cefditoren pivoxil (BioDeep_00000390022)
natural product
代谢物信息卡片
化学式: C25H28N6O7S3 (620.1181538)
中文名称: 头孢妥仑匹酯
谱图信息:
最多检出来源 Viridiplantae(plant) 85.71%
分子结构信息
SMILES: CC1=C(SC=N1)C=CC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)OCOC(=O)C(C)(C)C
InChI: InChI=1S/C25H28N6O7S3/c1-12-15(41-10-27-12)7-6-13-8-39-21-17(29-19(32)16(30-36-5)14-9-40-24(26)28-14)20(33)31(21)18(13)22(34)37-11-38-23(35)25(2,3)4/h6-7,9-10,17,21H,8,11H2,1-5H3,(H2,26,28)(H,29,32)/b7-6-,30-16-/t17-,21-/m1/s1
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
同义名列表
2 个代谢物同义名
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:560555
- KEGGdrug: D01628
- PubChem: 6437877
- PubChem: 6728941
- Metlin: METLIN43981
- ChEMBL: CHEMBL454446
- CAS: 1448435-17-3
- CAS: 117467-28-4
- MoNA: CCMSLIB00000078283
- MoNA: CCMSLIB00000078282
- MoNA: CCMSLIB00000078281
- PMhub: MS000240133
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Masanori Ito, Mitsumasa Fukuda, Yuka Suzuki, Hiroyuki Wakamoto, Eiichi Ishii. Carnitine-related hypoglycemia caused by 3 days of pivalate antibiotic therapy in a patient with severe muscular dystrophy: a case report.
BMC pediatrics.
2017 03; 17(1):73. doi:
10.1186/s12887-017-0835-7. [PMID: 28292283] - Nawal A Alarfaj, Fatma A Aly, Maha F El-Tohamy. Application of silver nanoparticles to the chemiluminescence determination of cefditoren pivoxil using the luminol-ferricyanide system.
Luminescence : the journal of biological and chemical luminescence.
2015 Feb; 30(1):91-7. doi:
10.1002/bio.2696. [PMID: 24850667] - Gojjala Venugopalarao, Rajasekhar Lakshmipathy, Nallani Chakravarthula Sarada. Preparation and characterization of cefditoren pivoxil-loaded liposomes for controlled in vitro and in vivo drug release.
International journal of nanomedicine.
2015; 10 Suppl 1(?):149-57. doi:
10.2147/ijn.s79994. [PMID: 26491316] - Kayoko Matsumoto, Nobuo Sato, Nayu Mitomi, Shigeki Shibasaki. Population pharmacokinetic analysis of cefditoren pivoxil in pediatric patients with infection.
The Japanese journal of antibiotics.
2013 Dec; 66(6):357-75. doi:
NULL. [PMID: 24649799] - Sheo B Singh, Diane Rindgen, Prudence Bradley, Lovji Cama, Wanying Sun, Michael J Hafey, Takao Suzuki, Nengxue Wang, Hao Wu, Basheng Zhang, Li Wang, Chongmin Ji, Hongshi Yu, Richard Soll, David B Olsen, Peter T Meinke, Deborah A Nicoll-Griffith. Design, synthesis, and evaluation of prodrugs of ertapenem.
ACS medicinal chemistry letters.
2013 Aug; 4(8):715-9. doi:
10.1021/ml400092n. [PMID: 24900737] - Teerapong Monmaturapoj, Preecha Montakantikul, Piroon Mootsikapun, Pramote Tragulpiankit. A prospective, randomized, double dummy, placebo-controlled trial of oral cefditoren pivoxil 400mg once daily as switch therapy after intravenous ceftriaxone in the treatment of acute pyelonephritis.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2012 Dec; 16(12):e843-9. doi:
10.1016/j.ijid.2012.07.009. [PMID: 22951426] - Thomas P Lodise, Martina Kinzig-Schippers, George L Drusano, Ulrich Loos, Friedrich Vogel, Jürgen Bulitta, Markus Hinder, Fritz Sörgel. Use of population pharmacokinetic modeling and Monte Carlo simulation to describe the pharmacodynamic profile of cefditoren in plasma and epithelial lining fluid.
Antimicrobial agents and chemotherapy.
2008 Jun; 52(6):1945-51. doi:
10.1128/aac.00736-06. [PMID: 17485507] - David Sevillano, Lorenzo Aguilar, Luis Alou, María-José Giménez, Martha Torrico, Natalia González, Fabio Cafini, María-Teresa Relaño, Pilar Coronel, José Prieto. Urine bactericidal activity against Escherichia coli isolates exhibiting different resistance phenotypes/genotypes in an in vitro pharmacodynamic model simulating urine concentrations obtained after oral administration of a 400-milligram single dose of cefditoren-pivoxil.
Antimicrobial agents and chemotherapy.
2008 Mar; 52(3):1184-6. doi:
10.1128/aac.01247-07. [PMID: 18160517] - M Torrico, L Aguilar, N González, M J Giménez, O Echeverría, F Cafini, D Sevillano, L Alou, P Coronel, J Prieto. influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhibiting an N526K mutation in the ftsI gene.
Antimicrobial agents and chemotherapy.
2007 Oct; 51(10):3699-706. doi:
10.1128/aac.01530-06. [PMID: 17664320] - Eric P Brass, Michael D Mayer, Darcy J Mulford, Therese K Stickler, Charles L Hoppel. Impact on carnitine homeostasis of short-term treatment with the pivalate prodrug cefditoren pivoxil.
Clinical pharmacology and therapeutics.
2003 Apr; 73(4):338-47. doi:
10.1016/s0009-9236(02)17636-3. [PMID: 12709724] - Malcolm J M Darkes, Greg L Plosker. Cefditoren pivoxil.
Drugs.
2002; 62(2):319-36; discussion 337. doi:
10.2165/00003495-200262020-00006. [PMID: 11817976] - J T Li, F Hou, H Lu, T Y Li, H Li. Phase I clinical trial of cefditoren pivoxil (ME 1207): pharmacokinetics in healthy volunteers.
Drugs under experimental and clinical research.
1997; 23(5-6):145-50. doi:
NULL. [PMID: 9515223] - T Motohiro, S Handa, S Yamada, S Oki, Y Yoshinaga, H Sasaki, M Aramaki, K Oda, Y Sakata, H Kato. [Basic and clinical studies on cefditoren pivoxil in pediatric field].
The Japanese journal of antibiotics.
1994 Apr; 47(4):409-27. doi:
NULL. [PMID: 8201769] - N Iwai, H Nakamura, M Miyazu, Y Watanabe. [Pharmacokinetic, bacteriological and clinical evaluation of cefditoren pivoxil in pediatrics].
The Japanese journal of antibiotics.
1994 Feb; 47(2):181-94. doi:
NULL. [PMID: 8151911] - R Fujii, S Chiba, K Numazaki, T Mori, I Terashima, H Meguro, A Mori, Y Toyonaga, K Sunakawa, Y Satoh. [Effect of cefditoren pivoxil on carnitine metabolism in pediatric patients].
The Japanese journal of antibiotics.
1993 Oct; 46(10):926-37. doi:
NULL. [PMID: 8254895] - Y Toyonaga, T Ishihara, T Sano, T Tezuka, H Nakamura. [Bacteriological, pharmacokinetic and clinical studies of cefditoren pivoxil in the pediatric field].
The Japanese journal of antibiotics.
1993 Jul; 46(7):604-28. doi:
. [PMID: 8371496] - T Tajima, M Kobayashi, S Negishi, S Nishimura, A Yoshida, S Kudo, M Gondou, T Nakayama, T Abe. [Pharmacokinetic, bacteriological and clinical studies on cefditoren pivoxil in children].
The Japanese journal of antibiotics.
1993 Jul; 46(7):589-95. doi:
NULL. [PMID: 8371494] - S Arakawa, S Takagi, S Kamidono, N Kataoka, O Tomioka, M Hazama, T Hirose, K Yamazaki, Y Kumamoto, K Hayashi. [Clinical long-term studies of the treatment of chronic complicated urinary tract infections. Utility and recurrence after 14-day treatment by cefditoren pivoxil].
The Japanese journal of antibiotics.
1993 Jan; 46(1):75-94. doi:
NULL. [PMID: 8455334]