Purmorphamine (BioDeep_00000391133)

   


代谢物信息卡片


9-cyclohexyl-N-[4-(morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine

化学式: C31H32N6O2 (520.2586612)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CCC(CC1)N2C=NC3=C(N=C(N=C32)OC4=CC=CC5=CC=CC=C54)NC6=CC=C(C=C6)N7CCOCC7
InChI: InChI=1S/C31H32N6O2/c1-2-9-25(10-3-1)37-21-32-28-29(33-23-13-15-24(16-14-23)36-17-19-38-20-18-36)34-31(35-30(28)37)39-27-12-6-8-22-7-4-5-11-26(22)27/h4-8,11-16,21,25H,1-3,9-10,17-20H2,(H,33,34,35)

描述信息

同义名列表

2 个代谢物同义名

Purmorphamine; 9-cyclohexyl-N-[4-(morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Lan Ho Wei, Mohammad Arastoo, Ioanna Georgiou, David R Manning, Natalia A Riobo-Del Galdo. Activation of the Gi protein-RHOA axis by non-canonical Hedgehog signaling is independent of primary cilia. PloS one. 2018; 13(8):e0203170. doi: 10.1371/journal.pone.0203170. [PMID: 30148884]
  • Shalabh Srivastava, Simon A Ramsbottom, Elisa Molinari, Sumaya Alkanderi, Andrew Filby, Kathryn White, Charline Henry, Sophie Saunier, Colin G Miles, John A Sayer. A human patient-derived cellular model of Joubert syndrome reveals ciliary defects which can be rescued with targeted therapies. Human molecular genetics. 2017 12; 26(23):4657-4667. doi: 10.1093/hmg/ddx347. [PMID: 28973549]
  • Agnes Lim, Kunyoo Shin, Chen Zhao, Sally Kawano, Philip A Beachy. Spatially restricted Hedgehog signalling regulates HGF-induced branching of the adult prostate. Nature cell biology. 2014 Dec; 16(12):1135-45. doi: 10.1038/ncb3057. [PMID: 25362352]
  • Joseph R Cohen, Daniel Z Resnick, Pawel Niewiadomski, Hongmei Dong, Linda M Liau, James A Waschek. Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures. BMC cancer. 2010 Dec; 10(?):676. doi: 10.1186/1471-2407-10-676. [PMID: 21143927]
  • Cynthia M Rominger, Wei-Lin Tiger Bee, Robert A Copeland, Elizabeth A Davenport, Aidan Gilmartin, Richard Gontarek, Keith R Hornberger, Lorena A Kallal, Zhihong Lai, Kenneth Lawrie, Quinn Lu, Lynette McMillan, Maggie Truong, Peter J Tummino, Brandon Turunen, Matthew Will, William J Zuercher, David H Rominger. Evidence for allosteric interactions of antagonist binding to the smoothened receptor. The Journal of pharmacology and experimental therapeutics. 2009 Jun; 329(3):995-1005. doi: 10.1124/jpet.109.152090. [PMID: 19304771]
  • Coralie Fontaine, Wendy Cousin, Magali Plaisant, Christian Dani, Pascal Peraldi. Hedgehog signaling alters adipocyte maturation of human mesenchymal stem cells. Stem cells (Dayton, Ohio). 2008 Apr; 26(4):1037-46. doi: 10.1634/stemcells.2007-0974. [PMID: 18258719]