Tyrphostin AG 1296 (BioDeep_00000388019)

   


代谢物信息卡片


6,7-Dimethoxy-2-phenylquinoxaline

化学式: C16H14N2O2 (266.1055224)
中文名称: 6,7-二甲氧基-2-苯基喹喔啉
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=C(C=C2C(=C1)N=CC(=N2)C3=CC=CC=C3)OC
InChI: InChI=1S/C16H14N2O2/c1-19-15-8-12-13(9-16(15)20-2)18-14(10-17-12)11-6-4-3-5-7-11/h3-10H,1-2H3

描述信息

D000970 - Antineoplastic Agents > D020032 - Tyrphostins

同义名列表

2 个代谢物同义名

6,7-Dimethoxy-2-phenylquinoxaline; Tyrphostin AG 1296



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Rie Marunaka, Akiyuki Taruno, Toshiro Yamamoto, Narisato Kanamura, Yoshinori Marunaka. Action of Protein Tyrosine Kinase Inhibitors on the Hypotonicity-Stimulated Trafficking Kinetics of Epithelial Na+ Channels (ENaC) in Renal Epithelial Cells: Analysis Using a Mathematical Model. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2018; 50(1):363-377. doi: 10.1159/000494012. [PMID: 30308504]
  • Annette Wiedon, Markus Tölle, Joschika Bastine, Mirjam Schuchardt, Tao Huang, Vera Jankowski, Joachim Jankowski, Walter Zidek, Markus van der Giet. Uridine adenosine tetraphosphate (Up4A) is a strong inductor of smooth muscle cell migration via activation of the P2Y2 receptor and cross-communication to the PDGF receptor. Biochemical and biophysical research communications. 2012 Jan; 417(3):1035-40. doi: 10.1016/j.bbrc.2011.12.088. [PMID: 22214933]
  • Chuen-Mao Yang, Hsi-Lung Hsieh, Chung-Chen Yao, Li-Der Hsiao, Chin-Ping Tseng, Chou Bing Wu. Protein kinase C-delta transactivates platelet-derived growth factor receptor-alpha in mechanical strain-induced collagenase 3 (matrix metalloproteinase-13) expression by osteoblast-like cells. The Journal of biological chemistry. 2009 Sep; 284(38):26040-50. doi: 10.1074/jbc.m109.040154. [PMID: 19633290]
  • Crisanto S Escano, Lindsay B Keever, Alexander A Gutweiler, Bradley T Andresen. Angiotensin II activates extracellular signal-regulated kinase independently of receptor tyrosine kinases in renal smooth muscle cells: implications for blood pressure regulation. The Journal of pharmacology and experimental therapeutics. 2008 Jan; 324(1):34-42. doi: 10.1124/jpet.107.126300. [PMID: 17911376]
  • Nathan G Dolloff, Mike R Russell, Nick Loizos, Alessandro Fatatis. Human bone marrow activates the Akt pathway in metastatic prostate cells through transactivation of the alpha-platelet-derived growth factor receptor. Cancer research. 2007 Jan; 67(2):555-62. doi: 10.1158/0008-5472.can-06-2593. [PMID: 17234763]
  • Maria C Mendonça, Sonia Q Doi, Steven Glerum, Donald F Sellitti. Increase of C-type natriuretic peptide expression by serum and platelet-derived growth factor-BB in human aortic smooth muscle cells is dependent on protein kinase C activation. Endocrinology. 2006 Sep; 147(9):4169-78. doi: 10.1210/en.2006-0239. [PMID: 16777970]
  • Silvia Svegliati Baroni, Mariarosaria Santillo, Federica Bevilacqua, Michele Luchetti, Tatiana Spadoni, Matteo Mancini, Paolo Fraticelli, Paola Sambo, Ada Funaro, Andrius Kazlauskas, Enrico V Avvedimento, Armando Gabrielli. Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis. The New England journal of medicine. 2006 Jun; 354(25):2667-76. doi: 10.1056/nejmoa052955. [PMID: 16790699]
  • Catherine M Waters, Jaclyn Long, Irina Gorshkova, Yuko Fujiwara, Michelle Connell, Kristen E Belmonte, Gabor Tigyi, Viswanathan Natarajan, Susan Pyne, Nigel J Pyne. Cell migration activated by platelet-derived growth factor receptor is blocked by an inverse agonist of the sphingosine 1-phosphate receptor-1. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2006 Mar; 20(3):509-11. doi: 10.1096/fj.05-4810fje. [PMID: 16319133]
  • Craig A Smith, Peter J McClive, Quanah Hudson, Andrew H Sinclair. Male-specific cell migration into the developing gonad is a conserved process involving PDGF signalling. Developmental biology. 2005 Aug; 284(2):337-50. doi: 10.1016/j.ydbio.2005.05.030. [PMID: 16005453]
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