bromopride (BioDeep_00000391074)
代谢物信息卡片
化学式: C14H22BrN3O2 (343.0895292)
中文名称: 溴灭吐灵
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCN(CC)CCNC(=O)C1=CC(=C(C=C1OC)N)Br
InChI: InChI=1S/C14H22BrN3O2/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3/h8-9H,4-7,16H2,1-3H3,(H,17,19)
描述信息
A - Alimentary tract and metabolism > A03 - Drugs for functional gastrointestinal disorders > A03F - Propulsives > A03FA - Propulsives
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
C78272 - Agent Affecting Nervous System > C66883 - Dopamine Antagonist
C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
D002491 - Central Nervous System Agents
Bromopride is a dopamine antagonist with prokinetic properties, widely used as an antiemetic.
同义名列表
1 个代谢物同义名
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:95304
- KEGGdrug: D07101
- PubChem: 2446
- Metlin: METLIN44333
- DrugBank: DB09018
- ChEMBL: CHEMBL399510
- CAS: 4093-35-0
- PMhub: MS000241254
- medchemexpress: HY-B1164
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040
. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964
. [PMID: 31515284] - Liliane Spazzapam Lima, Patrícia Los Weinert, Leonardo Pezza, Helena Redigolo Pezza. Sensitive flow-injection spectrophotometric analysis of bromopride.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2014 Dec; 133(?):597-604. doi:
10.1016/j.saa.2014.06.027
. [PMID: 24992919] - Christine E Dunne, Jennifer L Bushee, Upendra A Argikar. Metabolism of bromopride in mouse, rat, rabbit, dog, monkey, and human hepatocytes.
Drug metabolism and pharmacokinetics.
2013; 28(6):453-61. doi:
10.2133/dmpk.dmpk-13-rg-010
. [PMID: 23615565] - Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
10.1021/jm900403j
. [PMID: 19445515] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479
. [PMID: 18426954] - P Nazare, P Massaroti, L F Duarte, D R Campos, M A M Marchioretto, G Bernasconi, S Calafatti, F A P Barros, E C Meurer, J Pedrazzoli, L A B Moraes. Validated method for determination of bromopride in human plasma by liquid chromatography--electrospray tandem mass spectrometry: application to the bioequivalence study.
Journal of mass spectrometry : JMS.
2005 Sep; 40(9):1197-202. doi:
10.1002/jms.898
. [PMID: 16127659] - A G Nasello, D Gidali, L C de Sá-Rocha, L F Felicio. Differential effects of bromopride and domperidone on cholinesterase activity in rat tissues.
Life sciences.
1995; 56(3):151-6. doi:
10.1016/0024-3205(94)00429-v
. [PMID: 7823770] - A G Nasello, L F Felicio. Avoidance behavior, prolactin, HVA and DOPAC in offspring of bromopride-treated rats.
Pharmacology, biochemistry, and behavior.
1990 Nov; 37(3):571-5. doi:
10.1016/0091-3057(90)90030-l
. [PMID: 2087495] - L F Felício, A G Nasello. Effect of acute bromopride treatment on rat prolactin levels and sexual behavior.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
1989; 22(8):1011-4. doi:
NULL
. [PMID: 2633842] - L F Felicio, W L Miranda, A G Nasello. Prolactin levels in male and female rats perinatally treated with bromopride.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
1988; 21(1):133-6. doi:
NULL
. [PMID: 3179568] - C Vacca, S Maione, A Tozzi, E Marmo. Benzamides and cholinesterases.
Research communications in chemical pathology and pharmacology.
1987 Feb; 55(2):193-201. doi:
NULL
. [PMID: 3823608] - R R Brodie, L F Chasseaud, A Darragh, R F Lambe, L Rooney, T Taylor. Pharmacokinetics and bioavailability of the anti-emetic agent bromopride.
Biopharmaceutics & drug disposition.
1986 May; 7(3):215-22. doi:
10.1002/bdd.2510070302
. [PMID: 3730521] - R R Brodie, L F Chasseaud, L Rooney. Determination of bromopride in human plasma and urine by high-performance liquid chromatography.
Journal of chromatography.
1984 Oct; 310(2):353-60. doi:
10.1016/0378-4347(84)80100-0
. [PMID: 6511853] - B Metivier, A Servin, H Renault, C Jacquot. Pharmacokinetic study of digoxin-benzamide interaction in the rat.
International journal of nuclear medicine and biology.
1984; 11(1):103-5. doi:
10.1016/0047-0740(84)90043-3
. [PMID: 6735603] - L Jung, J Imbs, J C Koffel. [Bromopride: pharmacokinetics in dogs (author's transl)].
Arzneimittel-Forschung.
1982; 32(5):509-11. doi:
NULL
. [PMID: 7201828] - J Imbs, A Leibenguth, J C Koffel, L Jung. [Bromopride: metabolism and urinary elimination in dogs (author's transl)].
Arzneimittel-Forschung.
1982; 32(5):503-8. doi:
NULL
. [PMID: 7201827] - K Becker, V F Eckardt, K Sinterhauf. [Effect of bromopride on gastric acid secretion (author's transl)].
Arzneimittel-Forschung.
1980; 30(11):1926-8. doi:
NULL
. [PMID: 7193005]