SKI II (BioDeep_00000387771)

   


代谢物信息卡片


4-[[4-(4-chlorophenyl)-2-thiazolyl]amino]-phenol

化学式: C15H11ClN2OS (302.0281)
中文名称: 鞘氨醇激酶抑制剂
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CC=C1C2=CSC(=N2)NC3=CC=C(C=C3)O)Cl
InChI: InChI=1S/C15H11ClN2OS/c16-11-3-1-10(2-4-11)14-9-20-15(18-14)17-12-5-7-13(19)8-6-12/h1-9,19H,(H,17,18)

描述信息

同义名列表

4 个代谢物同义名

4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol; SKI II; 4-[[4-(4-chlorophenyl)-2-thiazolyl]amino]-phenol; Sphingosine Kinase Inhibitor 2



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Tiandi Ding, Ying Zhi, Weilin Xie, Qingqiang Yao, Bo Liu. Rational design of SphK inhibitors using crystal structures aided by computer. European journal of medicinal chemistry. 2021 Mar; 213(?):113164. doi: 10.1016/j.ejmech.2021.113164. [PMID: 33454547]
  • David R Adams, Salha Tawati, Giacomo Berretta, Paula Lopez Rivas, Jessica Baiget, Zhong Jiang, Aisha Alsfouk, Simon P Mackay, Nigel J Pyne, Susan Pyne. Topographical Mapping of Isoform-Selectivity Determinants for J-Channel-Binding Inhibitors of Sphingosine Kinases 1 and 2. Journal of medicinal chemistry. 2019 04; 62(7):3658-3676. doi: 10.1021/acs.jmedchem.9b00162. [PMID: 30889352]
  • Dominik Vogt, Julia Weber, Katja Ihlefeld, Astrid Brüggerhoff, Ewgenij Proschak, Holger Stark. Design, synthesis and evaluation of 2-aminothiazole derivatives as sphingosine kinase inhibitors. Bioorganic & medicinal chemistry. 2014 Oct; 22(19):5354-67. doi: 10.1016/j.bmc.2014.07.044. [PMID: 25150091]
  • Carmen B Rödl, Dominik Vogt, Simon B M Kretschmer, Katja Ihlefeld, Sebastian Barzen, Astrid Brüggerhoff, Janosch Achenbach, Ewgenij Proschak, Dieter Steinhilber, Holger Stark, Bettina Hofmann. Multi-dimensional target profiling of N,4-diaryl-1,3-thiazole-2-amines as potent inhibitors of eicosanoid metabolism. European journal of medicinal chemistry. 2014 Sep; 84(?):302-11. doi: 10.1016/j.ejmech.2014.07.025. [PMID: 25036790]
  • Francesca Cingolani, Mireia Casasampere, Pol Sanllehí, Josefina Casas, Jordi Bujons, Gemma Fabrias. Inhibition of dihydroceramide desaturase activity by the sphingosine kinase inhibitor SKI II. Journal of lipid research. 2014 Aug; 55(8):1711-20. doi: 10.1194/jlr.m049759. [PMID: 24875537]
  • Darin J Gustin, Yihong Li, Matthew L Brown, Xiaoshan Min, Mike J Schmitt, Malgorzata Wanska, Xiaodong Wang, Richard Connors, Sheere Johnstone, Mario Cardozo, Alan C Cheng, Shawn Jeffries, Brendon Franks, Shyun Li, Shanling Shen, Mariwil Wong, Holger Wesche, Guifen Xu, Timothy J Carlson, Matthew Plant, Kurt Morgenstern, Karen Rex, Joanna Schmitt, Angela Coxon, Nigel Walker, Frank Kayser, Zhulun Wang. Structure guided design of a series of sphingosine kinase (SphK) inhibitors. Bioorganic & medicinal chemistry letters. 2013 Aug; 23(16):4608-16. doi: 10.1016/j.bmcl.2013.06.030. [PMID: 23845219]
  • Keng Gat Lim, Francesca Tonelli, Evgeny Berdyshev, Irina Gorshkova, Tamara Leclercq, Stuart M Pitson, Robert Bittman, Susan Pyne, Nigel J Pyne. Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: functional differences between sphingosine kinase 1a and 1b. The international journal of biochemistry & cell biology. 2012 Sep; 44(9):1457-64. doi: 10.1016/j.biocel.2012.05.012. [PMID: 22634604]
  • Andrew J Kennedy, Thomas P Mathews, Yugesh Kharel, Saundra D Field, Morgan L Moyer, James E East, Joseph D Houck, Kevin R Lynch, Timothy L Macdonald. Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells. Journal of medicinal chemistry. 2011 May; 54(10):3524-48. doi: 10.1021/jm2001053. [PMID: 21495716]
  • Evgeny V Berdyshev, Irina Gorshkova, Peter Usatyuk, Satish Kalari, Yutong Zhao, Nigel J Pyne, Susan Pyne, Roger A Sabbadini, Joe G N Garcia, Viswanathan Natarajan. Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: role of sphingosine kinase 1 and S1P lyase. PloS one. 2011 Jan; 6(1):e16571. doi: 10.1371/journal.pone.0016571. [PMID: 21304987]
  • Carolyn Loveridge, Francesca Tonelli, Tamara Leclercq, Keng Gat Lim, Jaclyn S Long, Evgeny Berdyshev, Rothwelle J Tate, Viswanathan Natarajan, Stuart M Pitson, Nigel J Pyne, Susan Pyne. The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells. The Journal of biological chemistry. 2010 Dec; 285(50):38841-52. doi: 10.1074/jbc.m110.127993. [PMID: 20926375]
  • Arun K Sharma, Ugir Hossain Sk, Melissa A Gimbor, Jeremy A Hengst, Xujun Wang, Jong Yun, Shantu Amin. Synthesis and bioactivity of sphingosine kinase inhibitors and their novel aspirinyl conjugated analogs. European journal of medicinal chemistry. 2010 Sep; 45(9):4149-56. doi: 10.1016/j.ejmech.2010.06.005. [PMID: 20598402]
  • Mihwa Kim, Minjae Kim, Sang Won Park, Stuart M Pitson, H Thomas Lee. Isoflurane protects human kidney proximal tubule cells against necrosis via sphingosine kinase and sphingosine-1-phosphate generation. American journal of nephrology. 2010; 31(4):353-62. doi: 10.1159/000298339. [PMID: 20234131]
  • Kevin J French, Randy S Schrecengost, Brian D Lee, Yan Zhuang, Staci N Smith, Justin L Eberly, Jong K Yun, Charles D Smith. Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer research. 2003 Sep; 63(18):5962-9. doi: ". [PMID: 14522923]
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