1,9-Pyrazoloanthrone (BioDeep_00000389308)
Volatile Flavor Compounds
代谢物信息卡片
1,9-Pyrazoloanthrone
化学式: C14H8N2O (220.06365979999998)
中文名称: 蒽[1,9-cd]吡唑-6(2H)-酮, 1,9-吡唑并蒽酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C2C(=C1)C3=NNC4=CC=CC(=C43)C2=O
InChI: InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16)
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:90695
- PubChem: 8515
- DrugBank: DB01782
- ChEMBL: CHEMBL1725279
- ChEMBL: CHEMBL7064
- CAS: 129-56-6
- PMhub: MS000239363
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Wenwen Gao, Yanxi Wang, Siyu Liu, Guojin Li, Qi Shao, Cai Zhang, Liguang Cao, Kai Liu, Wenrui Gao, Zifeng Yang, Yifei Dong, Xiliang Du, Lin Lei, Guowen Liu, Xinwei Li. IRE1α-JNK axis activation contributes to intracellular lipid accumulation in calf hepatocytes.
Journal of dairy science.
2023 Nov; ?(?):. doi:
10.3168/jds.2022-23189. [PMID: 37939835] - Yaru Liu, Zhenyang Yan, Yafei Ren, Woyu Wang, Yinze Ke, Yifan Wang, Rongming Qi. Electroacupuncture inhibits hippocampal neuronal apoptosis and improves cognitive dysfunction in mice with vascular dementia via the JNK signaling pathway.
Acupuncture in medicine : journal of the British Medical Acupuncture Society.
2023 10; 41(5):284-296. doi:
10.1177/09645284221136878. [PMID: 36482691] - Yi Su, Xin Yin, Xin Huang, Qianqian Guo, Mingyuan Ma, Liheng Guo. Astragaloside IV ameliorates sepsis-induced myocardial dysfunction by regulating NOX4/JNK/BAX pathway.
Life sciences.
2022 Dec; 310(?):121123. doi:
10.1016/j.lfs.2022.121123. [PMID: 36302499] - Shuzhong Duan, Xinpan Chen, Yingjie Liu, Weikang Guo, Wenhu Liu. Endoplasmic reticulum stress mediates parathyroid hormone-induced apoptosis in vascular smooth muscle cells.
Renal failure.
2022 Dec; 44(1):126-136. doi:
10.1080/0886022x.2022.2027248. [PMID: 35172689] - M Zhang, W J Tu, Q Zhang, X L Wu, X Y Zou, S Jiang. Osteocalcin reduces fat accumulation and inflammatory reaction by inhibiting ROS-JNK signal pathway in chicken embryonic hepatocytes.
Poultry science.
2022 Nov; 101(11):102026. doi:
10.1016/j.psj.2022.102026. [PMID: 36174267] - Yun-Yun Zhang, Pan-Pan Feng, Hong-Fei Wang, Heng Zhang, Tao Liang, Xiao-Shan Hao, Feng-Ze Wang, Hong-Rong Fei. Licochalcone B induces DNA damage, cell cycle arrest, apoptosis, and enhances TRAIL sensitivity in hepatocellular carcinoma cells.
Chemico-biological interactions.
2022 Sep; 365(?):110076. doi:
10.1016/j.cbi.2022.110076. [PMID: 35948134] - W Zhang, Z Hu. [Jiangtang Sanhuang tablet inhibits endoplasmic reticulum stress and autophagy in diabetic mouse islet cells].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2022 Sep; 42(9):1317-1323. doi:
10.12122/j.issn.1673-4254.2022.09.07. [PMID: 36210704] - Yanli Liu, Xia Gong, Juan Wang, Yongxiang Wang, Yong Zhang, Tao Li, Juan Yan, Min Zhou, Benzhong Zhang. Investigation of nickel sulfate-induced cytotoxicity and underlying toxicological mechanisms in human umbilical vein endothelial cells through oxidative stress, inflammation, apoptosis, and MAPK signaling pathways.
Environmental toxicology.
2022 Aug; 37(8):2058-2071. doi:
10.1002/tox.23550. [PMID: 35499276] - Yuan Lin, Kanjana Wongkrajang, Xiaofei Shen, Ping Wang, Zongyuan Zhou, Thipphawan Chuprajob, Nilubon Sornkaew, Na Yang, Lijuan Yang, Xiaoxia Lu, Ratchanaporn Chokchaisiri, Apichart Suksamrarn, Guolin Zhang, Fei Wang. Discovery of diarylheptanoids that activate α7 nAchR-JAK2-STAT3 signaling in macrophages with anti-inflammatory activity in vitro and in vivo.
Bioorganic & medicinal chemistry.
2022 07; 66(?):116811. doi:
10.1016/j.bmc.2022.116811. [PMID: 35576655] - Yuan-Ting Yang, Ming-Ju Hsieh, Yi-Ching Chuang, Chia-Chieh Lin, Yu-Sheng Lo, Hsin-Yu Ho, V Bharath Kumar, Jiunn-Liang Ko. Anticancer effects of picrasidine I on oral squamous cell carcinoma.
Environmental toxicology.
2022 Mar; 37(3):627-636. doi:
10.1002/tox.23430. [PMID: 34894061] - Pei Zhang, Jiale Zhang, Huahong Quan, Pengtao Chen, Jingcheng Wang, Yuan Liang. Effects of butein on human osteosarcoma cell proliferation, apoptosis, and autophagy through oxidative stress.
Human & experimental toxicology.
2022 Jan; 41(?):9603271221074346. doi:
10.1177/09603271221074346. [PMID: 35130734] - Saurabh Pal, Neha Singh, Indra Dev, Vineeta Sharma, Pankaj Ramji Jagdale, Anjaneya Ayanur, Kausar Mahmood Ansari. TGF-β/Smad signaling pathway plays a crucial role in patulin-induced pro-fibrotic changes in rat kidney via modulation of slug and snail expression.
Toxicology and applied pharmacology.
2022 01; 434(?):115819. doi:
10.1016/j.taap.2021.115819. [PMID: 34896196] - Jia Li, Shunying Jin, Michelle T Barati, Sanjana Rane, Qian Lin, Yi Tan, Lu Cai, Madhavi J Rane. ERK and p38 MAPK inhibition controls NF-E2 degradation and profibrotic signaling in renal proximal tubule cells.
Life sciences.
2021 Dec; 287(?):120092. doi:
10.1016/j.lfs.2021.120092. [PMID: 34715142] - Yuanyuan Zhang, Bingke Ma, Shuangshuang Hao, Jiaqi Wang, Ruichen Zhang, Muhammad Ishfaq, Chenxi Shi, Liang Yuan, Rui Li, Changwen Li, Fangping Liu. Drug-induced liver injury: Oltipraz and C2-ceramide intervene HNF-1α/GSTA1 expression via JNK signaling pathway.
Journal of applied toxicology : JAT.
2021 12; 41(12):2011-2020. doi:
10.1002/jat.4181. [PMID: 33959992] - Junping Guo, Wei Chen, Beibei Bao, Dayong Zhang, Jianping Pan, Mao Zhang. Protective effect of berberine against LPS-induced endothelial cell injury via the JNK signaling pathway and autophagic mechanisms.
Bioengineered.
2021 12; 12(1):1324-1337. doi:
10.1080/21655979.2021.1915671. [PMID: 33896366] - Ziyin Li, Huiqin Chi, Wei Zhu, Guangyu Yang, Jia Song, Lijun Mo, Yitian Zhang, Yudi Deng, Feifei Xu, Jiani Yang, Zhini He, Xingfen Yang. Cadmium induces renal inflammation by activating the NLRP3 inflammasome through ROS/MAPK/NF-κB pathway in vitro and in vivo.
Archives of toxicology.
2021 Nov; 95(11):3497-3513. doi:
10.1007/s00204-021-03157-2. [PMID: 34510229] - Bharath Kumar Velmurugan, Jen-Tsun Lin, B Mahalakshmi, Chia-Chieh Lin, Yi-Ching Chuang, Yu-Sheng Lo, Hsin-Yu Ho, Ming-Ju Hsieh, Mu-Kuan Chen. Dehydrocrenatidine inhibits head and neck cancer cells invasion and migration by modulating JNK1/2 and ERK1/2 pathway and decreases MMP-2 expression.
Environmental toxicology.
2021 Sep; 36(9):1848-1856. doi:
10.1002/tox.23305. [PMID: 34076342] - Tomoyuki Hioki, Haruhiko Tokuda, Kumiko Tanabe, Woo Kim, Junko Tachi, Shinobu Yamaguchi, Rie Matsushima-Nishiwaki, Osamu Kozawa, Hiroki Iida. Amplification by tramadol of PGD2-induced osteoprotegerin synthesis in osteoblasts: Involvement of μ-opioid receptor and 5-HT transporter.
Prostaglandins, leukotrienes, and essential fatty acids.
2021 09; 172(?):102323. doi:
10.1016/j.plefa.2021.102323. [PMID: 34392133] - Haolei Li, Mengmeng Wang, Weili Kang, Ziman Lin, Fang Gan, Kehe Huang. Non-cytotoxic dosage of fumonisin B1 aggravates ochratoxin A-induced nephrocytotoxicity and apoptosis via ROS-dependent JNK/MAPK signaling pathway.
Toxicology.
2021 06; 457(?):152802. doi:
10.1016/j.tox.2021.152802. [PMID: 33905761] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Ying Wang, Ni Tang, Manyun Mao, Youyou Zhou, Yingfang Wu, Juan Li, Wei Zhang, Cong Peng, Xiang Chen, Jie Li. Fine particulate matter (PM2.5) promotes IgE-mediated mast cell activation through ROS/Gadd45b/JNK axis.
Journal of dermatological science.
2021 Apr; 102(1):47-57. doi:
10.1016/j.jdermsci.2021.02.004. [PMID: 33676788] - Xiaobin Fang, Jingyi Li, Xuechao Hao, Weiyi Zhang, Jie Zhong, Tao Zhu, Ren Liao. Exosomes From Packed Red Cells Induce Human Mast Cell Activation and the Production of Multiple Inflammatory Mediators.
Frontiers in immunology.
2021; 12(?):677905. doi:
10.3389/fimmu.2021.677905. [PMID: 34025676] - Guohua Huang, Jinwei Su, Wenqu Zhao, Zhixuan Deng, Ping Wang, Hangming Dong, Haijin Zhao, Shaoxi Cai. JNK modulates RAGE/β-catenin signaling and is essential for allergic airway inflammation in asthma.
Toxicology letters.
2021 Jan; 336(?):57-67. doi:
10.1016/j.toxlet.2020.10.002. [PMID: 33075463] - Ye Zhi, Chunhua Lu, Ganlin Zhu, Zhijie Li, Piaoyu Zhu, Yuting Liu, Weiwei Shi, Liling Su, Junkang Jiang, Jianhua Qu, Xinyuan Zhao. Positive regulation of the CREB phosphorylation via JNK-dependent pathway prevents antimony-induced neuronal apoptosis in PC12 cell and mice brain.
Neurotoxicology.
2020 12; 81(?):101-108. doi:
10.1016/j.neuro.2020.09.002. [PMID: 32920012] - Xiuting Zheng, Manyun Dai, Gangming Xu, Liming Chang, Julin Yang, Aiming Liu. Inhibition of inflammation by SP600125 in cholestatic liver injury is dependent on the administration‑based exposure profile.
International journal of molecular medicine.
2020 Dec; 46(6):2271-2279. doi:
10.3892/ijmm.2020.4742. [PMID: 33125089] - Guang-Chan Jing, Di Liu, Yu-Qin Liu, Meng-Ren Zhang. Nao-Fu-Cong ameliorates diabetic cognitive dysfunction by inhibition of JNK/CHOP/Bcl2-mediated apoptosis in vivo and in vitro.
Chinese journal of natural medicines.
2020 Sep; 18(9):704-713. doi:
10.1016/s1875-5364(20)60009-7. [PMID: 32928514] - Fatemah Fadel, Nora Al-Kandari, Farah Khashab, Farah Al-Saleh, May Al-Maghrebi. JNK inhibition alleviates oxidative DNA damage, germ cell apoptosis, and mitochondrial dysfunction in testicular ischemia reperfusion injury.
Acta biochimica et biophysica Sinica.
2020 Aug; 52(8):891-900. doi:
10.1093/abbs/gmaa074. [PMID: 32662511] - Xiaoxi Chen, Yu Zhao. Block of proliferation 1 promotes cell migration and invasion in human colorectal cancer cells via the JNK pathway.
Journal of clinical laboratory analysis.
2020 Jul; 34(7):e23283. doi:
10.1002/jcla.23283. [PMID: 32167616] - Joobyoung Yoon, Youngkyung Cho, Ki Yeon Kim, Min Ji Yoon, Hyo Seon Lee, Sangjun Davie Jeon, Yongcheol Cho, Chungho Kim, Moon Gyo Kim. A JUN N-terminal kinase inhibitor induces ectodomain shedding of the cancer-associated membrane protease Prss14/epithin via protein kinase CβII.
The Journal of biological chemistry.
2020 05; 295(20):7168-7177. doi:
10.1074/jbc.ra119.011206. [PMID: 32241917] - Chih-Ying Changchien, Meng-Ho Sung, Hsin-Han Chang, Wen-Chiuan Tsai, Yu-Sen Peng, Ying Chen. Uremic toxin indoxyl sulfate suppresses myocardial Cx43 assembly and expression via JNK activation.
Chemico-biological interactions.
2020 Mar; 319(?):108979. doi:
10.1016/j.cbi.2020.108979. [PMID: 32045570] - Xia Qin, Qianghu Tang, Xuejun Jiang, Jun Zhang, Bin Wang, Xuemei Liu, Yandan Zhang, Zhen Zou, Chengzhi Chen. Zinc Oxide Nanoparticles Induce Ferroptotic Neuronal Cell Death in vitro and in vivo.
International journal of nanomedicine.
2020; 15(?):5299-5315. doi:
10.2147/ijn.s250367. [PMID: 32884256] - Haiyang Yu, Chun-Li Wu, Xiangyu Wang, Qianhong Ban, Chunhua Quan, Mengbo Liu, Hangqi Dong, Jinfeng Li, Gi-Young Kim, Yung Hyun Choi, Zhenya Wang, Cheng-Yun Jin. SP600125 enhances C-2-induced cell death by the switch from autophagy to apoptosis in bladder cancer cells.
Journal of experimental & clinical cancer research : CR.
2019 Nov; 38(1):448. doi:
10.1186/s13046-019-1467-6. [PMID: 31685029] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Woo Kim, Haruhiko Tokuda, Tetsu Kawabata, Kazuhiko Fujita, Go Sakai, Daiki Nakashima, Junko Tachi, Gen Kuroyanagi, Rie Matsushima-Nishiwaki, Kumiko Tanabe, Takanobu Otsuka, Hiroki Iida, Osamu Kozawa. Enhancement by HSP90 inhibitor of PGD2-stimulated HSP27 induction in osteoblasts: Suppression of SAPK/JNK and p38 MAP kinase.
Prostaglandins & other lipid mediators.
2019 08; 143(?):106327. doi:
10.1016/j.prostaglandins.2019.03.002. [PMID: 30946899] - Ken-Ichiro Tanaka, Mikako Shimoda, Misato Kasai, Mayumi Ikeda, Yu Ishima, Masahiro Kawahara. Involvement of SAPK/JNK Signaling Pathway in Copper Enhanced Zinc-Induced Neuronal Cell Death.
Toxicological sciences : an official journal of the Society of Toxicology.
2019 05; 169(1):293-302. doi:
10.1093/toxsci/kfz043. [PMID: 30768131] - Chih-Ying Changchien, Yi-Hsuan Lin, Yu-Chen Cheng, Hsin-Han Chang, Yu-Sen Peng, Ying Chen. Indoxyl sulfate induces myotube atrophy by ROS-ERK and JNK-MAFbx cascades.
Chemico-biological interactions.
2019 May; 304(?):43-51. doi:
10.1016/j.cbi.2019.02.023. [PMID: 30849338] - Kyoung-Jae Won, Joo-Seop Park, Hyunyoung Jeong. Repression of hepatocyte nuclear factor 4 alpha by AP-1 underlies dyslipidemia associated with retinoic acid.
Journal of lipid research.
2019 04; 60(4):794-804. doi:
10.1194/jlr.m088880. [PMID: 30709899] - Qian-Qian Wang, Cui Zhai, Alafate Wahafu, Yan-Ting Zhu, Yong-Hui Liu, Lian-Qing Sun. Salvianolic acid B inhibits the development of diabetic peripheral neuropathy by suppressing autophagy and apoptosis.
The Journal of pharmacy and pharmacology.
2019 Mar; 71(3):417-428. doi:
10.1111/jphp.13044. [PMID: 30537209] - Dandan Yan, Xiaoqi Pan, Jianling Yao, Dun Wang, Xu Wu, Xiaoyi Chen, Nian Shi, Hong Yan. MAPKs and NF-κB-mediated acrylamide-induced neuropathy in rat striatum and human neuroblastoma cells SY5Y.
Journal of cellular biochemistry.
2019 03; 120(3):3898-3910. doi:
10.1002/jcb.27671. [PMID: 30368882] - Xiaoyang Xia, Xia Xiang, Fenghong Huang, Mingming Zheng, Zhen Zhang, Ling Han. Dietary canolol induces apoptosis in human cervical carcinoma HeLa cells through ROS-MAPK mediated mitochondrial signaling pathway: In vitro and in vivo.
Chemico-biological interactions.
2019 Feb; 300(?):138-150. doi:
10.1016/j.cbi.2019.01.016. [PMID: 30653946] - Xiaocui Chen, Liqun Li, Fuhong Liu, Josephine Hoh, Carolyn M Kapron, Ju Liu. Cadmium Induces Glomerular Endothelial Cell-Specific Expression of Complement Factor H via the -1635 AP-1 Binding Site.
Journal of immunology (Baltimore, Md. : 1950).
2019 02; 202(4):1210-1218. doi:
10.4049/jimmunol.1800081. [PMID: 30642982] - Pan Xu, Elhaseen Elamin, Montserrat Elizalde, Paul P H A Bours, Marieke J Pierik, Ad A M Masclee, Daisy M A E Jonkers. Modulation of Intestinal Epithelial Permeability by Plasma from Patients with Crohn's Disease in a Three-dimensional Cell Culture Model.
Scientific reports.
2019 02; 9(1):2030. doi:
10.1038/s41598-018-38322-8. [PMID: 30765731] - Feng-Ming Wang, Zhiai Hu, Xiaohua Liu, Jian Q Feng, Robert A Augsburger, James L Gutmann, Gerald N Glickman. Resveratrol represses tumor necrosis factor α/c-Jun N-terminal kinase signaling via autophagy in human dental pulp stem cells.
Archives of oral biology.
2019 Jan; 97(?):116-121. doi:
10.1016/j.archoralbio.2018.10.020. [PMID: 30384152] - Mengjie Jiang, Jinjin Fan, Xinli Qu, Songhui Li, Susan K Nilsson, Yu Bo Yang Sun, Yaping Chen, Di Yu, Dan Liu, Bi-Cheng Liu, Mingliang Tang, Wei Chen, Yi Ren, David J Nikolic-Paterson, Xiaoyun Jiang, Jinhua Li, Xueqing Yu. Combined Blockade of Smad3 and JNK Pathways Ameliorates Progressive Fibrosis in Folic Acid Nephropathy.
Frontiers in pharmacology.
2019; 10(?):880. doi:
10.3389/fphar.2019.00880. [PMID: 31447676] - Kenji Goto, Keiichi Hiramoto, Kazuya Ooi. Th2 and Th17 Induce Dry Skin in a Mouse Model of Arthritis.
Biological & pharmaceutical bulletin.
2019; 42(3):468-474. doi:
10.1248/bpb.b18-00803. [PMID: 30828078] - Yan-Hui Shen, Li-Ying Wang, Bao-Bao Zhang, Qi-Ming Hu, Pu Wang, Bai-Qiu He, Guan-Hu Bao, Jing-Yu Liang, Fei-Hua Wu. Ethyl Rosmarinate Protects High Glucose-Induced Injury in Human Endothelial Cells.
Molecules (Basel, Switzerland).
2018 Dec; 23(12):. doi:
10.3390/molecules23123372. [PMID: 30572638] - Yunxia Yang, Song Yu, Na Liu, Haibin Xu, Yunyun Gong, Yongning Wu, Peilong Wang, Xiaoou Su, Yucai Liao, Sarah De Saeger, Hans-Ulrich Humpf, Aibo Wu. Transcription Factor FOXO3a Is a Negative Regulator of Cytotoxicity of Fusarium mycotoxin in GES-1 Cells.
Toxicological sciences : an official journal of the Society of Toxicology.
2018 Dec; 166(2):370-381. doi:
10.1093/toxsci/kfy216. [PMID: 30169763] - Soo-Jin Kim, Thu-Huyen Pham, Yesol Bak, Hyung-Won Ryu, Sei-Ryang Oh, Do-Young Yoon. 7-Methoxy-luteolin-8-C-β-6-deoxy-xylo-pyranos-3-uloside exactly (mLU8C-PU) isolated from Arthraxon hispidus inhibits migratory and invasive responses mediated via downregulation of MMP-9 and IL-8 expression in MCF-7 breast cancer cells.
Environmental toxicology.
2018 Nov; 33(11):1143-1152. doi:
10.1002/tox.22620. [PMID: 30133131] - Xiaxia Wu, Hongwei Gao, Ying Hou, Jie Yu, Wen Sun, Ying Wang, Xiaoyan Chen, Yulin Feng, Qiong-Ming Xu, Xiuping Chen. Dihydronortanshinone, a natural product, alleviates LPS-induced inflammatory response through NF-κB, mitochondrial ROS, and MAPK pathways.
Toxicology and applied pharmacology.
2018 09; 355(?):1-8. doi:
10.1016/j.taap.2018.06.007. [PMID: 29906494] - Congrui Fu, Na Li, Yujia Yuan, Ri Wang, Jinting Chen, Jing Yang, Zan Guo, Sheng Wang, Yi Zhang, Yixian Liu, Jinghui Dong. Chronic intermittent hypobaric hypoxia provides vascular protection in the aorta of the 2-kidney, 1-clip rat model of hypertension.
Canadian journal of physiology and pharmacology.
2018 Aug; 96(8):807-814. doi:
10.1139/cjpp-2017-0356. [PMID: 29400080] - Marie-Christin Schulz, Luise Schumann, Ulrike Rottkord, Hans-Ulrich Humpf, Michael Gekle, Gerald Schwerdt. Synergistic action of the nephrotoxic mycotoxins ochratoxin A and citrinin at nanomolar concentrations in human proximal tubule-derived cells.
Toxicology letters.
2018 Jul; 291(?):149-157. doi:
10.1016/j.toxlet.2018.04.014. [PMID: 29673704] - Xiaoqi Pan, Xu Wu, Dandan Yan, Cheng Peng, Chaolong Rao, Hong Yan. Acrylamide-induced oxidative stress and inflammatory response are alleviated by N-acetylcysteine in PC12 cells: Involvement of the crosstalk between Nrf2 and NF-κB pathways regulated by MAPKs.
Toxicology letters.
2018 May; 288(?):55-64. doi:
10.1016/j.toxlet.2018.02.002. [PMID: 29426002] - Jiufei Duan, Jun Kang, Ting Deng, Xu Yang, Mingqing Chen. Exposure to DBP and High Iodine Aggravates Autoimmune Thyroid Disease Through Increasing the Levels of IL-17 and Thyroid-Binding Globulin in Wistar Rats.
Toxicological sciences : an official journal of the Society of Toxicology.
2018 05; 163(1):196-205. doi:
10.1093/toxsci/kfy019. [PMID: 29385629] - Xi-Bin Kao, Qun Chen, Yan Gao, Pin Fan, Jing-Hong Chen, Zhi-Lun Wang, Yan-Qi Wang, Ya-Ni Chen, Yong-Ping Yan. SP600125 blocks the proteolysis of cytoskeletal proteins in apoptosis induced by gas signaling molecule (NO) via decreasing the activation of caspase-3 in rabbit chondrocytes.
European journal of pharmacology.
2018 Apr; 824(?):40-47. doi:
10.1016/j.ejphar.2018.01.032. [PMID: 29409910] - Kyoko Senoo, Keisuke Yamashiro, Tadashi Yamamoto, Fumio Myokai, Mari Kawamura, Shogo Takashiba. Expression of optineurin isolated from rat-injured dental pulp and the effects on inflammatory signals in normal rat kidney cells.
Odontology.
2018 Apr; 106(2):135-144. doi:
10.1007/s10266-017-0314-5. [PMID: 28776281] - Gamze Bildik, Nazli Akin, Filiz Senbabaoglu, Yashar Esmalian, Gizem Nur Sahin, Defne Urman, Sercin Karahuseyinoglu, Umit Ince, Erhan Palaoglu, Cagatay Taskiran, Macit Arvas, Yilmaz Guzel, Kayhan Yakin, Ozgur Oktem. Endogenous c-Jun N-terminal kinase (JNK) activity marks the boundary between normal and malignant granulosa cells.
Cell death & disease.
2018 04; 9(4):421. doi:
10.1038/s41419-018-0459-3. [PMID: 29549247] - Di Zhu, Xue Deng, Xiao-Fei Han, Xiao-Xin Sun, Tao-Wen Pan, Lu-Ping Zheng, Yan-Qiu Liu. Wedelolactone Enhances Osteoblastogenesis through ERK- and JNK-mediated BMP2 Expression and Smad/1/5/8 Phosphorylation.
Molecules (Basel, Switzerland).
2018 Mar; 23(3):. doi:
10.3390/molecules23030561. [PMID: 29498687] - Christine Wenz, Dagmar Faust, Berenike Linz, Christian Turmann, Teodora Nikolova, John Bertin, Peter Gough, Peter Wipf, Anna Sophia Schröder, Stefan Krautwald, Cornelia Dietrich. t-BuOOH induces ferroptosis in human and murine cell lines.
Archives of toxicology.
2018 Feb; 92(2):759-775. doi:
10.1007/s00204-017-2066-y. [PMID: 28975372] - Huan Zhang, Xiuxia Liu, Shanshan Zhou, Ye Jia, Ying Li, Yuguo Song, Junnan Wang, Hao Wu. SP600125 suppresses Keap1 expression and results in NRF2-mediated prevention of diabetic nephropathy.
Journal of molecular endocrinology.
2018 02; 60(2):145-157. doi:
10.1530/jme-17-0260. [PMID: 29273684] - Wei Gao, Pei Lin, Eunson Hwang, Yushuai Wang, Zhengfei Yan, Hien T T Ngo, Tae-Hoo Yi. Pterocarpus santalinus L. Regulated Ultraviolet B Irradiation-induced Procollagen Reduction and Matrix Metalloproteinases Expression Through Activation of TGF-β/Smad and Inhibition of the MAPK/AP-1 Pathway in Normal Human Dermal Fibroblasts.
Photochemistry and photobiology.
2018 01; 94(1):139-149. doi:
10.1111/php.12835. [PMID: 28858391] - Jinhua Zhang, Daqiang Zhao, Ning Na, Heng Li, Bin Miao, Liangqing Hong, Zhengyu Huang. Renoprotective effect of erythropoietin via modulation of the STAT6/MAPK/NF-κB pathway in ischemia/reperfusion injury after renal transplantation.
International journal of molecular medicine.
2018 Jan; 41(1):25-32. doi:
10.3892/ijmm.2017.3204. [PMID: 29115389] - Jia-Fu Ji, Wan-Zhen Jiao, Yan Cheng, Hua Yan, Fan Su, Li-Li Chi. ShenFu Preparation Protects AML12 Cells Against Palmitic Acid-Induced Injury Through Inhibition of Both JNK/Nox4 and JNK/NFκB Pathways.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2018; 45(4):1617-1630. doi:
10.1159/000487728. [PMID: 29486473] - Joji Kusuyama, Tomokazu Ohnishi, Kenjiro Bandow, Muhammad Subhan Amir, Kaori Shima, Ichiro Semba, Tetsuya Matsuguchi. Constitutive activation of p46JNK2 is indispensable for C/EBPδ induction in the initial stage of adipogenic differentiation.
The Biochemical journal.
2017 10; 474(20):3421-3437. doi:
10.1042/bcj20170332. [PMID: 28887384] - Jeong Seon Kim, Eun Ju Kim, Hee-Sun Kim, Jonathan M Kurie, Young-Ho Ahn. MKK4 activates non-canonical NFκB signaling by promoting NFκB2-p100 processing.
Biochemical and biophysical research communications.
2017 09; 491(2):337-342. doi:
10.1016/j.bbrc.2017.07.099. [PMID: 28733031] - Liang Shi, Guoqing Zhang, Zhiyong Zheng, Bin Lu, Lili Ji. Andrographolide reduced VEGFA expression in hepatoma cancer cells by inactivating HIF-1α: The involvement of JNK and MTA1/HDCA.
Chemico-biological interactions.
2017 Aug; 273(?):228-236. doi:
10.1016/j.cbi.2017.06.024. [PMID: 28651835] - Bin-Fei Zhang, Peng-Fei Wang, Yu-Xuan Cong, Jin-Lai Lei, Hu Wang, Hai Huang, Shuang Han, Yan Zhuang. Anti-high mobility group box-1 (HMGB1) antibody attenuates kidney damage following experimental crush injury and the possible role of the tumor necrosis factor-α and c-Jun N-terminal kinase pathway.
Journal of orthopaedic surgery and research.
2017 Jul; 12(1):110. doi:
10.1186/s13018-017-0614-z. [PMID: 28701229] - Yeon Jeong Jang, Bongkyun Park, Hee-Weon Lee, Hye Jin Park, Hyun Jung Koo, Byung Oh Kim, Eun-Hwa Sohn, Sung Hee Um, Suhkneung Pyo. Sinigrin attenuates the progression of atherosclerosis in ApoE-/- mice fed a high-cholesterol diet potentially by inhibiting VCAM-1 expression.
Chemico-biological interactions.
2017 Jun; 272(?):28-36. doi:
10.1016/j.cbi.2017.05.006. [PMID: 28483571] - M V Shvedova, Ya D Anfinogenova, I A Schepetkin, D N Atochin. [JUN N-TERMINAL KINASES AND THEIR PHARMACOLOGICAL MODULATION OF ISCHE-MIC AND REPERFUSION INJURY OF THE BRAIN].
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova.
2017 Mar; 103(3):268-83. doi:
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Insect science.
2017 Feb; 24(1):17-26. doi:
10.1111/1744-7917.12285. [PMID: 26507465] - Jing-Yi Zhang, Gui-Bo Sun, Yun Luo, Min Wang, Wei Wang, Yu-Yang Du, Ying-Li Yu, Xiao-Bo Sun. Salvianolic Acid A Protects H9c2 Cells from Arsenic Trioxide-Induced Injury via Inhibition of the MAPK Signaling Pathway.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2017; 41(5):1957-1969. doi:
10.1159/000472409. [PMID: 28391263] - Hua Yan, Yanqiong Gao, Ying Zhang. Inhibition of JNK suppresses autophagy and attenuates insulin resistance in a rat model of nonalcoholic fatty liver disease.
Molecular medicine reports.
2017 Jan; 15(1):180-186. doi:
10.3892/mmr.2016.5966. [PMID: 27909723] - Hui Liu, Xibo Jing, Aiqiao Dong, Baobao Bai, Haiyan Wang. Overexpression of TIMP3 Protects Against Cardiac Ischemia/Reperfusion Injury by Inhibiting Myocardial Apoptosis Through ROS/Mapks Pathway.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2017; 44(3):1011-1023. doi:
10.1159/000485401. [PMID: 29179205] - Reo Nozaki, Toru Kono, Hiroki Bochimoto, Tsuyoshi Watanabe, Kaori Oketani, Yuichi Sakamaki, Naoto Okubo, Koji Nakagawa, Hiroshi Takeda. Zanthoxylum fruit extract from Japanese pepper promotes autophagic cell death in cancer cells.
Oncotarget.
2016 Oct; 7(43):70437-70446. doi:
10.18632/oncotarget.11926. [PMID: 27626481] - Gwang Hun Park, Hun Min Song, Jin Boo Jeong. The coffee diterpene kahweol suppresses the cell proliferation by inducing cyclin D1 proteasomal degradation via ERK1/2, JNK and GKS3β-dependent threonine-286 phosphorylation in human colorectal cancer cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2016 Sep; 95(?):142-8. doi:
10.1016/j.fct.2016.07.008. [PMID: 27424123] - Xuezhong Gong, Vladimir N Ivanov, Tom K Hei. 2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-κB, AP-1 and MAPK pathways in human proximal tubular cells.
Archives of toxicology.
2016 Sep; 90(9):2187-2200. doi:
10.1007/s00204-015-1600-z. [PMID: 26404762] - Eun-Yeong Kim, Hee-Jung Choi, Tae-Wook Chung, Jun-Yong Choi, Hyung Sik Kim, Yeon-Seop Jung, Syng-Ook Lee, Ki-Tae Ha. Water-extracted Perilla frutescens increases endometrial receptivity though leukemia inhibitory factor-dependent expression of integrins.
Journal of pharmacological sciences.
2016 Aug; 131(4):259-66. doi:
10.1016/j.jphs.2016.07.004. [PMID: 27562703] - Hongyan Zhang, Liqun Li, Yifan Wang, Fengyun Dong, Xiaocui Chen, Fuhong Liu, Dongmei Xu, Fan Yi, Carolyn M Kapron, Ju Liu. NF-κB signaling maintains the survival of cadmium-exposed human renal glomerular endothelial cells.
International journal of molecular medicine.
2016 Aug; 38(2):417-22. doi:
10.3892/ijmm.2016.2640. [PMID: 27315281] - Mi-Hee Yu, Syng-Ook Lee. Hydroquinone stimulates cell invasion through activator protein-1-dependent induction of MMP-9 in HepG2 human hepatoma cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2016 Mar; 89(?):120-5. doi:
10.1016/j.fct.2016.01.015. [PMID: 26807887] - Sheng-Hsuan Lin, Shean-Jaw Chiou, Wan-Ting Ho, Chao-Tang Chuang, Lea-Yea Chuang, Jinn-Yuh Guh. Arecoline-induced pro-fibrotic proteins in LLC-PK1 cells are dependent on c-Jun N-terminal kinase.
Toxicology.
2016 Feb; 344-346(?):53-60. doi:
10.1016/j.tox.2016.02.004. [PMID: 26908192] - Wen-Shin Wu, Chih-Chiang Chien, Yen-Chou Chen, Wen-Ta Chiu. Protein Kinase RNA-Like Endoplasmic Reticulum Kinase-Mediated Bcl-2 Protein Phosphorylation Contributes to Evodiamine-Induced Apoptosis of Human Renal Cell Carcinoma Cells.
PloS one.
2016; 11(8):e0160484. doi:
10.1371/journal.pone.0160484. [PMID: 27483435] - Sizhao Lu, Sathish Kumar Natarajan, Justin L Mott, Kusum K Kharbanda, Duygu Dee Harrison-Findik. Ceramide Induces Human Hepcidin Gene Transcription through JAK/STAT3 Pathway.
PloS one.
2016; 11(1):e0147474. doi:
10.1371/journal.pone.0147474. [PMID: 26807955] - Satoru Morishita, Keiko Tomita, Tomoji Ono, Michiaki Murakoshi, Kenji Saito, Keikichi Sugiyama, Hoyoku Nishino, Hisanori Kato. Lactoferrin attenuates fatty acid-induced lipotoxicity via Akt signaling in hepatocarcinoma cells.
Biochemistry and cell biology = Biochimie et biologie cellulaire.
2015 Dec; 93(6):566-73. doi:
10.1139/bcb-2015-0014. [PMID: 26335364] - Hui-Mei Wu, Lei Fang, Qi-Ying Shen, Rong-Yu Liu. SP600125 promotes resolution of allergic airway inflammation via TLR9 in an OVA-induced murine acute asthma model.
Molecular immunology.
2015 Oct; 67(2 Pt B):311-6. doi:
10.1016/j.molimm.2015.06.016. [PMID: 26139014] - Jie-Qiong Ma, Zhang Li, Wan-Ru Xie, Chan-Min Liu, Si-Si Liu. Quercetin protects mouse liver against CCl₄-induced inflammation by the TLR2/4 and MAPK/NF-κB pathway.
International immunopharmacology.
2015 Sep; 28(1):531-9. doi:
10.1016/j.intimp.2015.06.036. [PMID: 26218279] - Xiaoshuang Zhou, Chen Wang, Jihua Tian, Yanhong Wang, Yafeng Li, Zhaoyong Hu, Rongshan Li. Mitogen-activated protein kinase mediates mevalonate-stimulated human mesangial cell proliferation.
Molecular medicine reports.
2015 Aug; 12(2):2643-9. doi:
10.3892/mmr.2015.3715. [PMID: 25936991] - Li-Li Ji, Yu-Chen Sheng, Zhi-Yong Zheng, Liang Shi, Zheng-Tao Wang. The involvement of p62-Keap1-Nrf2 antioxidative signaling pathway and JNK in the protection of natural flavonoid quercetin against hepatotoxicity.
Free radical biology & medicine.
2015 Aug; 85(?):12-23. doi:
10.1016/j.freeradbiomed.2015.03.035. [PMID: 25881548] - Yang Li, Jiefang Wang, Guangming Chen, Shuiwang Feng, Panpan Wang, Xiaofeng Zhu, Ronghua Zhang. Quercetin promotes the osteogenic differentiation of rat mesenchymal stem cells via mitogen-activated protein kinase signaling.
Experimental and therapeutic medicine.
2015 Jun; 9(6):2072-2080. doi:
10.3892/etm.2015.2388. [PMID: 26136938] - Jianfeng Wang, Li Zhang, Ying Zhang, Meiling Luo, Qiong Wu, Lijun Yu, Haiying Chu. Transcriptional upregulation centra of HO-1 by EGB via the MAPKs/Nrf2 pathway in mouse C2C12 myoblasts.
Toxicology in vitro : an international journal published in association with BIBRA.
2015 Mar; 29(2):380-8. doi:
10.1016/j.tiv.2014.10.015. [PMID: 25449124] - Roxane E Vella, Nicolas J Pillon, Bader Zarrouki, Marine L Croze, Laetitia Koppe, Michel Guichardant, Sandra Pesenti, Marie-Agnès Chauvin, Jennifer Rieusset, Alain Géloën, Christophe O Soulage. Ozone exposure triggers insulin resistance through muscle c-Jun N-terminal kinase activation.
Diabetes.
2015 Mar; 64(3):1011-24. doi:
10.2337/db13-1181. [PMID: 25277399] - Chi-Rei Wu, Chia-Wen Tsai, Shu-Wei Chang, Chia-Yuan Lin, Li-Chun Huang, Chia-Wen Tsai. Carnosic acid protects against 6-hydroxydopamine-induced neurotoxicity in in vivo and in vitro model of Parkinson's disease: involvement of antioxidative enzymes induction.
Chemico-biological interactions.
2015 Jan; 225(?):40-6. doi:
10.1016/j.cbi.2014.11.011. [PMID: 25446857] - Naohiro Yamamoto, Takanobu Otsuka, Gen Kuroyanagi, Akira Kondo, Shingo Kainuma, Akira Nakakami, Rie Matsushima-Nishiwaki, Osamu Kozawa, Haruhiko Tokuda. Resveratrol reduces prostaglandin E1-stimulated osteoprotegerin synthesis in osteoblasts: suppression of stress-activated protein kinase/c-Jun N-terminal kinase.
Prostaglandins & other lipid mediators.
2015 Jan; 116-117(?):57-63. doi:
10.1016/j.prostaglandins.2015.01.003. [PMID: 25677506] - Zong-Zhuang Li, Zhen-Zhen Guo, Zhi Zhang, Qun-An Cao, Ya-Juan Zhu, Hua-Li Yao, Li-Li Wu, Qiu-Yan Dai. Nicotine-induced upregulation of VCAM-1, MMP-2, and MMP-9 through the α7-nAChR-JNK pathway in RAW264.7 and MOVAS cells.
Molecular and cellular biochemistry.
2015 Jan; 399(1-2):49-58. doi:
10.1007/s11010-014-2231-z. [PMID: 25381636] - Jee-Youn Kim, Ji-Young Choi, Hyeon-Ju Lee, Catherine Jeonghae Byun, Jung-Hyun Park, Jae Hoon Park, Ho-Seong Cho, Sung-Jin Cho, Sangmee Ahn Jo, Inho Jo. The Green Tea Component (-)-Epigallocatechin-3-Gallate Sensitizes Primary Endothelial Cells to Arsenite-Induced Apoptosis by Decreasing c-Jun N-Terminal Kinase-Mediated Catalase Activity.
PloS one.
2015; 10(9):e0138590. doi:
10.1371/journal.pone.0138590. [PMID: 26375285] - Jingjing Xie, Shouping Zhang, Yanxin Hu, Dirui Li, Jingmin Cui, Jia Xue, Guozhong Zhang, Levon M Khachigian, Jonathan Wong, Lunquan Sun, Ming Wang. Regulatory roles of c-jun in H5N1 influenza virus replication and host inflammation.
Biochimica et biophysica acta.
2014 Dec; 1842(12 Pt A):2479-88. doi:
10.1016/j.bbadis.2014.04.017. [PMID: 24780373] - Jeong-Eun Huh, Wong In Lee, Jung Won Kang, Dongwoo Nam, Do-Young Choi, Dong-Suk Park, Sang Hoon Lee, Jae-Dong Lee. Formononetin attenuates osteoclastogenesis via suppressing the RANKL-induced activation of NF-κB, c-Fos, and nuclear factor of activated T-cells cytoplasmic 1 signaling pathway.
Journal of natural products.
2014 Nov; 77(11):2423-31. doi:
10.1021/np500417d. [PMID: 25397676] - Eun-Ryeong Hahm, Joomin Lee, Shivendra V Singh. Role of mitogen-activated protein kinases and Mcl-1 in apoptosis induction by withaferin A in human breast cancer cells.
Molecular carcinogenesis.
2014 Nov; 53(11):907-16. doi:
10.1002/mc.22050. [PMID: 24019090] - Birendra Behera, Debasish Mishra, Bibhas Roy, K Sanjana P Devi, Rajan Narayan, Joyjyoti Das, Sudip K Ghosh, Tapas K Maiti. Abrus precatorius agglutinin-derived peptides induce ROS-dependent mitochondrial apoptosis through JNK and Akt/P38/P53 pathways in HeLa cells.
Chemico-biological interactions.
2014 Oct; 222(?):97-105. doi:
10.1016/j.cbi.2014.08.017. [PMID: 25305377] - Yosuke Kanno, Eri Kawashita, Akiko Kokado, Hiromi Kuretake, Kanako Ikeda, Kiyotaka Okada, Mariko Seishima, Shigeru Ueshima, Osamu Matsuo, Hiroyuki Matsuno. α2AP mediated myofibroblast formation and the development of renal fibrosis in unilateral ureteral obstruction.
Scientific reports.
2014 Aug; 4(?):5967. doi:
10.1038/srep05967. [PMID: 25095732] - D A Tipton, T B Carter, M Kh Dabbous. Inhibition of interleukin 1β-stimulated interleukin-6 production by cranberry components in human gingival epithelial cells: effects on nuclear factor κB and activator protein 1 activation pathways.
Journal of periodontal research.
2014 Aug; 49(4):437-47. doi:
10.1111/jre.12122. [PMID: 23952046]