Selisistat (BioDeep_00000388463)
代谢物信息卡片
6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
化学式: C13H13ClN2O (248.0716358)
中文名称: 6-氯-2,3,4,9-四氢-1H-咔唑-1-甲酰胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)C(=O)N
InChI: InChI=1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17)
描述信息
C26170 - Protective Agent > C1509 - Neuroprotective Agent
Selisistat (EX-527) is a potent and selective SirT1 (Sir2 in Drosophila melanogaster) inhibitor with an IC50 of 123 nM for SirT1. Selisistat alleviates pathology in multiple animal and cell models of Huntington's disease[1][2].
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:90369
- PubChem: 5113032
- DrugBank: DB13978
- ChEMBL: CHEMBL420311
- CAS: 49843-98-3
- PMhub: MS000238463
- medchemexpress: HY-15452
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mona N BinMowyna, Nora A AlFaris, Ekram A Al-Sanea, Jozaa Z AlTamimi, Tahany S Aldayel. Resveratrol attenuates against high-fat-diet-promoted non-alcoholic fatty liver disease in rats mainly by targeting the miR-34a/SIRT1 axis.
Archives of physiology and biochemistry.
2022 Mar; ?(?):1-16. doi:
10.1080/13813455.2022.2046106. [PMID: 35254877] - Guanyu Yang, Qingde Li, Jing Peng, Lin Jin, Xiaoyu Zhu, Dongxiao Zheng, Yingxia Zhang, Rong Wang, Yanting Song, Wenting Hu, Xi Xie. Fucoxanthin regulates Nrf2 signaling to decrease oxidative stress and improves renal fibrosis depending on Sirt1 in HG-induced GMCs and STZ-induced diabetic rats.
European journal of pharmacology.
2021 Dec; 913(?):174629. doi:
10.1016/j.ejphar.2021.174629. [PMID: 34780751] - Ghedeir M Alshammari, Wahidah H Al-Qahtani, Nora A AlFaris, Norah A Albekairi, Sultan Alqahtani, Refaat Eid, Abu ElGasim A Yagoub, Laila Naif Al-Harbi, Mohammed Abdo Yahya. Quercetin alleviates cadmium chloride-induced renal damage in rats by suppressing endoplasmic reticulum stress through SIRT1-dependent deacetylation of Xbp-1s and eIF2α.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Sep; 141(?):111862. doi:
10.1016/j.biopha.2021.111862. [PMID: 34246189] - Jisong Ahn, Min Jung Kim, Ahyoung Yoo, Jiyun Ahn, Tae Youl Ha, Chang Hwa Jung, Hyo Deok Seo, Young Jin Jang. Identifying Codium fragile extract components and their effects on muscle weight and exercise endurance.
Food chemistry.
2021 Aug; 353(?):129463. doi:
10.1016/j.foodchem.2021.129463. [PMID: 33743428] - Yuanyuan Huang, Jianlin Lu, Li Zhan, Ming Wang, Ronghua Shi, Xiao Yuan, Xinjiao Gao, Xing Liu, Jianye Zang, Wei Liu, Xuebiao Yao. Resveratrol-induced Sirt1 phosphorylation by LKB1 mediates mitochondrial metabolism.
The Journal of biological chemistry.
2021 08; 297(2):100929. doi:
10.1016/j.jbc.2021.100929. [PMID: 34216621] - Qinglian Wang, Bing Zhao, Jie Zhang, Jingshu Sun, Simeng Wang, Xinyu Zhang, Ying Xu, Rong Wang. Faster lipid β-oxidation rate by acetyl-CoA carboxylase 2 inhibition alleviates high-glucose-induced insulin resistance via SIRT1/PGC-1α in human podocytes.
Journal of biochemical and molecular toxicology.
2021 Jul; 35(7):e22797. doi:
10.1002/jbt.22797. [PMID: 33957017] - Yang Wang, Yujuan Wang, Nan Cai, Tianshu Xu, Fei He. Anti-inflammatory effects of curcumin in acute lung injury: In vivo and in vitro experimental model studies.
International immunopharmacology.
2021 Jul; 96(?):107600. doi:
10.1016/j.intimp.2021.107600. [PMID: 33798807] - Huang Qiong, Ling Han, Nanxue Zhang, Huyan Chen, Kexiang Yan, Zhenghua Zhang, Ying Ma, Jinhua Xu. Glycyrrhizin improves the pathogenesis of psoriasis partially through IL-17A and the SIRT1-STAT3 axis.
BMC immunology.
2021 05; 22(1):34. doi:
10.1186/s12865-021-00421-z. [PMID: 34044769] - B O S Camara, N M Ocarino, B M Bertassoli, C Malm, F R Araújo, A M S Reis, E C Jorge, E G L Alves, R Serakides. Differentiation of canine adipose mesenchymal stem cells into insulin-producing cells: comparison of different culture medium compositions.
Domestic animal endocrinology.
2021 01; 74(?):106572. doi:
10.1016/j.domaniend.2020.106572. [PMID: 33039930] - Xiang-Sheng Zhang, Yue Lu, Tao Tao, Han Wang, Guang-Jie Liu, Xun-Zhi Liu, Cang Liu, Da-Yong Xia, Chun-Hua Hang, Wei Li. Fucoxanthin Mitigates Subarachnoid Hemorrhage-Induced Oxidative Damage via Sirtuin 1-Dependent Pathway.
Molecular neurobiology.
2020 Dec; 57(12):5286-5298. doi:
10.1007/s12035-020-02095-x. [PMID: 32876840] - E M Abd-Ella, A F El-Kott, A E El-Kenawy, H S Khalifa, M M Bin-Meferij, A M Alramlawy. Dehydroepiandrosterone protects against acetaminophen-induced liver damage in rats by upregulation of Bcl-2 and activation of sirt signalling.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2020 Dec; 71(6):. doi:
10.26402/jpp.2020.6.02. [PMID: 33727425] - Yue-Ming Zhang, Xiao-Yu Qu, Li-Na Tao, Jing-Hui Zhai, Huan Gao, Yan-Qing Song, Si-Xi Zhang. XingNaoJing injection ameliorates cerebral ischaemia/reperfusion injury via SIRT1-mediated inflammatory response inhibition.
Pharmaceutical biology.
2020 Dec; 58(1):16-24. doi:
10.1080/13880209.2019.1698619. [PMID: 31854225] - Nima Rajabi, Alexander L Nielsen, Christian A Olsen. Dethioacylation by Sirtuins 1-3: Considerations for Drug Design Using Mechanism-Based Sirtuin Inhibition.
ACS medicinal chemistry letters.
2020 Oct; 11(10):1886-1892. doi:
10.1021/acsmedchemlett.9b00580. [PMID: 33062169] - Wei Hong, Zhanying Wei, Zhaohui Qiu, Zheng Li, Chensheng Fu, Zhibin Ye, Xiaoya Xu. Atorvastatin promotes bone formation in aged apoE-/- mice through the Sirt1-Runx2 axis.
Journal of orthopaedic surgery and research.
2020 Aug; 15(1):303. doi:
10.1186/s13018-020-01841-0. [PMID: 32762716] - Amit Kundu, Prasanta Dey, Jae Hyeon Park, In Su Kim, Seung Jun Kwack, Hyung Sik Kim. EX-527 Prevents the Progression of High-Fat Diet-Induced Hepatic Steatosis and Fibrosis by Upregulating SIRT4 in Zucker Rats.
Cells.
2020 04; 9(5):. doi:
10.3390/cells9051101. [PMID: 32365537] - Amit Kundu, Sachan Richa, Prasanta Dey, Kyeong Seok Kim, Ji Yeon Son, Hae Ri Kim, Seok-Yong Lee, Byung-Hoon Lee, Kwang Youl Lee, Sam Kacew, Byung Mu Lee, Hyung Sik Kim. Protective effect of EX-527 against high-fat diet-induced diabetic nephropathy in Zucker rats.
Toxicology and applied pharmacology.
2020 03; 390(?):114899. doi:
10.1016/j.taap.2020.114899. [PMID: 31981641] - Xiao-Lan Yao, Han Liu, Peng Li, Wen-Pei Chen, Shi-Xia Guan, Yang Chen, Yi-Na Wu, Bao-Qin Lin. Aqueous Extract of Whitmania Pigra Whitman Alleviates Thrombus Burden Via Sirtuin 1/NF-κB Pathway.
The Journal of surgical research.
2020 01; 245(?):441-452. doi:
10.1016/j.jss.2019.07.094. [PMID: 31445496] - Luciana L Ferreira, Marlene Cervantes, Hugo J C Froufe, Conceição Egas, Teresa Cunha-Oliveira, Paolo Sassone-Corsi, Paulo J Oliveira. Doxorubicin persistently rewires cardiac circadian homeostasis in mice.
Archives of toxicology.
2020 01; 94(1):257-271. doi:
10.1007/s00204-019-02626-z. [PMID: 31768571] - Ting-Jie Ye, Yan-Lin Lu, Xiao-Feng Yan, Xu-Dong Hu, Xiao-Ling Wang. High mobility group box-1 release from H2O2-injured hepatocytes due to sirt1 functional inhibition.
World journal of gastroenterology.
2019 Sep; 25(36):5434-5450. doi:
10.3748/wjg.v25.i36.5434. [PMID: 31576091] - Mitra Ansari Dezfouli, Maryam Zahmatkesh, Maryam Farahmandfar, Fariba Khodagholi. Melatonin protective effect against amyloid β-induced neurotoxicity mediated by mitochondrial biogenesis; involvement of hippocampal Sirtuin-1 signaling pathway.
Physiology & behavior.
2019 05; 204(?):65-75. doi:
10.1016/j.physbeh.2019.02.016. [PMID: 30769106] - Xiaolan Yao, Wenpei Chen, Jin Liu, Han Liu, Janis Y Zhan, Shixia Guan, Ziqi Lu, Ping Tang, Peng Li, Baoqin Lin. Deep Vein Thrombosis is Modulated by Inflammation Regulated via Sirtuin 1/NF-κB Signalling Pathway in a Rat Model.
Thrombosis and haemostasis.
2019 Mar; 119(3):421-430. doi:
10.1055/s-0038-1676987. [PMID: 30616245] - Si Shi, Shaoqing Lei, Chaoliang Tang, Kai Wang, Zhongyuan Xia. Melatonin attenuates acute kidney ischemia/reperfusion injury in diabetic rats by activation of the SIRT1/Nrf2/HO-1 signaling pathway.
Bioscience reports.
2019 01; 39(1):. doi:
10.1042/bsr20181614. [PMID: 30578379] - Anusara Daenthanasanmak, Supinya Iamsawat, Paramita Chakraborty, Hung D Nguyen, David Bastian, Chen Liu, Shikhar Mehrotra, Xue-Zhong Yu. Targeting Sirt-1 controls GVHD by inhibiting T-cell allo-response and promoting Treg stability in mice.
Blood.
2019 01; 133(3):266-279. doi:
10.1182/blood-2018-07-863233. [PMID: 30514750] - Winifred W Yau, Brijesh K Singh, Ronny Lesmana, Jin Zhou, Rohit A Sinha, Kiraely A Wong, Yajun Wu, Boon-Huat Bay, Shigeki Sugii, Lei Sun, Paul M Yen. Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy.
Autophagy.
2019 01; 15(1):131-150. doi:
10.1080/15548627.2018.1511263. [PMID: 30209975] - Qi-Yu Yang, Xiao-Dan Lai, Jing Ouyang, Jia-Dan Yang. Effects of Ginsenoside Rg3 on fatigue resistance and SIRT1 in aged rats.
Toxicology.
2018 11; 409(?):144-151. doi:
10.1016/j.tox.2018.08.010. [PMID: 30144466] - Shih-Hung Chan, Ching-Hsia Hung, Jhih-Yuan Shih, Pei-Ming Chu, Yung-Hsin Cheng, Huei-Chen Lin, Pei-Ling Hsieh, Kun-Ling Tsai. Exercise intervention attenuates hyperhomocysteinemia-induced aortic endothelial oxidative injury by regulating SIRT1 through mitigating NADPH oxidase/LOX-1 signaling.
Redox biology.
2018 04; 14(?):116-125. doi:
10.1016/j.redox.2017.08.016. [PMID: 28888894] - Jing Huang, Rui Tian, Yongqiang Yang, Rong Jiang, Jie Dai, Li Tang, Li Zhang. The SIRT1 inhibitor EX-527 suppresses mTOR activation and alleviates acute lung injury in mice with endotoxiemia.
Innate immunity.
2017 11; 23(8):678-686. doi:
10.1177/1753425917733531. [PMID: 28952835] - Marya S Sabir, Zainab Khan, Chengcheng Hu, Michael A Galligan, Christopher M Dussik, Sanchita Mallick, Angelika Dampf Stone, Shane F Batie, Elizabeth T Jacobs, G Kerr Whitfield, Mark R Haussler, Michael C Heck, Peter W Jurutka. SIRT1 enzymatically potentiates 1,25-dihydroxyvitamin D3 signaling via vitamin D receptor deacetylation.
The Journal of steroid biochemistry and molecular biology.
2017 09; 172(?):117-129. doi:
10.1016/j.jsbmb.2017.06.010. [PMID: 28636886] - Heng Zhang, Hao Yan, Xiaoliang Zhou, Huaqing Wang, Yiling Yang, Junling Zhang, Hui Wang. The protective effects of Resveratrol against radiation-induced intestinal injury.
BMC complementary and alternative medicine.
2017 Aug; 17(1):410. doi:
10.1186/s12906-017-1915-9. [PMID: 28814292] - Ling-Fang Wang, Xiao-Nv Wang, Cong-Cong Huang, Long Hu, Yun-Fei Xiao, Xiao-Hui Guan, Yi-Song Qian, Ke-Yu Deng, Hong-Bo Xin. Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1/AMPKα/SREBP1 signaling pathway.
Lipids in health and disease.
2017 Apr; 16(1):82. doi:
10.1186/s12944-017-0464-z. [PMID: 28449683] - Ning Zhang, Yan Hu, Chunchun Ding, Wenjing Zeng, Wen Shan, Hui Fan, Yan Zhao, Xue Shi, Lili Gao, Ting Xu, Ruiwen Wang, Dongyan Gao, Jihong Yao. Salvianolic acid B protects against chronic alcoholic liver injury via SIRT1-mediated inhibition of CRP and ChREBP in rats.
Toxicology letters.
2017 Feb; 267(?):1-10. doi:
10.1016/j.toxlet.2016.12.010. [PMID: 27989594] - Sadat A Aziz, Luisa A Wakeling, Satomi Miwa, Goiuri Alberdi, John E Hesketh, Dianne Ford. Metabolic programming of a beige adipocyte phenotype by genistein.
Molecular nutrition & food research.
2017 02; 61(2):. doi:
10.1002/mnfr.201600574. [PMID: 27670404] - Matthew H Levine, Zhonglin Wang, Haiyan Xiao, Jing Jiao, Liqing Wang, Tricia R Bhatti, Wayne W Hancock, Ulf H Beier. Targeting Sirtuin-1 prolongs murine renal allograft survival and function.
Kidney international.
2016 May; 89(5):1016-1026. doi:
10.1016/j.kint.2015.12.051. [PMID: 27083279] - Guang-Zhong Liu, Ting-Ting Hou, Yue Yuan, Peng-Zhou Hang, Jing-Jing Zhao, Li Sun, Guan-Qi Zhao, Jing Zhao, Jing-Mei Dong, Xiao-Bing Wang, Hang Shi, Yong-Wu Liu, Jing-Hua Zhou, Zeng-Xiang Dong, Yang Liu, Cheng-Chuang Zhan, Yue Li, Wei-Min Li. Fenofibrate inhibits atrial metabolic remodelling in atrial fibrillation through PPAR-α/sirtuin 1/PGC-1α pathway.
British journal of pharmacology.
2016 Mar; 173(6):1095-109. doi:
10.1111/bph.13438. [PMID: 26787506] - Zhenhua Zeng, Zhongqing Chen, Siqi Xu, Qin Zhang, Xingmin Wang, Youguang Gao, Ke-seng Zhao. Polydatin Protecting Kidneys against Hemorrhagic Shock-Induced Mitochondrial Dysfunction via SIRT1 Activation and p53 Deacetylation.
Oxidative medicine and cellular longevity.
2016; 2016(?):1737185. doi:
10.1155/2016/1737185. [PMID: 27057271] - Siqi Xu, Youguang Gao, Qin Zhang, Siwei Wei, Zhongqing Chen, Xingui Dai, Zhenhua Zeng, Ke-Seng Zhao. SIRT1/3 Activation by Resveratrol Attenuates Acute Kidney Injury in a Septic Rat Model.
Oxidative medicine and cellular longevity.
2016; 2016(?):7296092. doi:
10.1155/2016/7296092. [PMID: 28003866] - Yong Zhang, Ming-liang Chen, Yong Zhou, Long Yi, Yan-xiang Gao, Li Ran, Shi-hui Chen, Ting Zhang, Xi Zhou, Dan Zou, Bin Wu, Ying Wu, Hui Chang, Jun-dong Zhu, Qian-yong Zhang, Man-tian Mi. Resveratrol improves hepatic steatosis by inducing autophagy through the cAMP signaling pathway.
Molecular nutrition & food research.
2015 Aug; 59(8):1443-57. doi:
10.1002/mnfr.201500016. [PMID: 25943029] - Jing Pang, Ju Cui, Huan Gong, Chao Xi, Tie-Mei Zhang. Effect of NAD on PARP-mediated insulin sensitivity in oleic acid treated hepatocytes.
Journal of cellular physiology.
2015 Jul; 230(7):1607-13. doi:
10.1002/jcp.24907. [PMID: 25536389] - Sigurd D Süssmuth, Salman Haider, G Bernhard Landwehrmeyer, Ruth Farmer, Chris Frost, Giovanna Tripepi, Claus A Andersen, Marco Di Bacco, Claudia Lamanna, Enrica Diodato, Luisa Massai, Daniela Diamanti, Elisa Mori, Letizia Magnoni, Jens Dreyhaupt, Karin Schiefele, David Craufurd, Carsten Saft, Monika Rudzinska, Danuta Ryglewicz, Michael Orth, Sebastian Brzozy, Anna Baran, Giuseppe Pollio, Ralph Andre, Sarah J Tabrizi, Borje Darpo, Goran Westerberg. An exploratory double-blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington's disease.
British journal of clinical pharmacology.
2015 Mar; 79(3):465-76. doi:
10.1111/bcp.12512. [PMID: 25223731] - Goran Westerberg, Joseph A Chiesa, Claus A Andersen, Daniela Diamanti, Letizia Magnoni, Giuseppe Pollio, Borje Darpo, Meijian Zhou. Safety, pharmacokinetics, pharmacogenomics and QT concentration-effect modelling of the SirT1 inhibitor selisistat in healthy volunteers.
British journal of clinical pharmacology.
2015 Mar; 79(3):477-91. doi:
10.1111/bcp.12513. [PMID: 25223836] - Huaqing Cui, Zeeshan Kamal, Teng Ai, Yanli Xu, Swati S More, Daniel J Wilson, Liqiang Chen. Discovery of potent and selective sirtuin 2 (SIRT2) inhibitors using a fragment-based approach.
Journal of medicinal chemistry.
2014 Oct; 57(20):8340-57. doi:
10.1021/jm500777s. [PMID: 25275824] - Syed Quadri, Helmy M Siragy. Regulation of (pro)renin receptor expression in mIMCD via the GSK-3β-NFAT5-SIRT-1 signaling pathway.
American journal of physiology. Renal physiology.
2014 Sep; 307(5):F593-600. doi:
10.1152/ajprenal.00245.2014. [PMID: 24990896] - Murugavel Ponnusamy, Xiaoxu Zhou, Yanli Yan, Jinhua Tang, Evelyn Tolbert, Ting C Zhao, Rujun Gong, Shougang Zhuang. Blocking sirtuin 1 and 2 inhibits renal interstitial fibroblast activation and attenuates renal interstitial fibrosis in obstructive nephropathy.
The Journal of pharmacology and experimental therapeutics.
2014 Aug; 350(2):243-56. doi:
10.1124/jpet.113.212076. [PMID: 24833701] - M K Kemelo, L Wojnarová, N Kutinová Canová, H Farghali. D-galactosamine/lipopolysaccharide-induced hepatotoxicity downregulates sirtuin 1 in rat liver: role of sirtuin 1 modulation in hepatoprotection.
Physiological research.
2014; 63(5):615-23. doi:
10.33549/physiolres.932761. [PMID: 24908092] - Xuqin Zheng, Tao Sun, Xiaodong Wang. Activation of type 2 cannabinoid receptors (CB2R) promotes fatty acid oxidation through the SIRT1/PGC-1α pathway.
Biochemical and biophysical research communications.
2013 Jul; 436(3):377-81. doi:
10.1016/j.bbrc.2013.05.108. [PMID: 23747418] - Xia Zhou, Lucy X Fan, William E Sweeney, John M Denu, Ellis D Avner, Xiaogang Li. Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease.
The Journal of clinical investigation.
2013 Jul; 123(7):3084-98. doi:
10.1172/jci64401. [PMID: 23778143] - Yu Jin Jung, Jung Eun Lee, Ae Sin Lee, Kyung Pyo Kang, Sik Lee, Sung Kwang Park, Sang Yong Lee, Myung Kwan Han, Duk Hoon Kim, Won Kim. SIRT1 overexpression decreases cisplatin-induced acetylation of NF-κB p65 subunit and cytotoxicity in renal proximal tubule cells.
Biochemical and biophysical research communications.
2012 Mar; 419(2):206-10. doi:
10.1016/j.bbrc.2012.01.148. [PMID: 22330808] - Duk Hoon Kim, Yu Jin Jung, Jung Eun Lee, Ae Sin Lee, Kyung Pyo Kang, Sik Lee, Sung Kwang Park, Myung Kwan Han, Sang Yong Lee, Kunga Mohan Ramkumar, Mi Jeong Sung, Won Kim. SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53.
American journal of physiology. Renal physiology.
2011 Aug; 301(2):F427-35. doi:
10.1152/ajprenal.00258.2010. [PMID: 21593185] - Douglas A Velásquez, Gloria Martínez, Amparo Romero, María J Vázquez, Katia D Boit, Iria G Dopeso-Reyes, Miguel López, Anxo Vidal, Ruben Nogueiras, Carlos Diéguez. The central Sirtuin 1/p53 pathway is essential for the orexigenic action of ghrelin.
Diabetes.
2011 Apr; 60(4):1177-85. doi:
10.2337/db10-0802. [PMID: 21386086]