NVP-AEW541 (BioDeep_00000387269)

   


代谢物信息卡片


7-[cis-3-(1-azetidinylmethyl)cyclobutyl]-5-[3-(phenylmethoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, dihydrochloride

化学式: C27H29N5O (439.2371984)
中文名称: 7-[反式-3-(1-氮杂环丁烷甲基)环丁基]-5-[3-(苯甲氧基)苯基]-7H-吡咯[2,3-D]嘧啶-4-胺, NVP-AEW541
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CN(C1)CC2CC(C2)N3C=C(C4=C(N=CN=C43)N)C5=CC(=CC=C5)OCC6=CC=CC=C6
InChI: InChI=1S/C27H29N5O/c28-26-25-24(21-8-4-9-23(14-21)33-17-19-6-2-1-3-7-19)16-32(27(25)30-18-29-26)22-12-20(13-22)15-31-10-5-11-31/h1-4,6-9,14,16,18,20,22H,5,10-13,15,17H2,(H2,28,29,30)

描述信息

同义名列表

3 个代谢物同义名

7-[cis-3-(1-azetidinylmethyl)cyclobutyl]-5-[3-(phenylmethoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, dihydrochloride; NVP-AEW541; 7-[trans-3-(1-AzetidinylMethyl)cyclobutyl]-5-[3-(phenylMethoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tri Wahyuni, Arisa Kobayashi, Shota Tanaka, Yoshiaki Miyake, Ayaha Yamamoto, Anton Bahtiar, Shota Mori, Yusuke Kametani, Masashi Tomimatsu, Kotaro Matsumoto, Makiko Maeda, Masanori Obana, Yasushi Fujio. Maresin-1 induces cardiomyocyte hypertrophy through IGF-1 paracrine pathway. American journal of physiology. Cell physiology. 2021 07; 321(1):C82-C93. doi: 10.1152/ajpcell.00568.2020. [PMID: 34038245]
  • Dingding Gao, Nan Jin, Yixian Fu, Yueyue Zhu, Yujie Wang, Ting Wang, Yuehong Chen, Mingming Zhang, Qiang Xiao, Min Huang, Yingxia Li. Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors. European journal of medicinal chemistry. 2021 Apr; 216(?):113333. doi: 10.1016/j.ejmech.2021.113333. [PMID: 33689932]
  • Xu Ding, Wei Han, Jing Wang, Wei Yang, Xiao-Feng Chang, Zhi-Yun Zhu, Hong Qin, Jin-Zhe Zhang, Xu Wang, Huan-Min Wang. IGF-1 alleviates serum IgG-induced neuronal cytolysis through PI3K signaling in children with opsoclonus-myoclonus syndrome and neuroblastoma. Pediatric research. 2019 05; 85(6):885-894. doi: 10.1038/s41390-018-0251-1. [PMID: 30718793]
  • Aleksandra Bielen, Gary Box, Lara Perryman, Lynn Bjerke, Sergey Popov, Yann Jamin, Alexa Jury, Melanie Valenti, Alexis de Haven Brandon, Vanessa Martins, Vincent Romanet, Sebastien Jeay, Florence I Raynaud, Francesco Hofmann, Simon P Robinson, Suzanne A Eccles, Chris Jones. Dependence of Wilms tumor cells on signaling through insulin-like growth factor 1 in an orthotopic xenograft model targetable by specific receptor inhibition. Proceedings of the National Academy of Sciences of the United States of America. 2012 May; 109(20):E1267-76. doi: 10.1073/pnas.1105034109. [PMID: 22529373]
  • Patricia Maiso, Enrique M Ocio, Mercedes Garayoa, Juan C Montero, Francesco Hofmann, Carlos García-Echeverría, Johann Zimmermann, Atanasio Pandiella, Jesús F San Miguel. The insulin-like growth factor-I receptor inhibitor NVP-AEW541 provokes cell cycle arrest and apoptosis in multiple myeloma cells. British journal of haematology. 2008 May; 141(4):470-82. doi: 10.1111/j.1365-2141.2008.07049.x. [PMID: 18341634]
  • Maria C Manara, Lorena Landuzzi, Patrizia Nanni, Giordano Nicoletti, Diana Zambelli, Pier Luigi Lollini, Cristina Nanni, Francesco Hofmann, Carlos García-Echeverría, Piero Picci, Katia Scotlandi. Preclinical in vivo study of new insulin-like growth factor-I receptor--specific inhibitor in Ewing's sarcoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2007 Feb; 13(4):1322-30. doi: 10.1158/1078-0432.ccr-06-1518. [PMID: 17317844]
  • Barbara Tanno, Camillo Mancini, Roberta Vitali, Mariateresa Mancuso, Heather P McDowell, Carlo Dominici, Giuseppe Raschellà. Down-regulation of insulin-like growth factor I receptor activity by NVP-AEW541 has an antitumor effect on neuroblastoma cells in vitro and in vivo. Clinical cancer research : an official journal of the American Association for Cancer Research. 2006 Nov; 12(22):6772-80. doi: 10.1158/1078-0432.ccr-06-1479. [PMID: 17121898]
  • Walter H Gotlieb, Ilan Bruchim, Jing Gu, Ying Shi, Anne Camirand, Marie-José Blouin, Yunhua Zhao, Michael N Pollak. Insulin-like growth factor receptor I targeting in epithelial ovarian cancer. Gynecologic oncology. 2006 Feb; 100(2):389-96. doi: 10.1016/j.ygyno.2005.09.048. [PMID: 16300820]
  • Jefferson Terry, Joanna M Lubieniecka, Wanda Kwan, Suzanne Liu, Torsten O Nielsen. Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin prevents synovial sarcoma proliferation via apoptosis in in vitro models. Clinical cancer research : an official journal of the American Association for Cancer Research. 2005 Aug; 11(15):5631-8. doi: 10.1158/1078-0432.ccr-05-0398. [PMID: 16061882]