Taprostene (BioDeep_00000387834)

   


代谢物信息卡片


3-[(Z)-[(3aR,4R,5R,6aS)-4-[(1E,3S)-3-cyclohexyl-3-hydroxy-1-propenyl]hexahydro-5-hydroxy-2H-cyclopenta[b]furan-2-ylidene]methyl]-benzoic acid

化学式: C24H30O5 (398.2093)
中文名称: 前列腺素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CCC(CC1)C(C=CC2C(CC3C2CC(=CC4=CC(=CC=C4)C(=O)O)O3)O)O
InChI: InChI=1S/C24H30O5/c25-21(16-6-2-1-3-7-16)10-9-19-20-13-18(29-23(20)14-22(19)26)12-15-5-4-8-17(11-15)24(27)28/h4-5,8-12,16,19-23,25-26H,1-3,6-7,13-14H2,(H,27,28)/b10-9+,18-12-/t19-,20-,21-,22-,23+/m1/s1

描述信息

C78275 - Agent Affecting Blood or Body Fluid > C1327 - Antiplatelet Agent
D002317 - Cardiovascular Agents

同义名列表

4 个代谢物同义名

Taprostene; 3-[(Z)-[(3aR,4R,5R,6aS)-4-[(1E,3S)-3-cyclohexyl-3-hydroxy-1-propenyl]hexahydro-5-hydroxy-2H-cyclopenta[b]furan-2-ylidene]methyl]-benzoic acid; Rheocyclan; CG 4203



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Sylvia M Wilson, Neil A Sheddan, Robert Newton, Mark A Giembycz. Evidence for a second receptor for prostacyclin on human airway epithelial cells that mediates inhibition of CXCL9 and CXCL10 release. Molecular pharmacology. 2011 Mar; 79(3):586-95. doi: 10.1124/mol.110.069674. [PMID: 21173040]
  • M Spiecker, B Heinke, J Meyer, H Darius. In vitro analysis of synergistic effects of fibrinolytic agents and prostacyclin analogues. Haemostasis. 1997 Jul; 27(4):184-92. doi: 10.1159/000217455. [PMID: 9483173]
  • X L Ma, G Johnson, A M Lefer. Low doses of superoxide dismutase and a stable prostacyclin analogue protect in myocardial ischemia and reperfusion. Journal of the American College of Cardiology. 1992 Jan; 19(1):197-204. doi: 10.1016/0735-1097(92)90073-v. [PMID: 1729334]
  • J Schneider. Taprostene, a stable prostacyclin analogue, enhances the thrombolytic efficacy of saruplase (recombinant single-chain urokinase-type plasminogen activator) in rabbits with pulmonary embolized thrombi. Prostaglandins. 1991 Jun; 41(6):595-606. doi: 10.1016/0090-6980(91)90064-m. [PMID: 2052741]
  • D R VanAntwerp, L R Hedley, D A Spires, A M Strosberg, G Johnson, A M Lefer. Effects of prostacyclin and taprostene in splanchnic artery occlusion shock. Eicosanoids. 1991; 4(1):15-20. doi: NULL. [PMID: 2059456]
  • J Schneider. Beneficial effects of the prostacyclin analogue taprostene on cardiovascular, pulmonary and renal disturbances in endotoxin-shocked rabbits. Eicosanoids. 1991; 4(2):99-105. doi: NULL. [PMID: 1910868]
  • G Michel, U Seipp. In vitro studies with the stabilized epoprostenol analogue taprostene. Effect on platelets and erythrocytes. Arzneimittel-Forschung. 1990 Jul; 40(7):817-22. doi: NULL. [PMID: 2222558]
  • G Johnson, L E Furlan, N Aoki, A M Lefer. Endothelium and myocardial protecting actions of taprostene, a stable prostacyclin analogue, after acute myocardial ischemia and reperfusion in cats. Circulation research. 1990 May; 66(5):1362-70. doi: 10.1161/01.res.66.5.1362. [PMID: 2159389]
  • I Virgolini, P Fitscha, H Sinzinger, H Barth. Effects of taprostene, a stable prostacyclin analogue, on haemodynamics, platelet function and arachidonate metabolism in healthy volunteers. European journal of clinical pharmacology. 1990; 38(4):347-50. doi: 10.1007/bf00315573. [PMID: 2111774]
  • H Bitterman, B A Smith, D J Lefer, A M Lefer. Salutary effects of CG-4203, a novel, stable prostacyclin analog, in hemorrhagic shock. Journal of cardiovascular pharmacology. 1988 Sep; 12(3):293-9. doi: 10.1097/00005344-198809000-00006. [PMID: 2464101]
  • J Schneider. Salutary effects of the prostacyclin analogue CG 4203 in lethal endotoxemia in rats. Prostaglandins, leukotrienes, and essential fatty acids. 1988 Mar; 31(3):139-46. doi: 10.1016/0952-3278(88)90110-x. [PMID: 3287395]
  • H Bitterman, G L Stahl, A M Lefer. Protective effects of CG-4203, a novel stable prostacyclin analog, in traumatic shock. Prostaglandins. 1988 Jan; 35(1):41-50. doi: 10.1016/0090-6980(88)90273-0. [PMID: 3287456]
  • J Schneider. Stimulation of the plasma fibrinolytic activity in rats by the prostacyclin analogue CG 4203. Thrombosis research. 1987 Oct; 48(2):233-44. doi: 10.1016/0049-3848(87)90420-8. [PMID: 3321546]
  • B Müller, J Schneider, H H Hennies, L Flohé. Cardioprotective action of the new stable epoprostenol analogue CG 4203 in rat models of cardiac hypoxia and ischemia. Arzneimittel-Forschung. 1984; 34(11):1506-9. doi: NULL. [PMID: 6441579]
  • B Müller, J Schneider, K Wilsmann, W Lintz, L Flohé. Role of renin release in the hemodynamic, renal and dipsogenic actions of the prostacyclin analogue CG 4203 in conscious rats. Prostaglandins, leukotrienes, and medicine. 1983 Aug; 11(4):361-72. doi: 10.1016/0262-1746(83)90088-4. [PMID: 6353423]