-amyloid-induced tauopathy via activation of CK2α/SIRT1: targeting for cilostazol.
Journal of neuroscience research.
2014 Feb; 92(2):206-17. doi:
10.1002/jnr.23310
. [PMID: 24254769] - Jae-Hyoung Lee, Nam-Hee Jung, Byoung-Hoon Lee, Sang-Hoon Kim, Jin Hyun Jun. Suppression of Heme Oxygenase-1 by Prostaglandin E2-Protein Kinase A-A-Kinase Anchoring Protein Signaling Is Central for Augmented Cyclooxygenase-2 Expression in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages.
Allergy, asthma & immunology research.
2013 Sep; 5(5):329-36. doi:
10.4168/aair.2013.5.5.329
. [PMID: 24003391] - Lilian C Russo, Leandro M Castro, Fabio C Gozzo, Emer S Ferro. Inhibition of thimet oligopeptidase by siRNA alters specific intracellular peptides and potentiates isoproterenol signal transduction.
FEBS letters.
2012 Sep; 586(19):3287-92. doi:
10.1016/j.febslet.2012.07.002
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Journal of cellular biochemistry.
2012 Sep; 113(9):3019-28. doi:
10.1002/jcb.24180
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The European journal of neuroscience.
2012 Aug; 36(3):2293-301. doi:
10.1111/j.1460-9568.2012.08142.x
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Experimental animals.
2012; 61(2):119-24. doi:
10.1538/expanim.61.119
. [PMID: 22531726] - Liqun Ma, Jian Zhong, Zhigang Zhao, Zhidan Luo, Shuangtao Ma, Jing Sun, Hongbo He, Tianqi Zhu, Daoyan Liu, Zhiming Zhu, Martin Tepel. Activation of TRPV1 reduces vascular lipid accumulation and attenuates atherosclerosis.
Cardiovascular research.
2011 Dec; 92(3):504-13. doi:
10.1093/cvr/cvr245
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Naunyn-Schmiedeberg's archives of pharmacology.
2011 Jul; 384(1):59-70. doi:
10.1007/s00210-011-0630-1
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Free radical biology & medicine.
2011 Jun; 50(12):1737-48. doi:
10.1016/j.freeradbiomed.2011.03.026
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Journal of lipid research.
2011 Feb; 52(2):221-36. doi:
10.1194/jlr.m008771
. [PMID: 21097823] - Hironobu Iguchi, Tetsuo Mitsui, Maho Ishida, Shigenobu Kanba, Jun Arita. cAMP response element-binding protein (CREB) is required for epidermal growth factor (EGF)-induced cell proliferation and serum response element activation in neural stem cells isolated from the forebrain subventricular zone of adult mice.
Endocrine journal.
2011; 58(9):747-59. doi:
10.1507/endocrj.k11e-104
. [PMID: 21701076] - Naoaki Harada, Juan Zhao, Hiroki Kurihara, Naomi Nakagata, Kenji Okajima. Stimulation of Fc gammaRI on primary sensory neurons increases insulin-like growth factor-I production, thereby reducing reperfusion-induced renal injury in mice.
Journal of immunology (Baltimore, Md. : 1950).
2010 Jul; 185(2):1303-10. doi:
10.4049/jimmunol.0902051
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The international journal of biochemistry & cell biology.
2010 Feb; 42(2):346-58. doi:
10.1016/j.biocel.2009.11.021
. [PMID: 19948241] - Hidemi Ishii, Yuka Kojima, Yutaka Masuda, Kimihiko Takada, Katsuyoshi Sugimoto, Tomohiro Ikeda. Expression of thrombin-activatable fibrinolysis inhibitor (TAFI) is up-regulated by increase in intracellular cyclic AMP levels in cultured HepG2 cells.
Thrombosis and haemostasis.
2009 Dec; 102(6):1204-11. doi:
10.1160/th09-03-0194
. [PMID: 19967152] - Hao Zhen Cui, Hye Ran Choi, Deok Ho Choi, Kyung Woo Cho, Dae Gill Kang, Ho Sub Lee. Aqueous extract of Zanthoxylum schinifolium elicits contractile and secretory responses via beta1-adrenoceptor activation in beating rabbit atria.
Journal of ethnopharmacology.
2009 Nov; 126(2):300-7. doi:
10.1016/j.jep.2009.08.025
. [PMID: 19703535] - Megan O Nuwer, Kelly E Picchione, Arin Bhattacharjee. cAMP-dependent kinase does not modulate the Slack sodium-activated potassium channel.
Neuropharmacology.
2009 Sep; 57(3):219-26. doi:
10.1016/j.neuropharm.2009.06.006
. [PMID: 19540251] - Danusa Menegaz, Angela Rosso, Carine Royer, Laura D Leite, Adair R S Santos, Fátima R M B Silva. Role of 1alpha,25(OH)2 vitamin D3 on alpha-[1-(14)C]MeAIB accumulation in immature rat testis.
Steroids.
2009 Feb; 74(2):264-9. doi:
10.1016/j.steroids.2008.11.015
. [PMID: 19073199] - Toshiaki Kume, Ryo Ito, Ryota Taguchi, Yasuhiko Izumi, Hiroshi Katsuki, Tetsuhiro Niidome, Yuki Takada-Takatori, Hachiro Sugimoto, Akinori Akaike. Serofendic acid promotes stellation induced by cAMP and cGMP analogs in cultured cortical astrocytes.
Journal of pharmacological sciences.
2009 Jan; 109(1):110-8. doi:
10.1254/jphs.08254fp
. [PMID: 19122367] - Amanda L Tattersall, Robert J Wilkins. Modulation of Na+-H+ exchange isoforms NHE1 and NHE3 by insulin-like growth factor-1 in isolated bovine articular chondrocytes.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
2008 Nov; 26(11):1428-33. doi:
10.1002/jor.20617
. [PMID: 18404734] - Fabio Rossi, Antonella Castelli, Maria J Bianco, Cora Bertone, Marina Brama, Vittorio Santiemma. Ghrelin induces proliferation in human aortic endothelial cells via ERK1/2 and PI3K/Akt activation.
Peptides.
2008 Nov; 29(11):2046-51. doi:
10.1016/j.peptides.2008.07.002
. [PMID: 18675863] - Camila Nogueira Alves Bezerra, Adriana Castello Costa Girardi, Luciene Regina Carraro-Lacroix, Nancy Amaral Rebouças. Mechanisms underlying the long-term regulation of NHE3 by parathyroid hormone.
American journal of physiology. Renal physiology.
2008 May; 294(5):F1232-7. doi:
10.1152/ajprenal.00025.2007
. [PMID: 18322024] - Sunhapas Soodvilai, Zhanjun Jia, Tianxin Yang. Hydrogen peroxide stimulates chloride secretion in primary inner medullary collecting duct cells via mPGES-1-derived PGE2.
American journal of physiology. Renal physiology.
2007 Nov; 293(5):F1571-6. doi:
10.1152/ajprenal.00132.2007
. [PMID: 17699556] - Chien-Chen Lu, Shiow-Chwen Tsai. The cyclic AMP-dependent protein kinase A pathway is involved in progesterone effects on calcitonin secretion from TT cells.
Life sciences.
2007 Oct; 81(19-20):1411-20. doi:
10.1016/j.lfs.2007.08.046
. [PMID: 17963787] - Nicola Conran, Camila B Almeida, Carolina Lanaro, Renata Proença Ferreira, Fabiola Traina, Sara T O Saad, Fernando F Costa. Inhibition of caspase-dependent spontaneous apoptosis via a cAMP-protein kinase A dependent pathway in neutrophils from sickle cell disease patients.
British journal of haematology.
2007 Oct; 139(1):148-58. doi:
10.1111/j.1365-2141.2007.06748.x
. [PMID: 17711515] - Marcelo Einicker-Lamas, Michelle T C Nascimento, Cláudio A Masuda, Mecia M Oliveira, Celso Caruso-Neves. Trypanosoma cruzi epimastigotes: regulation of myo-inositol transport by effectors of protein kinases A and C.
Experimental parasitology.
2007 Oct; 117(2):171-7. doi:
10.1016/j.exppara.2007.04.011
. [PMID: 17586497] - Maaike Kockx, Dongni Lily Guo, Thierry Huby, Philippe Lesnik, Jason Kay, Tharani Sabaretnam, Eve Jary, Michael Hill, Katharina Gaus, John Chapman, Jennifer L Stow, Wendy Jessup, Leonard Kritharides. Secretion of apolipoprotein E from macrophages occurs via a protein kinase A and calcium-dependent pathway along the microtubule network.
Circulation research.
2007 Sep; 101(6):607-16. doi:
10.1161/circresaha.107.157198
. [PMID: 17660382] - Fabio Rossi, Cora Bertone, Silvia Petricca, Vittorio Santiemma. Ghrelin inhibits angiotensin II-induced migration of human aortic endothelial cells.
Atherosclerosis.
2007 Jun; 192(2):291-7. doi:
10.1016/j.atherosclerosis.2006.07.021
. [PMID: 16949080] - Naoya Asai, Toshifumi Fukuda, Zaiqi Wu, Atsushi Enomoto, Vassilis Pachnis, Masahide Takahashi, Frank Costantini. Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cells.
Development (Cambridge, England).
2006 Nov; 133(22):4507-16. doi:
10.1242/dev.02616
. [PMID: 17050626] - Guillermo A Yudowski, Manojkumar A Puthenveedu, Mark von Zastrow. Distinct modes of regulated receptor insertion to the somatodendritic plasma membrane.
Nature neuroscience.
2006 May; 9(5):622-7. doi:
10.1038/nn1679
. [PMID: 16604070] - Binnaz Ay, Adeyemi Iyanoye, Gary C Sieck, Y S Prakash, Christina M Pabelick. Cyclic nucleotide regulation of store-operated Ca2+ influx in airway smooth muscle.
American journal of physiology. Lung cellular and molecular physiology.
2006 Feb; 290(2):L278-83. doi:
10.1152/ajplung.00188.2005
. [PMID: 16155088] - Kazuyoshi Nakamura, Junko Hirano, Manabu Kubokawa. Regulation of an inwardly rectifying K+ channel by nitric oxide in cultured human proximal tubule cells.
American journal of physiology. Renal physiology.
2004 Sep; 287(3):F411-7. doi:
10.1152/ajprenal.00014.2004
. [PMID: 15140759] - Ilknur Ay, Meral Tuncer. Mechanism of CGRP-induced vasodilation in the rat isolated perfused kidney.
Pharmacology.
2004 Aug; 71(4):209-15. doi:
10.1159/000078087
. [PMID: 15240997] - Shih-Horng Huang, Wung-Jing Shen, Hui-Lin Yeo, Seu-Mei Wang. Signaling pathway of magnolol-stimulated lipolysis in sterol ester-loaded 3T3-L1 preadipocyes.
Journal of cellular biochemistry.
2004 Apr; 91(5):1021-9. doi:
10.1002/jcb.10788
. [PMID: 15034936] - Guim Kwon, Kirk L Pappan, Connie A Marshall, Jean E Schaffer, Michael L McDaniel. cAMP Dose-dependently prevents palmitate-induced apoptosis by both protein kinase A- and cAMP-guanine nucleotide exchange factor-dependent pathways in beta-cells.
The Journal of biological chemistry.
2004 Mar; 279(10):8938-45. doi:
10.1074/jbc.m310330200
. [PMID: 14688288] - Gábor Nagy, Kerstin Reim, Ulf Matti, Nils Brose, Thomas Binz, Jens Rettig, Erwin Neher, Jakob B Sørensen. Regulation of releasable vesicle pool sizes by protein kinase A-dependent phosphorylation of SNAP-25.
Neuron.
2004 Feb; 41(3):417-29. doi:
10.1016/s0896-6273(04)00038-8
. [PMID: 14766180] - Bharathi Aravamudan, Kendal Broadie. Synaptic Drosophila UNC-13 is regulated by antagonistic G-protein pathways via a proteasome-dependent degradation mechanism.
Journal of neurobiology.
2003 Feb; 54(3):417-38. doi:
10.1002/neu.10142
. [PMID: 12532395] - Detlef Lang, Martin Terstesse, Frank Dohle, Philip Bangen, Bernhard Banas, Hans-Gerd Pauels, Stefan Heidenreich. Protein kinase C (PKC) dependent induction of tissue factor (TF) by mesangial cells in response to inflammatory mediators and release during apoptosis.
British journal of pharmacology.
2002 Dec; 137(7):1116-24. doi:
10.1038/sj.bjp.0704967
. [PMID: 12429585] - Kazuyoshi Nakamura, Junko Hirano, Shun-Ichi Itazawa, Manabu Kubokawa. Protein kinase G activates inwardly rectifying K(+) channel in cultured human proximal tubule cells.
American journal of physiology. Renal physiology.
2002 Oct; 283(4):F784-91. doi:
10.1152/ajprenal.00023.2002
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American journal of physiology. Lung cellular and molecular physiology.
2002 Aug; 283(2):L428-32. doi:
10.1152/ajplung.00432.2001
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Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2002 Jun; 53(2):211-31. doi:
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Immunopharmacology and immunotoxicology.
2002 Feb; 24(1):97-112. doi:
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Experimental nephrology.
2002; 10(1):26-33. doi:
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Journal of the American Society of Nephrology : JASN.
2001 Jan; 12(1):19-28. doi:
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Japanese journal of pharmacology.
2001 Jan; 85(1):54-9. doi:
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Molecular pharmacology.
2001 Jan; 59(1):16-23. doi:
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Immunopharmacology and immunotoxicology.
2000 May; 22(2):279-95. doi:
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Neuroscience.
2000; 99(2):327-31. doi:
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Pflugers Archiv : European journal of physiology.
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Acta tropica.
1999 Jul; 73(2):93-108. doi:
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. [PMID: 10465050] - M Kubokawa, S Nakaya, Y Yoshioka, K Nakamura, F Sato, Y Mori, T Kubota. Activation of inwardly rectifying K+ channel in OK proximal tubule cells involves cGMP-dependent phosphorylation process.
The Japanese journal of physiology.
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Hepatology (Baltimore, Md.).
1998 Oct; 28(4):1031-41. doi:
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Hepatology (Baltimore, Md.).
1998 May; 27(5):1324-31. doi:
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Kidney & blood pressure research.
1998; 21(1):36-41. doi:
10.1159/000025841
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Molecular and cellular biochemistry.
1997 Feb; 167(1-2):41-9. doi:
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The Japanese journal of physiology.
1997 Feb; 47(1):111-9. doi:
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