JANEX-1 (BioDeep_00000388330)
代谢物信息卡片
4-[(6,7-dimethoxy-4-quinazolinyl)amino]-phenol
化学式: C16H15N3O3 (297.111336)
中文名称: JANEX-1
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COc1cc2ncnc(Nc3ccc(O)cc3)c2cc1OC
InChI:
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Young-Bin Oh, Min Ahn, Sang-Myeong Lee, Hyoung-Won Koh, Sun-Hwa Lee, Suhn Hee Kim, Byung-Hyun Park. Inhibition of Janus activated kinase-3 protects against myocardial ischemia and reperfusion injury in mice.
Experimental & molecular medicine.
2013 May; 45(?):e23. doi:
10.1038/emm.2013.43. [PMID: 23680658] - Watchara Linwong, Noriyasu Hirasawa, Suzue Aoyama, Hirofumi Hamada, Takashi Saito, Kazuo Ohuchi. Inhibition of the antigen-induced activation of rodent mast cells by putative Janus kinase 3 inhibitors WHI-P131 and WHI-P154 in a Janus kinase 3-independent manner.
British journal of pharmacology.
2005 Jul; 145(6):818-28. doi:
10.1038/sj.bjp.0706240. [PMID: 15852029] - Paul S Changelian, Mark E Flanagan, Douglas J Ball, Craig R Kent, Kelly S Magnuson, William H Martin, Bonnie J Rizzuti, Perry S Sawyer, Bret D Perry, William H Brissette, Sandra P McCurdy, Elizabeth M Kudlacz, Maryrose J Conklyn, Eileen A Elliott, Erika R Koslov, Michael B Fisher, Timothy J Strelevitz, Kwansik Yoon, David A Whipple, Jianmin Sun, Michael J Munchhof, John L Doty, Jeffrey M Casavant, Todd A Blumenkopf, Michael Hines, Matthew F Brown, Brett M Lillie, Chakrapani Subramanyam, Chang Shang-Poa, Anthony J Milici, Gretchen E Beckius, James D Moyer, Chunyan Su, Thasia G Woodworth, Anderson S Gaweco, Chan R Beals, Bruce H Littman, Douglas A Fisher, James F Smith, Panayiotis Zagouras, Holly A Magna, Mary J Saltarelli, Kimberly S Johnson, Linda F Nelms, Shelley G Des Etages, Lisa S Hayes, Thomas T Kawabata, Deborah Finco-Kent, Deanna L Baker, Michael Larson, Ming-Sing Si, Ricardo Paniagua, John Higgins, Bari Holm, Bruce Reitz, Yong-Jie Zhou, Randall E Morris, John J O'Shea, Dominic C Borie. Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor.
Science (New York, N.Y.).
2003 Oct; 302(5646):875-8. doi:
10.1126/science.1087061. [PMID: 14593182] - H E Tibbles, A Vassilev, H Wendorf, D Schonhoff, D Zhu, D Lorenz, B Waurzyniak, X P Liu, F M Uckun. Role of a JAK3-dependent biochemical signaling pathway in platelet activation and aggregation.
The Journal of biological chemistry.
2001 May; 276(21):17815-22. doi:
10.1074/jbc.m011405200. [PMID: 11278899] - R Malavija, C L Chen, X P Liu, F M Uckun. In vivo pharmacokinetics and anti-anaphylactic activity of the novel mast cell inhibitor 4-(4'-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P131).
American journal of therapeutics.
2001 Jan; 8(1):35-9. doi:
10.1097/00045391-200101000-00007. [PMID: 11304656] - F M Uckun, O Ek, X P Liu, C L Chen. In vivo toxicity and pharmacokinetic features of the janus kinase 3 inhibitor WHI-P131 [4-(4'hydroxyphenyl)-amino-6,7- dimethoxyquinazoline.
Clinical cancer research : an official journal of the American Association for Cancer Research.
1999 Oct; 5(10):2954-62. doi:
NULL. [PMID: 10537365] - C L Chen, R Malaviya, H Chen, X P Liu, F M Uckun. Quantitative high-performance liquid chromatographic method for pharmacokinetic studies of the potent mast cell inhibitor 4-(4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P131).
Journal of chromatography. B, Biomedical sciences and applications.
1999 Apr; 727(1-2):205-12. doi:
10.1016/s0378-4347(99)00047-x. [PMID: 10360439] - R K Narla, X P Liu, D Klis, F M Uckun. Inhibition of human glioblastoma cell adhesion and invasion by 4-(4'-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P131) and 4-(3'-bromo-4'-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P154).
Clinical cancer research : an official journal of the American Association for Cancer Research.
1998 Oct; 4(10):2463-71. doi:
NULL. [PMID: 9796979]