T0070907 (BioDeep_00000388964)
代谢物信息卡片
2-chloro-5-nitro-N-4-pyridinyl-benzamide
化学式: C12H8ClN3O3 (277.0254168)
中文名称: 2-氯-5-硝基-N-吡啶-苯甲酰胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=C(C=C1[N+](=O)[O-])C(=O)NC2=CC=NC=C2)Cl
InChI: InChI=1S/C12H8ClN3O3/c13-11-2-1-9(16(18)19)7-10(11)12(17)15-8-3-5-14-6-4-8/h1-7H,(H,14,15,17)
描述信息
T0070907 is a potent PPARγ antagonist with a Ki of 1 nM.
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:92553
- PubChem: 2777391
- Metlin: METLIN45368
- ChEMBL: CHEMBL510698
- CAS: 313516-66-4
- PMhub: MS000238997
- medchemexpress: HY-13202
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sierra D Riegl, Cassie Starnes, Dereje D Jima, Marine Baptissart, Anna Mae Diehl, Scott M Belcher, Michael Cowley. The imprinted gene Zac1 regulates steatosis in developmental cadmium-induced nonalcoholic fatty liver disease.
Toxicological sciences : an official journal of the Society of Toxicology.
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Pulmonary pharmacology & therapeutics.
2023 Jan; 79(?):102197. doi:
10.1016/j.pupt.2023.102197. [PMID: 36690317] - Douglas L Orsi, Steven J Ferrara, Stephan Siegel, Anders Friberg, Léa Bouché, Elisabeth Pook, Philip Lienau, Joseph P Bluck, Christopher T Lemke, Gizem Akcay, Timo Stellfeld, Hanna Meyer, Vera Pütter, Simon J Holton, Daniel Korr, Isabel Jerchel-Furau, Constantia Pantelidou, Craig A Strathdee, Matthew Meyerson, Knut Eis, Jonathan T Goldstein. Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists.
Bioorganic & medicinal chemistry.
2023 01; 78(?):117130. doi:
10.1016/j.bmc.2022.117130. [PMID: 36542958] - Qidong Ren, Xinni Xie, Chuanfang Zhao, Qing Wen, Ruiying Pan, Yuguo Du. 2,2',4,4'-Tetrabromodiphenyl Ether (PBDE 47) Selectively Stimulates Proatherogenic PPARγ Signatures in Human THP-1 Macrophages to Contribute to Foam Cell Formation.
Chemical research in toxicology.
2022 06; 35(6):1023-1035. doi:
10.1021/acs.chemrestox.2c00043. [PMID: 35575305] - Richard C Chang, Chloe S Thangavelu, Erika M Joloya, Angela Kuo, Zhuorui Li, Bruce Blumberg. Cannabidiol promotes adipogenesis of human and mouse mesenchymal stem cells via PPARγ by inducing lipogenesis but not lipolysis.
Biochemical pharmacology.
2022 03; 197(?):114910. doi:
10.1016/j.bcp.2022.114910. [PMID: 35026188] - Olivia Venezia, Sadia Islam, Christine Cho, Alicia R Timme-Laragy, Karilyn E Sant. Modulation of PPAR signaling disrupts pancreas development in the zebrafish, Danio rerio.
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Biology of reproduction.
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British journal of pharmacology.
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Endocrinology.
2017 02; 158(2):304-318. doi:
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Frontiers in pharmacology.
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Toxicology and applied pharmacology.
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Journal of neuroinflammation.
2015 Mar; 12(?):51. doi:
10.1186/s12974-015-0270-3. [PMID: 25889216] - Norihiro Yoshizaki, Takahiro Fujii, Hitoshi Masaki, Takeshi Okubo, Kunio Shimada, Ron Hashizume. Orange peel extract, containing high levels of polymethoxyflavonoid, suppressed UVB-induced COX-2 expression and PGE2 production in HaCaT cells through PPAR-γ activation.
Experimental dermatology.
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10.1111/exd.12394. [PMID: 25234831] - Eva-Maria Pferschy-Wenzig, Atanas G Atanasov, Clemens Malainer, Stefan M Noha, Olaf Kunert, Daniela Schuster, Elke H Heiss, Nicholas H Oberlies, Hildebert Wagner, Rudolf Bauer, Verena M Dirsch. Identification of isosilybin a from milk thistle seeds as an agonist of peroxisome proliferator-activated receptor gamma.
Journal of natural products.
2014 Apr; 77(4):842-7. doi:
10.1021/np400943b. [PMID: 24597776] - Young-Sool Hah, Hyun-Ho Joo, Young-Hoon Kang, Bong-Wook Park, Sun-Chul Hwang, Jong-Woo Kim, Iel-Yong Sung, Gyu-Jin Rho, Dong Kyun Woo, June-Ho Byun. Cultured human periosteal-derived cells have inducible adipogenic activity and can also differentiate into osteoblasts in a perioxisome proliferator-activated receptor-mediated fashion.
International journal of medical sciences.
2014; 11(11):1116-28. doi:
10.7150/ijms.9611. [PMID: 25170294] - X Wang, Y Sun, J Wong, D S Conklin. PPARγ maintains ERBB2-positive breast cancer stem cells.
Oncogene.
2013 Dec; 32(49):5512-21. doi:
10.1038/onc.2013.217. [PMID: 23770845] - Anke Jaudszus, Michael Gruen, Bernhard Watzl, Christina Ness, Alexander Roth, Alfred Lochner, Dagmar Barz, Holger Gabriel, Michael Rothe, Gerhard Jahreis. Evaluation of suppressive and pro-resolving effects of EPA and DHA in human primary monocytes and T-helper cells.
Journal of lipid research.
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10.1194/jlr.p031260. [PMID: 23349208] - Santosh Yadav, Muralidharan Anbalagan, Yongli Shi, Feng Wang, He Wang. Arsenic inhibits the adipogenic differentiation of mesenchymal stem cells by down-regulating peroxisome proliferator-activated receptor gamma and CCAAT enhancer-binding proteins.
Toxicology in vitro : an international journal published in association with BIBRA.
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PloS one.
2013; 8(10):e77481. doi:
10.1371/journal.pone.0077481. [PMID: 24155963] - Arisa Kawahara, Naoko Haraguchi, Hiroyuki Tsuchiya, Yoshito Ikeda, Susumu Hama, Kentaro Kogure. Peroxisome proliferator-activated receptor γ (PPARγ)-independent specific cytotoxicity against immature adipocytes induced by PPARγ antagonist T0070907.
Biological & pharmaceutical bulletin.
2013; 36(9):1428-34. doi:
10.1248/bpb.b13-00024. [PMID: 23995653] - O Hurtado, I Ballesteros, M I Cuartero, A Moraga, J M Pradillo, J Ramírez-Franco, D Bartolomé-Martín, D Pascual, M Torres, J Sánchez-Prieto, J B Salom, I Lizasoain, M A Moro. Daidzein has neuroprotective effects through ligand-binding-independent PPARγ activation.
Neurochemistry international.
2012 Jul; 61(1):119-27. doi:
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Acta biochimica et biophysica Sinica.
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International immunopharmacology.
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2008 May; 294(5):E898-909. doi:
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Brain research.
2008 Mar; 1200(?):146-58. doi:
10.1016/j.brainres.2008.01.047. [PMID: 18289512] - Hsiaoju Lee, Brian N Finck, Lynne A Jones, Michael J Welch, Robert H Mach. Synthesis and evaluation of a bromine-76-labeled PPARgamma antagonist 2-bromo-5-nitro-N-phenylbenzamide.
Nuclear medicine and biology.
2006 Oct; 33(7):847-54. doi:
10.1016/j.nucmedbio.2006.08.003. [PMID: 17045164] - Marika Collin, Oliver Murch, Christoph Thiemermann. Peroxisome proliferator-activated receptor-gamma antagonists GW9662 and T0070907 reduce the protective effects of lipopolysaccharide preconditioning against organ failure caused by endotoxemia.
Critical care medicine.
2006 Apr; 34(4):1131-8. doi:
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