Entinostat (BioDeep_00000389431)
代谢物信息卡片
Entinostat (MS-275)
化学式: C21H20N4O3 (376.15353300000004)
中文名称: 恩替诺特
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC(=O)OCC3=CN=CC=C3
InChI: InChI=1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)
描述信息
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01X - Other antineoplastic agents > L01XH - Histone deacetylase (hdac) inhibitors
D004791 - Enzyme Inhibitors > D056572 - Histone Deacetylase Inhibitors
C471 - Enzyme Inhibitor > C1946 - Histone Deacetylase Inhibitor
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent
D000970 - Antineoplastic Agents
同义名列表
2 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:132082
- KEGGdrug: D09338
- PubChem: 4261
- DrugBank: DB11841
- ChEMBL: CHEMBL27759
- CAS: 442532-99-2
- CAS: 209783-80-2
- PMhub: MS000239501
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Chang-Gun Lee, Soo-Jin Lee, Seokho Park, Sung-E Choi, Min-Woo Song, Hyo Won Lee, Hae Jin Kim, Yup Kang, Kwan Woo Lee, Hwan Myung Kim, Jong-Young Kwak, In-Jeong Lee, Ja Young Jeon. In Vivo Two-Photon Imaging Analysis of Dynamic Degradation of Hepatic Lipid Droplets in MS-275-Treated Mouse Liver.
International journal of molecular sciences.
2022 Sep; 23(17):. doi:
10.3390/ijms23179978. [PMID: 36077368] - Jianqing Lin, Jacob Elkon, Brittany Ricart, Erica Palmer, Christian Zevallos-Delgado, Satish Noonepalle, Brooke Burgess, Robert Siegel, Yan Ma, Alejandro Villagra. Phase I Study of Entinostat in Combination with Enzalutamide for Treatment of Patients with Metastatic Castration-Resistant Prostate Cancer.
The oncologist.
2021 12; 26(12):e2136-e2142. doi:
10.1002/onco.13957. [PMID: 34427023] - Norikazu Masuda, Kenji Tamura, Hiroyuki Yasojima, Akihiko Shimomura, Masataka Sawaki, Min-Jung Lee, Akira Yuno, Jane Trepel, Ryoko Kimura, Yozo Nishimura, Shigehira Saji, Hiroji Iwata. Phase 1 trial of entinostat as monotherapy and combined with exemestane in Japanese patients with hormone receptor-positive advanced breast cancer.
BMC cancer.
2021 Nov; 21(1):1269. doi:
10.1186/s12885-021-08973-4. [PMID: 34819039] - Shabir Ahmad Ganai, Pappu Srinivasan, Sundaraj Rajamanikandan, Basit Amin Shah, Suma Mohan, Mudasir Gani, Bilal Ahmad Padder, Raies A Qadri, M A Bhat, Zahoor Ahmad Baba, Manzoor Ahmad Yatoo. Delineating binding potential, stability of Sulforaphane-N-acetyl-cysteine in the active site of histone deacetylase 2 and testing its cytotoxicity against distinct cancer lines through stringent molecular dynamics, DFT and cell-based assays.
Chemical biology & drug design.
2021 09; 98(3):363-376. doi:
10.1111/cbdd.13854. [PMID: 33966346] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Shilpak Bele, Shravan Babu Girada, Aramita Ray, Abhishek Gupta, Srinivas Oruganti, Phanithi Prakash Babu, Rahul Sr Rayalla, Shashi Vardhan Kalivendi, Ahamed Ibrahim, Vishwajeet Puri, Venkateswar Adalla, Madhumohan R Katika, Richard DiMarchi, Prasenjit Mitra. MS-275, a class 1 histone deacetylase inhibitor augments glucagon-like peptide-1 receptor agonism to improve glycemic control and reduce obesity in diet-induced obese mice.
eLife.
2020 12; 9(?):. doi:
10.7554/elife.52212. [PMID: 33349332] - Bettina Zierfuss, Isabelle Weinhofer, Agnieszka Buda, Niko Popitsch, Lena Hess, Verena Moos, Simon Hametner, Stephan Kemp, Wolfgang Köhler, Sonja Forss-Petter, Christian Seiser, Johannes Berger. Targeting foam cell formation in inflammatory brain diseases by the histone modifier MS-275.
Annals of clinical and translational neurology.
2020 11; 7(11):2161-2177. doi:
10.1002/acn3.51200. [PMID: 32997393] - Kelly A Hyndman, Joshua S Speed, Luciano D Mendoza, John M Allan, Jackson Colson, Randee Sedaka, Chunhua Jin, Hyun Jun Jung, Samir El-Dahr, David M Pollock, Jennifer S Pollock. Fluid-electrolyte homeostasis requires histone deacetylase function.
JCI insight.
2020 08; 5(16):. doi:
10.1172/jci.insight.137792. [PMID: 32673289] - Andrew E Shouksmith, Justyna M Gawel, Nabanita Nawar, Diana Sina, Yasir S Raouf, Shazreh Bukhari, Liying He, Alexandra E Johns, Pimyupa Manaswiyoungkul, Olasunkanmi O Olaoye, Aaron D Cabral, Abootaleb Sedighi, Elvin D de Araujo, Patrick T Gunning. Class I/IIb-Selective HDAC Inhibitor Exhibits Oral Bioavailability and Therapeutic Efficacy in Acute Myeloid Leukemia.
ACS medicinal chemistry letters.
2020 Jan; 11(1):56-64. doi:
10.1021/acsmedchemlett.9b00471. [PMID: 31938464] - Shanshan Ma, Tengfei Liu, Ling Xu, Yaping Wang, Jiankang Zhou, Tuanjie Huang, Peng Li, Hongtao Liu, Yanting Zhang, Xinkui Zhou, Yuanbo Cui, Xingxing Zang, Yuming Wang, Fangxia Guan. Histone deacetylases inhibitor MS-275 suppresses human esophageal squamous cell carcinoma cell growth and progression via the PI3K/Akt/mTOR pathway.
Journal of cellular physiology.
2019 12; 234(12):22400-22410. doi:
10.1002/jcp.28805. [PMID: 31120582] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Qi Zhang, Qin Zhu, Ruyuan Deng, Feiye Zhou, Linlin Zhang, Shushu Wang, Kecheng Zhu, Xiao Wang, Libin Zhou, Qing Su. MS-275 induces hepatic FGF21 expression via H3K18ac-mediated CREBH signal.
Journal of molecular endocrinology.
2019 05; 62(4):187-196. doi:
10.1530/jme-18-0259. [PMID: 30893641] - Nicole Kiweler, Boris Brill, Matthias Wirth, Ines Breuksch, Teresa Laguna, Cornelia Dietrich, Susanne Strand, Günter Schneider, Bernd Groner, Falk Butter, Thorsten Heinzel, Walburgis Brenner, Oliver H Krämer. The histone deacetylases HDAC1 and HDAC2 are required for the growth and survival of renal carcinoma cells.
Archives of toxicology.
2018 07; 92(7):2227-2243. doi:
10.1007/s00204-018-2229-5. [PMID: 29845424] - Lucia Rossi, Cecilia Battistelli, Valeria de Turris, Valeria Noce, Clemens Zwergel, Sergio Valente, Alessandra Moioli, Andrea Manzione, Marco Palladino, Veronica Bordoni, Alessandro Domenici, Paolo Menè, Antonello Mai, Marco Tripodi, Raffaele Strippoli. HDAC1 inhibition by MS-275 in mesothelial cells limits cellular invasion and promotes MMT reversal.
Scientific reports.
2018 05; 8(1):8492. doi:
10.1038/s41598-018-26319-2. [PMID: 29855565] - Haiyue Zhang, Wenbin Zhang, Fangzhou Jiao, Xun Li, Hong Zhang, Luwen Wang, Zuojiong Gong. The Nephroprotective Effect of MS-275 on Lipopolysaccharide (LPS)-Induced Acute Kidney Injury by Inhibiting Reactive Oxygen Species (ROS)-Oxidative Stress and Endoplasmic Reticulum Stress.
Medical science monitor : international medical journal of experimental and clinical research.
2018 Apr; 24(?):2620-2630. doi:
10.12659/msm.906362. [PMID: 29704392] - Roberto Pili, David I Quinn, Hans J Hammers, Paul Monk, Saby George, Tanya B Dorff, Thomas Olencki, Li Shen, Ashley Orillion, Dominick Lamonica, Roberto S Fragomeni, Zsolt Szabo, Alan Hutson, Adrienne Groman, Susan M Perkins, Richard Piekarz, Michael A Carducci. Immunomodulation by Entinostat in Renal Cell Carcinoma Patients Receiving High-Dose Interleukin 2: A Multicenter, Single-Arm, Phase I/II Trial (NCI-CTEP#7870).
Clinical cancer research : an official journal of the American Association for Cancer Research.
2017 Dec; 23(23):7199-7208. doi:
10.1158/1078-0432.ccr-17-1178. [PMID: 28939740] - Protim Sarker, Atanu Banik, Roger Stromberg, Gudmundur H Gudmundsson, Rubhana Raqib, Birgitta Agerberth. Treatment with Entinostat Heals Experimental Cholera by Affecting Physical and Chemical Barrier Functions of Intestinal Epithelia.
Antimicrobial agents and chemotherapy.
2017 07; 61(7):. doi:
10.1128/aac.02570-16. [PMID: 28438947] - Lulu Ni, Lixin Wang, Chao Yao, Zhongya Ni, Fei Liu, Chenyuan Gong, Xiaowen Zhu, Xuewei Yan, Stephanie S Watowich, Dean A Lee, Shiguo Zhu. The histone deacetylase inhibitor valproic acid inhibits NKG2D expression in natural killer cells through suppression of STAT3 and HDAC3.
Scientific reports.
2017 03; 7(?):45266. doi:
10.1038/srep45266. [PMID: 28338101] - Sin Y Choi, Hae J Kee, Thomas Kurz, Finn K Hansen, Yuhee Ryu, Gwi R Kim, Ming Q Lin, Li Jin, Zhe H Piao, Myung H Jeong. Class I HDACs specifically regulate E-cadherin expression in human renal epithelial cells.
Journal of cellular and molecular medicine.
2016 12; 20(12):2289-2298. doi:
10.1111/jcmm.12919. [PMID: 27420561] - Charlene Siew-Hon Tan, Christabel Fung-Yih Ho, Swan-Ser Heng, Jui-Sheng Wu, Benny Kwong-Huat Tan, Yee-Kong Ng, Grace Y Sun, Teng-Nan Lin, Wei-Yi Ong. Clinacanthus nutans Extracts Modulate Epigenetic Link to Cytosolic Phospholipase A2 Expression in SH-SY5Y Cells and Primary Cortical Neurons.
Neuromolecular medicine.
2016 Sep; 18(3):441-52. doi:
10.1007/s12017-016-8404-z. [PMID: 27319010] - Abigail D G Nunn, Tullio Scopigno, Natalia Pediconi, Massimo Levrero, Henning Hagman, Juris Kiskis, Annika Enejder. The histone deacetylase inhibiting drug Entinostat induces lipid accumulation in differentiated HepaRG cells.
Scientific reports.
2016 06; 6(?):28025. doi:
10.1038/srep28025. [PMID: 27320682] - Joshua S Speed, Kelly A Hyndman. In vivo organ specific drug delivery with implantable peristaltic pumps.
Scientific reports.
2016 05; 6(?):26251. doi:
10.1038/srep26251. [PMID: 27185292] - Yanyang Li, Yongzhen Wang, Ning Xie, Ming Xu, Pengyu Qian, Yanjin Zhao, Shuxin Li. Design, synthesis and antiproliferative activities of novel benzamides derivatives as HDAC inhibitors.
European journal of medicinal chemistry.
2015 Jul; 100(?):270-6. doi:
10.1016/j.ejmech.2015.05.045. [PMID: 26140961] - Rong-Yi Chen, Yi-Ming Fan, Qiuyang Zhang, Sen Liu, Qingli Li, Guo-Lin Ke, Chen Li, Zongbing You. Estradiol inhibits Th17 cell differentiation through inhibition of RORγT transcription by recruiting the ERα/REA complex to estrogen response elements of the RORγT promoter.
Journal of immunology (Baltimore, Md. : 1950).
2015 Apr; 194(8):4019-28. doi:
10.4049/jimmunol.1400806. [PMID: 25769926] - Shiguo Zhu, Cecele J Denman, Zehra S Cobanoglu, Simin Kiany, Ching C Lau, Stephen M Gottschalk, Dennis P M Hughes, Eugenie S Kleinerman, Dean A Lee. The narrow-spectrum HDAC inhibitor entinostat enhances NKG2D expression without NK cell toxicity, leading to enhanced recognition of cancer cells.
Pharmaceutical research.
2015 Mar; 32(3):779-92. doi:
10.1007/s11095-013-1231-0. [PMID: 24203492] - Yongqing Li, Ting Zhao, Baoling Liu, Ihab Halaweish, Ralph Mazitschek, Xiuzhen Duan, Hasan B Alam. Inhibition of histone deacetylase 6 improves long-term survival in a lethal septic model.
The journal of trauma and acute care surgery.
2015 Feb; 78(2):378-85. doi:
10.1097/ta.0000000000000510. [PMID: 25757125] - Qing Wu, Qingwei Zhang, Congcong Wen, Lufeng Hu, Xianqin Wang, Guanyang Lin. The effect of MS-275 on CYP450 isoforms activity in rats by cocktail method.
International journal of clinical and experimental pathology.
2015; 8(8):9360-7. doi:
. [PMID: 26464689] - Xuezhi Yang, Qingwei Zhang, Mengchun Chen, Lufeng Hu. Pharmacokinetic interaction of entinostat and lapatinib following single and co-oral administration in rats.
Xenobiotica; the fate of foreign compounds in biological systems.
2014 Nov; 44(11):1009-13. doi:
10.3109/00498254.2014.919431. [PMID: 24831712] - Carmen S Tellez, Marcie J Grimes, Maria A Picchi, Yushi Liu, Thomas H March, Matthew D Reed, Aram Oganesian, Pietro Taverna, Steven A Belinsky. SGI-110 and entinostat therapy reduces lung tumor burden and reprograms the epigenome.
International journal of cancer.
2014 Nov; 135(9):2223-31. doi:
10.1002/ijc.28865. [PMID: 24668305] - Jinhua Tang, Yanli Yan, Ting C Zhao, George Bayliss, Haidong Yan, Shougang Zhuang. Class I histone deacetylase activity is required for proliferation of renal epithelial cells.
American journal of physiology. Renal physiology.
2013 Aug; 305(3):F244-54. doi:
10.1152/ajprenal.00126.2013. [PMID: 23698124] - Na Liu, Song He, Li Ma, Murugavel Ponnusamy, Jinhua Tang, Evelyn Tolbert, George Bayliss, Ting C Zhao, Haidong Yan, Shougang Zhuang. Blocking the class I histone deacetylase ameliorates renal fibrosis and inhibits renal fibroblast activation via modulating TGF-beta and EGFR signaling.
PloS one.
2013; 8(1):e54001. doi:
10.1371/journal.pone.0054001. [PMID: 23342059] - K Rao-Bindal, Z Zhou, E S Kleinerman. MS-275 sensitizes osteosarcoma cells to Fas ligand-induced cell death by increasing the localization of Fas in membrane lipid rafts.
Cell death & disease.
2012 Aug; 3(?):e369. doi:
10.1038/cddis.2012.101. [PMID: 22875006] - R Pili, B Salumbides, M Zhao, S Altiok, D Qian, J Zwiebel, M A Carducci, M A Rudek. Phase I study of the histone deacetylase inhibitor entinostat in combination with 13-cis retinoic acid in patients with solid tumours.
British journal of cancer.
2012 Jan; 106(1):77-84. doi:
10.1038/bjc.2011.527. [PMID: 22134508] - Li Shen, Michael Ciesielski, Swathi Ramakrishnan, Kiersten M Miles, Leigh Ellis, Paula Sotomayor, Protul Shrikant, Robert Fenstermaker, Roberto Pili. Class I histone deacetylase inhibitor entinostat suppresses regulatory T cells and enhances immunotherapies in renal and prostate cancer models.
PloS one.
2012; 7(1):e30815. doi:
10.1371/journal.pone.0030815. [PMID: 22303460] - M D Cantley, P M Bartold, V Marino, D P Fairlie, G T Le, A J Lucke, D R Haynes. Histone deacetylase inhibitors and periodontal bone loss.
Journal of periodontal research.
2011 Dec; 46(6):697-703. doi:
10.1111/j.1600-0765.2011.01392.x. [PMID: 21745207] - Paul Hamberg, Margaret M Woo, Lin-Chi Chen, Jaap Verweij, Maria Grazia Porro, Lily Zhao, Wenkui Li, Diane van der Biessen, Sunil Sharma, Thomas Hengelage, Maja de Jonge. Effect of ketoconazole-mediated CYP3A4 inhibition on clinical pharmacokinetics of panobinostat (LBH589), an orally active histone deacetylase inhibitor.
Cancer chemotherapy and pharmacology.
2011 Sep; 68(3):805-13. doi:
10.1007/s00280-011-1693-x. [PMID: 21706316] - Seema Somji, Scott H Garrett, Conrad Toni, Xu Dong Zhou, Yun Zheng, Amornpan Ajjimaporn, Mary Ann Sens, Donald A Sens. Differences in the epigenetic regulation of MT-3 gene expression between parental and Cd+2 or As+3 transformed human urothelial cells.
Cancer cell international.
2011 Feb; 11(1):2. doi:
10.1186/1475-2867-11-2. [PMID: 21303554] - Enrique M Ocio, Jesús F San Miguel. The DAC system and associations with multiple myeloma.
Investigational new drugs.
2010 Dec; 28 Suppl 1(?):S28-35. doi:
10.1007/s10637-010-9589-x. [PMID: 21120582] - Wei Qu, Yin-Dong Kang, Mei-Sheng Zhou, Li-Li Fu, Zhen-Hao Hua, Li-Ming Wang. Experimental study on inhibitory effects of histone deacetylase inhibitor MS-275 and TSA on bladder cancer cells.
Urologic oncology.
2010 Nov; 28(6):648-54. doi:
10.1016/j.urolonc.2008.11.018. [PMID: 19181544] - Matthew Danish, Erin R Gardner, Xiaohong Chen, William D Figg. Determination of a benzamide histone deacetylase inhibitor, MS-275, in human plasma by liquid chromatography with mass-spectrometric detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Jan; 877(3):355-9. doi:
10.1016/j.jchromb.2008.12.018. [PMID: 19117815] - Tsoching Chen, Min-Jung Lee, Yeong Sang Kim, Sunmin Lee, Shivaani Kummar, Martin Gutierrez, Stephen M Hewitt, Jane B Trepel, Ira W Levin. Pharmacodynamic assessment of histone deacetylase inhibitors: infrared vibrational spectroscopic imaging of protein acetylation.
Analytical chemistry.
2008 Aug; 80(16):6390-6. doi:
10.1021/ac800840y. [PMID: 18651756] - Lia Gore, Mace L Rothenberg, Cindy L O'Bryant, Mary Kay Schultz, Alan B Sandler, Denise Coffin, Candice McCoy, Astrid Schott, Catherine Scholz, S Gail Eckhardt. A phase I and pharmacokinetic study of the oral histone deacetylase inhibitor, MS-275, in patients with refractory solid tumors and lymphomas.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2008 Jul; 14(14):4517-25. doi:
10.1158/1078-0432.ccr-07-1461. [PMID: 18579665] - Philip Jones, Sergio Altamura, Raffaele De Francesco, Paola Gallinari, Armin Lahm, Petra Neddermann, Michael Rowley, Sergio Serafini, Christian Steinkühler. Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases.
Bioorganic & medicinal chemistry letters.
2008 Mar; 18(6):1814-9. doi:
10.1016/j.bmcl.2008.02.025. [PMID: 18308563] - Shivaani Kummar, Martin Gutierrez, Erin R Gardner, Erin Donovan, Kyunghwa Hwang, Eun Joo Chung, Min-Jung Lee, Kim Maynard, Mikhail Kalnitskiy, Alice Chen, Giovanni Melillo, Qin C Ryan, Barbara Conley, William D Figg, Jane B Trepel, James Zwiebel, James H Doroshow, Anthony J Murgo. Phase I trial of MS-275, a histone deacetylase inhibitor, administered weekly in refractory solid tumors and lymphoid malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2007 Sep; 13(18 Pt 1):5411-7. doi:
10.1158/1078-0432.ccr-07-0791. [PMID: 17875771] - Yukihiko Kato, Kiyoshi Yoshimura, Tahiro Shin, Henk Verheul, Hans Hammers, Tolib B Sanni, Brenda C Salumbides, Karen Van Erp, Richard Schulick, Roberto Pili. Synergistic in vivo antitumor effect of the histone deacetylase inhibitor MS-275 in combination with interleukin 2 in a murine model of renal cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2007 Aug; 13(15 Pt 1):4538-46. doi:
10.1158/1078-0432.ccr-07-0014. [PMID: 17671140] - Ming Zhao, Michelle A Rudek, Aleksandr Mnasakanyan, Carol Hartke, Roberto Pili, Sharyn D Baker. A liquid chromatography/tandem mass spectrometry assay to quantitate MS-275 in human plasma.
Journal of pharmaceutical and biomedical analysis.
2007 Jan; 43(2):784-7. doi:
10.1016/j.jpba.2006.08.006. [PMID: 16971082] - Milin R Acharya, Alex Sparreboom, Edward A Sausville, Barbara A Conley, James H Doroshow, Jurgen Venitz, William D Figg. Interspecies differences in plasma protein binding of MS-275, a novel histone deacetylase inhibitor.
Cancer chemotherapy and pharmacology.
2006 Feb; 57(3):275-81. doi:
10.1007/s00280-005-0058-8. [PMID: 16028097] - Xiao-Fei Wang, David Z Qian, Mingqiang Ren, Yukihiko Kato, Yongfeng Wei, Lu Zhang, Zoya Fansler, Doug Clark, Osamu Nakanishi, Roberto Pili. Epigenetic modulation of retinoic acid receptor beta2 by the histone deacetylase inhibitor MS-275 in human renal cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2005 May; 11(9):3535-42. doi:
10.1158/1078-0432.ccr-04-1092. [PMID: 15867257] - Kyunghwa Hwang, Milin R Acharya, Edward A Sausville, Suoping Zhai, Eunhee W Woo, Jürgen Venitz, William D Figg, Alex Sparreboom. Determination of MS-275, a novel histone deacetylase inhibitor, in human plasma by liquid chromatography-electrospray mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2004 May; 804(2):289-94. doi:
10.1016/j.jchromb.2004.01.023. [PMID: 15081922] - Sonia C Maggio, Roberto R Rosato, Lora B Kramer, Yun Dai, Mohamed Rahmani, David S Paik, Ann C Czarnik, Shawn G Payne, Sarah Spiegel, Steven Grant. The histone deacetylase inhibitor MS-275 interacts synergistically with fludarabine to induce apoptosis in human leukemia cells.
Cancer research.
2004 Apr; 64(7):2590-600. doi:
10.1158/0008-5472.can-03-2631. [PMID: 15059916] - Mohamed Rahmani, Chunrong Yu, Erin Reese, Wesam Ahmed, Karen Hirsch, Paul Dent, Steven Grant. Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21(CIP1/WAF1) induction rather than AKT inhibition.
Oncogene.
2003 Sep; 22(40):6231-42. doi:
10.1038/sj.onc.1206646. [PMID: 13679862]