SB 415286 (BioDeep_00000388498)

   


代谢物信息卡片


3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione

化学式: C16H10ClN3O5 (359.03089600000004)
中文名称: SB 415286
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C(=C1)C2=C(C(=O)NC2=O)NC3=CC(=C(C=C3)O)Cl)[N+](=O)[O-]
InChI: InChI=1S/C16H10ClN3O5/c17-10-7-8(5-6-12(10)21)18-14-13(15(22)19-16(14)23)9-3-1-2-4-11(9)20(24)25/h1-7,21H,(H2,18,19,22,23)

描述信息

同义名列表

3 个代谢物同义名

3-(3-Chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione; SB 415286; 3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Sooho Lee, Woo Kyeom Yang, Ji Ho Song, Young Min Ra, Jin-Hyun Jeong, Wonchae Choe, Insug Kang, Sung-Soo Kim, Joohun Ha. Anti-obesity effects of 3-hydroxychromone derivative, a novel small-molecule inhibitor of glycogen synthase kinase-3. Biochemical pharmacology. 2013 Apr; 85(7):965-76. doi: 10.1016/j.bcp.2012.12.023. [PMID: 23337568]
  • Eduard Sarró, Conxita Jacobs-Cachá, Emilio Itarte, Anna Meseguer. A pharmacologically-based array to identify targets of cyclosporine A-induced toxicity in cultured renal proximal tubule cells. Toxicology and applied pharmacology. 2012 Jan; 258(2):275-87. doi: 10.1016/j.taap.2011.11.007. [PMID: 22155090]
  • Goang-Won Cho, Min-Young Noh, Byung Yong Kang, Il-Whea Ku, Jiseon Park, Yoon-Ho Hong, Myung-Hwa Kim, Seung Hyun Kim. Development of a cellular tau enzyme-linked immunosorbent assay method for screening GSK-3β inhibitors. Assay and drug development technologies. 2011 Oct; 9(5):503-13. doi: 10.1089/adt.2010.0343. [PMID: 21561378]
  • Buer Sen, Zhihui Xie, Natasha Case, Meiyun Ma, Clinton Rubin, Janet Rubin. Mechanical strain inhibits adipogenesis in mesenchymal stem cells by stimulating a durable beta-catenin signal. Endocrinology. 2008 Dec; 149(12):6065-75. doi: 10.1210/en.2008-0687. [PMID: 18687779]
  • Marc Yeste-Velasco, Jaume Folch, Andres Jiménez, Victor Rimbau, Mercè Pallàs, Antoni Camins. GSK-3 beta inhibition and prevention of mitochondrial apoptosis inducing factor release are not involved in the antioxidant properties of SB-415286. European journal of pharmacology. 2008 Jul; 588(2-3):239-43. doi: 10.1016/j.ejphar.2008.04.019. [PMID: 18502415]
  • Laura Dugo, Marika Collin, David A Allen, Nimesh S A Patel, Inge Bauer, Eero Mervaala, Marjut Louhelainen, Simon J Foster, Muhammad M Yaqoob, Christoph Thiemermann. Inhibiting glycogen synthase kinase 3beta in sepsis. Novartis Foundation symposium. 2007; 280(?):128-42; discussion 142. doi: NULL. [PMID: 17380792]
  • Rizwan Farooqui, Shoutian Zhu, Gabriel Fenteany. Glycogen synthase kinase-3 acts upstream of ADP-ribosylation factor 6 and Rac1 to regulate epithelial cell migration. Experimental cell research. 2006 May; 312(9):1514-25. doi: 10.1016/j.yexcr.2006.01.018. [PMID: 16529739]
  • Laura Dugo, Marika Collin, David A Allen, Nimesh S A Patel, Inge Bauer, Eero M A Mervaala, Marjut Louhelainen, Simon J Foster, Muhammad M Yaqoob, Christoph Thiemermann. GSK-3beta inhibitors attenuate the organ injury/dysfunction caused by endotoxemia in the rat. Critical care medicine. 2005 Sep; 33(9):1903-12. doi: 10.1097/01.ccm.0000178350.21839.44. [PMID: 16148458]
  • E G Jordà, E Verdaguer, A M Canudas, A Jiménez, S Garcia de Arriba, C Allgaier, M Pallàs, A Camins. Implication of cyclin-dependent kinase 5 in the neuroprotective properties of lithium. Neuroscience. 2005; 134(3):1001-11. doi: 10.1016/j.neuroscience.2005.04.061. [PMID: 15979805]
  • Xuemin Wang, Maarten Janmaat, Anne Beugnet, Fiona E M Paulin, Christopher G Proud. Evidence that the dephosphorylation of Ser(535) in the epsilon-subunit of eukaryotic initiation factor (eIF) 2B is insufficient for the activation of eIF2B by insulin. The Biochemical journal. 2002 Oct; 367(Pt 2):475-81. doi: 10.1042/bj20020677. [PMID: 12133000]
  • P A Lochhead, M Coghlan, S Q Rice, C Sutherland. Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphatase and phosphoenolypyruvate carboxykinase gene expression. Diabetes. 2001 May; 50(5):937-46. doi: 10.2337/diabetes.50.5.937. [PMID: 11334436]