tulobuterol (BioDeep_00000388313)

   


代谢物信息卡片


tulobuterol

化学式: C12H18ClNO (227.1077)
中文名称: 妥布特罗
谱图信息: 最多检出来源 not specific(not specific) 0%

分子结构信息

SMILES: CC(C)(C)NCC(C1=CC=CC=C1Cl)O
InChI: InChI=1S/C12H18ClNO/c1-12(2,3)14-8-11(15)9-6-4-5-7-10(9)13/h4-7,11,14-15H,8H2,1-3H3

描述信息

R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03C - Adrenergics for systemic use > R03CC - Selective beta-2-adrenoreceptor agonists
R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03A - Adrenergics, inhalants > R03AC - Selective beta-2-adrenoreceptor agonists
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
C78273 - Agent Affecting Respiratory System > C29712 - Anti-asthmatic Agent > C319 - Bronchodilator
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
Tulobuterol (C-78 free base) is a long-acting β2-adrenoceptor agonist, which reduces the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma. Tulobuterol is also a sympathomimetic agent used as a transdermal patch, and increases normal diaphragm muscle strength[1].

同义名列表

3 个代谢物同义名

tulobuterol; C-78 (free base); Tulobuterol hydrochloride



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Yongjing Liu, Miaoduo Deng, Jia Yu, Zhen Jiang, Xingjie Guo. Capillary electrophoretic enantioseparation of basic drugs using a new single-isomer cyclodextrin derivative and theoretical study of the chiral recognition mechanism. Journal of separation science. 2016 May; 39(9):1766-75. doi: 10.1002/jssc.201501026. [PMID: 26935589]
  • Xiao Han, Ran Liu, Lifang Ji, Mei Hui, Qing Li, Liang Fang, Kaishun Bi. Determination of tulobuterol in rat plasma using a liquid chromatography-tandem mass spectrometry method and its application to a pharmacokinetic study of tulobuterol patch. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Jan; 1008(?):108-114. doi: 10.1016/j.jchromb.2015.11.017. [PMID: 26638035]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Xiang-Dang Du, Yin-Liang Wu, Hong-Ju Yang, Ting Yang. Simultaneous determination of 10 β2-agonists in swine urine using liquid chromatography-tandem mass spectrometry and multi-walled carbon nanotubes as a reversed dispersive solid phase extraction sorbent. Journal of chromatography. A. 2012 Oct; 1260(?):25-32. doi: 10.1016/j.chroma.2012.08.066. [PMID: 22959774]
  • Akinori Nakamura, Daisuke Mori, Kakuji Tojo. Evaluation of the predicted time-concentration profile of serum tulobuterol in human after transdermal application. Chemical & pharmaceutical bulletin. 2012; 60(3):300-5. doi: 10.1248/cpb.60.300. [PMID: 22382408]
  • Tetsuo Watanabe, Hiroki Satoh, Satoko Hori, Akiko Miki, Hisakazu Ohtani, Yasufumi Sawada. [Model analysis of tulobuterol patch formulations to explain the influence of drug release rate and transdermal transfer rate on the plasma concentration profile]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2011; 131(10):1483-92. doi: 10.1248/yakushi.131.1483. [PMID: 21963976]
  • Jianrong Nie, Mingli Zhu, Jin Lian, Yunshan Pan, Xianglian Deng, Cuiping Hu. [Determination of fifteen beta-agonists in animal urine by high performance liquid chromatography-tandem mass spectrometry]. Se pu = Chinese journal of chromatography. 2010 Aug; 28(8):759-64. doi: 10.3724/sp.j.1123.2010.00759. [PMID: 21261043]
  • Daniele Di Corcia, Veronica Morra, Marco Pazzi, Marco Vincenti. Simultaneous determination of beta2-agonists in human urine by fast-gas chromatography/mass spectrometry: method validation and clinical application. Biomedical chromatography : BMC. 2010 Apr; 24(4):358-66. doi: 10.1002/bmc.1300. [PMID: 19642085]
  • R J B Peters, J E Oosterink, A A M Stolker, C Georgakopoulos, M W F Nielen. Generic sample preparation combined with high-resolution liquid chromatography-time-of-flight mass spectrometry for unification of urine screening in doping-control laboratories. Analytical and bioanalytical chemistry. 2010 Apr; 396(7):2583-98. doi: 10.1007/s00216-010-3484-3. [PMID: 20155493]
  • T Yamagata, T Hirano, H Sugiura, S Yanagisawa, T Ichikawa, K Ueshima, K Akamatsu, M Nakanishi, K Matsunaga, Y Minakata, M Ichinose. Comparison of bronchodilatory properties of transdermal and inhaled long-acting beta 2-agonists. Pulmonary pharmacology & therapeutics. 2008; 21(1):160-5. doi: 10.1016/j.pupt.2007.05.004. [PMID: 17632023]
  • Xiaofei Jia, Jianqiang Qu, Juan Meng, Bing Shao. [Simultaneous determination of nine beta2-agonists residues in urines by ultra performance liquid chromatography-electrospray tandem mass spectrometry]. Wei sheng yan jiu = Journal of hygiene research. 2007 Jul; 36(4):489-92. doi: NULL. [PMID: 17953220]
  • Naoto Burioka, Miyako Takata, Masahiro Endo, Masanori Miyata, Kenichi Takeda, Hiroki Chikumi, Katsuyuki Tomita, Yasushi Fukuoka, Hirofumi Nakazaki, Hiroyuki Sano, Eiji Shimizu. Treatment with beta2-adrenoceptor agonist in vivo induces human clock gene, Per1, mRNA expression in peripheral blood. Chronobiology international. 2007; 24(1):183-9. doi: 10.1080/07420520601140043. [PMID: 17364588]
  • Fengguo Xu, Zunjian Zhang, Yuan Tian, Haoyan Jiao, Jiabi Liang, Guoqing Gong. High-performance liquid chromatography electrospray ionization mass spectrometry determination of tulobuterol in rabbit's plasma. Journal of pharmaceutical and biomedical analysis. 2005 Feb; 37(1):187-93. doi: 10.1016/j.jpba.2004.09.052. [PMID: 15664761]
  • Leslie C Dickson, James D MacNeil, Stephen Lee, Adrian C E Fesser. Determination of beta-agonist residues in bovine urine using liquid chromatography-tandem mass spectrometry. Journal of AOAC International. 2005 Jan; 88(1):46-56. doi: . [PMID: 15759725]
  • Christine Widstrand, Fredrik Larsson, Maurizio Fiori, Cinzia Civitareale, Sabrina Mirante, Gianfranco Brambilla. Evaluation of MISPE for the multi-residue extraction of beta-agonists from calves urine. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2004 May; 804(1):85-91. doi: 10.1016/j.jchromb.2003.12.034. [PMID: 15093162]
  • Takahiko Horiguchi, Rieko Kondo, Junichi Miyazaki, Hiroshi Torigoe, Soichi Tachikawa. [Clinical evaluation of tulobuterol patch in patients with mild or moderate persistent bronchial asthma-effects of long-term treatment on airway inflammation and hypersensitivity]. Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society. 2004 Feb; 42(2):132-7. doi: NULL. [PMID: 15007912]
  • Takahiko Horiguchi, Rieko Kondo, Junichi Miyazaki, Koji Fukumokto, Hiroshi Torigoe. Clinical evaluation of a transdermal therapeutic system of the beta2-agonist tulobuterol in patients with mild or moderate persistent bronchial asthma. Arzneimittel-Forschung. 2004; 54(5):280-5. doi: 10.1055/s-0031-1296971. [PMID: 15212190]
  • Hiroaki Kume, Masashi Kondo, Yasushi Ito, Ryujiro Suzuki, Kenichi Yamaki, Kenzo Takagi. Effects of sustained-release tulobuterol on asthma control and beta-adrenoceptor function. Clinical and experimental pharmacology & physiology. 2002 Dec; 29(12):1076-83. doi: 10.1046/j.1440-1681.2002.03777.x. [PMID: 12390295]
  • Hideo Kato, Osamu Nagata, Masahiro Yamazaki, Toshihiro Suzuki, Yoshihisa Nakano. [Development of transdermal formulation of tulobuterol for the treatment of bronchial asthma]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2002 Jan; 122(1):57-69. doi: 10.1248/yakushi.122.57. [PMID: 11828751]
  • T Wachs, R L Sheppard, J Henion. Design and applications of a self-aligning liquid junction-electrospray interface for capillary electrophoresis-mass spectrometry. Journal of chromatography. B, Biomedical applications. 1996 Oct; 685(2):335-42. doi: 10.1016/s0378-4347(96)00176-4. [PMID: 8953176]
  • Y Iikura, H Uchiyama, K Akimoto, M Ebisawa, N Sakaguchi, T Tsubaki, H Ishizu, H Kabayama, K Yagi, K Miura. Pharmacokinetics and pharmacodynamics of the tulobuterol patch, HN-078, in childhood asthma. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 1995 Feb; 74(2):147-51. doi: NULL. [PMID: 7697473]
  • R E Dudley, S E Patterson, S V Machotka, J W Kesterson. One-month inhalation toxicity study of tulobuterol hydrochloride in rats and dogs. Fundamental and applied toxicology : official journal of the Society of Toxicology. 1989 Nov; 13(4):694-701. doi: 10.1016/0272-0590(89)90327-8. [PMID: 2576008]
  • L M Thienpont, P G Verhaeghe, A P De Leenheer. Measurement of tulobuterol in human plasma by capillary gas chromatography and selected ion monitoring detection. Biomedical & environmental mass spectrometry. 1987 Nov; 14(11):613-6. doi: 10.1002/bms.1200141107. [PMID: 2962665]
  • S G Wood, L F Chasseaud. Determination of tulobuterol in human plasma by capillary gas chromatography. Journal of chromatography. 1987 Apr; 416(1):154-9. doi: 10.1016/0378-4347(87)80497-8. [PMID: 2885335]
  • L F Chasseaud, S G Wood. Pharmacokinetics of the bronchodilator tulobuterol in man after repeated oral doses. The Journal of international medical research. 1986; 14(5):223-7. doi: 10.1177/030006058601400501. [PMID: 3770288]
  • J Brès, A M Clauzel, M C Pistre, H Rachmat, F Bressolle. [Metabolism of beta-adrenergic substances. Therapeutic implications]. Bulletin europeen de physiopathologie respiratoire. 1985 Sep; 21(5):19s-34s. doi: . [PMID: 2865990]
  • F L Fort, C L Yang, M C Pratt, S Tekeli, I A Heyman, P K Cusick, J W Kesterson. Tulobuterol: one-month intravenous safety studies in rats and dogs. Drug and chemical toxicology. 1984; 7(3):283-98. doi: 10.3109/01480548409035109. [PMID: 6734468]
  • K Matsumura, O Kubo, T Sakashita, H Kato, K Watanabe, M Hirobe. Determination of serum tulobuterol concentrations by mass fragmentography: comparison with an electron-capture gas chromatographic method. Journal of pharmaceutical sciences. 1983 May; 72(5):570-2. doi: 10.1002/jps.2600720526. [PMID: 6864510]
  • K Matsumura, O Kubo, T Sakashita, H Kato, K Watanabe, M Hirobe. Studies on the metabolism of tulobuterol . HCl. Identification of basic urinary metabolites in the dog, rat, rabbit, and guinea pig. Drug metabolism and disposition: the biological fate of chemicals. 1982 Sep; 10(5):537-41. doi: NULL. [PMID: 6128206]
  • K Matsumura, O Kubo, T Tsukada, K Nishide, H Kato, K Watanabe, M Hirobe. Determination of tulobuterol in human serum by electron-capture gas-liquid chromatography. Journal of chromatography. 1982 Jun; 230(1):148-53. doi: 10.1016/s0378-4347(00)81442-5. [PMID: 7107755]
  • K Matsumura, Y Takahara, T Aratani, K Nishide, H Kato, N Kiriyama. [Studies on the metabolic fate of tulobuterol. V. Species differences in the metabolism and excretion in rat, dog, guinea pig and rabbit (author's transl)]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 1981 Feb; 101(2):198-201. doi: 10.1248/yakushi1947.101.2_198. [PMID: 7288576]
  • K Matsumura, O Kubo, T Sakashita, Y Adachi, H Kato, K Watanabe, M Hirobe. Quantitative determination of tulobuterol and its metabolites in human urine by mass fragmentography. Journal of chromatography. 1981 Jan; 222(1):53-60. doi: 10.1016/s0378-4347(00)81032-4. [PMID: 7217327]