XAV-939 (BioDeep_00000388990)

   


代谢物信息卡片


3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one

化学式: C14H11F3N2OS (312.0544152)
中文名称: 3,5,7,8-四氢-2-[4-(三氟甲基)苯基]-4H-硫代吡喃并[4,3-d]嘧啶-4-酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CSCC2=C1N=C(NC2=O)C3=CC=C(C=C3)C(F)(F)F
InChI: InChI=1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20)

描述信息

同义名列表

3 个代谢物同义名

3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one; XAV-939; XAV939



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kai Gao, Wenbo Shao, Tian Wei, Zihan Yan, Nianhu Li, Chaoliang Lv. Wnt-3a improves functional recovery after spinal cord injury by regulating the inflammatory and apoptotic response in rats via wnt/β-catenin signaling pathway. Brain research. 2024 01; 1822(?):148637. doi: 10.1016/j.brainres.2023.148637. [PMID: 37858855]
  • Ying Yang, Wei Zhou, Yihao Wang, Yunxuan Ge, Zheng Fan, Qingquan Liu, Yue Gao. Bavachin induces liver injury and cell apoptosis by targeting Wnt/β-catenin/DRP1 signaling pathway mediated mitochondrial dysfunction. Toxicology letters. 2023 Sep; 387(?):1-13. doi: 10.1016/j.toxlet.2023.09.006. [PMID: 37748667]
  • Cui Wang, Ji-Cong Chen, Hong-He Xiao, Liang Kong, Yu-Meng Zhao, Yu Tian, He Li, Jin-Ming Tian, Lin Cui, Cai-Ming Wen, Yi-Jun Shi, Jing-Xian Yang, De-Jing Shang. Jujuboside a promotes proliferation and neuronal differentiation of APPswe-overexpressing neural stem cells by activating Wnt/β-catenin signaling pathway. Neuroscience letters. 2022 02; 772(?):136473. doi: 10.1016/j.neulet.2022.136473. [PMID: 35077846]
  • Bing Tu, Bo Yu, Wei Wang, Juehong Li, Feng Yuan, Jing Zhu, Cunyi Fan. Inhibition of IL-17 prevents the progression of traumatic heterotopic ossification. Journal of cellular and molecular medicine. 2021 08; 25(16):7709-7719. doi: 10.1111/jcmm.16617. [PMID: 34189826]
  • Ye Zhang, Dan Zhao, Xutong Li, Beiyao Gao, Chengcheng Sun, Shaoting Zhou, Yanhong Ma, Xuemei Chen, Dongsheng Xu. The Wnt/β-Catenin Pathway Regulated Cytokines for Pathological Neuropathic Pain in Chronic Compression of Dorsal Root Ganglion Model. Neural plasticity. 2021; 2021(?):6680192. doi: 10.1155/2021/6680192. [PMID: 33959159]
  • Annika Fendler, Daniel Bauer, Jonas Busch, Klaus Jung, Annika Wulf-Goldenberg, Severine Kunz, Kun Song, Adam Myszczyszyn, Sefer Elezkurtaj, Bettina Erguen, Simone Jung, Wei Chen, Walter Birchmeier. Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients. Nature communications. 2020 02; 11(1):929. doi: 10.1038/s41467-020-14700-7. [PMID: 32066735]
  • Li Tao, Ying Gu, Jian Zheng, Jinkun Yang, Yingjie Zhu. Weichang'an suppressed migration and invasion of HCT116 cells by inhibiting Wnt/β-catenin pathway while upregulating ARHGAP25. Biotechnology and applied biochemistry. 2019 Sep; 66(5):787-793. doi: 10.1002/bab.1784. [PMID: 31169325]
  • Xin-Li Liu, Jin Meng, Xu-Tao Zhang, Xiao-Hua Liang, Feng Zhang, Guan-Ren Zhao, Tao Zhang. ING5 inhibits lung cancer invasion and epithelial-mesenchymal transition by inhibiting the WNT/β-catenin pathway. Thoracic cancer. 2019 04; 10(4):848-855. doi: 10.1111/1759-7714.13013. [PMID: 30810286]
  • Obinna N Obianom, Yong Ai, Yingjun Li, Wei Yang, Dong Guo, Hong Yang, Srilatha Sakamuru, Menghang Xia, Fengtian Xue, Yan Shu. Triazole-Based Inhibitors of the Wnt/β-Catenin Signaling Pathway Improve Glucose and Lipid Metabolisms in Diet-Induced Obese Mice. Journal of medicinal chemistry. 2019 01; 62(2):727-741. doi: 10.1021/acs.jmedchem.8b01408. [PMID: 30605343]
  • Ao Li, Yuchen Xu, Song Fan, Jialin Meng, Xufeng Shen, Qian Xiao, Yuan Li, Li Zhang, Xiansheng Zhang, Guanqing Wu, Chaozhao Liang, Dianqing Wu. Canonical Wnt inhibitors ameliorate cystogenesis in a mouse ortholog of human ADPKD. JCI insight. 2018 03; 3(5):. doi: 10.1172/jci.insight.95874. [PMID: 29515026]
  • Sai Chang, Wen-Chen Ruan, Ya-Zhou Xu, Yun-Jie Wang, Jie Pang, Lu-Yong Zhang, Hong Liao, Tao Pang. The natural product 4,10-aromadendranediol induces neuritogenesis in neuronal cells in vitro through activation of the ERK pathway. Acta pharmacologica Sinica. 2017 Jan; 38(1):29-40. doi: 10.1038/aps.2016.115. [PMID: 27840407]
  • Tim Koopmans, Stijn Crutzen, Mark H Menzen, Andrew J Halayko, Tillie-Louise Hackett, Darryl A Knight, Reinoud Gosens. Selective targeting of CREB-binding protein/β-catenin inhibits growth of and extracellular matrix remodelling by airway smooth muscle. British journal of pharmacology. 2016 12; 173(23):3327-3341. doi: 10.1111/bph.13620. [PMID: 27629364]
  • S Kuusela, H Wang, A A Wasik, H Suleiman, S Lehtonen. Tankyrase inhibition aggravates kidney injury in the absence of CD2AP. Cell death & disease. 2016 07; 7(?):e2302. doi: 10.1038/cddis.2016.217. [PMID: 27441654]
  • Haihua Zhang, Weixiao Nan, Shiyong Wang, Tietao Zhang, Huazhe Si, Fuhe Yang, Guangyu Li. Epidermal Growth Factor Promotes Proliferation and Migration of Follicular Outer Root Sheath Cells via Wnt/β-Catenin Signaling. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2016; 39(1):360-70. doi: 10.1159/000445630. [PMID: 27352380]
  • Dongwu Liu, Kangsen Mai, Yanjiao Zhang, Wei Xu, Qinghui Ai. Wnt/β-catenin signaling participates in the regulation of lipogenesis in the liver of juvenile turbot (Scophthalmus maximus L.). Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 2016 Jan; 191(?):155-62. doi: 10.1016/j.cbpb.2015.11.002. [PMID: 26545985]
  • Cathelijne W van den Berg, David A Elliott, Stefan R Braam, Christine L Mummery, Richard P Davis. Differentiation of Human Pluripotent Stem Cells to Cardiomyocytes Under Defined Conditions. Methods in molecular biology (Clifton, N.J.). 2016; 1353(?):163-80. doi: 10.1007/7651_2014_178. [PMID: 25626427]
  • Jing Chen, Jizhen Li, Zhigang Miao, Xingshun Xu, Chun-Feng Liu. XAV939, a small molecular inhibitor, provides neuroprotective effects on oligodentrocytes. Journal of neuroscience research. 2014 Oct; 92(10):1252-8. doi: 10.1002/jnr.23415. [PMID: 24861203]
  • Yasuhide Ohinata, Tomoyuki Tsukiyama. Establishment of trophoblast stem cells under defined culture conditions in mice. PloS one. 2014; 9(9):e107308. doi: 10.1371/journal.pone.0107308. [PMID: 25203285]
  • Renyue Bao, Tania Christova, Siyuan Song, Stephane Angers, Xiaojun Yan, Liliana Attisano. Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells. PloS one. 2012; 7(11):e48670. doi: 10.1371/journal.pone.0048670. [PMID: 23144924]